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The map label for this gene is norM [H]

Identifier: 148653453

GI number: 148653453

Start: 2048272

End: 2049642

Strand: Direct

Name: norM [H]

Synonym: PsycPRwf_1656

Alternate gene names: 148653453

Gene position: 2048272-2049642 (Clockwise)

Preceding gene: 148653448

Following gene: 148653454

Centisome position: 68.76

GC content: 47.48

Gene sequence:

>1371_bases
ATGTTGTCTAATTTATCTTTTTCTGAGTTTAAACAGCACAGTTTACGCTTAGGTACCTTAGTTCTTCCCATCTTAATTAC
TCAGTTTTGTCAGGCAGCGTTAGGCGTAGTCGATGCGCTGATGGCCGGCGGCGTTTCTGCTCTAGACTTGGCAGCAGTGT
CCATTGGCTCAGGTATTTGGCTGCCTTTGTTCTTGTTAGCCACAGGGACTTTGATTGCTACCACACCACTGATTGGCGAA
AAGATGGGGGAAAAACTGCCCCATCACGTACCACATATCACTCAGCAGTCCTTGTGGGCAGCATTATTTATTGGCGCCAT
TGGCCTGGTAGTGGTGTCCTTTACGCCTAATATTCTAGGCCCTATGGGCGTGCCAGCCGATATTCAGCCTAAGGCAGCGC
AATATCTACGCTTCGTAGCTTGGGGCTTTCCTGCTATTGCCTGCTATGCGGTACTGCGCAGCTATTGTGAGGCGCTCGGT
AGACCTGAGCCGGTCACTATTATCAGCTTAATTGGCTTATTTATTAATATTCCAATCAACTACATCTTTATCCACGGTTT
ATTTGGCATGCCAGAGCTTGGTGGCGCAGGCTGTGGTCTGGCTACCGCTTGTGTGCTGTGGATTAATGTCATCTTACTAT
CTATTTATTTGTTTTTCTCGAAGCACACAACCTTTGATGAGACCCGCTTCTTTTACAACTTCGCCAAACCTGATCGTCAG
CAAATCGGTAAGCTGTTTCGCTTAGGTGTCCCCATTGGCATCTCGATATTTTTTGAGGCAAGTTTATTTAGTCTGGCCTC
TATCGTAATTAGCCCCTTGGGTGCAGTGGCTGTGGCCTCTCACCAAGTGGCACTGGCGGTGACCTCTCAGCTGTTTATGA
TTCCGATGTCAGTGGCGATGGGTCTTACCATTATGGTCTCTAATCGCTATGGCGAGAAAAACTGGCTGGCCTTACAGCAA
GTGCAGCGCACGGGACTGATTTGGACCGTGGGTATCGCGTTGGTGAGTATGCTTGGGGTATGGTTGTTCCGTGAGAACTT
AGCCGATGCCTTTACCGATAATCCGGCCGTAAAAGCACAAGCGATGTATTTATTGCTATTTGCCATTGCCTATCAATTGG
TAGATGGATGGCAGGTCAACATAGCGGGTATCTTACGCGGTATGCAAGACACACAAGTGCCGATGTGGATCACTTTATTT
TGTTATTGGCTGGTGGCTTTACCATTAGGAACCTATTTGGTTCGTTATACCGACACAGGTGCACAAGGATTTTGGATGGC
ATTGGTCACTGGCCTGAGTTTATCTTCGGTGTTATTGACATTAAGGCTAATTTATCGTCAGCGCCAAGTTTTGAGCATAC
CTGCGCGCTAG

Upstream 100 bases:

>100_bases
AACTCTATATAAAAGGCGGCGCTGCATTGCTATCGCTATAAAAGCGTCTTCTTTTTGTCTCACTCTTTGGGCTGTCACCC
TTATATTTAGAAGTTATGTT

Downstream 100 bases:

>100_bases
CCCTTTAAATATAAGGGCTGTATCAACCCGCTTTAAATACTTATAGACAAAAATATGTCTGAAAATTCACAAGATTGGTC
ACAATTTGTTAATTTTTGCA

Product: MATE efflux family protein

Products: Proton [Cytoplasm]; multidrug [Periplasm] [C]

Alternate protein names: Multidrug-efflux transporter [H]

Number of amino acids: Translated: 456; Mature: 456

Protein sequence:

>456_residues
MLSNLSFSEFKQHSLRLGTLVLPILITQFCQAALGVVDALMAGGVSALDLAAVSIGSGIWLPLFLLATGTLIATTPLIGE
KMGEKLPHHVPHITQQSLWAALFIGAIGLVVVSFTPNILGPMGVPADIQPKAAQYLRFVAWGFPAIACYAVLRSYCEALG
RPEPVTIISLIGLFINIPINYIFIHGLFGMPELGGAGCGLATACVLWINVILLSIYLFFSKHTTFDETRFFYNFAKPDRQ
QIGKLFRLGVPIGISIFFEASLFSLASIVISPLGAVAVASHQVALAVTSQLFMIPMSVAMGLTIMVSNRYGEKNWLALQQ
VQRTGLIWTVGIALVSMLGVWLFRENLADAFTDNPAVKAQAMYLLLFAIAYQLVDGWQVNIAGILRGMQDTQVPMWITLF
CYWLVALPLGTYLVRYTDTGAQGFWMALVTGLSLSSVLLTLRLIYRQRQVLSIPAR

Sequences:

