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The map label for this gene is dld [H]

Identifier: 148652887

GI number: 148652887

Start: 1302634

End: 1304406

Strand: Direct

Name: dld [H]

Synonym: PsycPRwf_1080

Alternate gene names: 148652887

Gene position: 1302634-1304406 (Clockwise)

Preceding gene: 148652885

Following gene: 148652888

Centisome position: 43.73

GC content: 45.46

Gene sequence:

>1773_bases
ATGAGCGATATTCAATCAGCAGGCAGTACGGATCATATTTTCCCCTCAAAGCGGGTGACTTTGGGTACACTGACGCCCGA
TCAGGTGCTGCAACAGCTCACCCAACTGTTGGGTGCGGCTAATATACAAGCAGATCCCACAAAAAACGAATACTACCGAA
TGGGGTGGCGCTCTGGTGGCGGCAGTGCTTTGGCGGTATTGTTTCCGCAGACTTTGCTGCAGATTTGGCAAAGCTTAGAG
GTCTGTGTGGCAGGCGACTGCATTATCATCATGCAAGCGGCCAAAACAGGTCTGACAGAAGGCTCAGCACCCAACGGCGA
GGATTATGATCGACCGGTTATTGTTATTAATACACTGGCCTTAAATCAGCTGTATTTGGTCAATAATAACCAGCAGGTCA
TCAGCTTGCCAGGCGCCACATTGCATCAGTTACAAAAGCAGCTCAAGGCGGTCAATAGAGCGCCGCACTCAGTGATAGGA
TCATCGACTTTGGGCGCGACTATCGTGGGCGGCGTGTCCAATAATTCAGGTGGCGCTTTGGTAAAAAGAGGACCGGCTTA
CACTGAGCTGGCGTTATTTGCTCAAATCAATGAACAAGGTGAGCTGATATTGGTCAATCACTTAAATATCGATCTTGGGG
CGTCGCCAGAGCAAATCCTAACCAATCTACAAACCGGTAACTTTGATAAAACCAAGCTGTCAGATAATGGCAAAATGGCT
TCGGACAAAGAGTATGTGGCCCGTGTCAAAGATGTCGATGCAGATACGCCAAGCCGATTTAATGCAGACAAAAGAAGACT
TTATGAGGCCAGTGGCTGCGCCGGCAAGCTGGCAGTTTTTGCAGTGCGCCTGGACACTTATCCAATAGCTGCCCAAGAAA
AAACGTTTTATATCGGCAGCAATAGTATTGGTGAGCTTGCACAGTTAAGACGACAGATACTCTTAGGCTTTACCAATATT
CCTGAAGTTGGCGAGTATATGCACCGTGATATCTTCGATGTCTCAACCAAATACGGCAAAGATACTTTTTTAAGTATTAA
GCATTTAGGCACTGATACCTTGCCCAGATTGTTCTCCATCAAAGGCGCTATTGATGCGAAGCTGAACAAATGGTCTTGGA
TGCCAAAACATTTCACCGATAAAGTGATGCAGTTTATTGCCAATATTTTTCCCAACCATTTGCCCAAGCGAATGACGCAA
TATCGCAATAAGTACGAGCATCATCTTATCCTAAAAATGAGCGATGCAGGCATAATAGAGGCTCAGGTATTCTTGGAGAA
GTTTTTTGCCGACTCGACAACCGGAGATTATTTTGAGTGCAGCGATGAGGAATCAGAAAGTGCGTTTTTACATCGTTTTG
CCGCTGCTGGCGCCGCTTTAAGATATGAGGTGATACATCAAGAGGAGGTCGGCGATATATTGGCACTAGACATCGCCATT
CCTCGTAATGAGTTAGCTTGGTTTGAAGCGCTACCAGAAGAGATTAATCAGCATTTGGAGAAGAAGCTGTATTACGGACA
TTTCTTTTGTTACGTGTTCCATCAAGACTATATCTTAAAAAAAGGCAGCGATGCTCAGCAGGTCAAGCACTTCATGCTTG
AGCTTTTAAACACCAGAGGGGCCAAATATCCTGCTGAGCATAATGTGGGTCACTTATATGAAGCAGAGCCTGATTTGCAA
AACTTCTATCAGCGCTTAGATCCCACCAATAGCTTTAACCCTGGCATTGGAAAAATGTCAAAAACCAAGCGCAATTGTTC
TTGCTGTTTGTAA

Upstream 100 bases:

>100_bases
ATTTTACTCTCGTCAGCTGCGACATTCAGAGACACGATATGCACCGGTGTCATTGTGAGGGCAGTACTTTATATTCTTAA
TTATCAAGGGCATTGATGTT

Downstream 100 bases:

>100_bases
ATAGCGGCTAAAAATGTCTGATCCATAGGCGGCGTTATTGGACAACAAATGCCAGTTGAATACAACGATACGCTAAATTA
TTCACTTGTTTTTTAGACAT

Product: D-lactate dehydrogenase

Products: NA

Alternate protein names: Respiratory D-lactate dehydrogenase [H]

Number of amino acids: Translated: 590; Mature: 589

Protein sequence:

>590_residues
MSDIQSAGSTDHIFPSKRVTLGTLTPDQVLQQLTQLLGAANIQADPTKNEYYRMGWRSGGGSALAVLFPQTLLQIWQSLE
VCVAGDCIIIMQAAKTGLTEGSAPNGEDYDRPVIVINTLALNQLYLVNNNQQVISLPGATLHQLQKQLKAVNRAPHSVIG
SSTLGATIVGGVSNNSGGALVKRGPAYTELALFAQINEQGELILVNHLNIDLGASPEQILTNLQTGNFDKTKLSDNGKMA
SDKEYVARVKDVDADTPSRFNADKRRLYEASGCAGKLAVFAVRLDTYPIAAQEKTFYIGSNSIGELAQLRRQILLGFTNI
PEVGEYMHRDIFDVSTKYGKDTFLSIKHLGTDTLPRLFSIKGAIDAKLNKWSWMPKHFTDKVMQFIANIFPNHLPKRMTQ
YRNKYEHHLILKMSDAGIIEAQVFLEKFFADSTTGDYFECSDEESESAFLHRFAAAGAALRYEVIHQEEVGDILALDIAI
PRNELAWFEALPEEINQHLEKKLYYGHFFCYVFHQDYILKKGSDAQQVKHFMLELLNTRGAKYPAEHNVGHLYEAEPDLQ
NFYQRLDPTNSFNPGIGKMSKTKRNCSCCL

Sequences:

>Translated_590_residues
MSDIQSAGSTDHIFPSKRVTLGTLTPDQVLQQLTQLLGAANIQADPTKNEYYRMGWRSGGGSALAVLFPQTLLQIWQSLE
VCVAGDCIIIMQAAKTGLTEGSAPNGEDYDRPVIVINTLALNQLYLVNNNQQVISLPGATLHQLQKQLKAVNRAPHSVIG
SSTLGATIVGGVSNNSGGALVKRGPAYTELALFAQINEQGELILVNHLNIDLGASPEQILTNLQTGNFDKTKLSDNGKMA
SDKEYVARVKDVDADTPSRFNADKRRLYEASGCAGKLAVFAVRLDTYPIAAQEKTFYIGSNSIGELAQLRRQILLGFTNI
PEVGEYMHRDIFDVSTKYGKDTFLSIKHLGTDTLPRLFSIKGAIDAKLNKWSWMPKHFTDKVMQFIANIFPNHLPKRMTQ
YRNKYEHHLILKMSDAGIIEAQVFLEKFFADSTTGDYFECSDEESESAFLHRFAAAGAALRYEVIHQEEVGDILALDIAI
PRNELAWFEALPEEINQHLEKKLYYGHFFCYVFHQDYILKKGSDAQQVKHFMLELLNTRGAKYPAEHNVGHLYEAEPDLQ
NFYQRLDPTNSFNPGIGKMSKTKRNCSCCL
>Mature_589_residues
SDIQSAGSTDHIFPSKRVTLGTLTPDQVLQQLTQLLGAANIQADPTKNEYYRMGWRSGGGSALAVLFPQTLLQIWQSLEV
CVAGDCIIIMQAAKTGLTEGSAPNGEDYDRPVIVINTLALNQLYLVNNNQQVISLPGATLHQLQKQLKAVNRAPHSVIGS
STLGATIVGGVSNNSGGALVKRGPAYTELALFAQINEQGELILVNHLNIDLGASPEQILTNLQTGNFDKTKLSDNGKMAS
DKEYVARVKDVDADTPSRFNADKRRLYEASGCAGKLAVFAVRLDTYPIAAQEKTFYIGSNSIGELAQLRRQILLGFTNIP
EVGEYMHRDIFDVSTKYGKDTFLSIKHLGTDTLPRLFSIKGAIDAKLNKWSWMPKHFTDKVMQFIANIFPNHLPKRMTQY
RNKYEHHLILKMSDAGIIEAQVFLEKFFADSTTGDYFECSDEESESAFLHRFAAAGAALRYEVIHQEEVGDILALDIAIP
RNELAWFEALPEEINQHLEKKLYYGHFFCYVFHQDYILKKGSDAQQVKHFMLELLNTRGAKYPAEHNVGHLYEAEPDLQN
FYQRLDPTNSFNPGIGKMSKTKRNCSCCL

Specific function: First component of the membrane-bound D-lactate oxidase, which is believed to play an important role in the energization of the active transport of a variety of sugars and amino acids [H]

COG id: COG0277

COG function: function code C; FAD/FMN-containing dehydrogenases

Gene ontology:

Cell location: Cell membrane; Peripheral membrane protein; Cytoplasmic side [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 FAD-binding PCMH-type domain [H]

Homologues:

Organism=Escherichia coli, GI1788454, Length=554, Percent_Identity=57.4007220216607, Blast_Score=684, Evalue=0.0,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016172
- InterPro:   IPR016173
- InterPro:   IPR012256
- InterPro:   IPR016166
- InterPro:   IPR016167
- InterPro:   IPR016164
- InterPro:   IPR016168
- InterPro:   IPR015409
- InterPro:   IPR006094 [H]

Pfam domain/function: PF01565 FAD_binding_4; PF09330 Lact-deh-memb [H]

EC number: =1.1.1.28 [H]

Molecular weight: Translated: 65794; Mature: 65662

Theoretical pI: Translated: 6.70; Mature: 6.70

Prosite motif: PS00178 AA_TRNA_LIGASE_I ; PS00290 IG_MHC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDIQSAGSTDHIFPSKRVTLGTLTPDQVLQQLTQLLGAANIQADPTKNEYYRMGWRSGG
CCCCCCCCCCCCCCCCCCEEEECCCHHHHHHHHHHHHCCCCCCCCCCCCCCEEECCCCCC
GSALAVLFPQTLLQIWQSLEVCVAGDCIIIMQAAKTGLTEGSAPNGEDYDRPVIVINTLA
CCEEEHHHHHHHHHHHHHCCCEECCCEEEEEEHHHCCCCCCCCCCCCCCCCCEEEEEEEE
LNQLYLVNNNQQVISLPGATLHQLQKQLKAVNRAPHSVIGSSTLGATIVGGVSNNSGGAL
EEEEEEEECCCEEEECCCHHHHHHHHHHHHHHCCCHHHHCCCCCCCEEEECCCCCCCCEE
VKRGPAYTELALFAQINEQGELILVNHLNIDLGASPEQILTNLQTGNFDKTKLSDNGKMA
EECCCCHHHHHHEEEECCCCCEEEEEEECCCCCCCHHHHHHHCCCCCCCCCEECCCCCCC
SDKEYVARVKDVDADTPSRFNADKRRLYEASGCAGKLAVFAVRLDTYPIAAQEKTFYIGS
CCHHHHHHHHHCCCCCCCCCCHHHHHHHHHCCCCCCEEEEEEEECCCCCCCCCEEEEECC
NSIGELAQLRRQILLGFTNIPEVGEYMHRDIFDVSTKYGKDTFLSIKHLGTDTLPRLFSI
CCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCCCEEEEHHCCCCHHHHHHHH
KGAIDAKLNKWSWMPKHFTDKVMQFIANIFPNHLPKRMTQYRNKYEHHLILKMSDAGIIE
CCHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEECCCCCHH
AQVFLEKFFADSTTGDYFECSDEESESAFLHRFAAAGAALRYEVIHQEEVGDILALDIAI
HHHHHHHHHCCCCCCCCEECCCCCHHHHHHHHHHHHCHHHHHHHHHHHHCCCEEEEEEEC
PRNELAWFEALPEEINQHLEKKLYYGHFFCYVFHQDYILKKGSDAQQVKHFMLELLNTRG
CCCHHHHHHHHHHHHHHHHHHHHHHHEEEEEEEECHHHCCCCCCHHHHHHHHHHHHHHCC
AKYPAEHNVGHLYEAEPDLQNFYQRLDPTNSFNPGIGKMSKTKRNCSCCL
CCCCCCCCCCCEECCCCCHHHHHHHCCCCCCCCCCCCCCHHCCCCCCCCC
>Mature Secondary Structure 
SDIQSAGSTDHIFPSKRVTLGTLTPDQVLQQLTQLLGAANIQADPTKNEYYRMGWRSGG
CCCCCCCCCCCCCCCCCEEEECCCHHHHHHHHHHHHCCCCCCCCCCCCCCEEECCCCCC
GSALAVLFPQTLLQIWQSLEVCVAGDCIIIMQAAKTGLTEGSAPNGEDYDRPVIVINTLA
CCEEEHHHHHHHHHHHHHCCCEECCCEEEEEEHHHCCCCCCCCCCCCCCCCCEEEEEEEE
LNQLYLVNNNQQVISLPGATLHQLQKQLKAVNRAPHSVIGSSTLGATIVGGVSNNSGGAL
EEEEEEEECCCEEEECCCHHHHHHHHHHHHHHCCCHHHHCCCCCCCEEEECCCCCCCCEE
VKRGPAYTELALFAQINEQGELILVNHLNIDLGASPEQILTNLQTGNFDKTKLSDNGKMA
EECCCCHHHHHHEEEECCCCCEEEEEEECCCCCCCHHHHHHHCCCCCCCCCEECCCCCCC
SDKEYVARVKDVDADTPSRFNADKRRLYEASGCAGKLAVFAVRLDTYPIAAQEKTFYIGS
CCHHHHHHHHHCCCCCCCCCCHHHHHHHHHCCCCCCEEEEEEEECCCCCCCCCEEEEECC
NSIGELAQLRRQILLGFTNIPEVGEYMHRDIFDVSTKYGKDTFLSIKHLGTDTLPRLFSI
CCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCCCEEEEHHCCCCHHHHHHHH
KGAIDAKLNKWSWMPKHFTDKVMQFIANIFPNHLPKRMTQYRNKYEHHLILKMSDAGIIE
CCHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEECCCCCHH
AQVFLEKFFADSTTGDYFECSDEESESAFLHRFAAAGAALRYEVIHQEEVGDILALDIAI
HHHHHHHHHCCCCCCCCEECCCCCHHHHHHHHHHHHCHHHHHHHHHHHHCCCEEEEEEEC
PRNELAWFEALPEEINQHLEKKLYYGHFFCYVFHQDYILKKGSDAQQVKHFMLELLNTRG
CCCHHHHHHHHHHHHHHHHHHHHHHHEEEEEEEECHHHCCCCCCHHHHHHHHHHHHHHCC
AKYPAEHNVGHLYEAEPDLQNFYQRLDPTNSFNPGIGKMSKTKRNCSCCL
CCCCCCCCCCCEECCCCCHHHHHHHCCCCCCCCCCCCCCHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 6386470; 3882663; 9278503; 10944213 [H]