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The map label for this gene is prpC [H]

Identifier: 148653004

GI number: 148653004

Start: 1464312

End: 1465442

Strand: Direct

Name: prpC [H]

Synonym: PsycPRwf_1198

Alternate gene names: 148653004

Gene position: 1464312-1465442 (Clockwise)

Preceding gene: 148653003

Following gene: 148653005

Centisome position: 49.15

GC content: 48.63

Gene sequence:

>1131_bases
ATGGCAGCAGGTAAACAACTATCAGGCGCAGGCTTACGTGGTCAAGTAGCAGGTAAAACCGCATTATCAACCGTCGGTAA
ATCAGGCTCAGGCTTAACTTACCGTGGTTATGATGTCAAAGATTTAGCCGAAAACTGCATCTTTGAAGAAGTCGCCTATT
TATTGTTATACGGTAATTTGCCTACCCAAGCCCAGCTCGATGACTACAAAGCCACGCTAAAACAACTTCGTGATCTACCG
CAGCCACTAAAAGACGTATTAGAACGTATTCCACAAGATGCGCATCCAATGGATGTGCTGCGTACCGGCTGCTCGATGCT
AGGTAACTTAGAGCCAGAAAATAGCTTTGATGAGCAGCTGGAAAAAACTAACCGCATGCTATCAGCCTTCCCAGCGATTA
TTAACTACTGGTACCGCTTTAGCCACGAAGGCGTCAAGATTGACTGCGTGACCGATGCCGAAACCATTGGTGGTCACTTT
TTGCAATTATTAAAAGGTGACAAGCCAAGTGAGTTACATGAGCGTGTGATGAATGTGTCGCTTATCTTGTACGCTGAGCA
TGAGTTTAACGCCTCTACCTTTACCGCGCGTGTCTGTGCCTCCACCCTATCAGACATCTTCTCTTGTATCACAGGTGCCA
TCGGCTCATTACGTGGCCCGTTACACGGCGGCGCCAATGAAGCGGCGATGGAGCTTATTGAAGGCTTTGACTCGCCAGAA
GATGCAGAAGCCGGCTTACTGCGTATGCTAGATAACAAAGACAAGATTATGGGCTTTGGTCACGCGATTTATAGCGAATC
AGATCCACGTAACGTGATTATCAAGCAGTGGGCTGAAAAACTAGCCGCCGATGTCGGCGATGAGGTGTTATACCCAGTAT
CTGTGCGCTGTGAAGAGGTGATGTGGCGTGAGAAAAAACTGTTCTGTAACGCAGACTTCTTCCATGCGTCGACCTATAAC
TTTATGGGTATTCCAACCAAGCTATTCACGCCAATTTTCGTTTGCTCTCGCCTAACCGGTTGGGCCGCTCACGTATTTGA
GCAGCGTGCTGACAACCGTATTATCCGCCCAAGCGCCGAATATGTGGGCGAAGCGCCACGTGAGGTAACGCCTATCGCTG
AGCGCGGTTAG

Upstream 100 bases:

>100_bases
TGACTGCAGATTGTACAAATCGTACATCTAAGCAAACCAACACAGTGACGCTGCAACATACAAACTATTTCAGCCACCAA
ACAAAAAAAGGATTTTTACT

Downstream 100 bases:

>100_bases
TTTATAAAGTAGAGTCAGATTGTTTAGGGCTCTATCTTTTTTATTGAAGATAGGGCCTTATTTGTTAGATGATTATTTTG
TTAGATGATTGTATTTAATG

Product: methylcitrate synthase

Products: NA

Alternate protein names: Citrate synthase 2; Methylcitrate synthase [H]

Number of amino acids: Translated: 376; Mature: 375

Protein sequence:

>376_residues
MAAGKQLSGAGLRGQVAGKTALSTVGKSGSGLTYRGYDVKDLAENCIFEEVAYLLLYGNLPTQAQLDDYKATLKQLRDLP
QPLKDVLERIPQDAHPMDVLRTGCSMLGNLEPENSFDEQLEKTNRMLSAFPAIINYWYRFSHEGVKIDCVTDAETIGGHF
LQLLKGDKPSELHERVMNVSLILYAEHEFNASTFTARVCASTLSDIFSCITGAIGSLRGPLHGGANEAAMELIEGFDSPE
DAEAGLLRMLDNKDKIMGFGHAIYSESDPRNVIIKQWAEKLAADVGDEVLYPVSVRCEEVMWREKKLFCNADFFHASTYN
FMGIPTKLFTPIFVCSRLTGWAAHVFEQRADNRIIRPSAEYVGEAPREVTPIAERG

Sequences:

>Translated_376_residues
MAAGKQLSGAGLRGQVAGKTALSTVGKSGSGLTYRGYDVKDLAENCIFEEVAYLLLYGNLPTQAQLDDYKATLKQLRDLP
QPLKDVLERIPQDAHPMDVLRTGCSMLGNLEPENSFDEQLEKTNRMLSAFPAIINYWYRFSHEGVKIDCVTDAETIGGHF
LQLLKGDKPSELHERVMNVSLILYAEHEFNASTFTARVCASTLSDIFSCITGAIGSLRGPLHGGANEAAMELIEGFDSPE
DAEAGLLRMLDNKDKIMGFGHAIYSESDPRNVIIKQWAEKLAADVGDEVLYPVSVRCEEVMWREKKLFCNADFFHASTYN
FMGIPTKLFTPIFVCSRLTGWAAHVFEQRADNRIIRPSAEYVGEAPREVTPIAERG
>Mature_375_residues
AAGKQLSGAGLRGQVAGKTALSTVGKSGSGLTYRGYDVKDLAENCIFEEVAYLLLYGNLPTQAQLDDYKATLKQLRDLPQ
PLKDVLERIPQDAHPMDVLRTGCSMLGNLEPENSFDEQLEKTNRMLSAFPAIINYWYRFSHEGVKIDCVTDAETIGGHFL
QLLKGDKPSELHERVMNVSLILYAEHEFNASTFTARVCASTLSDIFSCITGAIGSLRGPLHGGANEAAMELIEGFDSPED
AEAGLLRMLDNKDKIMGFGHAIYSESDPRNVIIKQWAEKLAADVGDEVLYPVSVRCEEVMWREKKLFCNADFFHASTYNF
MGIPTKLFTPIFVCSRLTGWAAHVFEQRADNRIIRPSAEYVGEAPREVTPIAERG

Specific function: Catalyzes the synthesis of 2-methylcitrate from propionyl-CoA and oxaloacetate. Also catalyzes the condensation of oxaloacetate with acetyl-CoA but with a lower specificity [H]

COG id: COG0372

COG function: function code C; Citrate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the citrate synthase family [H]

Homologues:

Organism=Escherichia coli, GI1786527, Length=374, Percent_Identity=50.8021390374332, Blast_Score=397, Evalue=1e-112,
Organism=Escherichia coli, GI1786939, Length=360, Percent_Identity=32.7777777777778, Blast_Score=183, Evalue=1e-47,
Organism=Caenorhabditis elegans, GI17555174, Length=299, Percent_Identity=23.4113712374582, Blast_Score=89, Evalue=3e-18,
Organism=Saccharomyces cerevisiae, GI6319850, Length=394, Percent_Identity=23.3502538071066, Blast_Score=97, Evalue=3e-21,
Organism=Saccharomyces cerevisiae, GI6324328, Length=396, Percent_Identity=23.2323232323232, Blast_Score=91, Evalue=4e-19,
Organism=Drosophila melanogaster, GI21356863, Length=315, Percent_Identity=25.0793650793651, Blast_Score=77, Evalue=2e-14,
Organism=Drosophila melanogaster, GI24640126, Length=379, Percent_Identity=22.6912928759894, Blast_Score=77, Evalue=2e-14,
Organism=Drosophila melanogaster, GI24640124, Length=380, Percent_Identity=22.6315789473684, Blast_Score=76, Evalue=3e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011278
- InterPro:   IPR016142
- InterPro:   IPR016143
- InterPro:   IPR002020
- InterPro:   IPR016141
- InterPro:   IPR019810 [H]

Pfam domain/function: PF00285 Citrate_synt [H]

EC number: =2.3.3.5 [H]

Molecular weight: Translated: 41669; Mature: 41538

Theoretical pI: Translated: 4.98; Mature: 4.98

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAAGKQLSGAGLRGQVAGKTALSTVGKSGSGLTYRGYDVKDLAENCIFEEVAYLLLYGNL
CCCCCCCCCCCCCCCCCHHHHHHHHCCCCCCCEECCCCHHHHHHHHHHHHHHHHHHCCCC
PTQAQLDDYKATLKQLRDLPQPLKDVLERIPQDAHPMDVLRTGCSMLGNLEPENSFDEQL
CCCCHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCCCCHHHHH
EKTNRMLSAFPAIINYWYRFSHEGVKIDCVTDAETIGGHFLQLLKGDKPSELHERVMNVS
HHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCHHHHHHHHHHHHCCCCHHHHHHHHHCEE
LILYAEHEFNASTFTARVCASTLSDIFSCITGAIGSLRGPLHGGANEAAMELIEGFDSPE
EEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHCCCCCC
DAEAGLLRMLDNKDKIMGFGHAIYSESDPRNVIIKQWAEKLAADVGDEVLYPVSVRCEEV
CHHHHHHHHHCCCHHHEECHHHHCCCCCCHHHHHHHHHHHHHHHCCCCEECCHHHHHHHH
MWREKKLFCNADFFHASTYNFMGIPTKLFTPIFVCSRLTGWAAHVFEQRADNRIIRPSAE
HHHHHHHEECCCEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCEECCCHH
YVGEAPREVTPIAERG
HHCCCCCCCCCCCCCC
>Mature Secondary Structure 
AAGKQLSGAGLRGQVAGKTALSTVGKSGSGLTYRGYDVKDLAENCIFEEVAYLLLYGNL
CCCCCCCCCCCCCCCCHHHHHHHHCCCCCCCEECCCCHHHHHHHHHHHHHHHHHHCCCC
PTQAQLDDYKATLKQLRDLPQPLKDVLERIPQDAHPMDVLRTGCSMLGNLEPENSFDEQL
CCCCHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCCCCHHHHH
EKTNRMLSAFPAIINYWYRFSHEGVKIDCVTDAETIGGHFLQLLKGDKPSELHERVMNVS
HHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCHHHHHHHHHHHHCCCCHHHHHHHHHCEE
LILYAEHEFNASTFTARVCASTLSDIFSCITGAIGSLRGPLHGGANEAAMELIEGFDSPE
EEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHCCCCCC
DAEAGLLRMLDNKDKIMGFGHAIYSESDPRNVIIKQWAEKLAADVGDEVLYPVSVRCEEV
CHHHHHHHHHCCCHHHEECHHHHCCCCCCHHHHHHHHHHHHHHHCCCCEECCHHHHHHHH
MWREKKLFCNADFFHASTYNFMGIPTKLFTPIFVCSRLTGWAAHVFEQRADNRIIRPSAE
HHHHHHHEECCCEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCEECCCHH
YVGEAPREVTPIAERG
HHCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9278503; 8508809; 9325432 [H]