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The map label for this gene is coaBC [H]

Identifier: 148652304

GI number: 148652304

Start: 587286

End: 588536

Strand: Direct

Name: coaBC [H]

Synonym: PsycPRwf_0492

Alternate gene names: 148652304

Gene position: 587286-588536 (Clockwise)

Preceding gene: 148652300

Following gene: 148652305

Centisome position: 19.71

GC content: 46.68

Gene sequence:

>1251_bases
ATGAGCCCAATCTTTACGCCTGTCACCTCTGTCGCCCCTAATATTACTAAGGTTATCCTAGCCATCACTGGGGGTATTGC
CGCTTATAAATCTGCGATACTGGCCCGACTGCTCATTAAGTCAGGCTTTGAAGTGCGGGTTATCATGACTGCAGGCGCGC
AGCAGTTTATTACCCCTTTGACGTTGCAAGCATTGACGGGTAACGAGGTACATACCGAATTATTAGACACCAAAGCAGAA
GCCGGTATGGGTCATATTGAGCTGGCAAAGTGGGCAGATCTTATTGTTATAGCCCCAGCTTCAGCCAATACTTTGGCGCG
TTTGGCAATGGGCATGGCTGATGACTTACTAACCACCGTGTGTCTGGCCACAGCGGCGCCAGTGATGGTAGCGCCAGCGA
TGAATCAGCAAATGTGGGCGCATCCTGCCGTCCAGTTAAATGTACAAACTCTCAGTGACATGGGGTATGAAATCATTGAG
CCGGACAGTGGCGTGCAAGCTTGTGGCGATGTGGGATCAGGACGATTACCTGAGCCGGATATCTTACTGCGCCAAGTTAT
TAACTTCAAAGCCCGACTGACTGTAGCGCAGTGTTTAACAGGTAAAAAGGTCACCATTACCGCAGGACCAACTGTAGAGG
CGATTGATCCGGTACGATTCTTATCCAATCATTCCACCGGAAAGATGGGTTTTGCTTTGGCGCGAGCTTGCCGAGATGCT
GGAGCAGAAGTCACTTTGATTGCAGGTGGTAAAGTGAGCCTAATGACCCCGTTAAAGGTTAAGCGTATTGATGTGCTCTC
TGCAAATGACATGCTACAAGCGGCGACCCGCTCTGTGGAAGCCGGCTGTGATATCTTTATTGCTACAGCCGCTGTGGCCG
ATTATCGTACCCGTGATGCCGCCCCACAAAAAATCAAAAAAACTCAGGATGAAATGACCCTTGATTTGGTAAAAAACCCT
GATATTTTGGCCACCATTTCACACAGCTATCCAGATATGTTTGTGGTAGGCTTCGCCGCTGAAACTCAAGATGTAGAAAA
ATATGCCCGCGGCAAACTTGAGTCAAAGAACTTAGATATGATTGCTTGTAATGATGTGTCACGCAAAGACATAGGTTTTG
CCAGTGATGAAAATGCGATGCTGGTATTTTTTGCCAATCAGTATCAAAAACCCCCAGTTGAGTTAGAAAAAATGAGTAAA
GCTAACATAGCTGAACATTTAGTTAACCTAATAGGTAGTGTTTTAAATTAA

Upstream 100 bases:

>100_bases
AGCTATCCAAAACCGAGTCAAACTTGTTACCATAACCGCATTTTTATTGATAACAACTCAATTTATCGTCAGATAACTCT
CCAAAAGGTAGCTTTTGCTT

Downstream 100 bases:

>100_bases
TCTTGACTTTATAATACAGTTTAAGAGGGGGAGGGTTTTGCTTGACGCTCTCTTATCCTTGATATCTGACAGTTTATATC
TGCTGTTATAAATTTAATCA

Product: phosphopantothenoylcysteine decarboxylase/phosphopantothenate--cysteine ligase

Products: NA

Alternate protein names: DNA/pantothenate metabolism flavoprotein; Phosphopantothenoylcysteine decarboxylase; PPCDC; CoaC; Phosphopantothenate--cysteine ligase; CoaB; PPC synthetase; PPCS; Phosphopantothenoylcysteine synthase [H]

Number of amino acids: Translated: 416; Mature: 415

Protein sequence:

>416_residues
MSPIFTPVTSVAPNITKVILAITGGIAAYKSAILARLLIKSGFEVRVIMTAGAQQFITPLTLQALTGNEVHTELLDTKAE
AGMGHIELAKWADLIVIAPASANTLARLAMGMADDLLTTVCLATAAPVMVAPAMNQQMWAHPAVQLNVQTLSDMGYEIIE
PDSGVQACGDVGSGRLPEPDILLRQVINFKARLTVAQCLTGKKVTITAGPTVEAIDPVRFLSNHSTGKMGFALARACRDA
GAEVTLIAGGKVSLMTPLKVKRIDVLSANDMLQAATRSVEAGCDIFIATAAVADYRTRDAAPQKIKKTQDEMTLDLVKNP
DILATISHSYPDMFVVGFAAETQDVEKYARGKLESKNLDMIACNDVSRKDIGFASDENAMLVFFANQYQKPPVELEKMSK
ANIAEHLVNLIGSVLN

Sequences:

>Translated_416_residues
MSPIFTPVTSVAPNITKVILAITGGIAAYKSAILARLLIKSGFEVRVIMTAGAQQFITPLTLQALTGNEVHTELLDTKAE
AGMGHIELAKWADLIVIAPASANTLARLAMGMADDLLTTVCLATAAPVMVAPAMNQQMWAHPAVQLNVQTLSDMGYEIIE
PDSGVQACGDVGSGRLPEPDILLRQVINFKARLTVAQCLTGKKVTITAGPTVEAIDPVRFLSNHSTGKMGFALARACRDA
GAEVTLIAGGKVSLMTPLKVKRIDVLSANDMLQAATRSVEAGCDIFIATAAVADYRTRDAAPQKIKKTQDEMTLDLVKNP
DILATISHSYPDMFVVGFAAETQDVEKYARGKLESKNLDMIACNDVSRKDIGFASDENAMLVFFANQYQKPPVELEKMSK
ANIAEHLVNLIGSVLN
>Mature_415_residues
SPIFTPVTSVAPNITKVILAITGGIAAYKSAILARLLIKSGFEVRVIMTAGAQQFITPLTLQALTGNEVHTELLDTKAEA
GMGHIELAKWADLIVIAPASANTLARLAMGMADDLLTTVCLATAAPVMVAPAMNQQMWAHPAVQLNVQTLSDMGYEIIEP
DSGVQACGDVGSGRLPEPDILLRQVINFKARLTVAQCLTGKKVTITAGPTVEAIDPVRFLSNHSTGKMGFALARACRDAG
AEVTLIAGGKVSLMTPLKVKRIDVLSANDMLQAATRSVEAGCDIFIATAAVADYRTRDAAPQKIKKTQDEMTLDLVKNPD
ILATISHSYPDMFVVGFAAETQDVEKYARGKLESKNLDMIACNDVSRKDIGFASDENAMLVFFANQYQKPPVELEKMSKA
NIAEHLVNLIGSVLN

Specific function: Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine [H]

COG id: COG0452

COG function: function code H; Phosphopantothenoylcysteine synthetase/decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the PPC synthetase family [H]

Homologues:

Organism=Homo sapiens, GI71725351, Length=165, Percent_Identity=36.3636363636364, Blast_Score=99, Evalue=5e-21,
Organism=Escherichia coli, GI87082301, Length=387, Percent_Identity=51.6795865633075, Blast_Score=352, Evalue=2e-98,
Organism=Caenorhabditis elegans, GI17560194, Length=169, Percent_Identity=34.9112426035503, Blast_Score=83, Evalue=3e-16,
Organism=Saccharomyces cerevisiae, GI6322762, Length=191, Percent_Identity=31.9371727748691, Blast_Score=85, Evalue=2e-17,
Organism=Saccharomyces cerevisiae, GI6322925, Length=95, Percent_Identity=36.8421052631579, Blast_Score=65, Evalue=2e-11,
Organism=Drosophila melanogaster, GI24657262, Length=182, Percent_Identity=33.5164835164835, Blast_Score=93, Evalue=3e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005252
- InterPro:   IPR007085
- InterPro:   IPR003382 [H]

Pfam domain/function: PF04127 DFP; PF02441 Flavoprotein [H]

EC number: =4.1.1.36; =6.3.2.5 [H]

Molecular weight: Translated: 44466; Mature: 44335

Theoretical pI: Translated: 5.99; Mature: 5.99

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
4.1 %Met     (Translated Protein)
5.5 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
5.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSPIFTPVTSVAPNITKVILAITGGIAAYKSAILARLLIKSGFEVRVIMTAGAQQFITPL
CCCCCCCHHHHCCHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCEEEEEEECCCHHHHCHH
TLQALTGNEVHTELLDTKAEAGMGHIELAKWADLIVIAPASANTLARLAMGMADDLLTTV
EEEEECCCHHHHHHHHHHHHCCCCCEEHHCCCCEEEECCCCHHHHHHHHHHHHHHHHHHH
CLATAAPVMVAPAMNQQMWAHPAVQLNVQTLSDMGYEIIEPDSGVQACGDVGSGRLPEPD
HHHHCCCCEEECCCCCHHHCCCCEEEEEEEHHHCCCEEECCCCCHHHHCCCCCCCCCCHH
ILLRQVINFKARLTVAQCLTGKKVTITAGPTVEAIDPVRFLSNHSTGKMGFALARACRDA
HHHHHHHHHHHHEEHHHHHCCCEEEEECCCCCCCCCHHHHHCCCCCCHHHHHHHHHHHHC
GAEVTLIAGGKVSLMTPLKVKRIDVLSANDMLQAATRSVEAGCDIFIATAAVADYRTRDA
CCEEEEEECCEEEEECCCEEEEEEEECHHHHHHHHHHHHHCCCCEEEEHHHHHHHHCCCC
APQKIKKTQDEMTLDLVKNPDILATISHSYPDMFVVGFAAETQDVEKYARGKLESKNLDM
CHHHHHHHHHHHEEEEECCCCEEEEECCCCCCEEEEEEECCHHHHHHHHCCCCCCCCCCE
IACNDVSRKDIGFASDENAMLVFFANQYQKPPVELEKMSKANIAEHLVNLIGSVLN
EEECCCCCCCCCCCCCCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
SPIFTPVTSVAPNITKVILAITGGIAAYKSAILARLLIKSGFEVRVIMTAGAQQFITPL
CCCCCCHHHHCCHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCEEEEEEECCCHHHHCHH
TLQALTGNEVHTELLDTKAEAGMGHIELAKWADLIVIAPASANTLARLAMGMADDLLTTV
EEEEECCCHHHHHHHHHHHHCCCCCEEHHCCCCEEEECCCCHHHHHHHHHHHHHHHHHHH
CLATAAPVMVAPAMNQQMWAHPAVQLNVQTLSDMGYEIIEPDSGVQACGDVGSGRLPEPD
HHHHCCCCEEECCCCCHHHCCCCEEEEEEEHHHCCCEEECCCCCHHHHCCCCCCCCCCHH
ILLRQVINFKARLTVAQCLTGKKVTITAGPTVEAIDPVRFLSNHSTGKMGFALARACRDA
HHHHHHHHHHHHEEHHHHHCCCEEEEECCCCCCCCCHHHHHCCCCCCHHHHHHHHHHHHC
GAEVTLIAGGKVSLMTPLKVKRIDVLSANDMLQAATRSVEAGCDIFIATAAVADYRTRDA
CCEEEEEECCEEEEECCCEEEEEEEECHHHHHHHHHHHHHCCCCEEEEHHHHHHHHCCCC
APQKIKKTQDEMTLDLVKNPDILATISHSYPDMFVVGFAAETQDVEKYARGKLESKNLDM
CHHHHHHHHHHHEEEEECCCCEEEEECCCCCCEEEEEEECCHHHHHHHHCCCCCCCCCCE
IACNDVSRKDIGFASDENAMLVFFANQYQKPPVELEKMSKANIAEHLVNLIGSVLN
EEECCCCCCCCCCCCCCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]