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The map label for this gene is rnr [H]

Identifier: 148654034

GI number: 148654034

Start: 2778598

End: 2780910

Strand: Direct

Name: rnr [H]

Synonym: PsycPRwf_2237

Alternate gene names: 148654034

Gene position: 2778598-2780910 (Clockwise)

Preceding gene: 148654033

Following gene: 148654037

Centisome position: 93.27

GC content: 46.04

Gene sequence:

>2313_bases
ATGACCTGGAACGATCCTAACGCACAACAAGAAGCTCAAAACTACGAAAATCCTATCCCAAGCCGCTTGCTTATTTTGCA
AACCTTGGCCGATCAAGGAGAGCTTACTCACAAACAATTGGCCCAATCTTTTGGGATTGACAATGAAGATCAATTTGACG
CTTTAGGCAACCGCCTAAAGGCCATGGCCCGTGATGGCCAAGTCAACCGTGAAGGTAGACCTTATAAATACCGCGCTGTG
ACAAAGCAAGATGTGGTCACAGGTACCGTATCAGCGCATGCCAAAGGCTTCGGCTTTTTGGTACTTGATGACATGCCAGA
TTTGTTTTTGCATGAGAAACAGATGCGCTGGGTATTCAACGGTGATACCGTTAATGCTATCGGCACCACCACCGATAATC
GTGGCCGCACTGAAGGGCGTATTGTTGAGGTTATCGATCGCCAACAGACCCACTTTATCGGTACCTTAGAAAAAGATGAT
GAAGGCTATACCGTATCTTTGGCAAGCCCCAACAATCATCAACCGATTACCGTTACCGAAGACAATGTCAAGGCAGTGAA
TGCCAAGCCAGGTGTTGCGGTAAAAGTCGACATTATCGATTGGCCGACTCAACACGAATTTGCCACGGGTAAAATCGTTA
ACGTGATGGATGATGATAATGACCGTGAGGTAATTATTGAAACCACTTTGCTTAACTATGATATCCCAAGCGAATTTGGT
GCAGGTGTTATCAAGCAAGCCAATAGTTATAAAGAGCCTAACAAGAAAGATTTGCAAGGCCGCATTGATATCCGCGACTT
GCCAATGGTCACCATTGATGGTGAAGATTCACGCGACTTTGACGATGCGGTATATGCGGAGAAGCGTCCAGGCGGTAACT
ACCGTGTGGTAGTAGCCATCGCCGATGTGAGCCATTATGTCACCCCCAATTCAGCATTAGACCATGAAGCCTTCGAGCGG
GGTACTTCCGTATATTTCCCACATCATGTGGTACCAATGCTACCAGAAGTATTGTCTAATGGCCTGTGTTCATTGAACCC
AGGCGTTGACCGTCTATGCATGGTCGCCGATATTAAGTTATCACGCGCCGGCAATATCACCGGTTATGAGTTCTACCCTT
CTGTGATGCACTCTCAAGCCCGTTTGACCTATAACCAAGTCAATGATTACTTTGACGGTAATATGGAAAATGTTCCAGAC
TCTTTAACAGGCAATAAAGACGTTAAAAAATCTGTCGATACCATGCATCAGCTATACAAAGTATTGGTTAAAAAGCGCGA
AGAGCGCAATGCGATGGAGTTTGAGACACCTGAGACTTATATTAAGTTTAATGAAGAAGGCGGCATTGATGCCATCGTGC
CACGTACCCGTGGTGACTCGCACAAGCTGATTGAAGAGCTTATGTTATTGGCCAACACCTGTGCTGCTAACTTTGCCCTT
AAAAATGAGCTGCCCGTGTTATACCGTAATCACGATAAGCCAGATTCTGAGAAATCTCGTACAGTGCATGAATACGCCAA
AAACTTCGGTATCAGTTTCCCAGAGGAAAACCCCACTCAGGCGGACTACAAGCGGATTATCGAAGCCACCAAAGATCGTC
CAGATGCGGTGAGTATTCACAGCATGCTGCTGCGCTCTATGATGCAGGCCAACTACTCACCGGACAACATCGGTCACTTC
GGTCTTGCTTATGATGAATACTCACACTTTACCTCACCGATTCGCCGTTATCCTGACTTAATGCTGCACCGTGCTATTAA
GGCCAAAGTCACTGGTAAAAAACAACCGCAAATGGACTTTACGCTAGAAGAAGCCGGTCAGCAGACTTCAGATACGGAGC
GCCGTGCTGAAAAAGCCTCGCGCTTTGTTGAGAGCTGGTTAAAATGCCACTACATGAAAGATCATGTGGGTGAAGAGTTT
GATGGTGTGGTCACCACAGTCACCAGCTTCGGTCTATTTATCAATTTGACTGAATTGTTTATTGATGGCTTAGTGCACAT
CTCAAACGTGGGTAAAGACTACTTCGTTTATGATGAAAAGCAGCAGCAACTTATCGGCCAAGACAAAGGTATGGTCTATG
GTCTAGGCGACTTAGTACGTATTAAAGTGGCTGCGGTCAACATGGACTTATTGCAAATTGACTTTGAGCTTATTGCCAAG
CTTAAAGCCAGCGCCATGAACCAAACCAAAAAAGACGGTAAAGCCAACGCTAAACAAAAGCCATCGGCTCAAAACAGCAG
CGCTAAACATGGGGAAGACAAAAAACCGTCTCGTCGCCGTAGTAGCCGAGGCCGTGGTAAACCTAAGTCTTAG

Upstream 100 bases:

>100_bases
TTTATAAACACTGACTTGGTCAATTTAACTATCAAATCACTTGAACTATCAGACCACCCTTACATTTAAATTAAAACACA
AATAACTCATACGGTATTAT

Downstream 100 bases:

>100_bases
ACCGGTCTATAAGCTTACAACGCTTGAGACAAAAAAGTTGAACCGTTAAGCATAAAAAGGCGCCATTCAGTTATCTGGGT
GGCTTTTTTATTGGCTTATC

Product: ribonuclease R

Products: NA

Alternate protein names: RNase R; Protein vacB [H]

Number of amino acids: Translated: 770; Mature: 769

Protein sequence:

>770_residues
MTWNDPNAQQEAQNYENPIPSRLLILQTLADQGELTHKQLAQSFGIDNEDQFDALGNRLKAMARDGQVNREGRPYKYRAV
TKQDVVTGTVSAHAKGFGFLVLDDMPDLFLHEKQMRWVFNGDTVNAIGTTTDNRGRTEGRIVEVIDRQQTHFIGTLEKDD
EGYTVSLASPNNHQPITVTEDNVKAVNAKPGVAVKVDIIDWPTQHEFATGKIVNVMDDDNDREVIIETTLLNYDIPSEFG
AGVIKQANSYKEPNKKDLQGRIDIRDLPMVTIDGEDSRDFDDAVYAEKRPGGNYRVVVAIADVSHYVTPNSALDHEAFER
GTSVYFPHHVVPMLPEVLSNGLCSLNPGVDRLCMVADIKLSRAGNITGYEFYPSVMHSQARLTYNQVNDYFDGNMENVPD
SLTGNKDVKKSVDTMHQLYKVLVKKREERNAMEFETPETYIKFNEEGGIDAIVPRTRGDSHKLIEELMLLANTCAANFAL
KNELPVLYRNHDKPDSEKSRTVHEYAKNFGISFPEENPTQADYKRIIEATKDRPDAVSIHSMLLRSMMQANYSPDNIGHF
GLAYDEYSHFTSPIRRYPDLMLHRAIKAKVTGKKQPQMDFTLEEAGQQTSDTERRAEKASRFVESWLKCHYMKDHVGEEF
DGVVTTVTSFGLFINLTELFIDGLVHISNVGKDYFVYDEKQQQLIGQDKGMVYGLGDLVRIKVAAVNMDLLQIDFELIAK
LKASAMNQTKKDGKANAKQKPSAQNSSAKHGEDKKPSRRRSSRGRGKPKS

Sequences:

>Translated_770_residues
MTWNDPNAQQEAQNYENPIPSRLLILQTLADQGELTHKQLAQSFGIDNEDQFDALGNRLKAMARDGQVNREGRPYKYRAV
TKQDVVTGTVSAHAKGFGFLVLDDMPDLFLHEKQMRWVFNGDTVNAIGTTTDNRGRTEGRIVEVIDRQQTHFIGTLEKDD
EGYTVSLASPNNHQPITVTEDNVKAVNAKPGVAVKVDIIDWPTQHEFATGKIVNVMDDDNDREVIIETTLLNYDIPSEFG
AGVIKQANSYKEPNKKDLQGRIDIRDLPMVTIDGEDSRDFDDAVYAEKRPGGNYRVVVAIADVSHYVTPNSALDHEAFER
GTSVYFPHHVVPMLPEVLSNGLCSLNPGVDRLCMVADIKLSRAGNITGYEFYPSVMHSQARLTYNQVNDYFDGNMENVPD
SLTGNKDVKKSVDTMHQLYKVLVKKREERNAMEFETPETYIKFNEEGGIDAIVPRTRGDSHKLIEELMLLANTCAANFAL
KNELPVLYRNHDKPDSEKSRTVHEYAKNFGISFPEENPTQADYKRIIEATKDRPDAVSIHSMLLRSMMQANYSPDNIGHF
GLAYDEYSHFTSPIRRYPDLMLHRAIKAKVTGKKQPQMDFTLEEAGQQTSDTERRAEKASRFVESWLKCHYMKDHVGEEF
DGVVTTVTSFGLFINLTELFIDGLVHISNVGKDYFVYDEKQQQLIGQDKGMVYGLGDLVRIKVAAVNMDLLQIDFELIAK
LKASAMNQTKKDGKANAKQKPSAQNSSAKHGEDKKPSRRRSSRGRGKPKS
>Mature_769_residues
TWNDPNAQQEAQNYENPIPSRLLILQTLADQGELTHKQLAQSFGIDNEDQFDALGNRLKAMARDGQVNREGRPYKYRAVT
KQDVVTGTVSAHAKGFGFLVLDDMPDLFLHEKQMRWVFNGDTVNAIGTTTDNRGRTEGRIVEVIDRQQTHFIGTLEKDDE
GYTVSLASPNNHQPITVTEDNVKAVNAKPGVAVKVDIIDWPTQHEFATGKIVNVMDDDNDREVIIETTLLNYDIPSEFGA
GVIKQANSYKEPNKKDLQGRIDIRDLPMVTIDGEDSRDFDDAVYAEKRPGGNYRVVVAIADVSHYVTPNSALDHEAFERG
TSVYFPHHVVPMLPEVLSNGLCSLNPGVDRLCMVADIKLSRAGNITGYEFYPSVMHSQARLTYNQVNDYFDGNMENVPDS
LTGNKDVKKSVDTMHQLYKVLVKKREERNAMEFETPETYIKFNEEGGIDAIVPRTRGDSHKLIEELMLLANTCAANFALK
NELPVLYRNHDKPDSEKSRTVHEYAKNFGISFPEENPTQADYKRIIEATKDRPDAVSIHSMLLRSMMQANYSPDNIGHFG
LAYDEYSHFTSPIRRYPDLMLHRAIKAKVTGKKQPQMDFTLEEAGQQTSDTERRAEKASRFVESWLKCHYMKDHVGEEFD
GVVTTVTSFGLFINLTELFIDGLVHISNVGKDYFVYDEKQQQLIGQDKGMVYGLGDLVRIKVAAVNMDLLQIDFELIAKL
KASAMNQTKKDGKANAKQKPSAQNSSAKHGEDKKPSRRRSSRGRGKPKS

Specific function: 3'-5'exoribonuclease that participates in an essential cell function. Acts nonspecifically on poly(A), poly(U) and ribosomal RNAs. Required for the expression of virulence genes in enteroinvasive strains of E.coli [H]

COG id: COG0557

COG function: function code K; Exoribonuclease R

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 S1 motif domain [H]

Homologues:

Organism=Homo sapiens, GI190014625, Length=473, Percent_Identity=29.8097251585624, Blast_Score=192, Evalue=1e-48,
Organism=Homo sapiens, GI190014623, Length=473, Percent_Identity=29.8097251585624, Blast_Score=192, Evalue=1e-48,
Organism=Homo sapiens, GI19115966, Length=629, Percent_Identity=26.8680445151033, Blast_Score=171, Evalue=2e-42,
Organism=Homo sapiens, GI219521928, Length=629, Percent_Identity=26.8680445151033, Blast_Score=170, Evalue=4e-42,
Organism=Homo sapiens, GI134288890, Length=487, Percent_Identity=27.9260780287474, Blast_Score=160, Evalue=4e-39,
Organism=Homo sapiens, GI156105695, Length=298, Percent_Identity=24.496644295302, Blast_Score=74, Evalue=5e-13,
Organism=Homo sapiens, GI156105693, Length=198, Percent_Identity=28.2828282828283, Blast_Score=71, Evalue=5e-12,
Organism=Escherichia coli, GI87082383, Length=738, Percent_Identity=44.4444444444444, Blast_Score=596, Evalue=1e-171,
Organism=Escherichia coli, GI1787542, Length=648, Percent_Identity=26.6975308641975, Blast_Score=178, Evalue=1e-45,
Organism=Caenorhabditis elegans, GI17553506, Length=458, Percent_Identity=30.7860262008734, Blast_Score=187, Evalue=2e-47,
Organism=Caenorhabditis elegans, GI212645896, Length=414, Percent_Identity=31.4009661835749, Blast_Score=169, Evalue=7e-42,
Organism=Saccharomyces cerevisiae, GI6324552, Length=556, Percent_Identity=29.136690647482, Blast_Score=191, Evalue=4e-49,
Organism=Saccharomyces cerevisiae, GI6323943, Length=471, Percent_Identity=24.416135881104, Blast_Score=84, Evalue=6e-17,
Organism=Drosophila melanogaster, GI24649634, Length=468, Percent_Identity=29.7008547008547, Blast_Score=188, Evalue=1e-47,
Organism=Drosophila melanogaster, GI19922976, Length=437, Percent_Identity=27.9176201372998, Blast_Score=148, Evalue=1e-35,
Organism=Drosophila melanogaster, GI24654597, Length=437, Percent_Identity=27.9176201372998, Blast_Score=148, Evalue=1e-35,
Organism=Drosophila melanogaster, GI24654592, Length=437, Percent_Identity=27.9176201372998, Blast_Score=148, Evalue=2e-35,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011129
- InterPro:   IPR012340
- InterPro:   IPR016027
- InterPro:   IPR003029
- InterPro:   IPR022967
- InterPro:   IPR013223
- InterPro:   IPR001900
- InterPro:   IPR022966
- InterPro:   IPR004476
- InterPro:   IPR011805
- InterPro:   IPR013668 [H]

Pfam domain/function: PF08461 HTH_12; PF08206 OB_RNB; PF00773 RNB; PF00575 S1 [H]

EC number: 3.1.-.- [C]

Molecular weight: Translated: 86784; Mature: 86652

Theoretical pI: Translated: 6.12; Mature: 6.12

Prosite motif: PS00352 COLD_SHOCK ; PS50126 S1 ; PS01175 RIBONUCLEASE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTWNDPNAQQEAQNYENPIPSRLLILQTLADQGELTHKQLAQSFGIDNEDQFDALGNRLK
CCCCCCCHHHHHHHCCCCCCHHHHHHHHHHCCCCHHHHHHHHHCCCCCCHHHHHHHHHHH
AMARDGQVNREGRPYKYRAVTKQDVVTGTVSAHAKGFGFLVLDDMPDLFLHEKQMRWVFN
HHHHCCCCCCCCCCEEEEECCHHHHEEEEHHHCCCCEEEEEECCCCHHHHHHHHEEEEEC
GDTVNAIGTTTDNRGRTEGRIVEVIDRQQTHFIGTLEKDDEGYTVSLASPNNHQPITVTE
CCEEEEEECCCCCCCCCCCHHHEECCCCCHHEEEEEEECCCCEEEEEECCCCCCCEEEEC
DNVKAVNAKPGVAVKVDIIDWPTQHEFATGKIVNVMDDDNDREVIIETTLLNYDIPSEFG
CCCEEECCCCCCEEEEEEEECCCCCCCCCCCEEEEECCCCCCEEEEEEEEECCCCCHHHC
AGVIKQANSYKEPNKKDLQGRIDIRDLPMVTIDGEDSRDFDDAVYAEKRPGGNYRVVVAI
CHHHHHCCCCCCCCHHCCCCEEEEEECCEEEECCCCCCCCHHHHHHCCCCCCCEEEEEEE
ADVSHYVTPNSALDHEAFERGTSVYFPHHVVPMLPEVLSNGLCSLNPGVDRLCMVADIKL
ECCCCCCCCCCCCCHHHHHCCCEEECCCHHHHHHHHHHCCCCEECCCCCCCEEEEEEEEE
SRAGNITGYEFYPSVMHSQARLTYNQVNDYFDGNMENVPDSLTGNKDVKKSVDTMHQLYK
ECCCCCCCEEHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHH
VLVKKREERNAMEFETPETYIKFNEEGGIDAIVPRTRGDSHKLIEELMLLANTCAANFAL
HHHHHHHHCCCCCCCCCCEEEEECCCCCCEEECCCCCCCHHHHHHHHHHHHHHHHHCEEE
KNELPVLYRNHDKPDSEKSRTVHEYAKNFGISFPEENPTQADYKRIIEATKDRPDAVSIH
CCCCCEEECCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHCCCCCHHHHH
SMLLRSMMQANYSPDNIGHFGLAYDEYSHFTSPIRRYPDLMLHRAIKAKVTGKKQPQMDF
HHHHHHHHHCCCCCCCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCC
TLEEAGQQTSDTERRAEKASRFVESWLKCHYMKDHVGEEFDGVVTTVTSFGLFINLTELF
CHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHH
IDGLVHISNVGKDYFVYDEKQQQLIGQDKGMVYGLGDLVRIKVAAVNMDLLQIDFELIAK
HHHHHHHHHCCCCEEEECCHHHHHHCCCCCEEEECCCEEEEEEEEECCHHHHHHHHHHHH
LKASAMNQTKKDGKANAKQKPSAQNSSAKHGEDKKPSRRRSSRGRGKPKS
HHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHCCCCCCCC
>Mature Secondary Structure 
TWNDPNAQQEAQNYENPIPSRLLILQTLADQGELTHKQLAQSFGIDNEDQFDALGNRLK
CCCCCCHHHHHHHCCCCCCHHHHHHHHHHCCCCHHHHHHHHHCCCCCCHHHHHHHHHHH
AMARDGQVNREGRPYKYRAVTKQDVVTGTVSAHAKGFGFLVLDDMPDLFLHEKQMRWVFN
HHHHCCCCCCCCCCEEEEECCHHHHEEEEHHHCCCCEEEEEECCCCHHHHHHHHEEEEEC
GDTVNAIGTTTDNRGRTEGRIVEVIDRQQTHFIGTLEKDDEGYTVSLASPNNHQPITVTE
CCEEEEEECCCCCCCCCCCHHHEECCCCCHHEEEEEEECCCCEEEEEECCCCCCCEEEEC
DNVKAVNAKPGVAVKVDIIDWPTQHEFATGKIVNVMDDDNDREVIIETTLLNYDIPSEFG
CCCEEECCCCCCEEEEEEEECCCCCCCCCCCEEEEECCCCCCEEEEEEEEECCCCCHHHC
AGVIKQANSYKEPNKKDLQGRIDIRDLPMVTIDGEDSRDFDDAVYAEKRPGGNYRVVVAI
CHHHHHCCCCCCCCHHCCCCEEEEEECCEEEECCCCCCCCHHHHHHCCCCCCCEEEEEEE
ADVSHYVTPNSALDHEAFERGTSVYFPHHVVPMLPEVLSNGLCSLNPGVDRLCMVADIKL
ECCCCCCCCCCCCCHHHHHCCCEEECCCHHHHHHHHHHCCCCEECCCCCCCEEEEEEEEE
SRAGNITGYEFYPSVMHSQARLTYNQVNDYFDGNMENVPDSLTGNKDVKKSVDTMHQLYK
ECCCCCCCEEHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHH
VLVKKREERNAMEFETPETYIKFNEEGGIDAIVPRTRGDSHKLIEELMLLANTCAANFAL
HHHHHHHHCCCCCCCCCCEEEEECCCCCCEEECCCCCCCHHHHHHHHHHHHHHHHHCEEE
KNELPVLYRNHDKPDSEKSRTVHEYAKNFGISFPEENPTQADYKRIIEATKDRPDAVSIH
CCCCCEEECCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHCCCCCHHHHH
SMLLRSMMQANYSPDNIGHFGLAYDEYSHFTSPIRRYPDLMLHRAIKAKVTGKKQPQMDF
HHHHHHHHHCCCCCCCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCC
TLEEAGQQTSDTERRAEKASRFVESWLKCHYMKDHVGEEFDGVVTTVTSFGLFINLTELF
CHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHH
IDGLVHISNVGKDYFVYDEKQQQLIGQDKGMVYGLGDLVRIKVAAVNMDLLQIDFELIAK
HHHHHHHHHCCCCEEEECCHHHHHHCCCCCEEEECCCEEEEEEEEECCHHHHHHHHHHHH
LKASAMNQTKKDGKANAKQKPSAQNSSAKHGEDKKPSRRRSSRGRGKPKS
HHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7610040; 9278503; 3058695; 1400189; 9603904 [H]