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The map label for this gene is hemD [H]

Identifier: 148643564

GI number: 148643564

Start: 1530430

End: 1531203

Strand: Reverse

Name: hemD [H]

Synonym: Msm_1504

Alternate gene names: 148643564

Gene position: 1531203-1530430 (Counterclockwise)

Preceding gene: 148643565

Following gene: 148643563

Centisome position: 82.63

GC content: 31.27

Gene sequence:

>774_bases
ATGTCAAGACCCATTGTTGCAATTACAAGGCCTGCTGACAGATCTAAAGCAGCCTGCAAGATTGTTGAAGAGTTAGGAGG
TCAATATGTTCTAGCTCCTACTTTAGATTTAAAACCGGTAAATAGCGAATCTTTAAAGAATTTAATAGCTAATAAAGATT
TGCTGGATTGGATTGTTTTTACCTCTCCAACTACAATTACTTCCCTAAATCTTTTTTATCCTGATTTTTTAAAAAATTTA
GATTGCAAAGTAGCTGTAATTGGAAATAAAACCGGAAAAATAGCCGGCGAACAAGGCGTTAAAGTTGATTTAATACCTGA
AGATTTTACAGCAGAAGGTCTTTTAGAGGAATTTGAAAAAAGAAATATTACAAATCAGACCATTGGAATTCCAAGAACTG
CTTCTGCAAGACCTGTTCTGCCTGAAGGCTTAGAAAAACTTAACAATAAAGTTATAGTTGCTGAAGCTTACAAATCATTA
TTCCCAATGGATGAAGATAAAATCAATGATTTGATAGCTAAAATAGAAAATAATGAAATTGACGCAATTACTTTTACCAG
TCCTTTAACTGTTACTAATTTCTTTAAAATATCTAAAAACAAAGAAAAATTAGCTGATTTACTTTCCAATAATTTATTAA
CTGTCTGTATTGGTCCCATTACCGGTAAAATTTTAGACCAGTACAATATTAATTATATATATCCTGATACTTACACTGTT
CGTGATATGATGGAGTTATTATTCAAAACCTGGAGAAATTCACATGGAAGATAA

Upstream 100 bases:

>100_bases
ATTTTGTAATTTTTAATTATTAACAACAAATAATACATAAATAATATTAACTAATAAAATCAAAAATTATAATATTATTA
AATTATTTGGAGTAAATTAA

Downstream 100 bases:

>100_bases
AATAAGTATTATTCTACCTATTTTTAATGTCGGCCCTCATTTAAGAGGAGGAATTGATTCTTTAATCAACCAAACAATAG
GAAATGAAAATTTAGAAATC

Product: uroporphyrinogen III synthase, HemD

Products: NA

Alternate protein names: UROS; Hydroxymethylbilane hydrolyase [cyclizing]; Uroporphyrinogen-III cosynthase [H]

Number of amino acids: Translated: 257; Mature: 256

Protein sequence:

>257_residues
MSRPIVAITRPADRSKAACKIVEELGGQYVLAPTLDLKPVNSESLKNLIANKDLLDWIVFTSPTTITSLNLFYPDFLKNL
DCKVAVIGNKTGKIAGEQGVKVDLIPEDFTAEGLLEEFEKRNITNQTIGIPRTASARPVLPEGLEKLNNKVIVAEAYKSL
FPMDEDKINDLIAKIENNEIDAITFTSPLTVTNFFKISKNKEKLADLLSNNLLTVCIGPITGKILDQYNINYIYPDTYTV
RDMMELLFKTWRNSHGR

Sequences:

>Translated_257_residues
MSRPIVAITRPADRSKAACKIVEELGGQYVLAPTLDLKPVNSESLKNLIANKDLLDWIVFTSPTTITSLNLFYPDFLKNL
DCKVAVIGNKTGKIAGEQGVKVDLIPEDFTAEGLLEEFEKRNITNQTIGIPRTASARPVLPEGLEKLNNKVIVAEAYKSL
FPMDEDKINDLIAKIENNEIDAITFTSPLTVTNFFKISKNKEKLADLLSNNLLTVCIGPITGKILDQYNINYIYPDTYTV
RDMMELLFKTWRNSHGR
>Mature_256_residues
SRPIVAITRPADRSKAACKIVEELGGQYVLAPTLDLKPVNSESLKNLIANKDLLDWIVFTSPTTITSLNLFYPDFLKNLD
CKVAVIGNKTGKIAGEQGVKVDLIPEDFTAEGLLEEFEKRNITNQTIGIPRTASARPVLPEGLEKLNNKVIVAEAYKSLF
PMDEDKINDLIAKIENNEIDAITFTSPLTVTNFFKISKNKEKLADLLSNNLLTVCIGPITGKILDQYNINYIYPDTYTVR
DMMELLFKTWRNSHGR

Specific function: Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III [H]

COG id: COG1587

COG function: function code H; Uroporphyrinogen-III synthase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the uroporphyrinogen-III synthase family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003754 [H]

Pfam domain/function: PF02602 HEM4 [H]

EC number: =4.2.1.75 [H]

Molecular weight: Translated: 28766; Mature: 28634

Theoretical pI: Translated: 5.48; Mature: 5.48

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSRPIVAITRPADRSKAACKIVEELGGQYVLAPTLDLKPVNSESLKNLIANKDLLDWIVF
CCCCEEEEECCCCCHHHHHHHHHHHCCCEEEECCCCCCCCCHHHHHHHHHCCHHHHEEEE
TSPTTITSLNLFYPDFLKNLDCKVAVIGNKTGKIAGEQGVKVDLIPEDFTAEGLLEEFEK
CCCCCEEEEEEECHHHHCCCCEEEEEEECCCCCCCCCCCCEEEECCCCCCHHHHHHHHHH
RNITNQTIGIPRTASARPVLPEGLEKLNNKVIVAEAYKSLFPMDEDKINDLIAKIENNEI
CCCCCCCCCCCCCCCCCCCCHHHHHHHCCCEEEEEHHHHHCCCCHHHHHHHHHHHCCCCC
DAITFTSPLTVTNFFKISKNKEKLADLLSNNLLTVCIGPITGKILDQYNINYIYPDTYTV
CEEEECCCCEEEEEEEECCCHHHHHHHHHCCEEEEEECCHHHHHHHCCCCEEECCCCCCH
RDMMELLFKTWRNSHGR
HHHHHHHHHHHHCCCCC
>Mature Secondary Structure 
SRPIVAITRPADRSKAACKIVEELGGQYVLAPTLDLKPVNSESLKNLIANKDLLDWIVF
CCCEEEEECCCCCHHHHHHHHHHHCCCEEEECCCCCCCCCHHHHHHHHHCCHHHHEEEE
TSPTTITSLNLFYPDFLKNLDCKVAVIGNKTGKIAGEQGVKVDLIPEDFTAEGLLEEFEK
CCCCCEEEEEEECHHHHCCCCEEEEEEECCCCCCCCCCCCEEEECCCCCCHHHHHHHHHH
RNITNQTIGIPRTASARPVLPEGLEKLNNKVIVAEAYKSLFPMDEDKINDLIAKIENNEI
CCCCCCCCCCCCCCCCCCCCHHHHHHHCCCEEEEEHHHHHCCCCHHHHHHHHHHHCCCCC
DAITFTSPLTVTNFFKISKNKEKLADLLSNNLLTVCIGPITGKILDQYNINYIYPDTYTV
CEEEECCCCEEEEEEEECCCHHHHHHHHHCCEEEEEECCHHHHHHHCCCCEEECCCCCCH
RDMMELLFKTWRNSHGR
HHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9371463 [H]