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The map label for this gene is prs [H]

Identifier: 148653902

GI number: 148653902

Start: 2627784

End: 2628740

Strand: Direct

Name: prs [H]

Synonym: PsycPRwf_2105

Alternate gene names: 148653902

Gene position: 2627784-2628740 (Clockwise)

Preceding gene: 148653901

Following gene: 148653903

Centisome position: 88.21

GC content: 47.34

Gene sequence:

>957_bases
ATGCCATATCTGGCGATTTTTACGGGTAATGCCCACCCTGAGTTGGCAAAAACTGTCGCAGATCACTTACACATTCCTCT
TGGCCGTGCTGATGTCACGCGCTTCTCTGACGGTGAAATCGCTGTTGAGATTAAAGAGCACGTACGTGGTAAAGACGTCT
TCATTCTACAACCTACTTGCGCCCCTACCAACGATAACTTGATGGAAATCATGGTGATGGCTGATGCACTGCGTCGTTCA
AGTGCCGGTCGTATCACTGCGGTTATGCCCTACTTCGGCTATGCCCGTCAGGATCGTCGTCCCCGTTCAGCGCGTGTGCC
TATTTCGGCAAAAGTAGTGGCAGACATGCTAAACATCGTTAGCATTGATCGTGTGATGACTGTCGATTTGCACTCTGACC
AAATTCAAGGTTTCTTTGACATTCCAGTAGATAACATCTACGGTACGCCAGTATTGTTAAAAGACCTTAGAAAGCAAGGC
TACGACAACCTAATGGTTGTGTCACCAGACGTAGGTGGTGTTGTTCGTGCGCGTGCTATGGCCAAAGAGCTTGGCGGTAA
CACCGAGCTTGCCATCATCGACAAGCGTCGTGCTCGTGCTAATGAATCACAAGTTATGCATATCATTGGTGATGTAAAAG
ACCGTGATTGTGTGATTGTTGATGACATGGTAGATACCGCAGGCACGCTATGTAAAGCCGCCCAAGCCCTTAAAGACAAT
GGCGCCCGTCGCGTATTAGGTTATATCACTCACCCTGTATTATCGGGTAATGCGATTAAAACCATTGGCGAATCTGTGTT
GGATGAGCTGGTCGTAACGGACAGTATTCCTTTGTCTGATGAAGCTAAGGCTTGCAGCAAAATTCGTCAAGTGACCATTG
CTTCACTATTGGCCGAAAGCTTACGCCGTATCAACAATGAAGAGTCTATCAGTGCAATGTTTGAGTCTATCGACTAA

Upstream 100 bases:

>100_bases
AGTCCAGCTACCCCTGCCATTTTCTAAACGTTCAACTTTCTTCTTTATTTGTGCAGTCTCTACTGCTCCTCTCCTAAGTC
AAATAAATAGGACTTGAACC

Downstream 100 bases:

>100_bases
TCACTGCAGCCTGATGACTAACAAAAAAACCGCCCGCTAATGCCGGGCGGTTTTTTTGTGCTAGATTTTAATGCCCATTA
CCCGTATAATACGGCCTTTG

Product: ribose-phosphate pyrophosphokinase

Products: NA

Alternate protein names: RPPK; Phosphoribosyl pyrophosphate synthase; P-Rib-PP synthase; PRPP synthase [H]

Number of amino acids: Translated: 318; Mature: 317

Protein sequence:

>318_residues
MPYLAIFTGNAHPELAKTVADHLHIPLGRADVTRFSDGEIAVEIKEHVRGKDVFILQPTCAPTNDNLMEIMVMADALRRS
SAGRITAVMPYFGYARQDRRPRSARVPISAKVVADMLNIVSIDRVMTVDLHSDQIQGFFDIPVDNIYGTPVLLKDLRKQG
YDNLMVVSPDVGGVVRARAMAKELGGNTELAIIDKRRARANESQVMHIIGDVKDRDCVIVDDMVDTAGTLCKAAQALKDN
GARRVLGYITHPVLSGNAIKTIGESVLDELVVTDSIPLSDEAKACSKIRQVTIASLLAESLRRINNEESISAMFESID

Sequences:

>Translated_318_residues
MPYLAIFTGNAHPELAKTVADHLHIPLGRADVTRFSDGEIAVEIKEHVRGKDVFILQPTCAPTNDNLMEIMVMADALRRS
SAGRITAVMPYFGYARQDRRPRSARVPISAKVVADMLNIVSIDRVMTVDLHSDQIQGFFDIPVDNIYGTPVLLKDLRKQG
YDNLMVVSPDVGGVVRARAMAKELGGNTELAIIDKRRARANESQVMHIIGDVKDRDCVIVDDMVDTAGTLCKAAQALKDN
GARRVLGYITHPVLSGNAIKTIGESVLDELVVTDSIPLSDEAKACSKIRQVTIASLLAESLRRINNEESISAMFESID
>Mature_317_residues
PYLAIFTGNAHPELAKTVADHLHIPLGRADVTRFSDGEIAVEIKEHVRGKDVFILQPTCAPTNDNLMEIMVMADALRRSS
AGRITAVMPYFGYARQDRRPRSARVPISAKVVADMLNIVSIDRVMTVDLHSDQIQGFFDIPVDNIYGTPVLLKDLRKQGY
DNLMVVSPDVGGVVRARAMAKELGGNTELAIIDKRRARANESQVMHIIGDVKDRDCVIVDDMVDTAGTLCKAAQALKDNG
ARRVLGYITHPVLSGNAIKTIGESVLDELVVTDSIPLSDEAKACSKIRQVTIASLLAESLRRINNEESISAMFESID

Specific function: Utilized by both the de novo and the salvage pathways by which endogenously formed or exogenously added pyrimidine, purine, or pyridine bases are converted to the corresponding ribonucleoside monophosphates. [C]

COG id: COG0462

COG function: function code FE; Phosphoribosylpyrophosphate synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ribose-phosphate pyrophosphokinase family [H]

Homologues:

Organism=Homo sapiens, GI4506127, Length=319, Percent_Identity=47.3354231974922, Blast_Score=309, Evalue=2e-84,
Organism=Homo sapiens, GI4506129, Length=319, Percent_Identity=46.3949843260188, Blast_Score=307, Evalue=1e-83,
Organism=Homo sapiens, GI84875539, Length=321, Percent_Identity=45.7943925233645, Blast_Score=305, Evalue=3e-83,
Organism=Homo sapiens, GI28557709, Length=319, Percent_Identity=46.3949843260188, Blast_Score=302, Evalue=3e-82,
Organism=Homo sapiens, GI194018537, Length=345, Percent_Identity=34.7826086956522, Blast_Score=185, Evalue=6e-47,
Organism=Homo sapiens, GI4506133, Length=348, Percent_Identity=33.3333333333333, Blast_Score=184, Evalue=9e-47,
Organism=Homo sapiens, GI310128524, Length=148, Percent_Identity=27.7027027027027, Blast_Score=76, Evalue=3e-14,
Organism=Homo sapiens, GI310115209, Length=148, Percent_Identity=27.7027027027027, Blast_Score=76, Evalue=3e-14,
Organism=Homo sapiens, GI310118259, Length=148, Percent_Identity=27.7027027027027, Blast_Score=76, Evalue=3e-14,
Organism=Homo sapiens, GI310119946, Length=148, Percent_Identity=27.7027027027027, Blast_Score=76, Evalue=3e-14,
Organism=Escherichia coli, GI1787458, Length=315, Percent_Identity=66.984126984127, Blast_Score=446, Evalue=1e-127,
Organism=Caenorhabditis elegans, GI25149168, Length=319, Percent_Identity=42.3197492163009, Blast_Score=285, Evalue=2e-77,
Organism=Caenorhabditis elegans, GI17554702, Length=319, Percent_Identity=42.3197492163009, Blast_Score=285, Evalue=3e-77,
Organism=Caenorhabditis elegans, GI71989924, Length=319, Percent_Identity=42.3197492163009, Blast_Score=283, Evalue=8e-77,
Organism=Caenorhabditis elegans, GI17554704, Length=314, Percent_Identity=42.3566878980892, Blast_Score=281, Evalue=4e-76,
Organism=Caenorhabditis elegans, GI17570245, Length=341, Percent_Identity=33.4310850439883, Blast_Score=190, Evalue=7e-49,
Organism=Saccharomyces cerevisiae, GI6321776, Length=315, Percent_Identity=44.7619047619048, Blast_Score=270, Evalue=2e-73,
Organism=Saccharomyces cerevisiae, GI6320946, Length=314, Percent_Identity=41.4012738853503, Blast_Score=253, Evalue=3e-68,
Organism=Saccharomyces cerevisiae, GI6319403, Length=315, Percent_Identity=41.5873015873016, Blast_Score=252, Evalue=6e-68,
Organism=Saccharomyces cerevisiae, GI6322667, Length=206, Percent_Identity=38.8349514563107, Blast_Score=150, Evalue=2e-37,
Organism=Saccharomyces cerevisiae, GI6324511, Length=114, Percent_Identity=40.3508771929825, Blast_Score=99, Evalue=7e-22,
Organism=Drosophila melanogaster, GI21355239, Length=319, Percent_Identity=44.8275862068966, Blast_Score=291, Evalue=3e-79,
Organism=Drosophila melanogaster, GI45551540, Length=341, Percent_Identity=41.9354838709677, Blast_Score=282, Evalue=2e-76,
Organism=Drosophila melanogaster, GI24651458, Length=359, Percent_Identity=33.1476323119777, Blast_Score=199, Evalue=2e-51,
Organism=Drosophila melanogaster, GI24651456, Length=359, Percent_Identity=33.1476323119777, Blast_Score=199, Evalue=2e-51,
Organism=Drosophila melanogaster, GI281362873, Length=359, Percent_Identity=33.1476323119777, Blast_Score=199, Evalue=3e-51,
Organism=Drosophila melanogaster, GI24651454, Length=359, Percent_Identity=33.1476323119777, Blast_Score=199, Evalue=3e-51,
Organism=Drosophila melanogaster, GI24651462, Length=376, Percent_Identity=32.1808510638298, Blast_Score=194, Evalue=5e-50,
Organism=Drosophila melanogaster, GI24651464, Length=376, Percent_Identity=32.1808510638298, Blast_Score=194, Evalue=5e-50,
Organism=Drosophila melanogaster, GI45552010, Length=376, Percent_Identity=32.1808510638298, Blast_Score=194, Evalue=8e-50,

Paralogues:

None

Copy number: 160 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000842
- InterPro:   IPR005946
- InterPro:   IPR000836 [H]

Pfam domain/function: PF00156 Pribosyltran [H]

EC number: =2.7.6.1 [H]

Molecular weight: Translated: 34821; Mature: 34689

Theoretical pI: Translated: 6.18; Mature: 6.18

Prosite motif: PS00103 PUR_PYR_PR_TRANSFER ; PS00114 PRPP_SYNTHETASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPYLAIFTGNAHPELAKTVADHLHIPLGRADVTRFSDGEIAVEIKEHVRGKDVFILQPTC
CCEEEEEECCCCHHHHHHHHHHHCCCCCCCCCCEECCCCEEEEEHHHCCCCEEEEECCCC
APTNDNLMEIMVMADALRRSSAGRITAVMPYFGYARQDRRPRSARVPISAKVVADMLNIV
CCCCCCHHHHHHHHHHHHHCCCCCEEEECCHHCCHHHCCCCCCCCCCHHHHHHHHHHHHH
SIDRVMTVDLHSDQIQGFFDIPVDNIYGTPVLLKDLRKQGYDNLMVVSPDVGGVVRARAM
HHCCEEEEEECHHHCCEEEECCCCCCCCCHHHHHHHHHCCCCCEEEECCCCCHHHHHHHH
AKELGGNTELAIIDKRRARANESQVMHIIGDVKDRDCVIVDDMVDTAGTLCKAAQALKDN
HHHHCCCCEEEEEECHHHCCCHHHEEHEECCCCCCCEEEEHHHHHHHHHHHHHHHHHHCC
GARRVLGYITHPVLSGNAIKTIGESVLDELVVTDSIPLSDEAKACSKIRQVTIASLLAES
CHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHH
LRRINNEESISAMFESID
HHHCCCHHHHHHHHHHCC
>Mature Secondary Structure 
PYLAIFTGNAHPELAKTVADHLHIPLGRADVTRFSDGEIAVEIKEHVRGKDVFILQPTC
CEEEEEECCCCHHHHHHHHHHHCCCCCCCCCCEECCCCEEEEEHHHCCCCEEEEECCCC
APTNDNLMEIMVMADALRRSSAGRITAVMPYFGYARQDRRPRSARVPISAKVVADMLNIV
CCCCCCHHHHHHHHHHHHHCCCCCEEEECCHHCCHHHCCCCCCCCCCHHHHHHHHHHHHH
SIDRVMTVDLHSDQIQGFFDIPVDNIYGTPVLLKDLRKQGYDNLMVVSPDVGGVVRARAM
HHCCEEEEEECHHHCCEEEECCCCCCCCCHHHHHHHHHCCCCCEEEECCCCCHHHHHHHH
AKELGGNTELAIIDKRRARANESQVMHIIGDVKDRDCVIVDDMVDTAGTLCKAAQALKDN
HHHHCCCCEEEEEECHHHCCCHHHEEHEECCCCCCCEEEEHHHHHHHHHHHHHHHHHHCC
GARRVLGYITHPVLSGNAIKTIGESVLDELVVTDSIPLSDEAKACSKIRQVTIASLLAES
CHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHH
LRRINNEESISAMFESID
HHHCCCHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10984043 [H]