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The map label for this gene is pdxA [H]

Identifier: 148652713

GI number: 148652713

Start: 1078576

End: 1079700

Strand: Direct

Name: pdxA [H]

Synonym: PsycPRwf_0906

Alternate gene names: 148652713

Gene position: 1078576-1079700 (Clockwise)

Preceding gene: 148652709

Following gene: 148652714

Centisome position: 36.21

GC content: 48.89

Gene sequence:

>1125_bases
ATGAGCACAACTTATCCGCTGACCAAAACTTCCTCTATCAATATCAAACCTAGCAGTGCCTCGTTGGTGGTTACCACAGG
CGAGCCAGCGGGGATAGGGATGGACATCCTATTACAATTGGCCATGCAGCAAAAATTAGGCGAGCTGAGCTATCCGTTAA
TCGTGTTGGCTGATGAGGCCGCCTTACAGCAGCGCTTTGAGCTTATTTATGGTAGCGGTGTCTCTAAGCTAAGCGGGCCG
CTTTGGCAGCGGATTGAGTCGGTAAATGACTTGCAGCAGATATCAGGGCAGACAAAAGGCAACGCTTTACCGCAGTTTTA
TTTGTTGCACGTGGGCTGTGCTGAGCCTGTGGTGGCCGGACAACTTAATGTCAATAACGCCGCTATGGTGGTTCAGCAGT
TACAAATTGCGCATCAATGGGCAGCGTCAGGGGCTGCCAGTGCCATTGTCACCGGGCCACTGCAAAAATCGGTGCTAATA
GATGCCGGTATTACCTTAGAAGATGGCGGTATGTTCACCGGCCATACTGAGTTTTTTATGCAAAAAAGTGGCTGCCAAAA
AGTGGTAATGATGCTGGCCAATAGTGCCATGAAAGTAGCCTTGGTCACCATTCATATGCCCCTAAGACAAGTGGCTGATG
CCATAACGGCAGACAATGTGCGTCAGACAGTGCGCATTGTTTTGAATGATTTGCGCCAAAAGTTTGGCCTGCCAAATCCT
AAGATTTTAGTCTGTGGCCTTAATCCACATGCAGGAGAAGACGGCCATCTGGGCACTGAGGAGATTGATATTATTAATCC
GGTGCTGCGTGAGTTTCAGCAGCAAGGGGCGAATATTTCACTGGCCATGCCTGCAGATACTTTATTTACCACCCGTCACT
TACAAGATTGTGATGCGGTGATTGCCATGTATCATGATCAAGGGTTGCCGGTGTTAAAGTCTCACGGCTTTGGAGATACG
GTGAATTTAACTTTAGGGCTACCTTATATCCGCACCTCGGTGGATCATGGTACCGCACTTGATTTGGCAGGCAATTCGGC
CACAAGTGATGTTCAGCCAAGTAGCAGTAGCTTGTGGCAAGCGCTTATCATGGCTGAGGCAATGGTCCACTCACAGCAGA
AGTAA

Upstream 100 bases:

>100_bases
TTAATACCGCCACGGCTTAAAACCATCTGGCAGCATTTAACGGCAAATATAAAAACCATCACTCTATGTCATCCATGCGA
TAACCATTAAGGCCACCTTT

Downstream 100 bases:

>100_bases
GCTGAGCTTTTTAGCCACAAGCTCACGCTTTAGCACTGCAAATTATGCTACACTAAATCCTTTTTTAATTGATAAATATC
GACTTATGACGCAATCAGAC

Product: 4-hydroxythreonine-4-phosphate dehydrogenase

Products: NA

Alternate protein names: 4-(phosphohydroxy)-L-threonine dehydrogenase [H]

Number of amino acids: Translated: 374; Mature: 373

Protein sequence:

>374_residues
MSTTYPLTKTSSINIKPSSASLVVTTGEPAGIGMDILLQLAMQQKLGELSYPLIVLADEAALQQRFELIYGSGVSKLSGP
LWQRIESVNDLQQISGQTKGNALPQFYLLHVGCAEPVVAGQLNVNNAAMVVQQLQIAHQWAASGAASAIVTGPLQKSVLI
DAGITLEDGGMFTGHTEFFMQKSGCQKVVMMLANSAMKVALVTIHMPLRQVADAITADNVRQTVRIVLNDLRQKFGLPNP
KILVCGLNPHAGEDGHLGTEEIDIINPVLREFQQQGANISLAMPADTLFTTRHLQDCDAVIAMYHDQGLPVLKSHGFGDT
VNLTLGLPYIRTSVDHGTALDLAGNSATSDVQPSSSSLWQALIMAEAMVHSQQK

Sequences:

>Translated_374_residues
MSTTYPLTKTSSINIKPSSASLVVTTGEPAGIGMDILLQLAMQQKLGELSYPLIVLADEAALQQRFELIYGSGVSKLSGP
LWQRIESVNDLQQISGQTKGNALPQFYLLHVGCAEPVVAGQLNVNNAAMVVQQLQIAHQWAASGAASAIVTGPLQKSVLI
DAGITLEDGGMFTGHTEFFMQKSGCQKVVMMLANSAMKVALVTIHMPLRQVADAITADNVRQTVRIVLNDLRQKFGLPNP
KILVCGLNPHAGEDGHLGTEEIDIINPVLREFQQQGANISLAMPADTLFTTRHLQDCDAVIAMYHDQGLPVLKSHGFGDT
VNLTLGLPYIRTSVDHGTALDLAGNSATSDVQPSSSSLWQALIMAEAMVHSQQK
>Mature_373_residues
STTYPLTKTSSINIKPSSASLVVTTGEPAGIGMDILLQLAMQQKLGELSYPLIVLADEAALQQRFELIYGSGVSKLSGPL
WQRIESVNDLQQISGQTKGNALPQFYLLHVGCAEPVVAGQLNVNNAAMVVQQLQIAHQWAASGAASAIVTGPLQKSVLID
AGITLEDGGMFTGHTEFFMQKSGCQKVVMMLANSAMKVALVTIHMPLRQVADAITADNVRQTVRIVLNDLRQKFGLPNPK
ILVCGLNPHAGEDGHLGTEEIDIINPVLREFQQQGANISLAMPADTLFTTRHLQDCDAVIAMYHDQGLPVLKSHGFGDTV
NLTLGLPYIRTSVDHGTALDLAGNSATSDVQPSSSSLWQALIMAEAMVHSQQK

Specific function: Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) [H]

COG id: COG1995

COG function: function code H; Pyridoxal phosphate biosynthesis protein

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the pdxA family [H]

Homologues:

Organism=Escherichia coli, GI1786237, Length=356, Percent_Identity=48.876404494382, Blast_Score=297, Evalue=6e-82,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005255 [H]

Pfam domain/function: PF04166 PdxA [H]

EC number: =1.1.1.262 [H]

Molecular weight: Translated: 40071; Mature: 39939

Theoretical pI: Translated: 5.93; Mature: 5.93

Prosite motif: PS00136 SUBTILASE_ASP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTTYPLTKTSSINIKPSSASLVVTTGEPAGIGMDILLQLAMQQKLGELSYPLIVLADEA
CCCCCCCCCCCEEEECCCCCEEEEECCCCCCCCHHHHHHHHHHHHHCCCCCCEEEEECHH
ALQQRFELIYGSGVSKLSGPLWQRIESVNDLQQISGQTKGNALPQFYLLHVGCAEPVVAG
HHHHHHHHHHCCCCHHHCCHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEEECCCCCEEEC
QLNVNNAAMVVQQLQIAHQWAASGAASAIVTGPLQKSVLIDAGITLEDGGMFTGHTEFFM
EECCCHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCCEEEECCCEEECCCEECCCHHHHH
QKSGCQKVVMMLANSAMKVALVTIHMPLRQVADAITADNVRQTVRIVLNDLRQKFGLPNP
HHCCHHHHHHHHHCCCCEEEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
KILVCGLNPHAGEDGHLGTEEIDIINPVLREFQQQGANISLAMPADTLFTTRHLQDCDAV
CEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCEEEECCCHHHHHHHHHHHHHHH
IAMYHDQGLPVLKSHGFGDTVNLTLGLPYIRTSVDHGTALDLAGNSATSDVQPSSSSLWQ
HHHHCCCCCCEEECCCCCCEEEEEECCCHHHCCCCCCCEEEECCCCCCCCCCCCHHHHHH
ALIMAEAMVHSQQK
HHHHHHHHHHCCCC
>Mature Secondary Structure 
STTYPLTKTSSINIKPSSASLVVTTGEPAGIGMDILLQLAMQQKLGELSYPLIVLADEA
CCCCCCCCCCEEEECCCCCEEEEECCCCCCCCHHHHHHHHHHHHHCCCCCCEEEEECHH
ALQQRFELIYGSGVSKLSGPLWQRIESVNDLQQISGQTKGNALPQFYLLHVGCAEPVVAG
HHHHHHHHHHCCCCHHHCCHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEEECCCCCEEEC
QLNVNNAAMVVQQLQIAHQWAASGAASAIVTGPLQKSVLIDAGITLEDGGMFTGHTEFFM
EECCCHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCCEEEECCCEEECCCEECCCHHHHH
QKSGCQKVVMMLANSAMKVALVTIHMPLRQVADAITADNVRQTVRIVLNDLRQKFGLPNP
HHCCHHHHHHHHHCCCCEEEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
KILVCGLNPHAGEDGHLGTEEIDIINPVLREFQQQGANISLAMPADTLFTTRHLQDCDAV
CEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCEEEECCCHHHHHHHHHHHHHHH
IAMYHDQGLPVLKSHGFGDTVNLTLGLPYIRTSVDHGTALDLAGNSATSDVQPSSSSLWQ
HHHHCCCCCCEEECCCCCCEEEEEECCCHHHCCCCCCCEEEECCCCCCCCCCCCHHHHHH
ALIMAEAMVHSQQK
HHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12928499 [H]