>Translated_456_residues
MLSNLSFSEFKQHSLRLGTLVLPILITQFCQAALGVVDALMAGGVSALDLAAVSIGSGIWLPLFLLATGTLIATTPLIGE
KMGEKLPHHVPHITQQSLWAALFIGAIGLVVVSFTPNILGPMGVPADIQPKAAQYLRFVAWGFPAIACYAVLRSYCEALG
RPEPVTIISLIGLFINIPINYIFIHGLFGMPELGGAGCGLATACVLWINVILLSIYLFFSKHTTFDETRFFYNFAKPDRQ
QIGKLFRLGVPIGISIFFEASLFSLASIVISPLGAVAVASHQVALAVTSQLFMIPMSVAMGLTIMVSNRYGEKNWLALQQ
VQRTGLIWTVGIALVSMLGVWLFRENLADAFTDNPAVKAQAMYLLLFAIAYQLVDGWQVNIAGILRGMQDTQVPMWITLF
CYWLVALPLGTYLVRYTDTGAQGFWMALVTGLSLSSVLLTLRLIYRQRQVLSIPAR
>Mature_456_residues
MLSNLSFSEFKQHSLRLGTLVLPILITQFCQAALGVVDALMAGGVSALDLAAVSIGSGIWLPLFLLATGTLIATTPLIGE
KMGEKLPHHVPHITQQSLWAALFIGAIGLVVVSFTPNILGPMGVPADIQPKAAQYLRFVAWGFPAIACYAVLRSYCEALG
RPEPVTIISLIGLFINIPINYIFIHGLFGMPELGGAGCGLATACVLWINVILLSIYLFFSKHTTFDETRFFYNFAKPDRQ
QIGKLFRLGVPIGISIFFEASLFSLASIVISPLGAVAVASHQVALAVTSQLFMIPMSVAMGLTIMVSNRYGEKNWLALQQ
VQRTGLIWTVGIALVSMLGVWLFRENLADAFTDNPAVKAQAMYLLLFAIAYQLVDGWQVNIAGILRGMQDTQVPMWITLF
CYWLVALPLGTYLVRYTDTGAQGFWMALVTGLSLSSVLLTLRLIYRQRQVLSIPAR

Specific function: Multidrug efflux pump [H]

COG id: COG0534

COG function: function code V; Na+-driven multidrug efflux pump

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family [H]

Homologues:

Organism=Homo sapiens, GI153792564, Length=432, Percent_Identity=21.7592592592593, Blast_Score=70, Evalue=6e-12,
Organism=Escherichia coli, GI48994890, Length=435, Percent_Identity=39.5402298850575, Blast_Score=309, Evalue=2e-85,
Organism=Escherichia coli, GI226510954, Length=447, Percent_Identity=20.8053691275168, Blast_Score=69, Evalue=6e-13,
Organism=Saccharomyces cerevisiae, GI6321821, Length=395, Percent_Identity=22.0253164556962, Blast_Score=69, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002528 [H]

Pfam domain/function: PF01554 MatE [H]

EC number: NA

Molecular weight: Translated: 49763; Mature: 49763

Theoretical pI: Translated: 8.75; Mature: 8.75

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLSNLSFSEFKQHSLRLGTLVLPILITQFCQAALGVVDALMAGGVSALDLAAVSIGSGIW
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCHH
LPLFLLATGTLIATTPLIGEKMGEKLPHHVPHITQQSLWAALFIGAIGLVVVSFTPNILG
HHHHHHHCCHHHHHCCHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCC
PMGVPADIQPKAAQYLRFVAWGFPAIACYAVLRSYCEALGRPEPVTIISLIGLFINIPIN
CCCCCCCCCHHHHHHHHHHHHCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCHH
YIFIHGLFGMPELGGAGCGLATACVLWINVILLSIYLFFSKHTTFDETRFFYNFAKPDRQ
HEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHCCCCCCHH
QIGKLFRLGVPIGISIFFEASLFSLASIVISPLGAVAVASHQVALAVTSQLFMIPMSVAM
HHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
GLTIMVSNRYGEKNWLALQQVQRTGLIWTVGIALVSMLGVWLFRENLADAFTDNPAVKAQ
CEEEEEECCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHH
AMYLLLFAIAYQLVDGWQVNIAGILRGMQDTQVPMWITLFCYWLVALPLGTYLVRYTDTG
HHHHHHHHHHHHHHCCCEEEHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHEEEEECCC
AQGFWMALVTGLSLSSVLLTLRLIYRQRQVLSIPAR
CCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MLSNLSFSEFKQHSLRLGTLVLPILITQFCQAALGVVDALMAGGVSALDLAAVSIGSGIW
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCHH
LPLFLLATGTLIATTPLIGEKMGEKLPHHVPHITQQSLWAALFIGAIGLVVVSFTPNILG
HHHHHHHCCHHHHHCCHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCC
PMGVPADIQPKAAQYLRFVAWGFPAIACYAVLRSYCEALGRPEPVTIISLIGLFINIPIN
CCCCCCCCCHHHHHHHHHHHHCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCHH
YIFIHGLFGMPELGGAGCGLATACVLWINVILLSIYLFFSKHTTFDETRFFYNFAKPDRQ
HEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHCCCCCCHH
QIGKLFRLGVPIGISIFFEASLFSLASIVISPLGAVAVASHQVALAVTSQLFMIPMSVAM
HHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
GLTIMVSNRYGEKNWLALQQVQRTGLIWTVGIALVSMLGVWLFRENLADAFTDNPAVKAQ
CEEEEEECCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHH
AMYLLLFAIAYQLVDGWQVNIAGILRGMQDTQVPMWITLFCYWLVALPLGTYLVRYTDTG
HHHHHHHHHHHHHHCCCEEEHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHEEEEECCC
AQGFWMALVTGLSLSSVLLTLRLIYRQRQVLSIPAR
CCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; multidrug [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + multidrug [Cytoplasm] = Proton [Cytoplasm] + multidrug [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA