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The map label for this gene is sthA [H]

Identifier: 148652758

GI number: 148652758

Start: 1136850

End: 1138490

Strand: Direct

Name: sthA [H]

Synonym: PsycPRwf_0951

Alternate gene names: 148652758

Gene position: 1136850-1138490 (Clockwise)

Preceding gene: 148652757

Following gene: 148652759

Centisome position: 38.16

GC content: 44.79

Gene sequence:

>1641_bases
ATGTCTAAAAAACGTAAAGGTGATGAAACCAGCGATATTAACGATGACAAACAAAGCACTCAAACAGCGGCTAATGAGAT
TGGCAGTGCTGCACCTAGTGTGTTATCAGAAGTCAAAAAAACGCCTGTCAAAGCCAGTGACAGCTCGTTAGAGGACACCT
TGTTTCATCCAAACCTCATCAGTCCATTAGATAACGATCGCATTCGTATCAATTCTGGGTTCACTCGCGACTCTGAGCGC
CTAAAAAATGACAATCATGAGTATGAATATGATGCTGTCGTTGTTGGCGCAGGTCCTGCTGGGGAAGCGGCGGCCATGAA
GCTTGCCAAATCTGGCAAAAAAGTTGTGGTAGTCGATGCCCGTAGTCAAGTCGGTGGTAACTCAGCCCATGTGGGGACCA
TCCCCAGTAAGGCGCTACGTCAGTCTGTGTTCAACTTAATTAACTATCGCCGTGACCCTTTATTCTCTCAGGGCTTAGAC
TATTATCAGGTACCTTTAAATAAGGTGCTGACCAAAGCGCGTAAAGTCGTGCGTAATCAAGTAGATACGCATACCCGTTT
TTATGAGCGCAATCAGATTGAAGTGCGTCATGGCTGGGCAAGCTTTGTAGACAATCACACCTTGCATATCGAATTAGGTG
ACGGCTTAGGCTTTGAAACCATCACGTTTAACAAAGCCATTATCACAGTCGGTAGCCGTCCGTATCGTCCAGACTTGTTA
GATTTCGATCATCCACGCGTGTTTGACTCTGACAAAATCTTGCAAATGGATTATGTGGTCAAAAAAATCATCATCTATGG
TGCTGGCGTGATTGGCTGTGAATATGCTTCTATCTTCACCGGTCTTGGCTATAAAGTGGACTTAATCAATAACCACGACT
CATTGCTCAGCTATCTGGATAAAGAGATTAGCGATGCTTTATCGCATGACTTCCGTCAGTTTGGGGTATTGGTTCGCAAT
AACGAAGAGATTGAAAAGCTTGAGACCTATGACGACTGCGTTATTTTATATCTAAAAAGCGGTAAAAAAATCAAATCAGA
TGCCATTTTGTGGTCGAATGGTCGTTCAGGCAATACAGAAAGCCTAAACTTAGAGGGCATTGGCCTAAAAGCCAACAGCC
GAGGCCAGCTCAAAGTCGATGACACTTATCGTACTGAGGTTGAGAACATCTATGCTGCCGGTGATGTTATTGGCTGGCCA
TCACTGGCTTCTGCCGCTTATGACCAAGGCCGCTGTGCAGCTGCCTTCATGGTGGGTGATGAAGATGCTGAGCCGGTATC
TAGCGTACCTACTGGTATTTATACCATCCCTGAGATTTCAAGTATCGGTAAAACTGAGCAAGAATTGACCGATGAGAAAG
TACCTTATGAAGTGGGTCAGGCTTTCTTTAAGCATTTGGCACGTGCCCAAATCATCGGTGAGCGTTCAGGCGTACTAAAA
ATCTTATTCCACCGCGAAACCTTAGAGATTTTGGGTATCCACTGCTATGGTAATCATGCCTCTGAGATTATTCACATTGG
TCAAGCCGTTATGAAATGTGGTCACAATCTAGAGTACTTTGTGAATACCACCTTTAACTATCCCACCATGGCAGAAGCGT
ACCGTGTGGCTGCGTTAAATGGTCTAAACCGCGTATTTTAA

Upstream 100 bases:

>100_bases
AATAGCCAATATCAAAAAGTGATTCCGAAAAAAACATTTTGTGCCACTGAGCGATTGCCGTACCCACTGCAGCCAGAACT
ATAATACCAAAGAGGATGAT

Downstream 100 bases:

>100_bases
TCTAAGTGGTTCAGTGTTTAACTACCATAAAAAAGGAGACTGCTTGGCAGTCTCTTTTTTATGGTGCAATTACAGTTGCA
ACTTGTCAGCGGTTGGTGTT

Product: soluble pyridine nucleotide transhydrogenase

Products: NA

Alternate protein names: STH; NAD(P)(+) transhydrogenase [B-specific] [H]

Number of amino acids: Translated: 546; Mature: 545

Protein sequence:

>546_residues
MSKKRKGDETSDINDDKQSTQTAANEIGSAAPSVLSEVKKTPVKASDSSLEDTLFHPNLISPLDNDRIRINSGFTRDSER
LKNDNHEYEYDAVVVGAGPAGEAAAMKLAKSGKKVVVVDARSQVGGNSAHVGTIPSKALRQSVFNLINYRRDPLFSQGLD
YYQVPLNKVLTKARKVVRNQVDTHTRFYERNQIEVRHGWASFVDNHTLHIELGDGLGFETITFNKAIITVGSRPYRPDLL
DFDHPRVFDSDKILQMDYVVKKIIIYGAGVIGCEYASIFTGLGYKVDLINNHDSLLSYLDKEISDALSHDFRQFGVLVRN
NEEIEKLETYDDCVILYLKSGKKIKSDAILWSNGRSGNTESLNLEGIGLKANSRGQLKVDDTYRTEVENIYAAGDVIGWP
SLASAAYDQGRCAAAFMVGDEDAEPVSSVPTGIYTIPEISSIGKTEQELTDEKVPYEVGQAFFKHLARAQIIGERSGVLK
ILFHRETLEILGIHCYGNHASEIIHIGQAVMKCGHNLEYFVNTTFNYPTMAEAYRVAALNGLNRVF

Sequences:

>Translated_546_residues
MSKKRKGDETSDINDDKQSTQTAANEIGSAAPSVLSEVKKTPVKASDSSLEDTLFHPNLISPLDNDRIRINSGFTRDSER
LKNDNHEYEYDAVVVGAGPAGEAAAMKLAKSGKKVVVVDARSQVGGNSAHVGTIPSKALRQSVFNLINYRRDPLFSQGLD
YYQVPLNKVLTKARKVVRNQVDTHTRFYERNQIEVRHGWASFVDNHTLHIELGDGLGFETITFNKAIITVGSRPYRPDLL
DFDHPRVFDSDKILQMDYVVKKIIIYGAGVIGCEYASIFTGLGYKVDLINNHDSLLSYLDKEISDALSHDFRQFGVLVRN
NEEIEKLETYDDCVILYLKSGKKIKSDAILWSNGRSGNTESLNLEGIGLKANSRGQLKVDDTYRTEVENIYAAGDVIGWP
SLASAAYDQGRCAAAFMVGDEDAEPVSSVPTGIYTIPEISSIGKTEQELTDEKVPYEVGQAFFKHLARAQIIGERSGVLK
ILFHRETLEILGIHCYGNHASEIIHIGQAVMKCGHNLEYFVNTTFNYPTMAEAYRVAALNGLNRVF
>Mature_545_residues
SKKRKGDETSDINDDKQSTQTAANEIGSAAPSVLSEVKKTPVKASDSSLEDTLFHPNLISPLDNDRIRINSGFTRDSERL
KNDNHEYEYDAVVVGAGPAGEAAAMKLAKSGKKVVVVDARSQVGGNSAHVGTIPSKALRQSVFNLINYRRDPLFSQGLDY
YQVPLNKVLTKARKVVRNQVDTHTRFYERNQIEVRHGWASFVDNHTLHIELGDGLGFETITFNKAIITVGSRPYRPDLLD
FDHPRVFDSDKILQMDYVVKKIIIYGAGVIGCEYASIFTGLGYKVDLINNHDSLLSYLDKEISDALSHDFRQFGVLVRNN
EEIEKLETYDDCVILYLKSGKKIKSDAILWSNGRSGNTESLNLEGIGLKANSRGQLKVDDTYRTEVENIYAAGDVIGWPS
LASAAYDQGRCAAAFMVGDEDAEPVSSVPTGIYTIPEISSIGKTEQELTDEKVPYEVGQAFFKHLARAQIIGERSGVLKI
LFHRETLEILGIHCYGNHASEIIHIGQAVMKCGHNLEYFVNTTFNYPTMAEAYRVAALNGLNRVF

Specific function: Conversion of NADPH, generated by peripheral catabolic pathways, to NADH, which can enter the respiratory chain for energy generation [H]

COG id: COG1249

COG function: function code C; Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family [H]

Homologues:

Organism=Homo sapiens, GI91199540, Length=460, Percent_Identity=29.5652173913043, Blast_Score=190, Evalue=4e-48,
Organism=Homo sapiens, GI50301238, Length=460, Percent_Identity=25, Blast_Score=116, Evalue=5e-26,
Organism=Homo sapiens, GI22035672, Length=493, Percent_Identity=27.5862068965517, Blast_Score=108, Evalue=1e-23,
Organism=Homo sapiens, GI148277065, Length=485, Percent_Identity=24.1237113402062, Blast_Score=83, Evalue=8e-16,
Organism=Homo sapiens, GI148277071, Length=485, Percent_Identity=24.1237113402062, Blast_Score=82, Evalue=9e-16,
Organism=Homo sapiens, GI33519430, Length=485, Percent_Identity=24.1237113402062, Blast_Score=82, Evalue=1e-15,
Organism=Homo sapiens, GI33519428, Length=485, Percent_Identity=24.1237113402062, Blast_Score=82, Evalue=1e-15,
Organism=Homo sapiens, GI33519426, Length=485, Percent_Identity=24.1237113402062, Blast_Score=82, Evalue=1e-15,
Organism=Escherichia coli, GI87082354, Length=465, Percent_Identity=58.7096774193548, Blast_Score=556, Evalue=1e-159,
Organism=Escherichia coli, GI1786307, Length=461, Percent_Identity=28.6334056399132, Blast_Score=191, Evalue=9e-50,
Organism=Escherichia coli, GI87081717, Length=451, Percent_Identity=27.0509977827051, Blast_Score=149, Evalue=3e-37,
Organism=Escherichia coli, GI1789915, Length=442, Percent_Identity=27.1493212669683, Blast_Score=148, Evalue=1e-36,
Organism=Caenorhabditis elegans, GI32565766, Length=466, Percent_Identity=29.6137339055794, Blast_Score=194, Evalue=9e-50,
Organism=Caenorhabditis elegans, GI17557007, Length=473, Percent_Identity=24.3128964059197, Blast_Score=110, Evalue=2e-24,
Organism=Caenorhabditis elegans, GI71983419, Length=341, Percent_Identity=25.8064516129032, Blast_Score=100, Evalue=3e-21,
Organism=Caenorhabditis elegans, GI71983429, Length=341, Percent_Identity=25.8064516129032, Blast_Score=100, Evalue=3e-21,
Organism=Caenorhabditis elegans, GI17559934, Length=248, Percent_Identity=25, Blast_Score=66, Evalue=4e-11,
Organism=Saccharomyces cerevisiae, GI6321091, Length=472, Percent_Identity=26.0593220338983, Blast_Score=157, Evalue=4e-39,
Organism=Saccharomyces cerevisiae, GI6325240, Length=476, Percent_Identity=25, Blast_Score=144, Evalue=3e-35,
Organism=Saccharomyces cerevisiae, GI6325166, Length=462, Percent_Identity=27.2727272727273, Blast_Score=136, Evalue=1e-32,
Organism=Drosophila melanogaster, GI21358499, Length=497, Percent_Identity=30.1810865191147, Blast_Score=201, Evalue=1e-51,
Organism=Drosophila melanogaster, GI24640551, Length=493, Percent_Identity=26.369168356998, Blast_Score=140, Evalue=2e-33,
Organism=Drosophila melanogaster, GI24640553, Length=483, Percent_Identity=27.3291925465839, Blast_Score=140, Evalue=2e-33,
Organism=Drosophila melanogaster, GI24640549, Length=480, Percent_Identity=27.2916666666667, Blast_Score=139, Evalue=6e-33,
Organism=Drosophila melanogaster, GI17737741, Length=492, Percent_Identity=26.6260162601626, Blast_Score=134, Evalue=2e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016156
- InterPro:   IPR013027
- InterPro:   IPR004099
- InterPro:   IPR001327
- InterPro:   IPR022962 [H]

Pfam domain/function: PF00070 Pyr_redox; PF07992 Pyr_redox_2; PF02852 Pyr_redox_dim [H]

EC number: =1.6.1.1 [H]

Molecular weight: Translated: 60598; Mature: 60467

Theoretical pI: Translated: 6.21; Mature: 6.21

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKKRKGDETSDINDDKQSTQTAANEIGSAAPSVLSEVKKTPVKASDSSLEDTLFHPNLI
CCCCCCCCCCCCCCCCHHHHHHHHHHHCCHHHHHHHHHHHCCCCCCCCCCHHHHCCCCCC
SPLDNDRIRINSGFTRDSERLKNDNHEYEYDAVVVGAGPAGEAAAMKLAKSGKKVVVVDA
CCCCCCEEEEECCCCCCHHHHCCCCCCEEEEEEEEECCCCCHHHHHHHHHCCCEEEEEEC
RSQVGGNSAHVGTIPSKALRQSVFNLINYRRDPLFSQGLDYYQVPLNKVLTKARKVVRNQ
CCCCCCCCCEECCCCHHHHHHHHHHHHHCCCCCHHHCCCCCEEHHHHHHHHHHHHHHHHH
VDTHTRFYERNQIEVRHGWASFVDNHTLHIELGDGLGFETITFNKAIITVGSRPYRPDLL
HHHHHHHHHCCEEEEEECHHHHHCCCEEEEEECCCCCCEEEEECEEEEEECCCCCCCCCC
DFDHPRVFDSDKILQMDYVVKKIIIYGAGVIGCEYASIFTGLGYKVDLINNHDSLLSYLD
CCCCCCCCCCCCEEHHHHHHHHHHHHCCCHHHHHHHHHHHCCCEEEEEECCHHHHHHHHH
KEISDALSHDFRQFGVLVRNNEEIEKLETYDDCVILYLKSGKKIKSDAILWSNGRSGNTE
HHHHHHHHHHHHHHCEEEECCHHHHHHHCCCCEEEEEEECCCEECCCEEEEECCCCCCCC
SLNLEGIGLKANSRGQLKVDDTYRTEVENIYAAGDVIGWPSLASAAYDQGRCAAAFMVGD
EEEEEEEEEECCCCCCEEECCHHHHHHHHHEECCCCCCCCHHHHHHCCCCCEEEEEEECC
EDAEPVSSVPTGIYTIPEISSIGKTEQELTDEKVPYEVGQAFFKHLARAQIIGERSGVLK
CCCCCHHHCCCCEEECCCHHHCCCCHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCCCEEE
ILFHRETLEILGIHCYGNHASEIIHIGQAVMKCGHNLEYFVNTTFNYPTMAEAYRVAALN
EEEECCEEEEEEEEEECCCHHHHHHHHHHHHHCCCCCEEEEECCCCCCCHHHHHHHHHHH
GLNRVF
HHHHCC
>Mature Secondary Structure 
SKKRKGDETSDINDDKQSTQTAANEIGSAAPSVLSEVKKTPVKASDSSLEDTLFHPNLI
CCCCCCCCCCCCCCCHHHHHHHHHHHCCHHHHHHHHHHHCCCCCCCCCCHHHHCCCCCC
SPLDNDRIRINSGFTRDSERLKNDNHEYEYDAVVVGAGPAGEAAAMKLAKSGKKVVVVDA
CCCCCCEEEEECCCCCCHHHHCCCCCCEEEEEEEEECCCCCHHHHHHHHHCCCEEEEEEC
RSQVGGNSAHVGTIPSKALRQSVFNLINYRRDPLFSQGLDYYQVPLNKVLTKARKVVRNQ
CCCCCCCCCEECCCCHHHHHHHHHHHHHCCCCCHHHCCCCCEEHHHHHHHHHHHHHHHHH
VDTHTRFYERNQIEVRHGWASFVDNHTLHIELGDGLGFETITFNKAIITVGSRPYRPDLL
HHHHHHHHHCCEEEEEECHHHHHCCCEEEEEECCCCCCEEEEECEEEEEECCCCCCCCCC
DFDHPRVFDSDKILQMDYVVKKIIIYGAGVIGCEYASIFTGLGYKVDLINNHDSLLSYLD
CCCCCCCCCCCCEEHHHHHHHHHHHHCCCHHHHHHHHHHHCCCEEEEEECCHHHHHHHHH
KEISDALSHDFRQFGVLVRNNEEIEKLETYDDCVILYLKSGKKIKSDAILWSNGRSGNTE
HHHHHHHHHHHHHHCEEEECCHHHHHHHCCCCEEEEEEECCCEECCCEEEEECCCCCCCC
SLNLEGIGLKANSRGQLKVDDTYRTEVENIYAAGDVIGWPSLASAAYDQGRCAAAFMVGD
EEEEEEEEEECCCCCCEEECCHHHHHHHHHEECCCCCCCCHHHHHHCCCCCEEEEEEECC
EDAEPVSSVPTGIYTIPEISSIGKTEQELTDEKVPYEVGQAFFKHLARAQIIGERSGVLK
CCCCCHHHCCCCEEECCCHHHCCCCHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCCCEEE
ILFHRETLEILGIHCYGNHASEIIHIGQAVMKCGHNLEYFVNTTFNYPTMAEAYRVAALN
EEEECCEEEEEEEEEECCCHHHHHHHHHHHHHCCCCCEEEEECCCCCCCHHHHHHHHHHH
GLNRVF
HHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA