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The map label for this gene is aceA [C]

Identifier: 148653250

GI number: 148653250

Start: 1773186

End: 1774769

Strand: Direct

Name: aceA [C]

Synonym: PsycPRwf_1448

Alternate gene names: 148653250

Gene position: 1773186-1774769 (Clockwise)

Preceding gene: 148653243

Following gene: 148653251

Centisome position: 59.52

GC content: 44.51

Gene sequence:

>1584_bases
ATGTCAACTTATAAATCAGCTATTGACCATATCCGTGAAATTAAAGCAAAGCATGGCAACTGGCAGAATATCAGCGAATC
TGATGCTGCTCGTATGATGGTTCAAAACCGCTTCAAAACCGGTCTTGATATCGCTAAATACACGGCTGCTATCATGCGTA
AAGATATGGCAGAGTATGATGCAGATACATCTAAGTACACTCAGTCTCTAGGCGCATGGCATGGTTTTGTTGCACAACAA
ACTATGTATGCTAAGAAAAAATACTTCGGTACGACTGCTAAAACCTACATCTACCTATCAGGCTGGATGGTAGCGGCTCT
ACGCTCAGAGCTTGGCCCTTTACCTGACCAATCAATGCACGAAAAAACAACGGTTCCTGCGCTAATCGAAGAAATCTACA
CCTTCTTACGTCAAGCAGACGCGAAAGTATTAAATGATTATTTCCGTGAGCTTAACGCTGCTAAAGAAGCCGGTCAAGAT
ACTTCTGAAATCGAAGAAAAAATCAATAACTTTGATTCACACGTTGTGCCAATCATCGCTGACATCGACGCAGGTTTCGG
TAACGAAGAAGCAACTTACTTACTTACTAAAGCCATGATCGAAGCGGGTGCTTGTGCTATCCAGATCGAAAACCAAGTAT
CTGATGCAAAACAATGTGGTCACCAAGCCGGTAAAGTCACTGTACCACATGAAGACTTCATCTCTAAGCTTAACGCTATC
CGTTATGCATTCTTAGAGCTAGGCGTTGATGATGGTGTTATCGTTGCCCGTACCGACTCAGAAGGTGCATCACTTACTCA
AAAGATCCCAGTATCTGAAGAGCCAGGCGACCTTGCTTCTAAATACATCGACTTCATCGACGTTGAAGAAATCGACATCG
CTGATGCCAAAGAAAACGACGTACTATTAAAGCGTGACGGTAAATTAGTTCGCCCAGTTCGTCTAGCTAACGGTCTATAC
CAGTTCCGTGAAGATACCAACATCGACCGCGTTGTACTTGACTGTGTAACCGCTCTTGAAAATGGTGCTGACCTTCTATG
GATCGAAACACCGACTCCAGATGTTGCACACATCAAAATGATGGTTGACCGTATTAAAGAGCAGCAGCCTAAAGCGAAGC
TTGTATACAACAACAGCCCATCATTTAACTGGACGCTAAACTTCCGTAAGCAAGTGATTGCTCAGTGGGAAGAAGAAGGC
AAAGACATCTCAGCATACGACAAGAACAACTTGATGAGTGCTGATTATGATGGTACTGAGCTTGACGCTGCTGCTGACCA
AGCTGCGAAGAACTTCCAGAAAGATGCGTCACGTGAAGCCGGTGTATTCCATCACCTAATCACGCTACCAACTTACCACA
CCACAGCACTTAGCGTTCATGAGCTTGCTAAAGGCTACTTCGGTGAAGACGGTATGCTTGCTTATGCAGCTGGCGTACAA
CGTAAAGAAATCCGTGAAGGCATCTCTTGCGTTAAGCACCAAGCAATGGCCGGTTCAGACTTAGGTGATGATCACAAAGA
GATTTTCTCTGGTGACAACGCACTTAAAGCTGGCGGCGAGAAAAACACAATGAACCAGTTCTAA

Upstream 100 bases:

>100_bases
TTAAAGAGAGTTAAATAAAACTTCTTTATCTAACCGTTCAACATCTAGTAGTAAGAAGTATTTATTTCGCCTAACCCATC
CTCAATCAAGGAGACAATTG

Downstream 100 bases:

>100_bases
GAACTCTTTAGACCAAAGCTCTTTATAAAAGACGCTTCGTTCATCATTAACAAAGTCGCTCTAACCTCGGTTAGGGCGAC
TTTTTTTATGAACCTAGGCG

Product: isocitrate lyase

Products: NA

Alternate protein names: ICL; Isocitrase; Isocitratase [H]

Number of amino acids: Translated: 527; Mature: 526

Protein sequence:

>527_residues
MSTYKSAIDHIREIKAKHGNWQNISESDAARMMVQNRFKTGLDIAKYTAAIMRKDMAEYDADTSKYTQSLGAWHGFVAQQ
TMYAKKKYFGTTAKTYIYLSGWMVAALRSELGPLPDQSMHEKTTVPALIEEIYTFLRQADAKVLNDYFRELNAAKEAGQD
TSEIEEKINNFDSHVVPIIADIDAGFGNEEATYLLTKAMIEAGACAIQIENQVSDAKQCGHQAGKVTVPHEDFISKLNAI
RYAFLELGVDDGVIVARTDSEGASLTQKIPVSEEPGDLASKYIDFIDVEEIDIADAKENDVLLKRDGKLVRPVRLANGLY
QFREDTNIDRVVLDCVTALENGADLLWIETPTPDVAHIKMMVDRIKEQQPKAKLVYNNSPSFNWTLNFRKQVIAQWEEEG
KDISAYDKNNLMSADYDGTELDAAADQAAKNFQKDASREAGVFHHLITLPTYHTTALSVHELAKGYFGEDGMLAYAAGVQ
RKEIREGISCVKHQAMAGSDLGDDHKEIFSGDNALKAGGEKNTMNQF

Sequences:

>Translated_527_residues
MSTYKSAIDHIREIKAKHGNWQNISESDAARMMVQNRFKTGLDIAKYTAAIMRKDMAEYDADTSKYTQSLGAWHGFVAQQ
TMYAKKKYFGTTAKTYIYLSGWMVAALRSELGPLPDQSMHEKTTVPALIEEIYTFLRQADAKVLNDYFRELNAAKEAGQD
TSEIEEKINNFDSHVVPIIADIDAGFGNEEATYLLTKAMIEAGACAIQIENQVSDAKQCGHQAGKVTVPHEDFISKLNAI
RYAFLELGVDDGVIVARTDSEGASLTQKIPVSEEPGDLASKYIDFIDVEEIDIADAKENDVLLKRDGKLVRPVRLANGLY
QFREDTNIDRVVLDCVTALENGADLLWIETPTPDVAHIKMMVDRIKEQQPKAKLVYNNSPSFNWTLNFRKQVIAQWEEEG
KDISAYDKNNLMSADYDGTELDAAADQAAKNFQKDASREAGVFHHLITLPTYHTTALSVHELAKGYFGEDGMLAYAAGVQ
RKEIREGISCVKHQAMAGSDLGDDHKEIFSGDNALKAGGEKNTMNQF
>Mature_526_residues
STYKSAIDHIREIKAKHGNWQNISESDAARMMVQNRFKTGLDIAKYTAAIMRKDMAEYDADTSKYTQSLGAWHGFVAQQT
MYAKKKYFGTTAKTYIYLSGWMVAALRSELGPLPDQSMHEKTTVPALIEEIYTFLRQADAKVLNDYFRELNAAKEAGQDT
SEIEEKINNFDSHVVPIIADIDAGFGNEEATYLLTKAMIEAGACAIQIENQVSDAKQCGHQAGKVTVPHEDFISKLNAIR
YAFLELGVDDGVIVARTDSEGASLTQKIPVSEEPGDLASKYIDFIDVEEIDIADAKENDVLLKRDGKLVRPVRLANGLYQ
FREDTNIDRVVLDCVTALENGADLLWIETPTPDVAHIKMMVDRIKEQQPKAKLVYNNSPSFNWTLNFRKQVIAQWEEEGK
DISAYDKNNLMSADYDGTELDAAADQAAKNFQKDASREAGVFHHLITLPTYHTTALSVHELAKGYFGEDGMLAYAAGVQR
KEIREGISCVKHQAMAGSDLGDDHKEIFSGDNALKAGGEKNTMNQF

Specific function: Catalyzes the formation of succinate and glyoxylate from isocitrate, a key step of the glyoxylate cycle. May be involved in the assimilation of one-carbon compounds via the isocitrate lyase- positive serine pathway [H]

COG id: COG2224

COG function: function code C; Isocitrate lyase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the isocitrate lyase/PEP mutase superfamily. Isocitrate lyase family [H]

Homologues:

Organism=Escherichia coli, GI1790445, Length=518, Percent_Identity=28.1853281853282, Blast_Score=155, Evalue=5e-39,
Organism=Caenorhabditis elegans, GI71982926, Length=446, Percent_Identity=30.0448430493274, Blast_Score=151, Evalue=6e-37,
Organism=Caenorhabditis elegans, GI17561814, Length=446, Percent_Identity=30.0448430493274, Blast_Score=151, Evalue=7e-37,
Organism=Saccharomyces cerevisiae, GI6325263, Length=501, Percent_Identity=24.5508982035928, Blast_Score=121, Evalue=3e-28,
Organism=Saccharomyces cerevisiae, GI6320908, Length=170, Percent_Identity=35.2941176470588, Blast_Score=99, Evalue=1e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006254
- InterPro:   IPR000918
- InterPro:   IPR015813 [H]

Pfam domain/function: PF00463 ICL [H]

EC number: =4.1.3.1 [H]

Molecular weight: Translated: 58685; Mature: 58553

Theoretical pI: Translated: 4.85; Mature: 4.85

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTYKSAIDHIREIKAKHGNWQNISESDAARMMVQNRFKTGLDIAKYTAAIMRKDMAEYD
CCHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHC
ADTSKYTQSLGAWHGFVAQQTMYAKKKYFGTTAKTYIYLSGWMVAALRSELGPLPDQSMH
CCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEHHHHHHHHHHHHCCCCCCHHH
EKTTVPALIEEIYTFLRQADAKVLNDYFRELNAAKEAGQDTSEIEEKINNFDSHVVPIIA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCEEEEEE
DIDAGFGNEEATYLLTKAMIEAGACAIQIENQVSDAKQCGHQAGKVTVPHEDFISKLNAI
ECCCCCCCCHHHHHHHHHHHHCCCEEEEEHHHHHHHHHHHHCCCCEECCHHHHHHHHHHH
RYAFLELGVDDGVIVARTDSEGASLTQKIPVSEEPGDLASKYIDFIDVEEIDIADAKEND
HHHHHHCCCCCCEEEEEECCCCCCHHHCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCC
VLLKRDGKLVRPVRLANGLYQFREDTNIDRVVLDCVTALENGADLLWIETPTPDVAHIKM
EEEECCCCEECHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCEEEEECCCCCHHHHHH
MVDRIKEQQPKAKLVYNNSPSFNWTLNFRKQVIAQWEEEGKDISAYDKNNLMSADYDGTE
HHHHHHHCCCCEEEEECCCCCEEEEEHHHHHHHHHHHHCCCCCCCCCCCCCEECCCCCCH
LDAAADQAAKNFQKDASREAGVFHHLITLPTYHTTALSVHELAKGYFGEDGMLAYAAGVQ
HHHHHHHHHHHHHHHHCHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCCCEEHHHCCC
RKEIREGISCVKHQAMAGSDLGDDHKEIFSGDNALKAGGEKNTMNQF
HHHHHHHHHHHHHHHHCCCCCCCCHHHHHCCCCHHHCCCCCCCCCCC
>Mature Secondary Structure 
STYKSAIDHIREIKAKHGNWQNISESDAARMMVQNRFKTGLDIAKYTAAIMRKDMAEYD
CHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHC
ADTSKYTQSLGAWHGFVAQQTMYAKKKYFGTTAKTYIYLSGWMVAALRSELGPLPDQSMH
CCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEHHHHHHHHHHHHCCCCCCHHH
EKTTVPALIEEIYTFLRQADAKVLNDYFRELNAAKEAGQDTSEIEEKINNFDSHVVPIIA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCEEEEEE
DIDAGFGNEEATYLLTKAMIEAGACAIQIENQVSDAKQCGHQAGKVTVPHEDFISKLNAI
ECCCCCCCCHHHHHHHHHHHHCCCEEEEEHHHHHHHHHHHHCCCCEECCHHHHHHHHHHH
RYAFLELGVDDGVIVARTDSEGASLTQKIPVSEEPGDLASKYIDFIDVEEIDIADAKEND
HHHHHHCCCCCCEEEEEECCCCCCHHHCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCC
VLLKRDGKLVRPVRLANGLYQFREDTNIDRVVLDCVTALENGADLLWIETPTPDVAHIKM
EEEECCCCEECHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCEEEEECCCCCHHHHHH
MVDRIKEQQPKAKLVYNNSPSFNWTLNFRKQVIAQWEEEGKDISAYDKNNLMSADYDGTE
HHHHHHHCCCCEEEEECCCCCEEEEEHHHHHHHHHHHHCCCCCCCCCCCCCEECCCCCCH
LDAAADQAAKNFQKDASREAGVFHHLITLPTYHTTALSVHELAKGYFGEDGMLAYAAGVQ
HHHHHHHHHHHHHHHHCHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCCCEEHHHCCC
RKEIREGISCVKHQAMAGSDLGDDHKEIFSGDNALKAGGEKNTMNQF
HHHHHHHHHHHHHHHHCCCCCCCCHHHHHCCCCHHHCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10984043 [H]