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The map label for this gene is dapA

Identifier: 148642891

GI number: 148642891

Start: 789419

End: 790312

Strand: Reverse

Name: dapA

Synonym: Msm_0831

Alternate gene names: 148642891

Gene position: 790312-789419 (Counterclockwise)

Preceding gene: 148642892

Following gene: 148642890

Centisome position: 42.65

GC content: 35.57

Gene sequence:

>894_bases
ATGAATTTTGAAGGAACATATGTTGCAATGGTAACTCCATTTACTGATGATGGTAACATTGACGAAGAAGGATTTAGATC
CAATATTAATTATTTAATTGATAAAGGTGTAACTGGTTTGCTTGGTGCCGGAACTTCTGGTGAATCAGCTACATTAACTC
ATGAGGAACACAGAAAAGTAGTGGAAATTTTAATTGATGAAGTTGGTGGCAGAGTCGAAACAGTAGCCGGATCTGGTAGT
AATTCTACACATGAAGCTATTGAATTGACTAAATCTGCAGAAGAATTAGGTGCTGATGCCGCTTTAGTAATTACTCCTTA
TTACAATAAACCACAACAGCATGCATTAATTAAACATTATCAGGCTATTAGTGATGCAACTGATATTCCTATTATAGCAT
ATAATGTTCCGTCACGTACTGGTGTAGACATGAGTGTTGAAACTATTGTGGAATTAGCTAAAATTGATGGTGTGGATGCA
GTTAAAGAAGCTAGTGGGAGTGTAAATAAAGTATCCAAACTTTATAAAGCTTTAACAAAAGAAGGTCTTGAAGAAGATTT
CAATATATTGTCTGGTGAAGACGGCTTGACTTTACCAATCATGGCTTTAGGAGGAACTGGTGTAATCAGTGCATCAGCTA
ATGTTGATCCTAAGAGGATGGTTTTAATGGTTGACAGTATATTAAATGATGATTATACAAGGGCTCAGGAGCTTCATTAC
GAAATGATTGATGTAATTGACGCTCTTTTCATTGAAAGCAATCCTGTACCTGCAAAAACAGCAATGAACATAATGGGTCT
TCCTGCAGGACCTCTCAGGGCACCGTTAACAGATATGAAAGATGAAAATGTTGAAATTCTCAAAAATGCTTTAAAAGAAG
CAGATTTAATTTAA

Upstream 100 bases:

>100_bases
TCAACATTGTTGAGATTTCTTCCTCTCAAACTGCTGTGGTATTATTTGTCGATTGGAAAGATGGTGAAAAAGCACTTGAA
TTAATTAAAGAGGTTTTAAA

Downstream 100 bases:

>100_bases
GTTGGTAATATTTATGATTAAAGTAGCAGTCACCGGAGCAGCTGGAAGAATGGGCTCCGGTATTATTAGAAAAATAACAC
AGCAAGATGATATGGAAGTA

Product: dihydrodipicolinate synthase

Products: NA

Alternate protein names: DHDPS

Number of amino acids: Translated: 297; Mature: 297

Protein sequence:

>297_residues
MNFEGTYVAMVTPFTDDGNIDEEGFRSNINYLIDKGVTGLLGAGTSGESATLTHEEHRKVVEILIDEVGGRVETVAGSGS
NSTHEAIELTKSAEELGADAALVITPYYNKPQQHALIKHYQAISDATDIPIIAYNVPSRTGVDMSVETIVELAKIDGVDA
VKEASGSVNKVSKLYKALTKEGLEEDFNILSGEDGLTLPIMALGGTGVISASANVDPKRMVLMVDSILNDDYTRAQELHY
EMIDVIDALFIESNPVPAKTAMNIMGLPAGPLRAPLTDMKDENVEILKNALKEADLI

Sequences:

>Translated_297_residues
MNFEGTYVAMVTPFTDDGNIDEEGFRSNINYLIDKGVTGLLGAGTSGESATLTHEEHRKVVEILIDEVGGRVETVAGSGS
NSTHEAIELTKSAEELGADAALVITPYYNKPQQHALIKHYQAISDATDIPIIAYNVPSRTGVDMSVETIVELAKIDGVDA
VKEASGSVNKVSKLYKALTKEGLEEDFNILSGEDGLTLPIMALGGTGVISASANVDPKRMVLMVDSILNDDYTRAQELHY
EMIDVIDALFIESNPVPAKTAMNIMGLPAGPLRAPLTDMKDENVEILKNALKEADLI
>Mature_297_residues
MNFEGTYVAMVTPFTDDGNIDEEGFRSNINYLIDKGVTGLLGAGTSGESATLTHEEHRKVVEILIDEVGGRVETVAGSGS
NSTHEAIELTKSAEELGADAALVITPYYNKPQQHALIKHYQAISDATDIPIIAYNVPSRTGVDMSVETIVELAKIDGVDA
VKEASGSVNKVSKLYKALTKEGLEEDFNILSGEDGLTLPIMALGGTGVISASANVDPKRMVLMVDSILNDDYTRAQELHY
EMIDVIDALFIESNPVPAKTAMNIMGLPAGPLRAPLTDMKDENVEILKNALKEADLI

