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The map label for this gene is xapA [C]

Identifier: 148642725

GI number: 148642725

Start: 643899

End: 644657

Strand: Reverse

Name: xapA [C]

Synonym: Msm_0665

Alternate gene names: 148642725

Gene position: 644657-643899 (Counterclockwise)

Preceding gene: 148642726

Following gene: 148642724

Centisome position: 34.79

GC content: 37.15

Gene sequence:

>759_bases
ATGATTGGAATTATTGGCGGCAGCGGAGTTTATGAAATAACTCAGAAGGCAGACAGTGTTGAAAAAAAGTTAGTCAAAAC
AGACTATGGGGAAGTTGAAGTTTCTATTTTGGATATATTCAATAAAACAGTAGCTTTTATTCCAAGACATGCTGCAGGAC
ACAGTATCCCTCCACATAAAATCAATTTCAGAGCTAATATTGATGCACTTAGGAATGTAGGTGTTACACAGATAATAGCT
ACCAATTCTGTTGGGTCTATGAATCTGGAAATGCCTCCTGGATCATTTGTCATTCCCGATGACTTTTTAGATTTTACAGA
AAACAGGGATAAGACATACTTTGAAGACCATGTTGTTCATGTAGATGTAACTGAACCTTATTGCAGTCGTCTAAGGGATA
TAATGGCTGACTGTGGGGAAGTTATTACTGGCGGAACATATGTGTGTACACAGGGACCCAGATTTGAAACACCTGCTGAA
ATCAAAATGTTCAAACTTCTTGGAGGGGATTTGGTAGGTATGACTGGAGTTCCTGAAGTAACATTGGCTCGTGAAAGGGC
AATTTGTTACAATTCCATTTGTATAGTTTCAAATTATGCATCAGGCATTTCTGAAGATAACTTGACCATTGATGAAGTAT
TTGAAATGGTTAAGGCTAAAGAATCAGATTTGCTTGAATTGATTTATGAAATCATCAGGAATTTAGACGACGATTTTGAT
TGTCCTTGTCGCCATGCTTTAAATGGTGCTGAAGTTTAA

Upstream 100 bases:

>100_bases
CAAAGATGTGGACAGTGTAGTTAAAATATCTGACAGTACAGGAATAGCTAAACTTGTTGCAAAAGTAAAACCGTTAGCTG
TTACAAAAGGATAAGATAAG

Downstream 100 bases:

>100_bases
ATTCTTTTTTCAAAAAGATTTATTATTTATTTAACAAAATTTTATTTAGGTTGATGTTATGGCAAAAGTTATATTATTAA
ATTCCAGTCCTCGAGCTAAC

Product: 5'-methylthioadenosine phosphorylase

Products: ribose-1-phosphate; xanthine [C]

Alternate protein names: NA

Number of amino acids: Translated: 252; Mature: 252

Protein sequence:

>252_residues
MIGIIGGSGVYEITQKADSVEKKLVKTDYGEVEVSILDIFNKTVAFIPRHAAGHSIPPHKINFRANIDALRNVGVTQIIA
TNSVGSMNLEMPPGSFVIPDDFLDFTENRDKTYFEDHVVHVDVTEPYCSRLRDIMADCGEVITGGTYVCTQGPRFETPAE
IKMFKLLGGDLVGMTGVPEVTLARERAICYNSICIVSNYASGISEDNLTIDEVFEMVKAKESDLLELIYEIIRNLDDDFD
CPCRHALNGAEV

Sequences:

>Translated_252_residues
MIGIIGGSGVYEITQKADSVEKKLVKTDYGEVEVSILDIFNKTVAFIPRHAAGHSIPPHKINFRANIDALRNVGVTQIIA
TNSVGSMNLEMPPGSFVIPDDFLDFTENRDKTYFEDHVVHVDVTEPYCSRLRDIMADCGEVITGGTYVCTQGPRFETPAE
IKMFKLLGGDLVGMTGVPEVTLARERAICYNSICIVSNYASGISEDNLTIDEVFEMVKAKESDLLELIYEIIRNLDDDFD
CPCRHALNGAEV
>Mature_252_residues
MIGIIGGSGVYEITQKADSVEKKLVKTDYGEVEVSILDIFNKTVAFIPRHAAGHSIPPHKINFRANIDALRNVGVTQIIA
TNSVGSMNLEMPPGSFVIPDDFLDFTENRDKTYFEDHVVHVDVTEPYCSRLRDIMADCGEVITGGTYVCTQGPRFETPAE
IKMFKLLGGDLVGMTGVPEVTLARERAICYNSICIVSNYASGISEDNLTIDEVFEMVKAKESDLLELIYEIIRNLDDDFD
CPCRHALNGAEV

