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The map label for this gene is 148642616

Identifier: 148642616

GI number: 148642616

Start: 534388

End: 535992

Strand: Reverse

Name: 148642616

Synonym: Msm_0556

Alternate gene names: NA

Gene position: 535992-534388 (Counterclockwise)

Preceding gene: 148642624

Following gene: 148642615

Centisome position: 28.92

GC content: 32.34

Gene sequence:

>1605_bases
ATGAAAGTTTTAATTATTACTGGAAATTTGGCATATCCTTTAATTAAAAATGTTGTAGCTAATGCTAATGTTGAGGTTAT
CATTCATATAGCTGATAATACGCAGGTGGCTGCATTTTTAACTCCTAGAATTATTATTGATGAAATAAAAACTCATTTTG
CTAATCAATTAGGGGAAATTGACATGATTTTAGTTCCTGGTTTAATAAAAAAAGGAACCAGAGAAATAACAAAAGAATTG
GGAATTCCTACTTTTAAAGGTTCAACTGATGGGGCTGATTTGGCCATGGTCTTAAATTTAATTGATCAGATTGAATTGTC
TGAGGACAAACCTGCAGATAAACTGATTGAAGAAGAGAAAAGAAAAGAAGCTTTAAAATTCATTAATGATTTTGAAAATG
ATGAAGAAACAATCAAAAACTTATTAAAAAAACCTAATAACATCATGATTGGGAATCTTCCGGTAGGTGAAGATTTTCCA
ATGCGGGTGCTGTCTGAAATAGCTAATGCTCCATTTTTGTCAAAAGAAGCTTTAATTCATAAATGCCAATATTTTGTGGA
TTCTGGAGCTGATATGATTGATATAGGTATGGCTGCAGGTGAAGATTTTTCAGATAAGGTTCCTGAATTAATTGATACCT
TAAGGCCAATTGTTGGAGATAGGCCGTTAAGTATTGACACATTAAATGCAAAGGAAATAGAAGTAGCCGCAAAACATGGT
ATTGATTTAGTATTAAGTTTGGATTTGGGAAATAATTCCAAAGTACTTGATGTTTTAAAGGAAACCAATACTCCTGCTGT
TTTGCTTCCAACTAATTTTTCAGAAGGTTTCACTCCAAAAACTCCTGAAGAGAGAGTAAATGCAATGAACCAGCTAATTG
AAGATACAAAAGGTATTGATTATGTTGCAGATTTAATTTTGGATCCTGTAAACAGCAGCAGTATTGTTGAATCAATTATG
GCCTGCTTTGAATTTCATAAAACAAATAAGGCACCAATGTTTTTTGGAGTTGGAAATGTTACTGAACTGATGGATGCCGA
TTCGGGAGGAGTTAATGTTCTTCTTGCAGGAATAGGTATGGAATTGGGCGTAAGCATATTATTCACTCCAGAAGAAAGTG
GAAAAACAAGGGGCAGTGTTTATGAATTATCAACAGCATCTAAAATGATGTTTTTGGCTAAACATAGACAATCTATTCCA
AAAGACCTGGGAATTAACCTTGTTGAATTTAAAGATAAGCATAAAAGATTGGATATAATTGAAAATGAAACTGATGGGGT
TCCTGAAGTTAAACAGGCAAAACCTATGAAATTTGTAAGAGATAAAGCAGGGAGTTTCAAAATCAGTGTTGATTATGGAA
CTACTGTTAAATCCAGCAGGATTATAGCTACACATTTTAAAAAGAACAAAGCTGATCTGGTAATTGTTGGAAATACTGCA
AAAGAAATTTATGAAGAAATAATAAATAAAAAACTTGTAACAAGAATGGAACATGCAGCATATTTGGGCAGTGAGCTTCA
AAAAGCACAAATAGCTATGATTACTGGAAAAGAATATGTTCAGGACTTTGATTTATTTAAAAATCCGGATGAATTTAAAA
TTTAA

Upstream 100 bases:

>100_bases
ATTAATATTGTTAAGTGGAGTATATTTCTTTGTTTTGTAGTTACTTATAATAATTAAATAGTCATATAACTATTAATATT
ATGAATAAGTGGGGGAGTTT

Downstream 100 bases:

>100_bases
TTCTATTTTCAAAACTTTTAAATAAATGCATCATTAATACTTGTAATTATATAATAATAAAGAAGGTTTGATTGTGCAAA
TTGACGATTTATCTGTTAAA

Product: dihydropteroate synthase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 534; Mature: 534

Protein sequence:

>534_residues
MKVLIITGNLAYPLIKNVVANANVEVIIHIADNTQVAAFLTPRIIIDEIKTHFANQLGEIDMILVPGLIKKGTREITKEL
GIPTFKGSTDGADLAMVLNLIDQIELSEDKPADKLIEEEKRKEALKFINDFENDEETIKNLLKKPNNIMIGNLPVGEDFP
MRVLSEIANAPFLSKEALIHKCQYFVDSGADMIDIGMAAGEDFSDKVPELIDTLRPIVGDRPLSIDTLNAKEIEVAAKHG
IDLVLSLDLGNNSKVLDVLKETNTPAVLLPTNFSEGFTPKTPEERVNAMNQLIEDTKGIDYVADLILDPVNSSSIVESIM
ACFEFHKTNKAPMFFGVGNVTELMDADSGGVNVLLAGIGMELGVSILFTPEESGKTRGSVYELSTASKMMFLAKHRQSIP
KDLGINLVEFKDKHKRLDIIENETDGVPEVKQAKPMKFVRDKAGSFKISVDYGTTVKSSRIIATHFKKNKADLVIVGNTA
KEIYEEIINKKLVTRMEHAAYLGSELQKAQIAMITGKEYVQDFDLFKNPDEFKI

Sequences:

>Translated_534_residues
MKVLIITGNLAYPLIKNVVANANVEVIIHIADNTQVAAFLTPRIIIDEIKTHFANQLGEIDMILVPGLIKKGTREITKEL
GIPTFKGSTDGADLAMVLNLIDQIELSEDKPADKLIEEEKRKEALKFINDFENDEETIKNLLKKPNNIMIGNLPVGEDFP
MRVLSEIANAPFLSKEALIHKCQYFVDSGADMIDIGMAAGEDFSDKVPELIDTLRPIVGDRPLSIDTLNAKEIEVAAKHG
IDLVLSLDLGNNSKVLDVLKETNTPAVLLPTNFSEGFTPKTPEERVNAMNQLIEDTKGIDYVADLILDPVNSSSIVESIM
ACFEFHKTNKAPMFFGVGNVTELMDADSGGVNVLLAGIGMELGVSILFTPEESGKTRGSVYELSTASKMMFLAKHRQSIP
KDLGINLVEFKDKHKRLDIIENETDGVPEVKQAKPMKFVRDKAGSFKISVDYGTTVKSSRIIATHFKKNKADLVIVGNTA
KEIYEEIINKKLVTRMEHAAYLGSELQKAQIAMITGKEYVQDFDLFKNPDEFKI
>Mature_534_residues
MKVLIITGNLAYPLIKNVVANANVEVIIHIADNTQVAAFLTPRIIIDEIKTHFANQLGEIDMILVPGLIKKGTREITKEL
GIPTFKGSTDGADLAMVLNLIDQIELSEDKPADKLIEEEKRKEALKFINDFENDEETIKNLLKKPNNIMIGNLPVGEDFP
MRVLSEIANAPFLSKEALIHKCQYFVDSGADMIDIGMAAGEDFSDKVPELIDTLRPIVGDRPLSIDTLNAKEIEVAAKHG
IDLVLSLDLGNNSKVLDVLKETNTPAVLLPTNFSEGFTPKTPEERVNAMNQLIEDTKGIDYVADLILDPVNSSSIVESIM
ACFEFHKTNKAPMFFGVGNVTELMDADSGGVNVLLAGIGMELGVSILFTPEESGKTRGSVYELSTASKMMFLAKHRQSIP
KDLGINLVEFKDKHKRLDIIENETDGVPEVKQAKPMKFVRDKAGSFKISVDYGTTVKSSRIIATHFKKNKADLVIVGNTA
KEIYEEIINKKLVTRMEHAAYLGSELQKAQIAMITGKEYVQDFDLFKNPDEFKI

Specific function: Unknown. Does not possess dihydropteroate synthase (DHPS) activity since it does not catalyze the condensation of 6- hydroxymethyl-7,8-dihydropterin pyrophosphate (DHPP) and 4- aminobenzoate to form 7,8-dihydropteroate [H]

COG id: COG0294

COG function: function code H; Dihydropteroate synthase and related enzymes

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 pterin-binding domain [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005236
- InterPro:   IPR011005
- InterPro:   IPR000489 [H]

Pfam domain/function: PF00809 Pterin_bind [H]

EC number: NA

Molecular weight: Translated: 59034; Mature: 59034

Theoretical pI: Translated: 4.82; Mature: 4.82

Prosite motif: PS50972 PTERIN_BINDING

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKVLIITGNLAYPLIKNVVANANVEVIIHIADNTQVAAFLTPRIIIDEIKTHFANQLGEI
CEEEEEECCCHHHHHHHHHCCCCEEEEEEECCCCEEEEECCCHHHHHHHHHHHHHHHCCE
DMILVPGLIKKGTREITKELGIPTFKGSTDGADLAMVLNLIDQIELSEDKPADKLIEEEK
EEEEECHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHH
RKEALKFINDFENDEETIKNLLKKPNNIMIGNLPVGEDFPMRVLSEIANAPFLSKEALIH
HHHHHHHHHHCCCCHHHHHHHHCCCCCEEEECCCCCCCCHHHHHHHHHCCCCCHHHHHHH
KCQYFVDSGADMIDIGMAAGEDFSDKVPELIDTLRPIVGDRPLSIDTLNAKEIEVAAKHG
HHHHHHHCCCCEEEECCCCCCCHHHHHHHHHHHHHHHHCCCCCEEECCCCHHHHHHHHCC
IDLVLSLDLGNNSKVLDVLKETNTPAVLLPTNFSEGFTPKTPEERVNAMNQLIEDTKGID
CEEEEEEECCCCCHHHHHHHCCCCCEEEEECCCCCCCCCCCHHHHHHHHHHHHHHCCCHH
YVADLILDPVNSSSIVESIMACFEFHKTNKAPMFFGVGNVTELMDADSGGVNVLLAGIGM
HHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCCEEEECCCHHHHHCCCCCCCEEEEEECCH
ELGVSILFTPEESGKTRGSVYELSTASKMMFLAKHRQSIPKDLGINLVEFKDKHKRLDII
HHCEEEEECCCCCCCCCCCEEEEHHHHHHHHHHHHHHCCCHHHCCEEEEECCCCCCCCEE
ENETDGVPEVKQAKPMKFVRDKAGSFKISVDYGTTVKSSRIIATHFKKNKADLVIVGNTA
CCCCCCCCCHHHCCCHHHHHHCCCCEEEEEECCCCCCCCCEEEEECCCCCCCEEEECCCH
KEIYEEIINKKLVTRMEHAAYLGSELQKAQIAMITGKEYVQDFDLFKNPDEFKI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEECHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure
MKVLIITGNLAYPLIKNVVANANVEVIIHIADNTQVAAFLTPRIIIDEIKTHFANQLGEI
CEEEEEECCCHHHHHHHHHCCCCEEEEEEECCCCEEEEECCCHHHHHHHHHHHHHHHCCE
DMILVPGLIKKGTREITKELGIPTFKGSTDGADLAMVLNLIDQIELSEDKPADKLIEEEK
EEEEECHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHH
RKEALKFINDFENDEETIKNLLKKPNNIMIGNLPVGEDFPMRVLSEIANAPFLSKEALIH
HHHHHHHHHHCCCCHHHHHHHHCCCCCEEEECCCCCCCCHHHHHHHHHCCCCCHHHHHHH
KCQYFVDSGADMIDIGMAAGEDFSDKVPELIDTLRPIVGDRPLSIDTLNAKEIEVAAKHG
HHHHHHHCCCCEEEECCCCCCCHHHHHHHHHHHHHHHHCCCCCEEECCCCHHHHHHHHCC
IDLVLSLDLGNNSKVLDVLKETNTPAVLLPTNFSEGFTPKTPEERVNAMNQLIEDTKGID
CEEEEEEECCCCCHHHHHHHCCCCCEEEEECCCCCCCCCCCHHHHHHHHHHHHHHCCCHH
YVADLILDPVNSSSIVESIMACFEFHKTNKAPMFFGVGNVTELMDADSGGVNVLLAGIGM
HHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCCEEEECCCHHHHHCCCCCCCEEEEEECCH
ELGVSILFTPEESGKTRGSVYELSTASKMMFLAKHRQSIPKDLGINLVEFKDKHKRLDII
HHCEEEEECCCCCCCCCCCEEEEHHHHHHHHHHHHHHCCCHHHCCEEEEECCCCCCCCEE
ENETDGVPEVKQAKPMKFVRDKAGSFKISVDYGTTVKSSRIIATHFKKNKADLVIVGNTA
CCCCCCCCCHHHCCCHHHHHHCCCCEEEEEECCCCCCCCCEEEEECCCCCCCEEEECCCH
KEIYEEIINKKLVTRMEHAAYLGSELQKAQIAMITGKEYVQDFDLFKNPDEFKI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEECHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]