Specific function: Biosynthesis of diaminopimelate and lysine from aspartate semialdehyde; first step. [C]

COG id: COG0329

COG function: function code EM; Dihydrodipicolinate synthase/N-acetylneuraminate lyase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DHDPS family

Homologues:

Organism=Homo sapiens, GI31543060, Length=291, Percent_Identity=29.8969072164948, Blast_Score=141, Evalue=6e-34,
Organism=Homo sapiens, GI13540533, Length=302, Percent_Identity=24.5033112582781, Blast_Score=99, Evalue=4e-21,
Organism=Escherichia coli, GI1788823, Length=296, Percent_Identity=40.2027027027027, Blast_Score=232, Evalue=2e-62,
Organism=Escherichia coli, GI1786463, Length=244, Percent_Identity=31.9672131147541, Blast_Score=134, Evalue=6e-33,
Organism=Escherichia coli, GI87082415, Length=270, Percent_Identity=31.8518518518519, Blast_Score=134, Evalue=7e-33,
Organism=Escherichia coli, GI1789620, Length=289, Percent_Identity=28.3737024221453, Blast_Score=127, Evalue=7e-31,

Paralogues:

None

Copy number: 840 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): DAPA_METS3 (A5ULF8)

Other databases:

- EMBL:   CP000678
- RefSeq:   YP_001273404.1
- ProteinModelPortal:   A5ULF8
- SMR:   A5ULF8
- STRING:   A5ULF8
- GeneID:   5217260
- GenomeReviews:   CP000678_GR
- KEGG:   msi:Msm_0831
- eggNOG:   arNOG05039
- HOGENOM:   HBG358848
- OMA:   PAIITPF
- ProtClustDB:   PRK03170
- GO:   GO:0005737
- HAMAP:   MF_00418
- InterPro:   IPR013785
- InterPro:   IPR005263
- InterPro:   IPR002220
- InterPro:   IPR020625
- Gene3D:   G3DSA:3.20.20.70
- PANTHER:   PTHR12128
- PRINTS:   PR00146
- TIGRFAMs:   TIGR00674

Pfam domain/function: PF00701 DHDPS

EC number: =4.2.1.52

Molecular weight: Translated: 31879; Mature: 31879

Theoretical pI: Translated: 4.20; Mature: 4.20

Prosite motif: PS00665 DHDPS_1; PS00666 DHDPS_2

Important sites: ACT_SITE 162-162 BINDING 107-107

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNFEGTYVAMVTPFTDDGNIDEEGFRSNINYLIDKGVTGLLGAGTSGESATLTHEEHRKV
CCCCCEEEEEEEEECCCCCCCHHHHHCCCHHHHHCCCCEEEECCCCCCCCCCCHHHHHHH
VEILIDEVGGRVETVAGSGSNSTHEAIELTKSAEELGADAALVITPYYNKPQQHALIKHY
HHHHHHHHCCEEEEEECCCCCCHHHHHHHHHHHHHHCCCEEEEEECCCCCCHHHHHHHHH
QAISDATDIPIIAYNVPSRTGVDMSVETIVELAKIDGVDAVKEASGSVNKVSKLYKALTK
HHHCCCCCCCEEEEECCCCCCCCCCHHHHHHHHHCCCHHHHHHHCCCHHHHHHHHHHHHH
EGLEEDFNILSGEDGLTLPIMALGGTGVISASANVDPKRMVLMVDSILNDDYTRAQELHY
HHHHHHHCEECCCCCCEEEEEEECCCEEEEECCCCCHHHHHHHHHHHHCCCHHHHHHHHH
EMIDVIDALFIESNPVPAKTAMNIMGLPAGPLRAPLTDMKDENVEILKNALKEADLI
HHHHHHHHHHHCCCCCCHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCC
>Mature Secondary Structure
MNFEGTYVAMVTPFTDDGNIDEEGFRSNINYLIDKGVTGLLGAGTSGESATLTHEEHRKV
CCCCCEEEEEEEEECCCCCCCHHHHHCCCHHHHHCCCCEEEECCCCCCCCCCCHHHHHHH
VEILIDEVGGRVETVAGSGSNSTHEAIELTKSAEELGADAALVITPYYNKPQQHALIKHY
HHHHHHHHCCEEEEEECCCCCCHHHHHHHHHHHHHHCCCEEEEEECCCCCCHHHHHHHHH
QAISDATDIPIIAYNVPSRTGVDMSVETIVELAKIDGVDAVKEASGSVNKVSKLYKALTK
HHHCCCCCCCEEEEECCCCCCCCCCHHHHHHHHHCCCHHHHHHHCCCHHHHHHHHHHHHH
EGLEEDFNILSGEDGLTLPIMALGGTGVISASANVDPKRMVLMVDSILNDDYTRAQELHY
HHHHHHHCEECCCCCCEEEEEEECCCEEEEECCCCCHHHHHHHHHHHHCCCHHHHHHHHH
EMIDVIDALFIESNPVPAKTAMNIMGLPAGPLRAPLTDMKDENVEILKNALKEADLI
HHHHHHHHHHHCCCCCCHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA