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The map label for this gene is alkK [H]

Identifier: 148652888

GI number: 148652888

Start: 1304575

End: 1306245

Strand: Direct

Name: alkK [H]

Synonym: PsycPRwf_1081

Alternate gene names: 148652888

Gene position: 1304575-1306245 (Clockwise)

Preceding gene: 148652887

Following gene: 148652889

Centisome position: 43.79

GC content: 47.76

Gene sequence:

>1671_bases
ATGATGAATCATTACAACGCCGCTGCCCATGCTTACCAATTTCCACTGACCATCAAGCAGTTATTAAACCGCTCAAAAGT
CACTTCGCAAAATGAAGAGATTGTCTATGCGGATAAAAAACGCATGACCTATACGGAGCTGTTCTCACGTATCGGTAAGC
TTGCCAATGTCCTAGACAGTCTTAATTTAGATAAAGGGGATGTGGTGGCGGTGATGGACTGGGACAGCCACCGCTTTTTG
GAGTCTTACTTTGCCATTCCCATGTCGCAATATGTGCTGCAGACCGTCAACATCCGCTTGTCTCCAGACAAAGTGCTGTA
CACTATTAACCATGCCAAGCCCAGAGTGCTACTGCTAAACTCTGAGTTTGCGCCTATGGTAAAAGACTATCAGTTTGAGA
ACTCGTCGATTGAGCATATTATTTGGCTCGATGACAATGGGGTTAGTAGTGAGGGCGTGTTTGGTAATAACCAAGCACGG
TTGTTAGGTGAATATGAAGCGCTGCTTGCCGAGGCCAGTGATGAGTTTGAGTTTCAAGATTTTGATGAAAACACCATTGC
CACCACCTTTTATACCTCAGGCACCACGGGCAATCCTAAAGGGGTGTTCTTTAGTCACCGTCAAATTGTACTGCATGCGT
TAGCAGAAGCGGCAACCTTGGGTATATTGCCACAAAAGCAAGGGTTAGTGCTTGGCGATGTGTATATGCCGATGACACCC
ATGTTCCATGTGCTGGCATGGGGCTTTCCTTATACCGCAACCATGCTGGGCATGAAGCAGGTGTATCCGGGTCGTTATAT
GCCTGATGTGATGCTAAACTTAATTGAAACCGAGAAGGTGAGTATCACCCACTGCGTGCCGACTATTTTGCAGATGTTAC
TGAAGCAAGCAGAAGCTGAAGGCAAGCGCTTTGATGGTCTAAAAATGATCATTGGCGGCTCACGCTTAACCGAAGGCTTG
GCAAAAACAGCCCTGTCAGCCGGCATTGAGGTATATACCGGCTATGGCATGTCGGAGACGGCGCCACTGATTAGTTTGAC
TGAATTTAGATCAGATGATCCTGAGATGAGTCTAGAGGAAGAGGCGAAGCGACGTAGCCTAACCGGCAAGCCGGTCATAA
TGGTGGAGGCCAAAATTTGGGATGGTGATGGCAATGCGCTACCGCACGATGGTAAGCAAACCGGGGAGCTGGTGCTGCGC
GCGCCTTGGTTGACCCAGAGCTATTTCAAAAATGCCGATGCTGGCGTGGAGCTGTGGCAAGGCGGCTATATGCATACTCA
AGATATCGCCTTTATGACTGAAGATGGTACCTTAAAGATTACCGACCGCTTAAAAGATGTGATTAAGTCGGGTGGTGAGT
GGATATCGTCCTTGGAGATTGAGACCATTTTATCACTACACCCTGCTGTCGCAGACGTGGCCGTTATCGGTGTGCGCGAT
GAGAAATGGGGCGAGCGTCCACTGGCAGCGATTGTGTTAAAGCCAAACTGCCAGGATGTAACGGTTGAGGACATTAAAGC
CATTGCCGAAAAAGCCGCCGAAAAAGGCATGATTCCAAAGTATGGCGTGCCTGAATACTACAAGATTGTTGATGAATTAC
CAAAGACTTCAGTGGGCAAACATGACAAAAAAGTCATGCGTGAGCTATATGTGGGTCAAACAACCATTTAA

Upstream 100 bases:

