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The map label for this gene is hpd [H]

Identifier: 148652847

GI number: 148652847

Start: 1247267

End: 1248385

Strand: Direct

Name: hpd [H]

Synonym: PsycPRwf_1040

Alternate gene names: 148652847

Gene position: 1247267-1248385 (Clockwise)

Preceding gene: 148652840

Following gene: 148652848

Centisome position: 41.87

GC content: 48.53

Gene sequence:

>1119_bases
ATGGCAGATTTATTTGACAACCCTATGGGTCTTCGTGGTTTTGACTTCGTAGAGTTTGCCTCTCCTGAGCCTGCATTGGT
GGCAGAGCTTTTTGAAAAATTAGGCTTTACCCATGTGGCCAACCACAGATCCAAAGACGTGGCCTTGTATCGTCAAGGCG
ATATCAACCTTATTTTAAACCGAGAGCCGAGAAGTCAAGCCAGCTACTTCGTTGAAGAGCATGGTCCAGGTGCTTGTAGC
ATGGGCTTTCGAGTGGCTGACTCTCGACAAGCTTATAAGCGTGCCATCGAGCAAGGTGCACAGCCTGTTGAGATACCCAC
TGGGGTTATGGAGCTTAAGTTGCCAGCCATTAAAGGCATTGGCGGCTCGCTTATCTATCTGATTGACCGCTTTGAGGAAG
GTAGCTCTATTTATGATGTAGATTTTGAGTTTTTACCGGGTGTGGACAAGCATCCTAAAGGCTTTGGCTTTAAGGTTATC
GACCATTTAACTCATAACGTCTATCGTGGTCGTATGGCGTATTGGGCCGACTTCTATGAGCGTATCTTTAATTTTCGTGA
AATTCGCTACTTTGATATCAAAGGCGAATACACCGGCCTAACCAGCAAGGCCATGACGGCGCCTGATGGTAAAATCCGCA
TTCCGCTCAATGAAGAAGCACGTCAAGGTGGCGGCCAGATTGAAGAGTATCTCATGCAGTTTAATGGCGAGGGTATTCAG
CACATTGCGCTACTAAGTGATGACTTATTGGCCAGTATCGATCAGCTAAAAGCGGCCGGCATTCCGCTAATGACAGCGCC
CAATGATACCTATTACAAAATGCTTGATGAGCGTCTACCTGGGCATGGCGAGACAGTCTCAGAGCTACAGACCCGAGGCA
TCTTACTCGATGGCACCACAGAGGGCGGCACGCCAAGACTGCTGTTACAAATTTTCTCTGAGACCATTTTAGGCAGCCCG
GTGTTCTTTGAGTTTATCCAGCGCAAAGGCGATTATGAAGAAGGCTTCGGCGAGGGTAACTTCAAGGCGTTGTTTGAGTC
TATTGAGCGTGACCAGCTGCGCCGCGGTACCATTGATGCTGATGGGGCCTCAGACAAAGATACGGCCACTGCAGTTTAA

Upstream 100 bases:

>100_bases
TCTAATATGATTACAGCGTCAATAACTTTTATTGATGAATTAAGTTTTGCCAGTAATGGCCAAAATAATATGAGTTTTCA
TGAATTAAGGATGATTTAGC

Downstream 100 bases:

>100_bases
GCGGTATATATACAGCAAGGATGCTACGACATAGATGTTGGCGGTTAAGAGTGATTTTAGCCGCCCTTTGATTAAGGATA
ACTGGCATGGAACGCACTGC

Product: 4-hydroxyphenylpyruvate dioxygenase

Products: NA

Alternate protein names: 4HPPD; HPD; HPPDase [H]

Number of amino acids: Translated: 372; Mature: 371

Protein sequence:

>372_residues
MADLFDNPMGLRGFDFVEFASPEPALVAELFEKLGFTHVANHRSKDVALYRQGDINLILNREPRSQASYFVEEHGPGACS
MGFRVADSRQAYKRAIEQGAQPVEIPTGVMELKLPAIKGIGGSLIYLIDRFEEGSSIYDVDFEFLPGVDKHPKGFGFKVI
DHLTHNVYRGRMAYWADFYERIFNFREIRYFDIKGEYTGLTSKAMTAPDGKIRIPLNEEARQGGGQIEEYLMQFNGEGIQ
HIALLSDDLLASIDQLKAAGIPLMTAPNDTYYKMLDERLPGHGETVSELQTRGILLDGTTEGGTPRLLLQIFSETILGSP
VFFEFIQRKGDYEEGFGEGNFKALFESIERDQLRRGTIDADGASDKDTATAV

Sequences:

>Translated_372_residues
MADLFDNPMGLRGFDFVEFASPEPALVAELFEKLGFTHVANHRSKDVALYRQGDINLILNREPRSQASYFVEEHGPGACS
MGFRVADSRQAYKRAIEQGAQPVEIPTGVMELKLPAIKGIGGSLIYLIDRFEEGSSIYDVDFEFLPGVDKHPKGFGFKVI
DHLTHNVYRGRMAYWADFYERIFNFREIRYFDIKGEYTGLTSKAMTAPDGKIRIPLNEEARQGGGQIEEYLMQFNGEGIQ
HIALLSDDLLASIDQLKAAGIPLMTAPNDTYYKMLDERLPGHGETVSELQTRGILLDGTTEGGTPRLLLQIFSETILGSP
VFFEFIQRKGDYEEGFGEGNFKALFESIERDQLRRGTIDADGASDKDTATAV
>Mature_371_residues
ADLFDNPMGLRGFDFVEFASPEPALVAELFEKLGFTHVANHRSKDVALYRQGDINLILNREPRSQASYFVEEHGPGACSM
GFRVADSRQAYKRAIEQGAQPVEIPTGVMELKLPAIKGIGGSLIYLIDRFEEGSSIYDVDFEFLPGVDKHPKGFGFKVID
HLTHNVYRGRMAYWADFYERIFNFREIRYFDIKGEYTGLTSKAMTAPDGKIRIPLNEEARQGGGQIEEYLMQFNGEGIQH
IALLSDDLLASIDQLKAAGIPLMTAPNDTYYKMLDERLPGHGETVSELQTRGILLDGTTEGGTPRLLLQIFSETILGSPV
FFEFIQRKGDYEEGFGEGNFKALFESIERDQLRRGTIDADGASDKDTATAV

Specific function: Unknown

COG id: COG3185

COG function: function code ER; 4-hydroxyphenylpyruvate dioxygenase and related hemolysins

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 4HPPD family [H]

Homologues:

Organism=Homo sapiens, GI4504477, Length=335, Percent_Identity=28.6567164179104, Blast_Score=114, Evalue=1e-25,
Organism=Homo sapiens, GI285002264, Length=335, Percent_Identity=28.6567164179104, Blast_Score=114, Evalue=2e-25,
Organism=Homo sapiens, GI14249394, Length=233, Percent_Identity=27.8969957081545, Blast_Score=72, Evalue=8e-13,
Organism=Caenorhabditis elegans, GI17555220, Length=320, Percent_Identity=32.5, Blast_Score=133, Evalue=1e-31,
Organism=Caenorhabditis elegans, GI17550752, Length=228, Percent_Identity=33.3333333333333, Blast_Score=117, Evalue=1e-26,
Organism=Drosophila melanogaster, GI21356105, Length=309, Percent_Identity=31.7152103559871, Blast_Score=130, Evalue=1e-30,
Organism=Drosophila melanogaster, GI24667510, Length=309, Percent_Identity=32.3624595469256, Blast_Score=130, Evalue=1e-30,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005956
- InterPro:   IPR004360 [H]

Pfam domain/function: PF00903 Glyoxalase [H]

EC number: =1.13.11.27 [H]

Molecular weight: Translated: 41593; Mature: 41462

Theoretical pI: Translated: 4.65; Mature: 4.65

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MADLFDNPMGLRGFDFVEFASPEPALVAELFEKLGFTHVANHRSKDVALYRQGDINLILN
CCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCHHHHCCCCCCEEEEEECCEEEEEC
REPRSQASYFVEEHGPGACSMGFRVADSRQAYKRAIEQGAQPVEIPTGVMELKLPAIKGI
CCCCHHHHHHHHCCCCCCCCCCCEECCHHHHHHHHHHCCCCCEECCCCCEEEECCHHHCC
GGSLIYLIDRFEEGSSIYDVDFEFLPGVDKHPKGFGFKVIDHLTHNVYRGRMAYWADFYE
CCCEEEEEEHHCCCCCEEEECHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
RIFNFREIRYFDIKGEYTGLTSKAMTAPDGKIRIPLNEEARQGGGQIEEYLMQFNGEGIQ
HHHCHHHEEEEEECCCCCCCCCCCEECCCCEEEECCCHHHHCCCCHHHHHHHHHCCCCCE
HIALLSDDLLASIDQLKAAGIPLMTAPNDTYYKMLDERLPGHGETVSELQTRGILLDGTT
EEEHHHHHHHHHHHHHHHCCCCEEECCCCHHHHHHHHHCCCCCCHHHHHHHCCEEEECCC
EGGTPRLLLQIFSETILGSPVFFEFIQRKGDYEEGFGEGNFKALFESIERDQLRRGTIDA
CCCCHHHHHHHHHHHHCCCHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCC
DGASDKDTATAV
CCCCCCCCCCCC
>Mature Secondary Structure 
ADLFDNPMGLRGFDFVEFASPEPALVAELFEKLGFTHVANHRSKDVALYRQGDINLILN
CCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCHHHHCCCCCCEEEEEECCEEEEEC
REPRSQASYFVEEHGPGACSMGFRVADSRQAYKRAIEQGAQPVEIPTGVMELKLPAIKGI
CCCCHHHHHHHHCCCCCCCCCCCEECCHHHHHHHHHHCCCCCEECCCCCEEEECCHHHCC
GGSLIYLIDRFEEGSSIYDVDFEFLPGVDKHPKGFGFKVIDHLTHNVYRGRMAYWADFYE
CCCEEEEEEHHCCCCCEEEECHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
RIFNFREIRYFDIKGEYTGLTSKAMTAPDGKIRIPLNEEARQGGGQIEEYLMQFNGEGIQ
HHHCHHHEEEEEECCCCCCCCCCCEECCCCEEEECCCHHHHCCCCHHHHHHHHHCCCCCE
HIALLSDDLLASIDQLKAAGIPLMTAPNDTYYKMLDERLPGHGETVSELQTRGILLDGTT
EEEHHHHHHHHHHHHHHHCCCCEEECCCCHHHHHHHHHCCCCCCHHHHHHHCCEEEECCC
EGGTPRLLLQIFSETILGSPVFFEFIQRKGDYEEGFGEGNFKALFESIERDQLRRGTIDA
CCCCHHHHHHHHHHHHCCCHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCC
DGASDKDTATAV
CCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1572351; 10467142 [H]