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The map label for this gene is dapA

Identifier: 148653921

GI number: 148653921

Start: 2649884

End: 2650792

Strand: Direct

Name: dapA

Synonym: PsycPRwf_2124

Alternate gene names: 148653921

Gene position: 2649884-2650792 (Clockwise)

Preceding gene: 148653919

Following gene: 148653922

Centisome position: 88.95

GC content: 46.2

Gene sequence:

>909_bases
ATGAGTAACCGCTATTCTGACTTTAAAACCCAACTGCAAGGCTCAATGGTTGCCTTAGTAACCCCAATGAAAGCCAATGG
CGAAGTAGATTACCCGCGCTTAGCCGATCTGATTGACTGGCAAATTGAACAAGGCACTCACTGCTTGGTTGCCGTAGGTA
CCACCGGAGAGTCAGCCACGTTATCTATGCAAGAACACAGTGATGTTATCCACTTTTTTGTGAAACACGTAAACGGCCGA
GTGCCCGTAATAGCAGGTACTGGTGCCAACAATACTCAAGAGGCAATTCACCTAACCTCTGAGGCAAAAGCGGCCGGCGC
CGATTGCGCCCTTTTAGTAGCACCTTATTATAATAAGCCCACTCAAGAGGGGTTATACCAGCACTATAAAGCGATATCTG
AGGCTGTAGATATGCCGCAAATGCTTTATAATGTGCCAGGGCGTACTGTGGTCGATATTGCGCAAGAGACCGTAGAGCGT
TTGGCAGATTTTGACAACATTGTCGCCATAAAAGATGCCACCGGCTCGGTAGAACGTGGCAAGCTATTAATTGACGCTTT
AGGTGATCGTATCGTGGTGTTATCAGGTGATGATGGCACGGCGCTAGAGCTGATGAAACATGGTGCCAAAGGTAATATAT
CAGTAACGGCTAACATTGTGCCAAAAGCGATGAGTGATGTATTTAGTGCCGCCTTAAAAGGTGACTTTGAAACGGCCAAA
AAGGTGCATGACAGCATTGAGCCTTTGCACAAACTTATGTTCGTTGAATCAAGCCCCATTCCGGTCAAATATGCTTTAAA
TAAAATGGGCAAAATTGAGAAAGGCATCCGCTTACCTATGGTGTGGTTAAATGAGAAGTTTCATGACCAAGTGGACGCCG
GTTTACGAGCTGCCGGTTTGATTGACTAG

Upstream 100 bases:

>100_bases
CACAGTTTAACCCAACTCAGTTTTACGCCGCTTAGGGTGAGCCAAACGAGTTCAGATAACATTAGTTAAAACAAATTAGT
TAAAATAACAAGGCAATATT

Downstream 100 bases:

>100_bases
ATTTAAAGCAGTTATACCCATTATTAAGATCAGTGGTTACGACTAAGACCAATGATTACGACCAACCGTTTCAACGCCTG
TACTTTGATACATAGTACTT

Product: dihydrodipicolinate synthase

Products: NA

Alternate protein names: DHDPS

Number of amino acids: Translated: 302; Mature: 301

Protein sequence:

>302_residues
MSNRYSDFKTQLQGSMVALVTPMKANGEVDYPRLADLIDWQIEQGTHCLVAVGTTGESATLSMQEHSDVIHFFVKHVNGR
VPVIAGTGANNTQEAIHLTSEAKAAGADCALLVAPYYNKPTQEGLYQHYKAISEAVDMPQMLYNVPGRTVVDIAQETVER
LADFDNIVAIKDATGSVERGKLLIDALGDRIVVLSGDDGTALELMKHGAKGNISVTANIVPKAMSDVFSAALKGDFETAK
KVHDSIEPLHKLMFVESSPIPVKYALNKMGKIEKGIRLPMVWLNEKFHDQVDAGLRAAGLID

Sequences:

>Translated_302_residues
MSNRYSDFKTQLQGSMVALVTPMKANGEVDYPRLADLIDWQIEQGTHCLVAVGTTGESATLSMQEHSDVIHFFVKHVNGR
VPVIAGTGANNTQEAIHLTSEAKAAGADCALLVAPYYNKPTQEGLYQHYKAISEAVDMPQMLYNVPGRTVVDIAQETVER
LADFDNIVAIKDATGSVERGKLLIDALGDRIVVLSGDDGTALELMKHGAKGNISVTANIVPKAMSDVFSAALKGDFETAK
KVHDSIEPLHKLMFVESSPIPVKYALNKMGKIEKGIRLPMVWLNEKFHDQVDAGLRAAGLID
>Mature_301_residues
SNRYSDFKTQLQGSMVALVTPMKANGEVDYPRLADLIDWQIEQGTHCLVAVGTTGESATLSMQEHSDVIHFFVKHVNGRV
PVIAGTGANNTQEAIHLTSEAKAAGADCALLVAPYYNKPTQEGLYQHYKAISEAVDMPQMLYNVPGRTVVDIAQETVERL
ADFDNIVAIKDATGSVERGKLLIDALGDRIVVLSGDDGTALELMKHGAKGNISVTANIVPKAMSDVFSAALKGDFETAKK
VHDSIEPLHKLMFVESSPIPVKYALNKMGKIEKGIRLPMVWLNEKFHDQVDAGLRAAGLID

Specific function: Biosynthesis of diaminopimelate and lysine from aspartate semialdehyde; first step. [C]

COG id: COG0329

COG function: function code EM; Dihydrodipicolinate synthase/N-acetylneuraminate lyase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DHDPS family

Homologues:

Organism=Homo sapiens, GI31543060, Length=244, Percent_Identity=27.8688524590164, Blast_Score=96, Evalue=3e-20,
Organism=Homo sapiens, GI13540533, Length=301, Percent_Identity=27.906976744186, Blast_Score=86, Evalue=4e-17,
Organism=Escherichia coli, GI1788823, Length=291, Percent_Identity=47.4226804123711, Blast_Score=271, Evalue=4e-74,
Organism=Escherichia coli, GI1786463, Length=239, Percent_Identity=32.6359832635983, Blast_Score=129, Evalue=2e-31,
Organism=Escherichia coli, GI87082415, Length=282, Percent_Identity=30.8510638297872, Blast_Score=126, Evalue=2e-30,
Organism=Escherichia coli, GI1789620, Length=286, Percent_Identity=26.9230769230769, Blast_Score=105, Evalue=4e-24,

Paralogues:

None

Copy number: 840 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): DAPA_PSYWF (A5WHC3)

Other databases:

- EMBL:   CP000713
- RefSeq:   YP_001281014.1
- ProteinModelPortal:   A5WHC3
- SMR:   A5WHC3
- STRING:   A5WHC3
- GeneID:   5205415
- GenomeReviews:   CP000713_GR
- KEGG:   prw:PsycPRwf_2124
- eggNOG:   COG0329
- HOGENOM:   HBG358848
- OMA:   GMYRHFK
- ProtClustDB:   PRK03170
- BioCyc:   PSP56811:PSYCPRWF_2124-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00418
- InterPro:   IPR013785
- InterPro:   IPR005263
- InterPro:   IPR002220
- InterPro:   IPR020625
- Gene3D:   G3DSA:3.20.20.70
- PANTHER:   PTHR12128
- PRINTS:   PR00146
- TIGRFAMs:   TIGR00674

Pfam domain/function: PF00701 DHDPS

EC number: =4.2.1.52

Molecular weight: Translated: 32772; Mature: 32641

Theoretical pI: Translated: 5.78; Mature: 5.78

Prosite motif: PS00665 DHDPS_1; PS00666 DHDPS_2

Important sites: ACT_SITE 171-171 BINDING 116-116

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSNRYSDFKTQLQGSMVALVTPMKANGEVDYPRLADLIDWQIEQGTHCLVAVGTTGESAT
CCCCHHHHHHHHCCCEEEEEECCCCCCCCCCHHHHHHHHHHHCCCCEEEEEEECCCCCEE
LSMQEHSDVIHFFVKHVNGRVPVIAGTGANNTQEAIHLTSEAKAAGADCALLVAPYYNKP
EEHHHHHHHHHHHHHHHCCCEEEEECCCCCCCHHHEEECCHHCCCCCCEEEEEECCCCCC
TQEGLYQHYKAISEAVDMPQMLYNVPGRTVVDIAQETVERLADFDNIVAIKDATGSVERG
HHHHHHHHHHHHHHHHCCHHHHHCCCCCHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCC
KLLIDALGDRIVVLSGDDGTALELMKHGAKGNISVTANIVPKAMSDVFSAALKGDFETAK
EEEEEECCCEEEEEECCCCHHHHHHHCCCCCCEEEEECHHHHHHHHHHHHHHCCCHHHHH
KVHDSIEPLHKLMFVESSPIPVKYALNKMGKIEKGIRLPMVWLNEKFHDQVDAGLRAAGL
HHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCCCCHHHCCHHHHHHHCCCCCCCC
ID
CC
>Mature Secondary Structure 
SNRYSDFKTQLQGSMVALVTPMKANGEVDYPRLADLIDWQIEQGTHCLVAVGTTGESAT
CCCHHHHHHHHCCCEEEEEECCCCCCCCCCHHHHHHHHHHHCCCCEEEEEEECCCCCEE
LSMQEHSDVIHFFVKHVNGRVPVIAGTGANNTQEAIHLTSEAKAAGADCALLVAPYYNKP
EEHHHHHHHHHHHHHHHCCCEEEEECCCCCCCHHHEEECCHHCCCCCCEEEEEECCCCCC
TQEGLYQHYKAISEAVDMPQMLYNVPGRTVVDIAQETVERLADFDNIVAIKDATGSVERG
HHHHHHHHHHHHHHHHCCHHHHHCCCCCHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCC
KLLIDALGDRIVVLSGDDGTALELMKHGAKGNISVTANIVPKAMSDVFSAALKGDFETAK
EEEEEECCCEEEEEECCCCHHHHHHHCCCCCCEEEEECHHHHHHHHHHHHHHCCCHHHHH
KVHDSIEPLHKLMFVESSPIPVKYALNKMGKIEKGIRLPMVWLNEKFHDQVDAGLRAAGL
HHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCCCCHHHCCHHHHHHHCCCCCCCC
ID
CC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA