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The map label for this gene is lon [H]

Identifier: 148653776

GI number: 148653776

Start: 2465179

End: 2467758

Strand: Direct

Name: lon [H]

Synonym: PsycPRwf_1979

Alternate gene names: 148653776

Gene position: 2465179-2467758 (Clockwise)

Preceding gene: 148653774

Following gene: 148653777

Centisome position: 82.75

GC content: 48.88

Gene sequence:

>2580_bases
ATGAGTAAATCCGATAACAACTATGACAGTGATTTTGAGCAGCAATTTGAAGACAACATCGATAACGAAGTTGATTCTAC
AGCCGATGCTCAAGAGTCTGACGTAGTGACAGATTTTGAGCCGACGGATGTGGCACTGAGTATTGACCAAGAAGCCAGCT
CGCTACCTTTGCTTGCGCTGCGTGACGTGGTGGTTTATCCGCACATGCAAATTGCCTTGTTTGTCGGTCGTGACCCCTCT
ATTAAAGCCATTAACGCCGCTAAAAAAAGCCATGATGACCAAGTATTGGTCGTGGCCCAAAAGGATTCGCTGAGCGAAGA
CATCCATCAAGAGAACCTATATCAGTATGGTACGGTGTGCCGTATCGTAAGCACCATGCCACACGACAGTGATGAAAACT
GTATTAAGGTGCTTATTGAAGGCGAAAACCGCGTGCGCTTAGATAAGGTAACCGAACAAGACGATGGAATGCTTGTGGGC
GACTATACCTATAGCGCCATTACCTTGACGATGAATGAGTCGCAGCAAAAAAACACCTTAGAGGCACTGCGTCAGCTGTT
CGCTAACTACGCTGAAGCTCGCCTGCGCAATAGCCGCGAATTAATCCGCGTCTCTGAACGCATCGATCACTTATTAGAGC
TGGTGTATTTTATCGCCACTCGTGTCTCTATGGATCTTGAGGCCAAACAGCAATTGCTCGAAAAAGACGACATCGCGCTG
CACATTAATACCATCACTGAGTATTTGGCCAAGCAAAGTGCTGAGCAGTCGATTGAGCAAGAAATCCAAGATGCGGTTCG
CCGTCAAATGGAGAGCAACCAGCGCGAGTACTATTTAAACGAGAAGATGAAGGCCATCAAAAATGAGCTTTCTGAAATCA
GTGATGGCTCTTTTGACAGTGAAGATGATCTTGAAGAGTTAGAGGCCCGCTTAAAAGAAGCTGACCTGCCTGAAGATGTG
CGCAAAAAAGCGGAGCAAGAGTTTAAGAAGCTTAAAATGATGCCGCCGGCGTCAAGTGAATCCTCAGTGGTGCGCAACTA
CATCGACTGGATCTTAGATACCCCCTGGAACAAAGCCAGTAAGGTATCTATCAAGCTTGATAAGGCAGAAGAAGTGCTTG
ATGCGGACCACTATGGTCTACAAGATGTCAAAGACCGCATCTTAGAATATCTGGCCGTTCAATCACGCGTCAAAAAGCTA
CGTGGTCCCATTCTTTGTCTGGTAGGTCCTCCAGGTGTGGGTAAAACCTCACTGGGTGAATCTATTGCCCGAGCCACTGG
CCGTAAATTTGTGCGTATGGCCTTAGGCGGCGTGCGTGATGAGGCAGAAATCCGTGGTCACCGCCGTACTTACATCGGGG
CTATGCCGGGTAAAATTGTCCAATCACTGGCCAAAGTTGAGGTAAAAAACCCGCTATTTTTGCTTGATGAAATCGACAAA
ATGGCGCAAGACTTCCGTGGTGATCCAGCCTCAGCACTGCTTGAAGTACTTGACCCCTCACAGAACGATAAGTTTAACGA
CCACTATCTAGATTTGGACCTGGACTTATCGCAAGTGATGTTTATCTGTACCGCCAACAGCATGGACATTCCACCTGCCC
TGCTCGACCGTATGGAGGTGATTCGTCTGCCAGGCTACACGGAAGACGAAAAAATCAACATCGCTGAGAAGTACTTGGTG
CCCAAAGCCATCAAGCAAAACGGGCTAAAAAATGACGAGATTGAAATTGTGCCAGAAGCTTTGCACAGCATCGTTCAGCG
TTATACCCGTGAAGCTGGTGTGCGTAATCTTGAGCGTGAGGTCAACAAGATTTGCCGTAAGGTGGTACGCGAGTCTATTG
AGAAATATGGCGCTAAGCCGACCAAAAAGACCAAGATTGAGACCGTTGTGGTAGATGCCGATAACATCAGCGACTACTTA
GGCGTGCATCAATACGACTTTGGTCTGGCAGAAGAAGCGCCTGAAGTGGGCCGTGTCACTGGCCTAGCTTGGACCAGCGT
GGGCGGTGAGTTACTCACCATTGAGACCATCACTATGCCCGGTAAAGGCGACTTTGTGTATACCGGATCACTGGGTGACG
TGATGAAAGAGTCTATTCGTGCTGCGATGAGTGTGGTACGTGCCCGTGGGGAGATGATTGGCATTGACTACGAGACCTTT
AAGTCAAAAGATGTGCACGTACATATGCCAGAAGGTGCCACACCAAAAGATGGTCCGTCAGCCGGTATTGCCTTGACCAC
CGCCTTAGTGTCTGCGATGACTGGCATTGCCATCCGCCCAGACATCGCTATGACAGGCGAGGTGACCTTACGTGGCAAAG
TGCTGCGCATTGGTGGCCTTAAAGAGAAGCTATTAGCGGCTCACCGTGGTGGTATTAAGCACGTGTTAATCCCAGCCTCT
AACGAGCGTGATCTGGTTGAGATTCCAGATAATGTTAAAGAGGGCTTGACCATCCAGCCGGTATCTACCATTGATGAGGT
GCTTCAGGCGGCCTTGGTTGAGATGCCAAAGCCACTGGCTCCCAATAAAGTTAAGGTGGCGGTAGACACGACCAAAGCTG
AGCCAGCACTACGCAGCTAA

Upstream 100 bases:

>100_bases
CAAAATAAGCTTGCAATTATACTCAGTCACCACCATTTAGTTAGTCATAGCATAAAAAACTTCCCTAAAAATGGGTTGTG
TCACACGATAAGGAAAAAAT

Downstream 100 bases:

>100_bases
TCTAAAGGCGGGCTTAGCCACCGCCGTCTATCAAATCATTGACGTAAAAAATGCCGTCCAATTAACTTGGACGGCATTTT
TTATTCCTCAAGCTTTCACG

Product: ATP-dependent protease La

Products: NA

Alternate protein names: ATP-dependent protease La [H]

Number of amino acids: Translated: 859; Mature: 858

Protein sequence:

>859_residues
MSKSDNNYDSDFEQQFEDNIDNEVDSTADAQESDVVTDFEPTDVALSIDQEASSLPLLALRDVVVYPHMQIALFVGRDPS
IKAINAAKKSHDDQVLVVAQKDSLSEDIHQENLYQYGTVCRIVSTMPHDSDENCIKVLIEGENRVRLDKVTEQDDGMLVG
DYTYSAITLTMNESQQKNTLEALRQLFANYAEARLRNSRELIRVSERIDHLLELVYFIATRVSMDLEAKQQLLEKDDIAL
HINTITEYLAKQSAEQSIEQEIQDAVRRQMESNQREYYLNEKMKAIKNELSEISDGSFDSEDDLEELEARLKEADLPEDV
RKKAEQEFKKLKMMPPASSESSVVRNYIDWILDTPWNKASKVSIKLDKAEEVLDADHYGLQDVKDRILEYLAVQSRVKKL
RGPILCLVGPPGVGKTSLGESIARATGRKFVRMALGGVRDEAEIRGHRRTYIGAMPGKIVQSLAKVEVKNPLFLLDEIDK
MAQDFRGDPASALLEVLDPSQNDKFNDHYLDLDLDLSQVMFICTANSMDIPPALLDRMEVIRLPGYTEDEKINIAEKYLV
PKAIKQNGLKNDEIEIVPEALHSIVQRYTREAGVRNLEREVNKICRKVVRESIEKYGAKPTKKTKIETVVVDADNISDYL
GVHQYDFGLAEEAPEVGRVTGLAWTSVGGELLTIETITMPGKGDFVYTGSLGDVMKESIRAAMSVVRARGEMIGIDYETF
KSKDVHVHMPEGATPKDGPSAGIALTTALVSAMTGIAIRPDIAMTGEVTLRGKVLRIGGLKEKLLAAHRGGIKHVLIPAS
NERDLVEIPDNVKEGLTIQPVSTIDEVLQAALVEMPKPLAPNKVKVAVDTTKAEPALRS

Sequences:

>Translated_859_residues
MSKSDNNYDSDFEQQFEDNIDNEVDSTADAQESDVVTDFEPTDVALSIDQEASSLPLLALRDVVVYPHMQIALFVGRDPS
IKAINAAKKSHDDQVLVVAQKDSLSEDIHQENLYQYGTVCRIVSTMPHDSDENCIKVLIEGENRVRLDKVTEQDDGMLVG
DYTYSAITLTMNESQQKNTLEALRQLFANYAEARLRNSRELIRVSERIDHLLELVYFIATRVSMDLEAKQQLLEKDDIAL
HINTITEYLAKQSAEQSIEQEIQDAVRRQMESNQREYYLNEKMKAIKNELSEISDGSFDSEDDLEELEARLKEADLPEDV
RKKAEQEFKKLKMMPPASSESSVVRNYIDWILDTPWNKASKVSIKLDKAEEVLDADHYGLQDVKDRILEYLAVQSRVKKL
RGPILCLVGPPGVGKTSLGESIARATGRKFVRMALGGVRDEAEIRGHRRTYIGAMPGKIVQSLAKVEVKNPLFLLDEIDK
MAQDFRGDPASALLEVLDPSQNDKFNDHYLDLDLDLSQVMFICTANSMDIPPALLDRMEVIRLPGYTEDEKINIAEKYLV
PKAIKQNGLKNDEIEIVPEALHSIVQRYTREAGVRNLEREVNKICRKVVRESIEKYGAKPTKKTKIETVVVDADNISDYL
GVHQYDFGLAEEAPEVGRVTGLAWTSVGGELLTIETITMPGKGDFVYTGSLGDVMKESIRAAMSVVRARGEMIGIDYETF
KSKDVHVHMPEGATPKDGPSAGIALTTALVSAMTGIAIRPDIAMTGEVTLRGKVLRIGGLKEKLLAAHRGGIKHVLIPAS
NERDLVEIPDNVKEGLTIQPVSTIDEVLQAALVEMPKPLAPNKVKVAVDTTKAEPALRS
>Mature_858_residues
SKSDNNYDSDFEQQFEDNIDNEVDSTADAQESDVVTDFEPTDVALSIDQEASSLPLLALRDVVVYPHMQIALFVGRDPSI
KAINAAKKSHDDQVLVVAQKDSLSEDIHQENLYQYGTVCRIVSTMPHDSDENCIKVLIEGENRVRLDKVTEQDDGMLVGD
YTYSAITLTMNESQQKNTLEALRQLFANYAEARLRNSRELIRVSERIDHLLELVYFIATRVSMDLEAKQQLLEKDDIALH
INTITEYLAKQSAEQSIEQEIQDAVRRQMESNQREYYLNEKMKAIKNELSEISDGSFDSEDDLEELEARLKEADLPEDVR
KKAEQEFKKLKMMPPASSESSVVRNYIDWILDTPWNKASKVSIKLDKAEEVLDADHYGLQDVKDRILEYLAVQSRVKKLR
GPILCLVGPPGVGKTSLGESIARATGRKFVRMALGGVRDEAEIRGHRRTYIGAMPGKIVQSLAKVEVKNPLFLLDEIDKM
AQDFRGDPASALLEVLDPSQNDKFNDHYLDLDLDLSQVMFICTANSMDIPPALLDRMEVIRLPGYTEDEKINIAEKYLVP
KAIKQNGLKNDEIEIVPEALHSIVQRYTREAGVRNLEREVNKICRKVVRESIEKYGAKPTKKTKIETVVVDADNISDYLG
VHQYDFGLAEEAPEVGRVTGLAWTSVGGELLTIETITMPGKGDFVYTGSLGDVMKESIRAAMSVVRARGEMIGIDYETFK
SKDVHVHMPEGATPKDGPSAGIALTTALVSAMTGIAIRPDIAMTGEVTLRGKVLRIGGLKEKLLAAHRGGIKHVLIPASN
ERDLVEIPDNVKEGLTIQPVSTIDEVLQAALVEMPKPLAPNKVKVAVDTTKAEPALRS

Specific function: ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced

COG id: COG0466

COG function: function code O; ATP-dependent Lon protease, bacterial type

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 Lon domain [H]

Homologues:

Organism=Homo sapiens, GI31377667, Length=563, Percent_Identity=45.1154529307282, Blast_Score=518, Evalue=1e-147,
Organism=Homo sapiens, GI21396489, Length=613, Percent_Identity=42.2512234910277, Blast_Score=487, Evalue=1e-137,
Organism=Escherichia coli, GI1786643, Length=783, Percent_Identity=54.1507024265645, Blast_Score=828, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17505831, Length=703, Percent_Identity=38.9758179231863, Blast_Score=480, Evalue=1e-135,
Organism=Caenorhabditis elegans, GI17556486, Length=543, Percent_Identity=40.5156537753223, Blast_Score=433, Evalue=1e-121,
Organism=Saccharomyces cerevisiae, GI6319449, Length=633, Percent_Identity=43.9178515007899, Blast_Score=509, Evalue=1e-145,
Organism=Drosophila melanogaster, GI221513036, Length=618, Percent_Identity=43.8511326860841, Blast_Score=518, Evalue=1e-147,
Organism=Drosophila melanogaster, GI24666867, Length=618, Percent_Identity=43.8511326860841, Blast_Score=518, Evalue=1e-146,

Paralogues:

None

Copy number: 2,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR003959
- InterPro:   IPR008269
- InterPro:   IPR004815
- InterPro:   IPR003111
- InterPro:   IPR008268
- InterPro:   IPR001984
- InterPro:   IPR015947
- InterPro:   IPR020568 [H]

Pfam domain/function: PF00004 AAA; PF02190 LON; PF05362 Lon_C [H]

EC number: =3.4.21.53 [H]

Molecular weight: Translated: 95833; Mature: 95702

Theoretical pI: Translated: 4.70; Mature: 4.70

Prosite motif: PS01046 LON_SER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKSDNNYDSDFEQQFEDNIDNEVDSTADAQESDVVTDFEPTDVALSIDQEASSLPLLAL
CCCCCCCCCCHHHHHHHHCCCCHHCCCCCCCCCCCCCCCCCCCEEEEECCCCCCCCHHHH
RDVVVYPHMQIALFVGRDPSIKAINAAKKSHDDQVLVVAQKDSLSEDIHQENLYQYGTVC
HHHHHCCCEEEEEEECCCCCCHHHHHHHCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHH
RIVSTMPHDSDENCIKVLIEGENRVRLDKVTEQDDGMLVGDYTYSAITLTMNESQQKNTL
HHHHHCCCCCCCCEEEEEEECCCEEEEECCCCCCCCEEEEEEEEEEEEEEECCCHHHHHH
EALRQLFANYAEARLRNSRELIRVSERIDHLLELVYFIATRVSMDLEAKQQLLEKDDIAL
HHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCEEE
HINTITEYLAKQSAEQSIEQEIQDAVRRQMESNQREYYLNEKMKAIKNELSEISDGSFDS
EHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCCCC
EDDLEELEARLKEADLPEDVRKKAEQEFKKLKMMPPASSESSVVRNYIDWILDTPWNKAS
CCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCCCCCC
KVSIKLDKAEEVLDADHYGLQDVKDRILEYLAVQSRVKKLRGPILCLVGPPGVGKTSLGE
EEEEEECHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCHHHHH
SIARATGRKFVRMALGGVRDEAEIRGHRRTYIGAMPGKIVQSLAKVEVKNPLFLLDEIDK
HHHHHHHHHHHHHHHCCCCCHHHHCCCCCEEECCCCHHHHHHHHHHHHCCCCHHHHHHHH
MAQDFRGDPASALLEVLDPSQNDKFNDHYLDLDLDLSQVMFICTANSMDIPPALLDRMEV
HHHHHCCCHHHHHHHHHCCCCCCCCCCCEEEECCCHHHEEEEEECCCCCCCHHHHHHHHH
IRLPGYTEDEKINIAEKYLVPKAIKQNGLKNDEIEIVPEALHSIVQRYTREAGVRNLERE
HCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
VNKICRKVVRESIEKYGAKPTKKTKIETVVVDADNISDYLGVHQYDFGLAEEAPEVGRVT
HHHHHHHHHHHHHHHHCCCCCCCCEEEEEEEECCCCHHHHCCHHCCCCCHHCCCCHHHEE
GLAWTSVGGELLTIETITMPGKGDFVYTGSLGDVMKESIRAAMSVVRARGEMIGIDYETF
EEEECCCCCEEEEEEEEEECCCCCEEEECCHHHHHHHHHHHHHHHHHHCCCEEECCHHHH
KSKDVHVHMPEGATPKDGPSAGIALTTALVSAMTGIAIRPDIAMTGEVTLRGKVLRIGGL
CCCCEEEECCCCCCCCCCCCCHHHHHHHHHHHHHCCEECCCCEEECCEEEEEEEEEECCH
KEKLLAAHRGGIKHVLIPASNERDLVEIPDNVKEGLTIQPVSTIDEVLQAALVEMPKPLA
HHHHHHHHCCCCEEEEEECCCCCCEEECCCHHHCCCEECCHHHHHHHHHHHHHHCCCCCC
PNKVKVAVDTTKAEPALRS
CCEEEEEEECCCCCCCCCC
>Mature Secondary Structure 
SKSDNNYDSDFEQQFEDNIDNEVDSTADAQESDVVTDFEPTDVALSIDQEASSLPLLAL
CCCCCCCCCHHHHHHHHCCCCHHCCCCCCCCCCCCCCCCCCCEEEEECCCCCCCCHHHH
RDVVVYPHMQIALFVGRDPSIKAINAAKKSHDDQVLVVAQKDSLSEDIHQENLYQYGTVC
HHHHHCCCEEEEEEECCCCCCHHHHHHHCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHH
RIVSTMPHDSDENCIKVLIEGENRVRLDKVTEQDDGMLVGDYTYSAITLTMNESQQKNTL
HHHHHCCCCCCCCEEEEEEECCCEEEEECCCCCCCCEEEEEEEEEEEEEEECCCHHHHHH
EALRQLFANYAEARLRNSRELIRVSERIDHLLELVYFIATRVSMDLEAKQQLLEKDDIAL
HHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCEEE
HINTITEYLAKQSAEQSIEQEIQDAVRRQMESNQREYYLNEKMKAIKNELSEISDGSFDS
EHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCCCC
EDDLEELEARLKEADLPEDVRKKAEQEFKKLKMMPPASSESSVVRNYIDWILDTPWNKAS
CCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCCCCCC
KVSIKLDKAEEVLDADHYGLQDVKDRILEYLAVQSRVKKLRGPILCLVGPPGVGKTSLGE
EEEEEECHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCHHHHH
SIARATGRKFVRMALGGVRDEAEIRGHRRTYIGAMPGKIVQSLAKVEVKNPLFLLDEIDK
HHHHHHHHHHHHHHHCCCCCHHHHCCCCCEEECCCCHHHHHHHHHHHHCCCCHHHHHHHH
MAQDFRGDPASALLEVLDPSQNDKFNDHYLDLDLDLSQVMFICTANSMDIPPALLDRMEV
HHHHHCCCHHHHHHHHHCCCCCCCCCCCEEEECCCHHHEEEEEECCCCCCCHHHHHHHHH
IRLPGYTEDEKINIAEKYLVPKAIKQNGLKNDEIEIVPEALHSIVQRYTREAGVRNLERE
HCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
VNKICRKVVRESIEKYGAKPTKKTKIETVVVDADNISDYLGVHQYDFGLAEEAPEVGRVT
HHHHHHHHHHHHHHHHCCCCCCCCEEEEEEEECCCCHHHHCCHHCCCCCHHCCCCHHHEE
GLAWTSVGGELLTIETITMPGKGDFVYTGSLGDVMKESIRAAMSVVRARGEMIGIDYETF
EEEECCCCCEEEEEEEEEECCCCCEEEECCHHHHHHHHHHHHHHHHHHCCCEEECCHHHH
KSKDVHVHMPEGATPKDGPSAGIALTTALVSAMTGIAIRPDIAMTGEVTLRGKVLRIGGL
CCCCEEEECCCCCCCCCCCCCHHHHHHHHHHHHHCCEECCCCEEECCEEEEEEEEEECCH
KEKLLAAHRGGIKHVLIPASNERDLVEIPDNVKEGLTIQPVSTIDEVLQAALVEMPKPLA
HHHHHHHHCCCCEEEEEECCCCCCEEECCCHHHCCCEECCHHHHHHHHHHHHHHCCCCCC
PNKVKVAVDTTKAEPALRS
CCEEEEEEECCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA