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The map label for this gene is purK [H]

Identifier: 148654002

GI number: 148654002

Start: 2744833

End: 2746032

Strand: Direct

Name: purK [H]

Synonym: PsycPRwf_2205

Alternate gene names: 148654002

Gene position: 2744833-2746032 (Clockwise)

Preceding gene: 148654001

Following gene: 148654003

Centisome position: 92.14

GC content: 51.08

Gene sequence:

>1200_bases
ATGACCACAGCCAACGCTTATCCTGCCAACCAAACCATCCGCACCATCGGTATTCTAGGTGGCGGTCAACTCGGTATGAT
GCTGGCAGAAGCCGCACTACCTTTGGGCTACCGCTGCGTATTTTTAGAAGACGCGCCCCATTGCCCCGCCTCACTATACG
GCCAAGTCTTTACCAGTGAGCAATTAGACGACTTCGTTGCTGCAGCCGATGTGTTTACCTTAGAGTTTGAAAACACGCCT
GCCAAAACGGTGGCTTGGCTCAAGCAGCTGTCAGATGAGGGCACCAAGCAAGGGATGTATCCACCACCACAAGCCTTAGA
GGTGGCGCAGGACCGCTTAAGCGAAAAATCTTTATTTAATGAGCTGGGTATCCAGACCGTGCCATTTAAGAGCGTCAGCT
CAGAGCAAGAGTTGCAAGCGGCTGCCCAAGAGCTGGGGCTACCGTTGGTATTAAAGACCAGCCGCGGCGGTTATGATGGT
AAGGGTCAATTTGTACTAAAAACAGAAGCAGATATCAATGAGGCCTGGCAGGCTTTGGGGGAGGCTGTGACCGGCAAAGG
CAACTTGACCCCCACTCCAGCACCGCTTATCGCAGAAGGATTTATTAACTTTAGCCGCGAAGTTTCTATCATCGCCACCC
GTGCTCAAGATGGCAGCATGCGCACCTATGACTTGGTAGAAAACCACCACCACAATGGTATATTGGCCAAGTCGCAAGCG
CCTGCCGTGGGTACCAGCCACTTATTGCCTGCTGCTAAGTCTGCCATTGAAACCTTAATGAACCACTTAGATTATGTCGG
TACTATGGCACTTGAGCTGTTCGTCAGCAAAGATGCTGCGGGTAAAGATACCATTTTGGCCAATGAGATCGCGCCTCGGG
TACACAACTCAGGACATTGGAGCATTGAGGGGGCGGTCACCAGTCAATTCGAGAACCACATCCGTGCTGTGGTCGGTCTA
CCACTGGGTGATACCGATAATGTTTATCCGTCAATGATGATTAATGTCTTGGGCCAATATCCCAATATTGAGGAGGTACT
AAAAATCGATGGCGCTCATTATCACACCTATCACAAAGAGGAGCGTGACGATCGCAAGATTGCCCACATAACCTTGATGC
CAAATGACGTGGCTGCCCTTGAGCAGGCCTTGGCTGCTTTGGTACGTGCCTTGCCTAATAAGATGGGGCTCGAGTCTTGA

Upstream 100 bases:

>100_bases
TATTTTTGTGCGATACCCTTGTTGTCCAAATCATCTTATTATTTATTGTTATTTTTACGGTTTTGACTTCTCCTACTTTT
CACTAATTTAAGAGCCAAAC

Downstream 100 bases:

>100_bases
GCTTAGATACTCAAGCTACCAATCTGGCCAAACCACAAGCGGGCATGACCATCTGGATTGACGCCGATGCTTGCCCCTTG
GTGGTGAAAGATCTGATTAC

Product: phosphoribosylaminoimidazole carboxylase, ATPase

Products: NA

Alternate protein names: N5-CAIR synthase; 5-(carboxyamino)imidazole ribonucleotide synthetase [H]

Number of amino acids: Translated: 399; Mature: 398

Protein sequence:

>399_residues
MTTANAYPANQTIRTIGILGGGQLGMMLAEAALPLGYRCVFLEDAPHCPASLYGQVFTSEQLDDFVAAADVFTLEFENTP
AKTVAWLKQLSDEGTKQGMYPPPQALEVAQDRLSEKSLFNELGIQTVPFKSVSSEQELQAAAQELGLPLVLKTSRGGYDG
KGQFVLKTEADINEAWQALGEAVTGKGNLTPTPAPLIAEGFINFSREVSIIATRAQDGSMRTYDLVENHHHNGILAKSQA
PAVGTSHLLPAAKSAIETLMNHLDYVGTMALELFVSKDAAGKDTILANEIAPRVHNSGHWSIEGAVTSQFENHIRAVVGL
PLGDTDNVYPSMMINVLGQYPNIEEVLKIDGAHYHTYHKEERDDRKIAHITLMPNDVAALEQALAALVRALPNKMGLES

Sequences:

>Translated_399_residues
MTTANAYPANQTIRTIGILGGGQLGMMLAEAALPLGYRCVFLEDAPHCPASLYGQVFTSEQLDDFVAAADVFTLEFENTP
AKTVAWLKQLSDEGTKQGMYPPPQALEVAQDRLSEKSLFNELGIQTVPFKSVSSEQELQAAAQELGLPLVLKTSRGGYDG
KGQFVLKTEADINEAWQALGEAVTGKGNLTPTPAPLIAEGFINFSREVSIIATRAQDGSMRTYDLVENHHHNGILAKSQA
PAVGTSHLLPAAKSAIETLMNHLDYVGTMALELFVSKDAAGKDTILANEIAPRVHNSGHWSIEGAVTSQFENHIRAVVGL
PLGDTDNVYPSMMINVLGQYPNIEEVLKIDGAHYHTYHKEERDDRKIAHITLMPNDVAALEQALAALVRALPNKMGLES
>Mature_398_residues
TTANAYPANQTIRTIGILGGGQLGMMLAEAALPLGYRCVFLEDAPHCPASLYGQVFTSEQLDDFVAAADVFTLEFENTPA
KTVAWLKQLSDEGTKQGMYPPPQALEVAQDRLSEKSLFNELGIQTVPFKSVSSEQELQAAAQELGLPLVLKTSRGGYDGK
GQFVLKTEADINEAWQALGEAVTGKGNLTPTPAPLIAEGFINFSREVSIIATRAQDGSMRTYDLVENHHHNGILAKSQAP
AVGTSHLLPAAKSAIETLMNHLDYVGTMALELFVSKDAAGKDTILANEIAPRVHNSGHWSIEGAVTSQFENHIRAVVGLP
LGDTDNVYPSMMINVLGQYPNIEEVLKIDGAHYHTYHKEERDDRKIAHITLMPNDVAALEQALAALVRALPNKMGLES

Specific function: Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR) [H]

COG id: COG0026

COG function: function code F; Phosphoribosylaminoimidazole carboxylase (NCAIR synthetase)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ATP-grasp domain [H]

Homologues:

Organism=Escherichia coli, GI1786733, Length=380, Percent_Identity=34.2105263157895, Blast_Score=191, Evalue=9e-50,
Organism=Escherichia coli, GI1788155, Length=331, Percent_Identity=24.773413897281, Blast_Score=77, Evalue=2e-15,
Organism=Saccharomyces cerevisiae, GI6324702, Length=394, Percent_Identity=32.741116751269, Blast_Score=192, Evalue=8e-50,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005875
- InterPro:   IPR011761
- InterPro:   IPR003135
- InterPro:   IPR013815
- InterPro:   IPR013816
- InterPro:   IPR013817
- InterPro:   IPR016185
- InterPro:   IPR011054 [H]

Pfam domain/function: PF02222 ATP-grasp [H]

EC number: =6.3.4.18 [H]

Molecular weight: Translated: 43155; Mature: 43024

Theoretical pI: Translated: 4.85; Mature: 4.85

Prosite motif: PS50975 ATP_GRASP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTANAYPANQTIRTIGILGGGQLGMMLAEAALPLGYRCVFLEDAPHCPASLYGQVFTSE
CCCCCCCCCCCCEEEEEEECCCHHHHHHHHHHCCCCEEEEEECCCCCCCHHHHHHHHHHH
QLDDFVAAADVFTLEFENTPAKTVAWLKQLSDEGTKQGMYPPPQALEVAQDRLSEKSLFN
HHHHHHHHHHEEEEEECCCCHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHH
ELGIQTVPFKSVSSEQELQAAAQELGLPLVLKTSRGGYDGKGQFVLKTEADINEAWQALG
HCCCCCCCCCCCCCHHHHHHHHHHCCCCEEEEECCCCCCCCCCEEEEECCCHHHHHHHHH
EAVTGKGNLTPTPAPLIAEGFINFSREVSIIATRAQDGSMRTYDLVENHHHNGILAKSQA
HHHCCCCCCCCCCCHHHHHHHHCCCCCEEEEEEECCCCCCEEHHHHHCCCCCCEEECCCC
PAVGTSHLLPAAKSAIETLMNHLDYVGTMALELFVSKDAAGKDTILANEIAPRVHNSGHW
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEHHHHHHHCCCCCCE
SIEGAVTSQFENHIRAVVGLPLGDTDNVYPSMMINVLGQYPNIEEVLKIDGAHYHTYHKE
EEEHHHHHHHHHHHHHHEECCCCCCCCCCHHHHHHHHCCCCCHHHHHHHCCCEEECCCCC
ERDDRKIAHITLMPNDVAALEQALAALVRALPNKMGLES
CCCCCEEEEEEECCCHHHHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure 
TTANAYPANQTIRTIGILGGGQLGMMLAEAALPLGYRCVFLEDAPHCPASLYGQVFTSE
CCCCCCCCCCCEEEEEEECCCHHHHHHHHHHCCCCEEEEEECCCCCCCHHHHHHHHHHH
QLDDFVAAADVFTLEFENTPAKTVAWLKQLSDEGTKQGMYPPPQALEVAQDRLSEKSLFN
HHHHHHHHHHEEEEEECCCCHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHH
ELGIQTVPFKSVSSEQELQAAAQELGLPLVLKTSRGGYDGKGQFVLKTEADINEAWQALG
HCCCCCCCCCCCCCHHHHHHHHHHCCCCEEEEECCCCCCCCCCEEEEECCCHHHHHHHHH
EAVTGKGNLTPTPAPLIAEGFINFSREVSIIATRAQDGSMRTYDLVENHHHNGILAKSQA
HHHCCCCCCCCCCCHHHHHHHHCCCCCEEEEEEECCCCCCEEHHHHHCCCCCCEEECCCC
PAVGTSHLLPAAKSAIETLMNHLDYVGTMALELFVSKDAAGKDTILANEIAPRVHNSGHW
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEHHHHHHHCCCCCCE
SIEGAVTSQFENHIRAVVGLPLGDTDNVYPSMMINVLGQYPNIEEVLKIDGAHYHTYHKE
EEEHHHHHHHHHHHHHHEECCCCCCCCCCHHHHHHHHCCCCCHHHHHHHCCCEEECCCCC
ERDDRKIAHITLMPNDVAALEQALAALVRALPNKMGLES
CCCCCEEEEEEECCCHHHHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8816818; 10984043 [H]