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The map label for this gene is lysC [H]

Identifier: 148642892

GI number: 148642892

Start: 790309

End: 791529

Strand: Reverse

Name: lysC [H]

Synonym: Msm_0832

Alternate gene names: 148642892

Gene position: 791529-790309 (Counterclockwise)

Preceding gene: 148642893

Following gene: 148642891

Centisome position: 42.71

GC content: 33.91

Gene sequence:

>1221_bases
ATGGATTTAATAGTAGCGAAATTCGGAGGTACATCGGTTGGAGATGGCTCCAGAATTAGAAAAGCAGCGCAATCTGTGGT
AAATGAATATATGAAAGGTAATCAATTAGTTGTAGTTGTTTCTGCAGTTAATAATGCAACTGATGAGTTAATTGAATTGT
CTAATGAAGCTATTGGTGGAGGTTTAACTGATAAGCAAAAGGCAGAAATAATGGCTATGGGTGAATTAACTAGCTCAAGA
TTATTTGCTGCAGCTATTGAATCTTTAGGTGTAAAGGCAGAATTTATCGATCCATACAATGATAAATGGCCGGTTATAAC
TGATTCCAATTCACTCAATGCCAAAATTGATTTTGCAACAACTGATAAAAAATGCGAAGGAATAAAAAATCTTATTAGCC
AAGGTATTATCCCAGTTATTTGCGGATTTTTAGGAAAAGGTCCTAGTGGTGAAATTACGACTATTGGGAGGGGCGGCAGT
GATGTAACTGCATTTTTACTTGGGCATTGTTTAAGTGCCAATAATGTAGTTATTGTCACTGATGTTGACGGAGTAATGTC
AACTGACCCTAATAAAATAGAAGAAGCTGAATTATTAGATGAAATTTCTGTTGAAGAAATGAGGGACTTAGCTACTCATG
GAGCACAGGTTTTACATCCTCATGCTCTAAAATATAAAGATCCGCTTATAAGTGCAAAAATTATCAACTTCAATAATGGT
GATTTAAGTTCTGAAGGTACAAAAATAACTGGCCCTTTTGAAGGAGACATGTTAAAAACTGTATCTTTGTATAAAAATCC
TATTTCTGTCATTGCTATTGTTGGAGAAGAAATGCTCAAAAAAGTGGGACTTTTAGCAGATTTAACTTCATGTCTTGCAG
AAAATGAAATTAACATATTTGGCATTTCAGCAGGTCAGAATTCTATAACTGTATTTGTAGAAAAAAAGGATTCTGATAAA
GCATATCATTTATTACACAGTTGGGTAATTGATGAAGATGTTTTAAGTTCATTGTCTCTTGGTGATGATACAGCTATGAT
TACTGTAGTCAGTCCTGAGTTTATCGATGAACCTGGCATTATTTCTAATATTACAAACCCGCTTAGAAAAAACGATATCA
ACATTGTTGAGATTTCTTCCTCTCAAACTGCTGTGGTATTATTTGTCGATTGGAAAGATGGTGAAAAAGCACTTGAATTA
ATTAAAGAGGTTTTAAAATGA

Upstream 100 bases:

>100_bases
TATTTTAAAAGTTTATTAATGTGTTTATTCATATAAATAATTAGGTATTTTTGTTTAATCAAAAATCTAGTGAAATTTTT
ATGGAAATAGGTGAATATTA

Downstream 100 bases:

>100_bases
ATTTTGAAGGAACATATGTTGCAATGGTAACTCCATTTACTGATGATGGTAACATTGACGAAGAAGGATTTAGATCCAAT
ATTAATTATTTAATTGATAA

Product: aspartate kinase

Products: NA

Alternate protein names: Aspartate kinase [H]

Number of amino acids: Translated: 406; Mature: 406

Protein sequence:

>406_residues
MDLIVAKFGGTSVGDGSRIRKAAQSVVNEYMKGNQLVVVVSAVNNATDELIELSNEAIGGGLTDKQKAEIMAMGELTSSR
LFAAAIESLGVKAEFIDPYNDKWPVITDSNSLNAKIDFATTDKKCEGIKNLISQGIIPVICGFLGKGPSGEITTIGRGGS
DVTAFLLGHCLSANNVVIVTDVDGVMSTDPNKIEEAELLDEISVEEMRDLATHGAQVLHPHALKYKDPLISAKIINFNNG
DLSSEGTKITGPFEGDMLKTVSLYKNPISVIAIVGEEMLKKVGLLADLTSCLAENEINIFGISAGQNSITVFVEKKDSDK
AYHLLHSWVIDEDVLSSLSLGDDTAMITVVSPEFIDEPGIISNITNPLRKNDINIVEISSSQTAVVLFVDWKDGEKALEL
IKEVLK

Sequences:

>Translated_406_residues
MDLIVAKFGGTSVGDGSRIRKAAQSVVNEYMKGNQLVVVVSAVNNATDELIELSNEAIGGGLTDKQKAEIMAMGELTSSR
LFAAAIESLGVKAEFIDPYNDKWPVITDSNSLNAKIDFATTDKKCEGIKNLISQGIIPVICGFLGKGPSGEITTIGRGGS
DVTAFLLGHCLSANNVVIVTDVDGVMSTDPNKIEEAELLDEISVEEMRDLATHGAQVLHPHALKYKDPLISAKIINFNNG
DLSSEGTKITGPFEGDMLKTVSLYKNPISVIAIVGEEMLKKVGLLADLTSCLAENEINIFGISAGQNSITVFVEKKDSDK
AYHLLHSWVIDEDVLSSLSLGDDTAMITVVSPEFIDEPGIISNITNPLRKNDINIVEISSSQTAVVLFVDWKDGEKALEL
IKEVLK
>Mature_406_residues
MDLIVAKFGGTSVGDGSRIRKAAQSVVNEYMKGNQLVVVVSAVNNATDELIELSNEAIGGGLTDKQKAEIMAMGELTSSR
LFAAAIESLGVKAEFIDPYNDKWPVITDSNSLNAKIDFATTDKKCEGIKNLISQGIIPVICGFLGKGPSGEITTIGRGGS
DVTAFLLGHCLSANNVVIVTDVDGVMSTDPNKIEEAELLDEISVEEMRDLATHGAQVLHPHALKYKDPLISAKIINFNNG
DLSSEGTKITGPFEGDMLKTVSLYKNPISVIAIVGEEMLKKVGLLADLTSCLAENEINIFGISAGQNSITVFVEKKDSDK
AYHLLHSWVIDEDVLSSLSLGDDTAMITVVSPEFIDEPGIISNITNPLRKNDINIVEISSSQTAVVLFVDWKDGEKALEL
IKEVLK

Specific function: Catalyzes 2 nonconsecutive reactions in the common biosynthetic pathway leading from Asp to diaminopimelate and Lys, to Met, and to Thr and Ile. [C]

COG id: COG0527

COG function: function code E; Aspartokinases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 ACT domains [H]

Homologues:

Organism=Escherichia coli, GI1786183, Length=356, Percent_Identity=26.685393258427, Blast_Score=113, Evalue=2e-26,
Organism=Escherichia coli, GI1790455, Length=455, Percent_Identity=24.8351648351648, Blast_Score=94, Evalue=2e-20,
Organism=Escherichia coli, GI1790376, Length=171, Percent_Identity=29.8245614035088, Blast_Score=77, Evalue=2e-15,
Organism=Saccharomyces cerevisiae, GI6320893, Length=364, Percent_Identity=25, Blast_Score=90, Evalue=7e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR001048
- InterPro:   IPR005260
- InterPro:   IPR001341
- InterPro:   IPR018042 [H]

Pfam domain/function: PF00696 AA_kinase; PF01842 ACT [H]

EC number: =2.7.2.4 [H]

Molecular weight: Translated: 43552; Mature: 43552

Theoretical pI: Translated: 4.37; Mature: 4.37

Prosite motif: PS00324 ASPARTOKINASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDLIVAKFGGTSVGDGSRIRKAAQSVVNEYMKGNQLVVVVSAVNNATDELIELSNEAIGG
CCEEEEECCCCCCCCCHHHHHHHHHHHHHHHCCCEEEEEEEECCCHHHHHHHHHHHHCCC
GLTDKQKAEIMAMGELTSSRLFAAAIESLGVKAEFIDPYNDKWPVITDSNSLNAKIDFAT
CCCCCHHHHEEEECCHHHHHHHHHHHHHHCCEEEEECCCCCCCCEEECCCCCEEEEEEEC
TDKKCEGIKNLISQGIIPVICGFLGKGPSGEITTIGRGGSDVTAFLLGHCLSANNVVIVT
CCHHHHHHHHHHHCCCHHHHHHHHCCCCCCCEEEECCCCCHHHHHHHHHHCCCCCEEEEE
DVDGVMSTDPNKIEEAELLDEISVEEMRDLATHGAQVLHPHALKYKDPLISAKIINFNNG
ECCCCCCCCCCHHHHHHHHHHCCHHHHHHHHHCCHHHCCCCHHCCCCCCEEEEEEECCCC
DLSSEGTKITGPFEGDMLKTVSLYKNPISVIAIVGEEMLKKVGLLADLTSCLAENEINIF
CCCCCCCEEECCCCCCHHHHHHHHCCCHHEEEHHHHHHHHHHHHHHHHHHHHHCCCCEEE
GISAGQNSITVFVEKKDSDKAYHLLHSWVIDEDVLSSLSLGDDTAMITVVSPEFIDEPGI
EEECCCCEEEEEEEECCCCHHHHHHHHHHCCHHHHHHCCCCCCCEEEEEECHHHCCCCCC
ISNITNPLRKNDINIVEISSSQTAVVLFVDWKDGEKALELIKEVLK
HHHHCCHHHHCCCCEEEECCCCEEEEEEEECCCCHHHHHHHHHHHC
>Mature Secondary Structure
MDLIVAKFGGTSVGDGSRIRKAAQSVVNEYMKGNQLVVVVSAVNNATDELIELSNEAIGG
CCEEEEECCCCCCCCCHHHHHHHHHHHHHHHCCCEEEEEEEECCCHHHHHHHHHHHHCCC
GLTDKQKAEIMAMGELTSSRLFAAAIESLGVKAEFIDPYNDKWPVITDSNSLNAKIDFAT
CCCCCHHHHEEEECCHHHHHHHHHHHHHHCCEEEEECCCCCCCCEEECCCCCEEEEEEEC
TDKKCEGIKNLISQGIIPVICGFLGKGPSGEITTIGRGGSDVTAFLLGHCLSANNVVIVT
CCHHHHHHHHHHHCCCHHHHHHHHCCCCCCCEEEECCCCCHHHHHHHHHHCCCCCEEEEE
DVDGVMSTDPNKIEEAELLDEISVEEMRDLATHGAQVLHPHALKYKDPLISAKIINFNNG
ECCCCCCCCCCHHHHHHHHHHCCHHHHHHHHHCCHHHCCCCHHCCCCCCEEEEEEECCCC
DLSSEGTKITGPFEGDMLKTVSLYKNPISVIAIVGEEMLKKVGLLADLTSCLAENEINIF
CCCCCCCEEECCCCCCHHHHHHHHCCCHHEEEHHHHHHHHHHHHHHHHHHHHHCCCCEEE
GISAGQNSITVFVEKKDSDKAYHLLHSWVIDEDVLSSLSLGDDTAMITVVSPEFIDEPGI
EEECCCCEEEEEEEECCCCHHHHHHHHHHCCHHHHHHCCCCCCCEEEEEECHHHCCCCCC
ISNITNPLRKNDINIVEISSSQTAVVLFVDWKDGEKALELIKEVLK
HHHHCCHHHHCCCCEEEECCCCEEEEEEEECCCCHHHHHHHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9923682 [H]