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The map label for this gene is trpC [H]

Identifier: 148643203

GI number: 148643203

Start: 1122019

End: 1122795

Strand: Reverse

Name: trpC [H]

Synonym: Msm_1143

Alternate gene names: 148643203

Gene position: 1122795-1122019 (Counterclockwise)

Preceding gene: 148643204

Following gene: 162330297

Centisome position: 60.59

GC content: 29.86

Gene sequence:

>777_bases
ATGTTAGATAAAATAGTTGAAAAAACAAAAGAAAGAGTATCTGAAAATAAAAAGGTTAATTCATTAGACAGACTCAAATA
TAAAATACTCAATATTGATGTCAAATTCAATTATCCTTTTAAAAAAGCTTTAAGCAGTGATGATATTGCAATTATTGCAG
AGGTTAAAAAGGCATCACCTTCTAAAGGTTTAATAGCTGAAAATTTTGATTATGTAAACATTGCAAAAGAGTATGAAGCT
GCAGGCGCATCAGCTATTTCAGTTTTAACAGAACCTTACTTTTTTCAGGGTTCTGATGATTATTTAAAGAAAATAGCTAA
AAATGTTAAAATTCCAGTACTCAGAAAGGATTTTGTTGTTGATGAGTACATGATTTATGAAGCTAAATTACTTGGAGCAT
CTGCAGTATTGCTGATTGCAGCTATTTTGTCTGATGAACAATTGGAACAGTATTTGACTATAACTCGTGTTTTGGGAATG
TCTGCTATTGTTGAAGCTCATGATGAAAATGAAATTAAAAGGGCAATTGATGCAGGTGCAGATATTGTCGGTGTAAACAA
TAGAAATTTAAAAGATTTCAGTGTAGATATTGAAAATAGTATTCGTCTACGTAGATGTGTAGATGAAGATATTATATTTA
TTTCTGAAAGTGGTATTAAAACAAAAGAAGATATTGCCAGATTAAAAGAAAATAATGTTGATGCAGTTTTAATAGGTGAA
ACTTTAATGAAATCACCAGACAAAAAGGTGATGATTCGGGAGTTGAAGAATGGTTAA

Upstream 100 bases:

>100_bases
TCTATAGAAGATGGTGTTAGATTAGCCAGTGAAATTATTGATTCTGGCAGGGCTAAAAAACAGCTTGAAAAATTCATCGA
ATATACAAACAGTTGATTTC

Downstream 100 bases:

>100_bases
AATTAAAATCTGCGGACTTAAAAGACTGGAGGATATTGAACTTGCAAACAGGTATAAAATAGATTATGCAGGTTTTGTAT
TTGCTGAGAGCAAAAGAAAA

Product: indole-3-glycerol-phosphate synthase

Products: NA

Alternate protein names: IGPS [H]

Number of amino acids: Translated: 258; Mature: 258

Protein sequence:

>258_residues
MLDKIVEKTKERVSENKKVNSLDRLKYKILNIDVKFNYPFKKALSSDDIAIIAEVKKASPSKGLIAENFDYVNIAKEYEA
AGASAISVLTEPYFFQGSDDYLKKIAKNVKIPVLRKDFVVDEYMIYEAKLLGASAVLLIAAILSDEQLEQYLTITRVLGM
SAIVEAHDENEIKRAIDAGADIVGVNNRNLKDFSVDIENSIRLRRCVDEDIIFISESGIKTKEDIARLKENNVDAVLIGE
TLMKSPDKKVMIRELKNG

Sequences:

>Translated_258_residues
MLDKIVEKTKERVSENKKVNSLDRLKYKILNIDVKFNYPFKKALSSDDIAIIAEVKKASPSKGLIAENFDYVNIAKEYEA
AGASAISVLTEPYFFQGSDDYLKKIAKNVKIPVLRKDFVVDEYMIYEAKLLGASAVLLIAAILSDEQLEQYLTITRVLGM
SAIVEAHDENEIKRAIDAGADIVGVNNRNLKDFSVDIENSIRLRRCVDEDIIFISESGIKTKEDIARLKENNVDAVLIGE
TLMKSPDKKVMIRELKNG
>Mature_258_residues
MLDKIVEKTKERVSENKKVNSLDRLKYKILNIDVKFNYPFKKALSSDDIAIIAEVKKASPSKGLIAENFDYVNIAKEYEA
AGASAISVLTEPYFFQGSDDYLKKIAKNVKIPVLRKDFVVDEYMIYEAKLLGASAVLLIAAILSDEQLEQYLTITRVLGM
SAIVEAHDENEIKRAIDAGADIVGVNNRNLKDFSVDIENSIRLRRCVDEDIIFISESGIKTKEDIARLKENNVDAVLIGE
TLMKSPDKKVMIRELKNG

Specific function: Bifunctional Enzyme That Catalyzes Two Sequential Steps Of Tryptophan Biosynthetic Pathway. The First Reaction Is Catalyzed By The Isomerase, Coded By The Trpf Domain; The Second Reaction Is Catalyzed By The Synthase, Coded By The Trpc Domain. [C]

COG id: COG0134

COG function: function code E; Indole-3-glycerol phosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the trpC family [H]

Homologues:

Organism=Escherichia coli, GI87081863, Length=219, Percent_Identity=39.7260273972603, Blast_Score=150, Evalue=8e-38,
Organism=Saccharomyces cerevisiae, GI6322638, Length=268, Percent_Identity=39.5522388059701, Blast_Score=167, Evalue=2e-42,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR013798
- InterPro:   IPR001468
- InterPro:   IPR011060 [H]

Pfam domain/function: PF00218 IGPS [H]

EC number: =4.1.1.48 [H]

Molecular weight: Translated: 28980; Mature: 28980

Theoretical pI: Translated: 5.31; Mature: 5.31

Prosite motif: PS00614 IGPS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLDKIVEKTKERVSENKKVNSLDRLKYKILNIDVKFNYPFKKALSSDDIAIIAEVKKASP
CCHHHHHHHHHHHHHCCCCCHHHHHEEEEEEEEEEECCCHHHHCCCCCEEEEEEEHHCCC
SKGLIAENFDYVNIAKEYEAAGASAISVLTEPYFFQGSDDYLKKIAKNVKIPVLRKDFVV
CCCCEECCCCEEEHHHHHHHCCCHHHHHHCCCCEECCCHHHHHHHHHCCCCCEEHHHHHH
DEYMIYEAKLLGASAVLLIAAILSDEQLEQYLTITRVLGMSAIVEAHDENEIKRAIDAGA
HHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCC
DIVGVNNRNLKDFSVDIENSIRLRRCVDEDIIFISESGIKTKEDIARLKENNVDAVLIGE
CEEECCCCCCCEEEEEHHHCHHHHHHCCCCEEEEECCCCCCHHHHHHHHHCCCCEEEECH
TLMKSPDKKVMIRELKNG
HHHCCCCHHHHHHHHCCC
>Mature Secondary Structure
MLDKIVEKTKERVSENKKVNSLDRLKYKILNIDVKFNYPFKKALSSDDIAIIAEVKKASP
CCHHHHHHHHHHHHHCCCCCHHHHHEEEEEEEEEEECCCHHHHCCCCCEEEEEEEHHCCC
SKGLIAENFDYVNIAKEYEAAGASAISVLTEPYFFQGSDDYLKKIAKNVKIPVLRKDFVV
CCCCEECCCCEEEHHHHHHHCCCHHHHHHCCCCEECCCHHHHHHHHHCCCCCEEHHHHHH
DEYMIYEAKLLGASAVLLIAAILSDEQLEQYLTITRVLGMSAIVEAHDENEIKRAIDAGA
HHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCC
DIVGVNNRNLKDFSVDIENSIRLRRCVDEDIIFISESGIKTKEDIARLKENNVDAVLIGE
CEEECCCCCCCEEEEEHHHCHHHHHHCCCCEEEEECCCCCCHHHHHHHHHCCCCEEEECH
TLMKSPDKKVMIRELKNG
HHHCCCCHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA