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The map label for this gene is secY [H]

Identifier: 148642798

GI number: 148642798

Start: 709261

End: 710625

Strand: Reverse

Name: secY [H]

Synonym: Msm_0738

Alternate gene names: 148642798

Gene position: 710625-709261 (Counterclockwise)

Preceding gene: 148642799

Following gene: 148642797

Centisome position: 38.35

GC content: 33.99

Gene sequence:

>1365_bases
ATGTCATCATTAAAAGTTTTAGAGCCATTATTTAGGTTTTTACCAGAAGTAAAATCTCCTGTTCATCATGAAGATTTTAA
TGAAAAACTTAAATGGACTGCTCTTATTTTGGTATTATACTTTATATTAACTGAAATACCATTATATGGTTTGAGTTCTG
CAGCAGTGGACCAGTTTGCTCAGTTAAGAGCAGTTATGGCGGGAAGTTTCGGTTCAATTTTAACATTAGGAATTGGACCT
ATTGTAACTGCTTCAATTGTATTGCAATTATTAGTTGGTTCCAAGTTGTTAGATTTGGATTTGTCTTCTCCTGAGGATAA
GTCACAGTATCAGGCCACACAAAAAATATTATCCATCGTCTTCACAATGTTTGAAGCTGGTGTATTGGTATTGACAGGTA
GTTTAGTACCAATTGATAATTCATATCTTGGTGTATTATTCCTTCAACTTGTTATTGGAGCAATATTGATAATTTATCTT
GATGAAGTTATATCCAAATGGGGATTTGGTAGTGGTATTGGTTTATTTATTGCAGCTGGTGTTTGTGAAGCCATTATTGT
AGGTACATTCAGTTTCATACCTGGACCTGGCGGTGTTTATGGTGGAGCAATTCCTGCATTTATCCAATCCTTCTGGTCAA
GTTCTATTGACTTTTCAGTATTAATTCCATTAATTGCAACAGCAGCTGTATTCTTTGTTGTTGTATATGGTGAATCTATG
AGAGTGGAAATTCCTATTTCTCATGGTTCAGTAAGGGGACATGGAAGAATTAGAGGTTCTGTTGGTAAATATCCATTAAA
ATTTGTATATGCAAGTAACATGCCTGTTATTTTAACCAGTGCATTGCTTGTAAACGTTTCACTTCTTGCAAGTGTCTTCC
AAAAAATTGGTTTCCCAATTTTGGGTGAAATTGTTAACGGTAAGGCTGTAAGCGGTATTGCATTATATTTATCTACACCG
AATGATGTTAGTTTATTGGTAACTGATCCTGTTCGTGTAATTGTCTATGCATTTTTCTTCTTACTTTGTGCAGTTTTATT
CTCATATCTTTGGGTTGAAATTAGTGGATTAAATGCTAAGAAAATTTCAGAACAACTTTACAAGTCTGGTATTCAGATAC
CAGGTTTCAGAAGCAGTAAACGTCAATTATATAAAATATTGAAAAAATACATTCCGGCACTTACCATTATAAGTGGTCTT
TATGTTGGTATAATTGCATTTTGTGCAGACTTAACTGGAGCATTAGGTGGAGGTACTGGTGTATTGCTTACTGTTGGTAT
TATACATAAAATATATGAGGAAATGGCTGAAGAACAACTCATGTCAGCAAATCCAGTACTTAGGAAATTTTTAGGAGGAG
AATAA

Upstream 100 bases:

>100_bases
CAATTTTCTGCTTCAGCTATTGAAAAAATTGAAGAAATGGGAGGAGAAGCTATCGAATTATAGTTTCTTTTTTTCTTTTC
TTTTTTATTAGAGGAATAAA

Downstream 100 bases:

>100_bases
TTATTCTTCTTCATTAATCTTTTTAAAATGGGGGATTAAATTGAAATTGGTAGTATTAACAGGTATTCCAGGTTCTGGAA
GTACCACTTTGCTTAATAAA

Product: preprotein translocase subunit SecY

Products: NA

Alternate protein names: Protein transport protein SEC61 subunit alpha homolog [H]

Number of amino acids: Translated: 454; Mature: 453

Protein sequence:

>454_residues
MSSLKVLEPLFRFLPEVKSPVHHEDFNEKLKWTALILVLYFILTEIPLYGLSSAAVDQFAQLRAVMAGSFGSILTLGIGP
IVTASIVLQLLVGSKLLDLDLSSPEDKSQYQATQKILSIVFTMFEAGVLVLTGSLVPIDNSYLGVLFLQLVIGAILIIYL
DEVISKWGFGSGIGLFIAAGVCEAIIVGTFSFIPGPGGVYGGAIPAFIQSFWSSSIDFSVLIPLIATAAVFFVVVYGESM
RVEIPISHGSVRGHGRIRGSVGKYPLKFVYASNMPVILTSALLVNVSLLASVFQKIGFPILGEIVNGKAVSGIALYLSTP
NDVSLLVTDPVRVIVYAFFFLLCAVLFSYLWVEISGLNAKKISEQLYKSGIQIPGFRSSKRQLYKILKKYIPALTIISGL
YVGIIAFCADLTGALGGGTGVLLTVGIIHKIYEEMAEEQLMSANPVLRKFLGGE

Sequences:

>Translated_454_residues
MSSLKVLEPLFRFLPEVKSPVHHEDFNEKLKWTALILVLYFILTEIPLYGLSSAAVDQFAQLRAVMAGSFGSILTLGIGP
IVTASIVLQLLVGSKLLDLDLSSPEDKSQYQATQKILSIVFTMFEAGVLVLTGSLVPIDNSYLGVLFLQLVIGAILIIYL
DEVISKWGFGSGIGLFIAAGVCEAIIVGTFSFIPGPGGVYGGAIPAFIQSFWSSSIDFSVLIPLIATAAVFFVVVYGESM
RVEIPISHGSVRGHGRIRGSVGKYPLKFVYASNMPVILTSALLVNVSLLASVFQKIGFPILGEIVNGKAVSGIALYLSTP
NDVSLLVTDPVRVIVYAFFFLLCAVLFSYLWVEISGLNAKKISEQLYKSGIQIPGFRSSKRQLYKILKKYIPALTIISGL
YVGIIAFCADLTGALGGGTGVLLTVGIIHKIYEEMAEEQLMSANPVLRKFLGGE
>Mature_453_residues
SSLKVLEPLFRFLPEVKSPVHHEDFNEKLKWTALILVLYFILTEIPLYGLSSAAVDQFAQLRAVMAGSFGSILTLGIGPI
VTASIVLQLLVGSKLLDLDLSSPEDKSQYQATQKILSIVFTMFEAGVLVLTGSLVPIDNSYLGVLFLQLVIGAILIIYLD
EVISKWGFGSGIGLFIAAGVCEAIIVGTFSFIPGPGGVYGGAIPAFIQSFWSSSIDFSVLIPLIATAAVFFVVVYGESMR
VEIPISHGSVRGHGRIRGSVGKYPLKFVYASNMPVILTSALLVNVSLLASVFQKIGFPILGEIVNGKAVSGIALYLSTPN
DVSLLVTDPVRVIVYAFFFLLCAVLFSYLWVEISGLNAKKISEQLYKSGIQIPGFRSSKRQLYKILKKYIPALTIISGLY
VGIIAFCADLTGALGGGTGVLLTVGIIHKIYEEMAEEQLMSANPVLRKFLGGE

Specific function: Involved in protein export. Interacts with secE to allow the translocation of proteins across the plasma membrane, by forming part of a channel [H]

COG id: COG0201

COG function: function code U; Preprotein translocase subunit SecY

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the secY/SEC61-alpha family [H]

Homologues:

Organism=Homo sapiens, GI14589847, Length=473, Percent_Identity=34.2494714587738, Blast_Score=240, Evalue=2e-63,
Organism=Homo sapiens, GI7019415, Length=473, Percent_Identity=33.4038054968288, Blast_Score=236, Evalue=3e-62,
Organism=Homo sapiens, GI217330618, Length=471, Percent_Identity=32.9087048832272, Blast_Score=211, Evalue=2e-54,
Organism=Homo sapiens, GI217330616, Length=413, Percent_Identity=33.6561743341404, Blast_Score=202, Evalue=5e-52,
Organism=Caenorhabditis elegans, GI17543770, Length=466, Percent_Identity=33.4763948497854, Blast_Score=238, Evalue=4e-63,
Organism=Saccharomyces cerevisiae, GI6323411, Length=486, Percent_Identity=34.156378600823, Blast_Score=242, Evalue=8e-65,
Organism=Saccharomyces cerevisiae, GI6319760, Length=467, Percent_Identity=23.7687366167024, Blast_Score=102, Evalue=1e-22,
Organism=Drosophila melanogaster, GI19920826, Length=473, Percent_Identity=33.615221987315, Blast_Score=238, Evalue=5e-63,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002208
- InterPro:   IPR023201
- InterPro:   IPR019561 [H]

Pfam domain/function: PF10559 Plug_translocon; PF00344 SecY [H]

EC number: NA

Molecular weight: Translated: 48921; Mature: 48789

Theoretical pI: Translated: 8.03; Mature: 8.03

Prosite motif: PS00687 ALDEHYDE_DEHYDR_GLU ; PS00755 SECY_1 ; PS00756 SECY_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSSLKVLEPLFRFLPEVKSPVHHEDFNEKLKWTALILVLYFILTEIPLYGLSSAAVDQFA
CCCHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHH
QLRAVMAGSFGSILTLGIGPIVTASIVLQLLVGSKLLDLDLSSPEDKSQYQATQKILSIV
HHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCEEECCCCCCCCHHHHHHHHHHHHHH
FTMFEAGVLVLTGSLVPIDNSYLGVLFLQLVIGAILIIYLDEVISKWGFGSGIGLFIAAG
HHHHHCCHHEEECCEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHH
VCEAIIVGTFSFIPGPGGVYGGAIPAFIQSFWSSSIDFSVLIPLIATAAVFFVVVYGESM
HHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCCE
RVEIPISHGSVRGHGRIRGSVGKYPLKFVYASNMPVILTSALLVNVSLLASVFQKIGFPI
EEEEEECCCCCCCCCCEECCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHCCCCH
LGEIVNGKAVSGIALYLSTPNDVSLLVTDPVRVIVYAFFFLLCAVLFSYLWVEISGLNAK
HHHHHCCCEECCEEEEEECCCCCEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHH
KISEQLYKSGIQIPGFRSSKRQLYKILKKYIPALTIISGLYVGIIAFCADLTGALGGGTG
HHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCH
VLLTVGIIHKIYEEMAEEQLMSANPVLRKFLGGE
HHHHHHHHHHHHHHHHHHHHHCCCHHHHHHCCCC
>Mature Secondary Structure 
SSLKVLEPLFRFLPEVKSPVHHEDFNEKLKWTALILVLYFILTEIPLYGLSSAAVDQFA
CCHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHH
QLRAVMAGSFGSILTLGIGPIVTASIVLQLLVGSKLLDLDLSSPEDKSQYQATQKILSIV
HHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCEEECCCCCCCCHHHHHHHHHHHHHH
FTMFEAGVLVLTGSLVPIDNSYLGVLFLQLVIGAILIIYLDEVISKWGFGSGIGLFIAAG
HHHHHCCHHEEECCEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHH
VCEAIIVGTFSFIPGPGGVYGGAIPAFIQSFWSSSIDFSVLIPLIATAAVFFVVVYGESM
HHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCCE
RVEIPISHGSVRGHGRIRGSVGKYPLKFVYASNMPVILTSALLVNVSLLASVFQKIGFPI
EEEEEECCCCCCCCCCEECCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHCCCCH
LGEIVNGKAVSGIALYLSTPNDVSLLVTDPVRVIVYAFFFLLCAVLFSYLWVEISGLNAK
HHHHHCCCEECCEEEEEECCCCCEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHH
KISEQLYKSGIQIPGFRSSKRQLYKILKKYIPALTIISGLYVGIIAFCADLTGALGGGTG
HHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCH
VLLTVGIIHKIYEEMAEEQLMSANPVLRKFLGGE
HHHHHHHHHHHHHHHHHHHHHCCCHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9371463 [H]