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The map label for this gene is phhA [H]

Identifier: 148652848

GI number: 148652848

Start: 1248472

End: 1249269

Strand: Direct

Name: phhA [H]

Synonym: PsycPRwf_1041

Alternate gene names: 148652848

Gene position: 1248472-1249269 (Clockwise)

Preceding gene: 148652847

Following gene: 148652849

Centisome position: 41.91

GC content: 47.87

Gene sequence:

>798_bases
ATGGAACGCACTGCGTTATCGACAAAACAGCCCTACGTCTCGCACACGCCAGATGAACAGGGCCACATTATTTATAGCGA
CTGTGAAAATCAAATGTGGCAGGCGCTGCTTGAGCGTCAGTTAACTCAGCTACCAGGGCGGGCTTGCCCTGAGTATTTAC
AAGGTCTGGATAAATTGGCCTTGCCGCACACTCACATTCCGCAGCTGCCGGATATTGATGCGGTACTGCTAGAGGCCACA
GGGTGGCGCACCGCTATGGTACCAGCGCTAATAAGCTTTGGTAAGTTTTTTAAACTGCTTGCCAATAAGCAGTTTCCGGT
AGCGACTTTTATTCGCCGTAAACAGGACATGGATTACATCCAAGAGCCGGATATTTTTCATGAAATTGTCGGCCATTGTC
CTTTGTTAACTCACCCAGCCTTTGCCGCTTTTAATGAAACCTATGGCAAGTTAGGTCTTGAAGCCACTGCTCAAGAGCGG
GTGTTTTTGGCACGTATGTACTGGTTTACCATTGAGTTTGGCTTGGTGGGACATCACCCAGTAGATCGACGTATTTATGG
CGGCGGGATCTTAAGCTCACCTTCTGAGACGCTATATGCGCTAAGCGGCGAGCCCGATTACCGTGAGTTTAATCTCATTG
ATGTGCTGCGCACTCCCTATAGAATTGATCATATCCAGCCCATTTATTATGTGCTTGATGATTTAGAAACTTTATTTGAA
ATCGCGGATAGTGATGTGATGGGGGCGGTGCATCAGGCACAGCAGTTGGGTTTGTTTGAGCCTTGCTATGCGCTTTAA

Upstream 100 bases:

>100_bases
CCACTGCAGTTTAAGCGGTATATATACAGCAAGGATGCTACGACATAGATGTTGGCGGTTAAGAGTGATTTTAGCCGCCC
TTTGATTAAGGATAACTGGC

Downstream 100 bases:

>100_bases
CGTCGCCGACCTATTTTTACTTAACATGTGTATATGAATCTGAATAAAACAAGGATGTAACCATGACCCAATTATCTCAA
GCCAGCTGTGAAGTTTGCCG

Product: phenylalanine 4-monooxygenase

Products: NA

Alternate protein names: PAH; Phe-4-monooxygenase [H]

Number of amino acids: Translated: 265; Mature: 265

Protein sequence:

>265_residues
MERTALSTKQPYVSHTPDEQGHIIYSDCENQMWQALLERQLTQLPGRACPEYLQGLDKLALPHTHIPQLPDIDAVLLEAT
GWRTAMVPALISFGKFFKLLANKQFPVATFIRRKQDMDYIQEPDIFHEIVGHCPLLTHPAFAAFNETYGKLGLEATAQER
VFLARMYWFTIEFGLVGHHPVDRRIYGGGILSSPSETLYALSGEPDYREFNLIDVLRTPYRIDHIQPIYYVLDDLETLFE
IADSDVMGAVHQAQQLGLFEPCYAL

Sequences:

>Translated_265_residues
MERTALSTKQPYVSHTPDEQGHIIYSDCENQMWQALLERQLTQLPGRACPEYLQGLDKLALPHTHIPQLPDIDAVLLEAT
GWRTAMVPALISFGKFFKLLANKQFPVATFIRRKQDMDYIQEPDIFHEIVGHCPLLTHPAFAAFNETYGKLGLEATAQER
VFLARMYWFTIEFGLVGHHPVDRRIYGGGILSSPSETLYALSGEPDYREFNLIDVLRTPYRIDHIQPIYYVLDDLETLFE
IADSDVMGAVHQAQQLGLFEPCYAL
>Mature_265_residues
MERTALSTKQPYVSHTPDEQGHIIYSDCENQMWQALLERQLTQLPGRACPEYLQGLDKLALPHTHIPQLPDIDAVLLEAT
GWRTAMVPALISFGKFFKLLANKQFPVATFIRRKQDMDYIQEPDIFHEIVGHCPLLTHPAFAAFNETYGKLGLEATAQER
VFLARMYWFTIEFGLVGHHPVDRRIYGGGILSSPSETLYALSGEPDYREFNLIDVLRTPYRIDHIQPIYYVLDDLETLFE
IADSDVMGAVHQAQQLGLFEPCYAL

Specific function: Unknown

COG id: COG3186

COG function: function code E; Phenylalanine-4-hydroxylase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the biopterin-dependent aromatic amino acid hydroxylase family [H]

