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The map label for this gene is 148642303

Identifier: 148642303

GI number: 148642303

Start: 228862

End: 229758

Strand: Reverse

Name: 148642303

Synonym: Msm_0243

Alternate gene names: NA

Gene position: 229758-228862 (Counterclockwise)

Preceding gene: 148642304

Following gene: 148642302

Centisome position: 12.4

GC content: 29.99

Gene sequence:

>897_bases
ATGATATATGTGGAAAATAAAGATTTAGTTATTCCTGGTGAAGTATTGGCAGATGACGAATACTACTCAGGAAGAGGTAC
CTTTAAAGAGAATGGTAAAATTTGTTCTTCTTTAATGGGACTAGTTTCTTTAAGGAATAAAAAAATTAGAGTTATTCCTC
TTAAAAGTAAATATGTTCCTAAAAAAGGAGATGTAGTTATTGGTAAAATTAAAGATGTCAGATTCTCCATGTGGGATGTA
GATATTAATTCCCCATATTCCGGAATTTTACCTGCTTTTGAAGTGTTTGGAAGAGAGAAAAAAGAACTCAACAAGGTATT
TGATGTTGGGGATGTTCTATTTTTAAGAGTTGTTGATGTTGATGAAGTTAAAAAAGTCAAACTGGGCTTAAAAGGCAGAG
GAATGGGTAAATTTAGAGGAGGAATAATTGTAGATATTACTCCAACCAAAGTTCCTAGATTAATAGGTAAAAAAGGTTCT
ATGATCAACATGATTAAGGATAAAACCAATTGTAAGATAATTGTTGGTCAAAATGGTCTTGTTTGGGTTAAAGGTGAGGA
AGATATGGAACAGCTTACTAAAGATATTATCCATATGATTGAAGCTGAGGCTCATACTTCCGGTTTAACAAATAAAGTTA
AAAATAAACTATCTTTAGCTATTGATGGTGAATTGCCACAAGAAGATGACTATAGTGATGATTATGAAGAATTAGAAAAA
CCTAAACTTCAAAATTTCAAAGAAGAATTGGAACAGGAAGAAAAAGAAGAACAGTCAAAAAAAGATAGTACTGATTTTTA
TAAAGTAATTGAAGAATTAAAAAAGAAAAATAAAAAGGATAAACCTTTGTCCTATGGTAATAATTCTGGCAATTCTTATA
TATTGAATAACAGATAA

Upstream 100 bases:

>100_bases
TCAAGATGATTTCGCCGCTAAAATGGCTGAAATTTCAAGTGGTGAAGCAGAAACGAAAACTATCAAATAATTAAATTAAT
TTTCAACTTATGGGATTTTT

Downstream 100 bases:

>100_bases
TTCTTTGATGATTATGAGGTTGATATGATGTCTGAAATGATAAGAGAGGACGGCAGAAAATATAATGAATTACGCCCTAT
AAAAATTGAAGCAGGTGTTC

Product: exosome complex RNA-binding protein Rrp4

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 298; Mature: 298

Protein sequence:

>298_residues
MIYVENKDLVIPGEVLADDEYYSGRGTFKENGKICSSLMGLVSLRNKKIRVIPLKSKYVPKKGDVVIGKIKDVRFSMWDV
DINSPYSGILPAFEVFGREKKELNKVFDVGDVLFLRVVDVDEVKKVKLGLKGRGMGKFRGGIIVDITPTKVPRLIGKKGS
MINMIKDKTNCKIIVGQNGLVWVKGEEDMEQLTKDIIHMIEAEAHTSGLTNKVKNKLSLAIDGELPQEDDYSDDYEELEK
PKLQNFKEELEQEEKEEQSKKDSTDFYKVIEELKKKNKKDKPLSYGNNSGNSYILNNR

Sequences:

>Translated_298_residues
MIYVENKDLVIPGEVLADDEYYSGRGTFKENGKICSSLMGLVSLRNKKIRVIPLKSKYVPKKGDVVIGKIKDVRFSMWDV
DINSPYSGILPAFEVFGREKKELNKVFDVGDVLFLRVVDVDEVKKVKLGLKGRGMGKFRGGIIVDITPTKVPRLIGKKGS
MINMIKDKTNCKIIVGQNGLVWVKGEEDMEQLTKDIIHMIEAEAHTSGLTNKVKNKLSLAIDGELPQEDDYSDDYEELEK
PKLQNFKEELEQEEKEEQSKKDSTDFYKVIEELKKKNKKDKPLSYGNNSGNSYILNNR
>Mature_298_residues
MIYVENKDLVIPGEVLADDEYYSGRGTFKENGKICSSLMGLVSLRNKKIRVIPLKSKYVPKKGDVVIGKIKDVRFSMWDV
DINSPYSGILPAFEVFGREKKELNKVFDVGDVLFLRVVDVDEVKKVKLGLKGRGMGKFRGGIIVDITPTKVPRLIGKKGS
MINMIKDKTNCKIIVGQNGLVWVKGEEDMEQLTKDIIHMIEAEAHTSGLTNKVKNKLSLAIDGELPQEDDYSDDYEELEK
PKLQNFKEELEQEEKEEQSKKDSTDFYKVIEELKKKNKKDKPLSYGNNSGNSYILNNR

Specific function: Probably involved in degradation of a variety of RNA species; could act a RNA-binding component of the exosome (Potential)

COG id: COG1097

COG function: function code J; RNA-binding protein Rrp4 and related proteins (contain S1 domain and KH domain)

Gene ontology:

Cell location: Cytoplasm (Potential)

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 S1 motif domain

Homologues:

Organism=Homo sapiens, GI19923403, Length=188, Percent_Identity=28.1914893617021, Blast_Score=75, Evalue=8e-14,
Organism=Saccharomyces cerevisiae, GI6321860, Length=198, Percent_Identity=28.7878787878788, Blast_Score=78, Evalue=2e-15,
Organism=Drosophila melanogaster, GI24762324, Length=190, Percent_Identity=32.1052631578947, Blast_Score=88, Evalue=8e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): ECR1_METS3 (A5UJS0)

Other databases:

- EMBL:   CP000678
- RefSeq:   YP_001272816.1
- ProteinModelPortal:   A5UJS0
- SMR:   A5UJS0
- STRING:   A5UJS0
- GeneID:   5216607
- GenomeReviews:   CP000678_GR
- KEGG:   msi:Msm_0243
- eggNOG:   arNOG07880
- HOGENOM:   HBG392276
- OMA:   GQNGRIW
- ProtClustDB:   PRK04163
- GO:   GO:0005737
- HAMAP:   MF_00623
- InterPro:   IPR004087
- InterPro:   IPR004088
- InterPro:   IPR018111
- InterPro:   IPR012340
- InterPro:   IPR016027
- InterPro:   IPR003029
- InterPro:   IPR022967
- Gene3D:   G3DSA:2.40.50.140
- SMART:   SM00322
- SMART:   SM00316

Pfam domain/function: PF00013 KH_1; SSF50249 Nucleic_acid_OB

EC number: NA

Molecular weight: Translated: 33844; Mature: 33844

Theoretical pI: Translated: 8.84; Mature: 8.84

Prosite motif: PS50084 KH_TYPE_1; PS50126 S1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIYVENKDLVIPGEVLADDEYYSGRGTFKENGKICSSLMGLVSLRNKKIRVIPLKSKYVP
CEEECCCCEEECCHHEECCCEECCCCCCCCCHHHHHHHHHHHHHCCCCEEEEEECCCCCC
KKGDVVIGKIKDVRFSMWDVDINSPYSGILPAFEVFGREKKELNKVFDVGDVLFLRVVDV
CCCCEEEEEECCCEEEEEEEECCCCCCHHHHHHHHHCCCHHHHHHHHHHCCEEEEEEECH
DEVKKVKLGLKGRGMGKFRGGIIVDITPTKVPRLIGKKGSMINMIKDKTNCKIIVGQNGL
HHHHHHHCCCCCCCCCCCCCCEEEEECCCHHHHHHCCCCCEEEEEECCCCEEEEECCCCE
VWVKGEEDMEQLTKDIIHMIEAEAHTSGLTNKVKNKLSLAIDGELPQEDDYSDDYEELEK
EEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEECCCCCCCCCCCCCHHHHCC
PKLQNFKEELEQEEKEEQSKKDSTDFYKVIEELKKKNKKDKPLSYGNNSGNSYILNNR
CHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCEEEECCC
>Mature Secondary Structure
MIYVENKDLVIPGEVLADDEYYSGRGTFKENGKICSSLMGLVSLRNKKIRVIPLKSKYVP
CEEECCCCEEECCHHEECCCEECCCCCCCCCHHHHHHHHHHHHHCCCCEEEEEECCCCCC
KKGDVVIGKIKDVRFSMWDVDINSPYSGILPAFEVFGREKKELNKVFDVGDVLFLRVVDV
CCCCEEEEEECCCEEEEEEEECCCCCCHHHHHHHHHCCCHHHHHHHHHHCCEEEEEEECH
DEVKKVKLGLKGRGMGKFRGGIIVDITPTKVPRLIGKKGSMINMIKDKTNCKIIVGQNGL
HHHHHHHCCCCCCCCCCCCCCEEEEECCCHHHHHHCCCCCEEEEEECCCCEEEEECCCCE
VWVKGEEDMEQLTKDIIHMIEAEAHTSGLTNKVKNKLSLAIDGELPQEDDYSDDYEELEK
EEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEECCCCCCCCCCCCCHHHHCC
PKLQNFKEELEQEEKEEQSKKDSTDFYKVIEELKKKNKKDKPLSYGNNSGNSYILNNR
CHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA