Click here to switch to the map view.

The map label for this gene is folC [H]

Identifier: 148652567

GI number: 148652567

Start: 903579

End: 904934

Strand: Direct

Name: folC [H]

Synonym: PsycPRwf_0758

Alternate gene names: 148652567

Gene position: 903579-904934 (Clockwise)

Preceding gene: 148652566

Following gene: 148652568

Centisome position: 30.33

GC content: 47.57

Gene sequence:

>1356_bases
ATGACCCCACAAATTAACGATGTTAATGCACCCACGTTGACCAGTCCTTTGTCAGATTGGATTTATTATATGCAGCAAAT
CCATGTATCCGCCATCGATATGGGTTTGTCTCGAGTGCTACCTGTCGCTGAGCGATTGGGCTTGGTAAAGTCTGCCAAAG
AAGATGCCTATGTTTTTATGGTTGCAGGTACCAATGGTAAAGGCTCAACAACTGCGGTTATTAGCGCAGTGTGTCAGCAG
GCCGGCTACAAAACCGCGCTTTATCAATCGCCGCATCTAATTGATTTTAATGAGCGGGTGCGTATTGATGGCAAGCCAGT
TGGTGACCAAGTACTTATCGATGCGTTTTATCAAGTTGAGCAGGCGCGGCTGGCTTGTGATTTGACCTTGTCATTTTTTG
AGATGACCACGCTTGCGGCCATGCTCATTTTTGCCGAGGCCCATTGCGATGTTTGGGTATTAGAGGTGGGACTAGGTGGC
CGCTTAGATGTGGTGAATATTATTGATGCTGATTTGGCTGTGATTACCAATATTGGTATTGACCATGTGGACTGGCTGGG
GGATACGCGCGAGAAGATTGGCTTTGAAAAAGCAGGTATCTTGCGTGAGGGTGTACCGCTCATCTATGGTGAGACAGACA
TGCCGCACTCGGTGCGAAGTCAAGTTGAGGCCTTAAATTGCCCTTGTTTTCAGGTGGGCAAAGACTATGACTTTATCCTG
CCAGACTCAGGCCGGTCTGGCTTATCACAGTCAGACTTAGAGGCGCACTGGCAGTTTAGTGGTGCTGCTGTGACCATGCA
ATTGCCTATACCCAAGCTGTCATTGGTAAATACTACCAATGCCGTGGCGGCACTTTTAGCCTCTCCATTAAAAATTGAGG
CGGCAGATATTGAGGCGGCATTAGCAAAAGTTACCTTAGCTGGCCGCTTCGATGCTCGCGACTTGCTGGGTCGTCATTGG
TTATTTGATGTGGCTCATAATGAGCGTGGTATGAGCTTTTTGCTCAGTCAGTTTGTGCCTTTGTGGCAGCAACATAAAGC
CCGTTATCCTACGGCTAAGTTACATTTGGTGTTCTCTATGCTGGCTGATAAAGACATCAGCCATGTGGTTGAATTACTGG
TTAACTCAAACCTACCGATTCACACTTGGCATGTGGCTGAGATTGACCATCCGCGGGCAGCACATGTTTCTGAGCTTATT
GACGTGCTCAAGCAGCATCAGCAAAGCGCCATTATTACCTATGAGCGTTTGTCCGTTATTGGTGAAGCAGTTGCCGCAAC
CACTTATCCTGAAGATCTTATCTTGGTTTGTGGCTCTTTTCACACCATAGGAGAGGTGCTACAGCCCTTGGTATAA

Upstream 100 bases:

>100_bases
AGTTATTTAGCACCTAGGATTGTATTCTTATAAGCAGCCCTTAAACGCTAAGGGTTGCTTATCTATTTTTGAGCGAAGAG
ATATTGTGAGCATACCCTCT

Downstream 100 bases:

>100_bases
TATCGATAAGTTATGAGTCACTCACAAAAGCGCAGCGCGTCATATAGGCACTGCGCTTTTTTTTATCTCCTTAATATCTT
AACTATTTATTCCTATTAAA

Product: FolC bifunctional protein

Products: NA

Alternate protein names: Folylpolyglutamate synthase; Folylpoly-gamma-glutamate synthetase; FPGS; Tetrahydrofolylpolyglutamate synthase; Tetrahydrofolate synthase; Dihydrofolate synthase [H]

Number of amino acids: Translated: 451; Mature: 450

Protein sequence:

>451_residues
MTPQINDVNAPTLTSPLSDWIYYMQQIHVSAIDMGLSRVLPVAERLGLVKSAKEDAYVFMVAGTNGKGSTTAVISAVCQQ
AGYKTALYQSPHLIDFNERVRIDGKPVGDQVLIDAFYQVEQARLACDLTLSFFEMTTLAAMLIFAEAHCDVWVLEVGLGG
RLDVVNIIDADLAVITNIGIDHVDWLGDTREKIGFEKAGILREGVPLIYGETDMPHSVRSQVEALNCPCFQVGKDYDFIL
PDSGRSGLSQSDLEAHWQFSGAAVTMQLPIPKLSLVNTTNAVAALLASPLKIEAADIEAALAKVTLAGRFDARDLLGRHW
LFDVAHNERGMSFLLSQFVPLWQQHKARYPTAKLHLVFSMLADKDISHVVELLVNSNLPIHTWHVAEIDHPRAAHVSELI
DVLKQHQQSAIITYERLSVIGEAVAATTYPEDLILVCGSFHTIGEVLQPLV

Sequences:

>Translated_451_residues
MTPQINDVNAPTLTSPLSDWIYYMQQIHVSAIDMGLSRVLPVAERLGLVKSAKEDAYVFMVAGTNGKGSTTAVISAVCQQ
AGYKTALYQSPHLIDFNERVRIDGKPVGDQVLIDAFYQVEQARLACDLTLSFFEMTTLAAMLIFAEAHCDVWVLEVGLGG
RLDVVNIIDADLAVITNIGIDHVDWLGDTREKIGFEKAGILREGVPLIYGETDMPHSVRSQVEALNCPCFQVGKDYDFIL
PDSGRSGLSQSDLEAHWQFSGAAVTMQLPIPKLSLVNTTNAVAALLASPLKIEAADIEAALAKVTLAGRFDARDLLGRHW
LFDVAHNERGMSFLLSQFVPLWQQHKARYPTAKLHLVFSMLADKDISHVVELLVNSNLPIHTWHVAEIDHPRAAHVSELI
DVLKQHQQSAIITYERLSVIGEAVAATTYPEDLILVCGSFHTIGEVLQPLV
>Mature_450_residues
TPQINDVNAPTLTSPLSDWIYYMQQIHVSAIDMGLSRVLPVAERLGLVKSAKEDAYVFMVAGTNGKGSTTAVISAVCQQA
GYKTALYQSPHLIDFNERVRIDGKPVGDQVLIDAFYQVEQARLACDLTLSFFEMTTLAAMLIFAEAHCDVWVLEVGLGGR
LDVVNIIDADLAVITNIGIDHVDWLGDTREKIGFEKAGILREGVPLIYGETDMPHSVRSQVEALNCPCFQVGKDYDFILP
DSGRSGLSQSDLEAHWQFSGAAVTMQLPIPKLSLVNTTNAVAALLASPLKIEAADIEAALAKVTLAGRFDARDLLGRHWL
FDVAHNERGMSFLLSQFVPLWQQHKARYPTAKLHLVFSMLADKDISHVVELLVNSNLPIHTWHVAEIDHPRAAHVSELID
VLKQHQQSAIITYERLSVIGEAVAATTYPEDLILVCGSFHTIGEVLQPLV

Specific function: Conversion of folates to polyglutamate derivatives [H]

COG id: COG0285

COG function: function code H; Folylpolyglutamate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the folylpolyglutamate synthase family [H]

Homologues:

Organism=Homo sapiens, GI66932984, Length=213, Percent_Identity=32.3943661971831, Blast_Score=122, Evalue=5e-28,
Organism=Homo sapiens, GI66932990, Length=213, Percent_Identity=32.3943661971831, Blast_Score=122, Evalue=5e-28,
Organism=Escherichia coli, GI1788654, Length=439, Percent_Identity=37.129840546697, Blast_Score=273, Evalue=1e-74,
Organism=Caenorhabditis elegans, GI17553148, Length=158, Percent_Identity=35.4430379746835, Blast_Score=117, Evalue=9e-27,
Organism=Caenorhabditis elegans, GI17553150, Length=158, Percent_Identity=35.4430379746835, Blast_Score=117, Evalue=9e-27,
Organism=Caenorhabditis elegans, GI71984923, Length=158, Percent_Identity=35.4430379746835, Blast_Score=117, Evalue=1e-26,
Organism=Saccharomyces cerevisiae, GI6323760, Length=442, Percent_Identity=26.9230769230769, Blast_Score=128, Evalue=1e-30,
Organism=Saccharomyces cerevisiae, GI6324815, Length=192, Percent_Identity=32.2916666666667, Blast_Score=104, Evalue=4e-23,
Organism=Drosophila melanogaster, GI24641571, Length=168, Percent_Identity=36.9047619047619, Blast_Score=106, Evalue=3e-23,
Organism=Drosophila melanogaster, GI24581568, Length=171, Percent_Identity=32.7485380116959, Blast_Score=94, Evalue=1e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR018109
- InterPro:   IPR001645
- InterPro:   IPR004101
- InterPro:   IPR013221 [H]

Pfam domain/function: PF02875 Mur_ligase_C; PF08245 Mur_ligase_M [H]

EC number: =6.3.2.17; =6.3.2.12 [H]

Molecular weight: Translated: 49568; Mature: 49437

Theoretical pI: Translated: 5.03; Mature: 5.03

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTPQINDVNAPTLTSPLSDWIYYMQQIHVSAIDMGLSRVLPVAERLGLVKSAKEDAYVFM
CCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEE
VAGTNGKGSTTAVISAVCQQAGYKTALYQSPHLIDFNERVRIDGKPVGDQVLIDAFYQVE
EECCCCCCCHHHHHHHHHHHCCCCEEEECCCCEECCCCEEEECCCCCCHHHHHHHHHHHH
QARLACDLTLSFFEMTTLAAMLIFAEAHCDVWVLEVGLGGRLDVVNIIDADLAVITNIGI
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCEEEEEECCCCHHHHHHCCC
DHVDWLGDTREKIGFEKAGILREGVPLIYGETDMPHSVRSQVEALNCPCFQVGKDYDFIL
CHHHHCCCCHHHCCCHHHCHHHCCCCEEECCCCCCHHHHHHHHHHCCCHHCCCCCCEEEE
PDSGRSGLSQSDLEAHWQFSGAAVTMQLPIPKLSLVNTTNAVAALLASPLKIEAADIEAA
CCCCCCCCCCCCCHHHEEECCEEEEEEECCCCEEEECCHHHHHHHHCCCCEEEHHHHHHH
LAKVTLAGRFDARDLLGRHWLFDVAHNERGMSFLLSQFVPLWQQHKARYPTAKLHLVFSM
HHHEEEECCCCHHHHHHHHHEEEECCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHH
LADKDISHVVELLVNSNLPIHTWHVAEIDHPRAAHVSELIDVLKQHQQSAIITYERLSVI
HHCCCHHHHHHHHHCCCCCEEEEEEEECCCCCHHHHHHHHHHHHHHHHHHEEHHHHHHHH
GEAVAATTYPEDLILVCGSFHTIGEVLQPLV
HHHHHHCCCCCCCEEEECCHHHHHHHHHHCC
>Mature Secondary Structure 
TPQINDVNAPTLTSPLSDWIYYMQQIHVSAIDMGLSRVLPVAERLGLVKSAKEDAYVFM
CCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEE
VAGTNGKGSTTAVISAVCQQAGYKTALYQSPHLIDFNERVRIDGKPVGDQVLIDAFYQVE
EECCCCCCCHHHHHHHHHHHCCCCEEEECCCCEECCCCEEEECCCCCCHHHHHHHHHHHH
QARLACDLTLSFFEMTTLAAMLIFAEAHCDVWVLEVGLGGRLDVVNIIDADLAVITNIGI
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCEEEEEECCCCHHHHHHCCC
DHVDWLGDTREKIGFEKAGILREGVPLIYGETDMPHSVRSQVEALNCPCFQVGKDYDFIL
CHHHHCCCCHHHCCCHHHCHHHCCCCEEECCCCCCHHHHHHHHHHCCCHHCCCCCCEEEE
PDSGRSGLSQSDLEAHWQFSGAAVTMQLPIPKLSLVNTTNAVAALLASPLKIEAADIEAA
CCCCCCCCCCCCCHHHEEECCEEEEEEECCCCEEEECCHHHHHHHHCCCCEEEHHHHHHH
LAKVTLAGRFDARDLLGRHWLFDVAHNERGMSFLLSQFVPLWQQHKARYPTAKLHLVFSM
HHHEEEECCCCHHHHHHHHHEEEECCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHH
LADKDISHVVELLVNSNLPIHTWHVAEIDHPRAAHVSELIDVLKQHQQSAIITYERLSVI
HHCCCHHHHHHHHHCCCCCEEEEEEEECCCCCHHHHHHHHHHHHHHHHHHEEHHHHHHHH
GEAVAATTYPEDLILVCGSFHTIGEVLQPLV
HHHHHHCCCCCCCEEEECCHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 3040739; 3040734; 9205837; 9278503; 1989505 [H]