Homologues:

Organism=Homo sapiens, GI4759248, Length=218, Percent_Identity=33.0275229357798, Blast_Score=114, Evalue=9e-26,
Organism=Homo sapiens, GI88900503, Length=188, Percent_Identity=35.6382978723404, Blast_Score=109, Evalue=2e-24,
Organism=Homo sapiens, GI88900501, Length=192, Percent_Identity=34.8958333333333, Blast_Score=109, Evalue=3e-24,
Organism=Homo sapiens, GI88900505, Length=192, Percent_Identity=34.8958333333333, Blast_Score=109, Evalue=3e-24,
Organism=Homo sapiens, GI31795563, Length=220, Percent_Identity=33.6363636363636, Blast_Score=108, Evalue=4e-24,
Organism=Homo sapiens, GI4557819, Length=215, Percent_Identity=33.953488372093, Blast_Score=107, Evalue=1e-23,
Organism=Caenorhabditis elegans, GI71980736, Length=222, Percent_Identity=30.1801801801802, Blast_Score=115, Evalue=2e-26,
Organism=Caenorhabditis elegans, GI17531391, Length=221, Percent_Identity=33.4841628959276, Blast_Score=112, Evalue=2e-25,
Organism=Caenorhabditis elegans, GI115532103, Length=229, Percent_Identity=30.1310043668122, Blast_Score=102, Evalue=3e-22,
Organism=Caenorhabditis elegans, GI115533973, Length=229, Percent_Identity=30.1310043668122, Blast_Score=102, Evalue=3e-22,
Organism=Caenorhabditis elegans, GI71980731, Length=155, Percent_Identity=29.0322580645161, Blast_Score=78, Evalue=4e-15,
Organism=Drosophila melanogaster, GI17136774, Length=218, Percent_Identity=34.4036697247706, Blast_Score=128, Evalue=4e-30,
Organism=Drosophila melanogaster, GI17136776, Length=218, Percent_Identity=34.4036697247706, Blast_Score=128, Evalue=4e-30,
Organism=Drosophila melanogaster, GI62472054, Length=224, Percent_Identity=34.8214285714286, Blast_Score=119, Evalue=2e-27,
Organism=Drosophila melanogaster, GI24660393, Length=224, Percent_Identity=34.8214285714286, Blast_Score=119, Evalue=2e-27,
Organism=Drosophila melanogaster, GI24654994, Length=197, Percent_Identity=32.48730964467, Blast_Score=103, Evalue=1e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001273
- InterPro:   IPR018301
- InterPro:   IPR019774
- InterPro:   IPR005960 [H]

Pfam domain/function: PF00351 Biopterin_H [H]

EC number: =1.14.16.1 [H]

Molecular weight: Translated: 30255; Mature: 30255

Theoretical pI: Translated: 4.99; Mature: 4.99

Prosite motif: PS00367 BIOPTERIN_HYDROXYL

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MERTALSTKQPYVSHTPDEQGHIIYSDCENQMWQALLERQLTQLPGRACPEYLQGLDKLA
CCCCCCCCCCCCCCCCCCCCCCEEHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHC
LPHTHIPQLPDIDAVLLEATGWRTAMVPALISFGKFFKLLANKQFPVATFIRRKQDMDYI
CCCCCCCCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCHHH
QEPDIFHEIVGHCPLLTHPAFAAFNETYGKLGLEATAQERVFLARMYWFTIEFGLVGHHP
CCCHHHHHHHHCCCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHEECCCCCCC
VDRRIYGGGILSSPSETLYALSGEPDYREFNLIDVLRTPYRIDHIQPIYYVLDDLETLFE
CCCEEECCCCCCCCCCEEEEECCCCCCCHHHHHHHHHCCHHCCCCCHHHHHHHHHHHHHH
IADSDVMGAVHQAQQLGLFEPCYAL
HHCCHHHHHHHHHHHCCCCCHHHCC
>Mature Secondary Structure
MERTALSTKQPYVSHTPDEQGHIIYSDCENQMWQALLERQLTQLPGRACPEYLQGLDKLA
CCCCCCCCCCCCCCCCCCCCCCEEHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHC
LPHTHIPQLPDIDAVLLEATGWRTAMVPALISFGKFFKLLANKQFPVATFIRRKQDMDYI
CCCCCCCCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCHHH
QEPDIFHEIVGHCPLLTHPAFAAFNETYGKLGLEATAQERVFLARMYWFTIEFGLVGHHP
CCCHHHHHHHHCCCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHEECCCCCCC
VDRRIYGGGILSSPSETLYALSGEPDYREFNLIDVLRTPYRIDHIQPIYYVLDDLETLFE
CCCEEECCCCCCCCCCEEEEECCCCCCCHHHHHHHHHCCHHCCCCCHHHHHHHHHHHHHH
IADSDVMGAVHQAQQLGLFEPCYAL
HHCCHHHHHHHHHHHCCCCCHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8108417; 10984043 [H]