>100_bases
TACGCTAAATTATTCACTTGTTTTTTAGACATTTATAGAAATCGAACACTGAATGTATTACAGTAGGGGCATTAATGAAA
TACACTTAAAAGGAATTAGA

Downstream 100 bases:

>100_bases
GTTAAGCAGATCATCAGGAAGCGCAATTCAATGATTGCTTCAATGAATGAGATATAAAAATAAAAGCCGTAGCCCTTATG
CTGCGGCTTTTTGTGTAAAT

Product: AMP-dependent synthetase and ligase

Products: D-carnitinyl-CoA; crotonobetainyl-CoA; L-carnitinyl-CoA [C]

Alternate protein names: Medium-chain acyl-CoA synthetase [H]

Number of amino acids: Translated: 556; Mature: 556

Protein sequence:

>556_residues
MMNHYNAAAHAYQFPLTIKQLLNRSKVTSQNEEIVYADKKRMTYTELFSRIGKLANVLDSLNLDKGDVVAVMDWDSHRFL
ESYFAIPMSQYVLQTVNIRLSPDKVLYTINHAKPRVLLLNSEFAPMVKDYQFENSSIEHIIWLDDNGVSSEGVFGNNQAR
LLGEYEALLAEASDEFEFQDFDENTIATTFYTSGTTGNPKGVFFSHRQIVLHALAEAATLGILPQKQGLVLGDVYMPMTP
MFHVLAWGFPYTATMLGMKQVYPGRYMPDVMLNLIETEKVSITHCVPTILQMLLKQAEAEGKRFDGLKMIIGGSRLTEGL
AKTALSAGIEVYTGYGMSETAPLISLTEFRSDDPEMSLEEEAKRRSLTGKPVIMVEAKIWDGDGNALPHDGKQTGELVLR
APWLTQSYFKNADAGVELWQGGYMHTQDIAFMTEDGTLKITDRLKDVIKSGGEWISSLEIETILSLHPAVADVAVIGVRD
EKWGERPLAAIVLKPNCQDVTVEDIKAIAEKAAEKGMIPKYGVPEYYKIVDELPKTSVGKHDKKVMRELYVGQTTI

Sequences:

>Translated_556_residues
MMNHYNAAAHAYQFPLTIKQLLNRSKVTSQNEEIVYADKKRMTYTELFSRIGKLANVLDSLNLDKGDVVAVMDWDSHRFL
ESYFAIPMSQYVLQTVNIRLSPDKVLYTINHAKPRVLLLNSEFAPMVKDYQFENSSIEHIIWLDDNGVSSEGVFGNNQAR
LLGEYEALLAEASDEFEFQDFDENTIATTFYTSGTTGNPKGVFFSHRQIVLHALAEAATLGILPQKQGLVLGDVYMPMTP
MFHVLAWGFPYTATMLGMKQVYPGRYMPDVMLNLIETEKVSITHCVPTILQMLLKQAEAEGKRFDGLKMIIGGSRLTEGL
AKTALSAGIEVYTGYGMSETAPLISLTEFRSDDPEMSLEEEAKRRSLTGKPVIMVEAKIWDGDGNALPHDGKQTGELVLR
APWLTQSYFKNADAGVELWQGGYMHTQDIAFMTEDGTLKITDRLKDVIKSGGEWISSLEIETILSLHPAVADVAVIGVRD
EKWGERPLAAIVLKPNCQDVTVEDIKAIAEKAAEKGMIPKYGVPEYYKIVDELPKTSVGKHDKKVMRELYVGQTTI
>Mature_556_residues
MMNHYNAAAHAYQFPLTIKQLLNRSKVTSQNEEIVYADKKRMTYTELFSRIGKLANVLDSLNLDKGDVVAVMDWDSHRFL
ESYFAIPMSQYVLQTVNIRLSPDKVLYTINHAKPRVLLLNSEFAPMVKDYQFENSSIEHIIWLDDNGVSSEGVFGNNQAR
LLGEYEALLAEASDEFEFQDFDENTIATTFYTSGTTGNPKGVFFSHRQIVLHALAEAATLGILPQKQGLVLGDVYMPMTP
MFHVLAWGFPYTATMLGMKQVYPGRYMPDVMLNLIETEKVSITHCVPTILQMLLKQAEAEGKRFDGLKMIIGGSRLTEGL
AKTALSAGIEVYTGYGMSETAPLISLTEFRSDDPEMSLEEEAKRRSLTGKPVIMVEAKIWDGDGNALPHDGKQTGELVLR
APWLTQSYFKNADAGVELWQGGYMHTQDIAFMTEDGTLKITDRLKDVIKSGGEWISSLEIETILSLHPAVADVAVIGVRD
EKWGERPLAAIVLKPNCQDVTVEDIKAIAEKAAEKGMIPKYGVPEYYKIVDELPKTSVGKHDKKVMRELYVGQTTI

Specific function: Could Catalyze The Transfer Of CoA To Crotonobetaine Or Carnitine. [C]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATP-dependent AMP-binding enzyme family [H]

Homologues:

Organism=Homo sapiens, GI42544132, Length=527, Percent_Identity=25.426944971537, Blast_Score=125, Evalue=1e-28,
Organism=Homo sapiens, GI156151445, Length=564, Percent_Identity=24.645390070922, Blast_Score=121, Evalue=2e-27,
Organism=Homo sapiens, GI28416953, Length=547, Percent_Identity=24.6800731261426, Blast_Score=104, Evalue=2e-22,
Organism=Homo sapiens, GI122937307, Length=527, Percent_Identity=26.5654648956357, Blast_Score=104, Evalue=3e-22,
Organism=Homo sapiens, GI38505220, Length=531, Percent_Identity=25.6120527306968, Blast_Score=102, Evalue=9e-22,
Organism=Homo sapiens, GI187761345, Length=403, Percent_Identity=26.302729528536, Blast_Score=97, Evalue=4e-20,
Organism=Homo sapiens, GI187761343, Length=403, Percent_Identity=26.302729528536, Blast_Score=97, Evalue=4e-20,
Organism=Homo sapiens, GI58082049, Length=513, Percent_Identity=22.2222222222222, Blast_Score=89, Evalue=1e-17,
Organism=Homo sapiens, GI157311624, Length=513, Percent_Identity=22.0272904483431, Blast_Score=88, Evalue=3e-17,
Organism=Homo sapiens, GI157311622, Length=513, Percent_Identity=22.0272904483431, Blast_Score=88, Evalue=3e-17,
Organism=Homo sapiens, GI115511026, Length=527, Percent_Identity=23.5294117647059, Blast_Score=86, Evalue=8e-17,
Organism=Escherichia coli, GI221142682, Length=520, Percent_Identity=25.1923076923077, Blast_Score=154, Evalue=2e-38,
Organism=Escherichia coli, GI145693145, Length=376, Percent_Identity=30.8510638297872, Blast_Score=149, Evalue=3e-37,
Organism=Escherichia coli, GI1788107, Length=530, Percent_Identity=27.1698113207547, Blast_Score=146, Evalue=3e-36,
Organism=Escherichia coli, GI1786810, Length=536, Percent_Identity=24.6268656716418, Blast_Score=114, Evalue=2e-26,
Organism=Escherichia coli, GI1790505, Length=550, Percent_Identity=25.0909090909091, Blast_Score=104, Evalue=1e-23,
Organism=Escherichia coli, GI1788595, Length=313, Percent_Identity=25.2396166134185, Blast_Score=81, Evalue=2e-16,
Organism=Escherichia coli, GI1786529, Length=563, Percent_Identity=24.1563055062167, Blast_Score=67, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI71994690, Length=538, Percent_Identity=26.2081784386617, Blast_Score=142, Evalue=4e-34,
Organism=Caenorhabditis elegans, GI71994694, Length=538, Percent_Identity=26.2081784386617, Blast_Score=142, Evalue=4e-34,
Organism=Caenorhabditis elegans, GI71994703, Length=538, Percent_Identity=26.2081784386617, Blast_Score=142, Evalue=4e-34,
Organism=Caenorhabditis elegans, GI17559526, Length=380, Percent_Identity=27.6315789473684, Blast_Score=132, Evalue=5e-31,
Organism=Caenorhabditis elegans, GI17531443, Length=546, Percent_Identity=23.992673992674, Blast_Score=127, Evalue=2e-29,
Organism=Caenorhabditis elegans, GI17538037, Length=542, Percent_Identity=23.6162361623616, Blast_Score=117, Evalue=2e-26,
Organism=Caenorhabditis elegans, GI17557194, Length=547, Percent_Identity=24.4972577696526, Blast_Score=116, Evalue=2e-26,
Organism=Caenorhabditis elegans, GI17560308, Length=594, Percent_Identity=26.0942760942761, Blast_Score=112, Evalue=4e-25,
Organism=Caenorhabditis elegans, GI71996755, Length=513, Percent_Identity=24.5614035087719, Blast_Score=111, Evalue=1e-24,
Organism=Caenorhabditis elegans, GI17558820, Length=542, Percent_Identity=23.4317343173432, Blast_Score=103, Evalue=2e-22,
Organism=Caenorhabditis elegans, GI17560140, Length=366, Percent_Identity=25.1366120218579, Blast_Score=100, Evalue=1e-21,
Organism=Caenorhabditis elegans, GI71985884, Length=371, Percent_Identity=23.1805929919137, Blast_Score=96, Evalue=6e-20,
Organism=Caenorhabditis elegans, GI17556552, Length=366, Percent_Identity=25.9562841530055, Blast_Score=79, Evalue=8e-15,
Organism=Saccharomyces cerevisiae, GI6319699, Length=384, Percent_Identity=26.5625, Blast_Score=106, Evalue=1e-23,
Organism=Saccharomyces cerevisiae, GI6319264, Length=550, Percent_Identity=22.9090909090909, Blast_Score=84, Evalue=7e-17,
Organism=Drosophila melanogaster, GI21355181, Length=509, Percent_Identity=25.147347740668, Blast_Score=132, Evalue=8e-31,
Organism=Drosophila melanogaster, GI18859661, Length=383, Percent_Identity=29.5039164490862, Blast_Score=128, Evalue=1e-29,
Organism=Drosophila melanogaster, GI24581924, Length=580, Percent_Identity=25.1724137931034, Blast_Score=116, Evalue=3e-26,
Organism=Drosophila melanogaster, GI21356947, Length=550, Percent_Identity=23.0909090909091, Blast_Score=101, Evalue=1e-21,
Organism=Drosophila melanogaster, GI24653035, Length=549, Percent_Identity=21.8579234972678, Blast_Score=88, Evalue=1e-17,
Organism=Drosophila melanogaster, GI24648260, Length=522, Percent_Identity=21.8390804597701, Blast_Score=83, Evalue=6e-16,
Organism=Drosophila melanogaster, GI20130357, Length=379, Percent_Identity=26.6490765171504, Blast_Score=81, Evalue=2e-15,
Organism=Drosophila melanogaster, GI24648257, Length=560, Percent_Identity=22.3214285714286, Blast_Score=80, Evalue=5e-15,
Organism=Drosophila melanogaster, GI161076582, Length=538, Percent_Identity=21.3754646840149, Blast_Score=77, Evalue=3e-14,
Organism=Drosophila melanogaster, GI24648253, Length=519, Percent_Identity=20.8092485549133, Blast_Score=73, Evalue=7e-13,
Organism=Drosophila melanogaster, GI24648255, Length=511, Percent_Identity=21.1350293542074, Blast_Score=72, Evalue=1e-12,
Organism=Drosophila melanogaster, GI21356441, Length=320, Percent_Identity=22.8125, Blast_Score=69, Evalue=9e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020845
- InterPro:   IPR000873 [H]

Pfam domain/function: PF00501 AMP-binding [H]

EC number: 6.3.2.- [C]

Molecular weight: Translated: 62146; Mature: 62146

Theoretical pI: Translated: 5.05; Mature: 5.05

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
4.0 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMNHYNAAAHAYQFPLTIKQLLNRSKVTSQNEEIVYADKKRMTYTELFSRIGKLANVLDS
CCCCCCCHHHHEECCHHHHHHHCHHHCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHH
LNLDKGDVVAVMDWDSHRFLESYFAIPMSQYVLQTVNIRLSPDKVLYTINHAKPRVLLLN
CCCCCCCEEEEEECCCHHHHHHHHHCCHHHHHHHHEEEEECCCEEEEEEECCCCEEEEEC
SEFAPMVKDYQFENSSIEHIIWLDDNGVSSEGVFGNNQARLLGEYEALLAEASDEFEFQD
CCCCCHHHCCCCCCCCCCEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCC
FDENTIATTFYTSGTTGNPKGVFFSHRQIVLHALAEAATLGILPQKQGLVLGDVYMPMTP
CCCCEEEEEEEECCCCCCCCCEEECHHHHHHHHHHHHHHHCCCCCCCCEEEEEHHCCHHH
MFHVLAWGFPYTATMLGMKQVYPGRYMPDVMLNLIETEKVSITHCVPTILQMLLKQAEAE
HHHHHHCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHCCCEEHHHHHHHHHHHHHHHHHHC
GKRFDGLKMIIGGSRLTEGLAKTALSAGIEVYTGYGMSETAPLISLTEFRSDDPEMSLEE
CCCCCCEEEEECCHHHHHHHHHHHHHCCCEEEECCCCCCCCCCEEEHHHCCCCCCCCHHH
EAKRRSLTGKPVIMVEAKIWDGDGNALPHDGKQTGELVLRAPWLTQSYFKNADAGVELWQ
HHHHHCCCCCCEEEEEEEEECCCCCCCCCCCCCCCCEEEECCCCCHHHHCCCCCCCCHHC
GGYMHTQDIAFMTEDGTLKITDRLKDVIKSGGEWISSLEIETILSLHPAVADVAVIGVRD
CCCEEECCEEEEECCCCEEEHHHHHHHHHCCCHHHHHHHHHHHHHHCCCHHCEEEEEECC
EKWGERPLAAIVLKPNCQDVTVEDIKAIAEKAAEKGMIPKYGVPEYYKIVDELPKTSVGK
CCCCCCCEEEEEECCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHCCCCCCCC
HDKKVMRELYVGQTTI
HHHHHHHHHHCCCCCC
>Mature Secondary Structure
MMNHYNAAAHAYQFPLTIKQLLNRSKVTSQNEEIVYADKKRMTYTELFSRIGKLANVLDS
CCCCCCCHHHHEECCHHHHHHHCHHHCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHH
LNLDKGDVVAVMDWDSHRFLESYFAIPMSQYVLQTVNIRLSPDKVLYTINHAKPRVLLLN
CCCCCCCEEEEEECCCHHHHHHHHHCCHHHHHHHHEEEEECCCEEEEEEECCCCEEEEEC
SEFAPMVKDYQFENSSIEHIIWLDDNGVSSEGVFGNNQARLLGEYEALLAEASDEFEFQD
CCCCCHHHCCCCCCCCCCEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCC
FDENTIATTFYTSGTTGNPKGVFFSHRQIVLHALAEAATLGILPQKQGLVLGDVYMPMTP
CCCCEEEEEEEECCCCCCCCCEEECHHHHHHHHHHHHHHHCCCCCCCCEEEEEHHCCHHH
MFHVLAWGFPYTATMLGMKQVYPGRYMPDVMLNLIETEKVSITHCVPTILQMLLKQAEAE
HHHHHHCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHCCCEEHHHHHHHHHHHHHHHHHHC
GKRFDGLKMIIGGSRLTEGLAKTALSAGIEVYTGYGMSETAPLISLTEFRSDDPEMSLEE
CCCCCCEEEEECCHHHHHHHHHHHHHCCCEEEECCCCCCCCCCEEEHHHCCCCCCCCHHH
EAKRRSLTGKPVIMVEAKIWDGDGNALPHDGKQTGELVLRAPWLTQSYFKNADAGVELWQ
HHHHHCCCCCCEEEEEEEEECCCCCCCCCCCCCCCCEEEECCCCCHHHHCCCCCCCCHHC
GGYMHTQDIAFMTEDGTLKITDRLKDVIKSGGEWISSLEIETILSLHPAVADVAVIGVRD
CCCEEECCEEEEECCCCEEEHHHHHHHHHCCCHHHHHHHHHHHHHHCCCHHCEEEEEECC
EKWGERPLAAIVLKPNCQDVTVEDIKAIAEKAAEKGMIPKYGVPEYYKIVDELPKTSVGK
CCCCCCCEEEEEECCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHCCCCCCCC
HDKKVMRELYVGQTTI
HHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Coenzyme A; D-carnitine; Coenzyme A; crotono-betaine; L-carnitine [C]

Specific reaction: Coenzyme A + D-carnitine = D-carnitinyl-CoA Coenzyme A + crotono-betaine = crotonobetainyl-CoA Coenzyme A + L-carnitine = L-carnitinyl-CoA [C]

General reaction: Ligases; Forming Carbon-Sulfur Bonds; Acid-Thiol Ligases [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1453953 [H]