Specific function: The Nucleoside Phosphorylases Catalyze The Phosphorolytic Breakdown Of The N-Glycosidic Bond In The Nucleoside Molecule, With The Formation Of The Corresponding Free Bases And Pentose-1-Phosphate. This Protein Can Degrade All Purine Nucleosides Except Ade

COG id: COG0005

COG function: function code F; Purine nucleoside phosphorylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PNP/MTAP phosphorylase family [H]

Homologues:

Organism=Homo sapiens, GI47132622, Length=245, Percent_Identity=33.0612244897959, Blast_Score=142, Evalue=3e-34,
Organism=Escherichia coli, GI1788746, Length=178, Percent_Identity=28.0898876404494, Blast_Score=75, Evalue=6e-15,
Organism=Caenorhabditis elegans, GI71980569, Length=244, Percent_Identity=33.1967213114754, Blast_Score=122, Evalue=1e-28,
Organism=Saccharomyces cerevisiae, GI6323045, Length=221, Percent_Identity=32.1266968325792, Blast_Score=119, Evalue=5e-28,
Organism=Saccharomyces cerevisiae, GI6323238, Length=195, Percent_Identity=29.2307692307692, Blast_Score=62, Evalue=8e-11,
Organism=Drosophila melanogaster, GI20130079, Length=211, Percent_Identity=35.0710900473934, Blast_Score=134, Evalue=4e-32,
Organism=Drosophila melanogaster, GI221459247, Length=248, Percent_Identity=32.258064516129, Blast_Score=130, Evalue=6e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010044
- InterPro:   IPR000845
- InterPro:   IPR001369
- InterPro:   IPR018099 [H]

Pfam domain/function: PF01048 PNP_UDP_1 [H]

EC number: 2.4.2.- [C]

Molecular weight: Translated: 27845; Mature: 27845

Theoretical pI: Translated: 4.38; Mature: 4.38

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.8 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
5.6 %Cys+Met (Translated Protein)
2.8 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
5.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIGIIGGSGVYEITQKADSVEKKLVKTDYGEVEVSILDIFNKTVAFIPRHAAGHSIPPHK
CEEEECCCCHHHHHHHHHHHHHHHHHCCCCCEEEHHHHHHHHHHHHCCCCCCCCCCCCCE
INFRANIDALRNVGVTQIIATNSVGSMNLEMPPGSFVIPDDFLDFTENRDKTYFEDHVVH
EEEEECHHHHHCCCEEEEEEECCCCCEEEECCCCCEECCHHHHHHHCCCCCCEEECEEEE
VDVTEPYCSRLRDIMADCGEVITGGTYVCTQGPRFETPAEIKMFKLLGGDLVGMTGVPEV
EECCCHHHHHHHHHHHHHHHHHCCCEEEECCCCCCCCCHHHHHHHHHCCCEECCCCCCCH
TLARERAICYNSICIVSNYASGISEDNLTIDEVFEMVKAKESDLLELIYEIIRNLDDDFD
HHHHHHHHHHHCEEEEEHHHCCCCCCCCCHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCC
CPCRHALNGAEV
CCHHHCCCCCCC
>Mature Secondary Structure
MIGIIGGSGVYEITQKADSVEKKLVKTDYGEVEVSILDIFNKTVAFIPRHAAGHSIPPHK
CEEEECCCCHHHHHHHHHHHHHHHHHCCCCCEEEHHHHHHHHHHHHCCCCCCCCCCCCCE
INFRANIDALRNVGVTQIIATNSVGSMNLEMPPGSFVIPDDFLDFTENRDKTYFEDHVVH
EEEEECHHHHHCCCEEEEEEECCCCCEEEECCCCCEECCHHHHHHHCCCCCCEEECEEEE
VDVTEPYCSRLRDIMADCGEVITGGTYVCTQGPRFETPAEIKMFKLLGGDLVGMTGVPEV
EECCCHHHHHHHHHHHHHHHHHCCCEEEECCCCCCCCCHHHHHHHHHCCCEECCCCCCCH
TLARERAICYNSICIVSNYASGISEDNLTIDEVFEMVKAKESDLLELIYEIIRNLDDDFD
HHHHHHHHHHHCEEEEEHHHCCCCCCCCCHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCC
CPCRHALNGAEV
CCHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: xanthosine; phosphate [C]

Specific reaction: xanthosine + phosphate = ribose-1-phosphate + xanthine [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]