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The map label for this gene is pepQ [H]

Identifier: 148642532

GI number: 148642532

Start: 448724

End: 449767

Strand: Reverse

Name: pepQ [H]

Synonym: Msm_0472

Alternate gene names: 148642532

Gene position: 449767-448724 (Counterclockwise)

Preceding gene: 148642543

Following gene: 148642531

Centisome position: 24.27

GC content: 30.27

Gene sequence:

>1044_bases
ATGAAAGGTGTAAAAATGGAAATAAATGAATTTCATATTAACAATATTTTAAAAGACATGGAAAAAAAGGAGTATCAGGG
TTATTTGCTTGCACAATTTACAAATATTCACTATATTTCAAATTACAGACCTACTAGTTTTGCTTTTTGTGTTATAAAAG
AAGATCCAATTATTTATGCATCAAAAATGGATATGGAGATAGCTAATAAAACATCAACAATTGAAGTTAAAGAATTTACT
TCATTTTCAGACATGCTTGGAGAGCTTAAAAAGGAAGGAATTTCCAATTTGGCTATTGAACCGAGTTTGGTTTACAGTAC
ATATGAAAAATTCAAAGATTCTTTCAATATAAAATCTGAAACATTTATTGATGCTCAAAGACAAATTAAAACAGCTGATG
AAATAGATAAAATCCAAAAAGCAACACAGATTGCTCAAAAAGCATTTGTTGATTTGGATATTTTAAACAATACAAATCCT
GAAAATATTGTTGCTCTGGAATTGGACAACTTAATGAGAAAATATGGTGCGAATGGCAGTTCTTTTGATACTATTGTAAC
AAGCGGTTCAAATTCAAGTCTGCCTCATGCAACACCTCAGGATAAACAGTTGGAAAAACCAATATTGATTGACTGGGGAG
CAAAATATCATGGGTACTGTTCAGATAATACAAGAACTATTGTGTATACAGAAAAACAAAATGAAATTTGTGATATTGTA
GCAGAAGCTCATGATAAGGCTATAAAAGCAATTAAACCAGGTCTTAAATGCTGTGAAATTGATAAGGTGGCTCGTGATAT
TATAAGTGAATATGGTTATGGTGATAATTACATTCACTCAACAGGCCATAGTGTAGGTTTGGATATTCATGAAATACCTA
CATTTTCAACTAAGGACAAAACAGTAATTGAGAAGGGCATGGTTATTACAGTTGAACCAGGAATTTATCTGGAAGATAAT
TTTGGTGTCAGACTTGAAGATACAATAGCTATTGAAAAAAATAAAGGAAGAATAATTGGTGATTTACCTTTAATTATTGA
ATAA

Upstream 100 bases:

>100_bases
AGATTAAATGCTATTTAATAATTTTAAAATAAAAATTATATATGACTGTTGTTCCAATATTTTGAAAGATATTAAAACCA
GAAAAATATAATGTTTATTG

Downstream 100 bases:

>100_bases
GTTTTCAAAAATTGATTTAATTTACAACTGAGATTTTATATATTTTAAAGTTGTATTTTAATCTATGGAATCTAAAATTA
TTTATTCATTATCTTTATTT

Product: Xaa-Pro aminopeptidase

Products: NA

Alternate protein names: X-Pro dipeptidase; Imidodipeptidase; Proline dipeptidase; Prolidase [H]

Number of amino acids: Translated: 347; Mature: 347

Protein sequence:

>347_residues
MKGVKMEINEFHINNILKDMEKKEYQGYLLAQFTNIHYISNYRPTSFAFCVIKEDPIIYASKMDMEIANKTSTIEVKEFT
SFSDMLGELKKEGISNLAIEPSLVYSTYEKFKDSFNIKSETFIDAQRQIKTADEIDKIQKATQIAQKAFVDLDILNNTNP
ENIVALELDNLMRKYGANGSSFDTIVTSGSNSSLPHATPQDKQLEKPILIDWGAKYHGYCSDNTRTIVYTEKQNEICDIV
AEAHDKAIKAIKPGLKCCEIDKVARDIISEYGYGDNYIHSTGHSVGLDIHEIPTFSTKDKTVIEKGMVITVEPGIYLEDN
FGVRLEDTIAIEKNKGRIIGDLPLIIE

Sequences:

>Translated_347_residues
MKGVKMEINEFHINNILKDMEKKEYQGYLLAQFTNIHYISNYRPTSFAFCVIKEDPIIYASKMDMEIANKTSTIEVKEFT
SFSDMLGELKKEGISNLAIEPSLVYSTYEKFKDSFNIKSETFIDAQRQIKTADEIDKIQKATQIAQKAFVDLDILNNTNP
ENIVALELDNLMRKYGANGSSFDTIVTSGSNSSLPHATPQDKQLEKPILIDWGAKYHGYCSDNTRTIVYTEKQNEICDIV
AEAHDKAIKAIKPGLKCCEIDKVARDIISEYGYGDNYIHSTGHSVGLDIHEIPTFSTKDKTVIEKGMVITVEPGIYLEDN
FGVRLEDTIAIEKNKGRIIGDLPLIIE
>Mature_347_residues
MKGVKMEINEFHINNILKDMEKKEYQGYLLAQFTNIHYISNYRPTSFAFCVIKEDPIIYASKMDMEIANKTSTIEVKEFT
SFSDMLGELKKEGISNLAIEPSLVYSTYEKFKDSFNIKSETFIDAQRQIKTADEIDKIQKATQIAQKAFVDLDILNNTNP
ENIVALELDNLMRKYGANGSSFDTIVTSGSNSSLPHATPQDKQLEKPILIDWGAKYHGYCSDNTRTIVYTEKQNEICDIV
AEAHDKAIKAIKPGLKCCEIDKVARDIISEYGYGDNYIHSTGHSVGLDIHEIPTFSTKDKTVIEKGMVITVEPGIYLEDN
FGVRLEDTIAIEKNKGRIIGDLPLIIE

Specific function: Splits dipeptides with a prolyl in the C-terminal position and a nonpolar amino acid at the N-terminal position [H]

COG id: COG0006

COG function: function code E; Xaa-Pro aminopeptidase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M24B family. Archaeal-type prolidase subfamily [H]

Homologues:

Organism=Homo sapiens, GI264681563, Length=165, Percent_Identity=33.3333333333333, Blast_Score=80, Evalue=3e-15,
Organism=Homo sapiens, GI11559925, Length=261, Percent_Identity=25.2873563218391, Blast_Score=75, Evalue=1e-13,
Organism=Escherichia coli, GI1788728, Length=265, Percent_Identity=37.3584905660377, Blast_Score=186, Evalue=3e-48,
Organism=Escherichia coli, GI1789275, Length=251, Percent_Identity=27.4900398406374, Blast_Score=101, Evalue=8e-23,
Organism=Caenorhabditis elegans, GI17509539, Length=163, Percent_Identity=31.2883435582822, Blast_Score=76, Evalue=2e-14,
Organism=Saccharomyces cerevisiae, GI6320922, Length=242, Percent_Identity=28.099173553719, Blast_Score=84, Evalue=3e-17,
Organism=Saccharomyces cerevisiae, GI6321118, Length=283, Percent_Identity=24.3816254416961, Blast_Score=73, Evalue=6e-14,
Organism=Drosophila melanogaster, GI19920384, Length=258, Percent_Identity=27.906976744186, Blast_Score=90, Evalue=2e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000587
- InterPro:   IPR001714
- InterPro:   IPR000994
- InterPro:   IPR001131 [H]

Pfam domain/function: PF01321 Creatinase_N; PF00557 Peptidase_M24 [H]

EC number: =3.4.13.9 [H]

Molecular weight: Translated: 39179; Mature: 39179

Theoretical pI: Translated: 4.91; Mature: 4.91

Prosite motif: PS00491 PROLINE_PEPTIDASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKGVKMEINEFHINNILKDMEKKEYQGYLLAQFTNIHYISNYRPTSFAFCVIKEDPIIYA
CCCCEEEHHHHHHHHHHHHHHHHHHCCEEEEEEEEEEEEECCCCCEEEEEEEECCCEEEE
SKMDMEIANKTSTIEVKEFTSFSDMLGELKKEGISNLAIEPSLVYSTYEKFKDSFNIKSE
EECCEEECCCCCEEEEHHHCCHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHCCCCCCH
TFIDAQRQIKTADEIDKIQKATQIAQKAFVDLDILNNTNPENIVALELDNLMRKYGANGS
HHHHHHHHHCCHHHHHHHHHHHHHHHHHHEEEEEECCCCCCCEEEEEHHHHHHHHCCCCC
SFDTIVTSGSNSSLPHATPQDKQLEKPILIDWGAKYHGYCSDNTRTIVYTEKQNEICDIV
CCEEEEECCCCCCCCCCCCCCCCCCCCEEEECCCCCCEEECCCCEEEEEECCCCHHHHHH
AEAHDKAIKAIKPGLKCCEIDKVARDIISEYGYGDNYIHSTGHSVGLDIHEIPTFSTKDK
HHHHHHHHHHHCCCCCEEHHHHHHHHHHHHCCCCCCEEECCCCCCCCCHHHCCCCCCCCC
TVIEKGMVITVEPGIYLEDNFGVRLEDTIAIEKNKGRIIGDLPLIIE
HHHHCCEEEEECCCEEEECCCCEEEEEEEEEECCCCEEEECCCEEEC
>Mature Secondary Structure
MKGVKMEINEFHINNILKDMEKKEYQGYLLAQFTNIHYISNYRPTSFAFCVIKEDPIIYA
CCCCEEEHHHHHHHHHHHHHHHHHHCCEEEEEEEEEEEEECCCCCEEEEEEEECCCEEEE
SKMDMEIANKTSTIEVKEFTSFSDMLGELKKEGISNLAIEPSLVYSTYEKFKDSFNIKSE
EECCEEECCCCCEEEEHHHCCHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHCCCCCCH
TFIDAQRQIKTADEIDKIQKATQIAQKAFVDLDILNNTNPENIVALELDNLMRKYGANGS
HHHHHHHHHCCHHHHHHHHHHHHHHHHHHEEEEEECCCCCCCEEEEEHHHHHHHHCCCCC
SFDTIVTSGSNSSLPHATPQDKQLEKPILIDWGAKYHGYCSDNTRTIVYTEKQNEICDIV
CCEEEEECCCCCCCCCCCCCCCCCCCCEEEECCCCCCEEECCCCEEEEEECCCCHHHHHH
AEAHDKAIKAIKPGLKCCEIDKVARDIISEYGYGDNYIHSTGHSVGLDIHEIPTFSTKDK
HHHHHHHHHHHCCCCCEEHHHHHHHHHHHHCCCCCCEEECCCCCCCCCHHHCCCCCCCCC
TVIEKGMVITVEPGIYLEDNFGVRLEDTIAIEKNKGRIIGDLPLIIE
HHHHCCEEEEECCCEEEECCCCEEEEEEEEEECCCCEEEECCCEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9679194 [H]