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The map label for this gene is ndk

Identifier: 148642263

GI number: 148642263

Start: 195157

End: 195609

Strand: Reverse

Name: ndk

Synonym: Msm_0203

Alternate gene names: 148642263

Gene position: 195609-195157 (Counterclockwise)

Preceding gene: 148642264

Following gene: 148642262

Centisome position: 10.56

GC content: 33.33

Gene sequence:

>453_bases
ATGATTCAAAAAAGTTTTGTAATGATGAAACCGGACGCAGTTCAAAGACGTCTTATGGGTAAAATATTATCCCGTTTTGA
AGAAAAAGGTCTTCAAATCGTTGCTGTAAAGTTAATGCAAATTGATGAAGATTTAGCAAAAACTCATTATGGAGAACATG
CAGATAAACCATTTTTCGGTAGTTTAATTGAATACATTACATCTTCCCCATCTCTTGCTATGGTAATTGAAGGAGAAGAA
GCTATCAGTACTATCAGAAAATTAGTTGGAGCAACCAATCCTTTAGAAGCAGACCTCGGAACTATTAGAGGAGATTTTGC
TATGGACACTGGTAGAAACATTATTCATGCTTCTGACTCTCCAGATTCTGCAGAAAGAGAAATCAATTTATTCTTTAATG
AAGATGAAATTTGCGATTACGAAATCGTTGATAACAAATTAATTTACGAATAA

Upstream 100 bases:

>100_bases
TTAAAAAAGACGGTTCTATTTATTTCTTTTGTAGCAGTAAATGTGAAAAAAACATGATTAAACTTGGTAGAGTTCCAAGA
AAAGTTAAATGGGTTAAAGA

Downstream 100 bases:

>100_bases
TTATTATTTAAGATAACATGAAAATCAGATCCCCAATTGTATCAGTTTTAGGACATGTAGACCACGGTAAGACCACTTTA
TTGGATTATATTAGAGGAAG

Product: nucleoside diphosphate kinase

Products: NA

Alternate protein names: NDK; NDP kinase; Nucleoside-2-P kinase

Number of amino acids: Translated: 150; Mature: 150

Protein sequence:

>150_residues
MIQKSFVMMKPDAVQRRLMGKILSRFEEKGLQIVAVKLMQIDEDLAKTHYGEHADKPFFGSLIEYITSSPSLAMVIEGEE
AISTIRKLVGATNPLEADLGTIRGDFAMDTGRNIIHASDSPDSAEREINLFFNEDEICDYEIVDNKLIYE

Sequences:

>Translated_150_residues
MIQKSFVMMKPDAVQRRLMGKILSRFEEKGLQIVAVKLMQIDEDLAKTHYGEHADKPFFGSLIEYITSSPSLAMVIEGEE
AISTIRKLVGATNPLEADLGTIRGDFAMDTGRNIIHASDSPDSAEREINLFFNEDEICDYEIVDNKLIYE
>Mature_150_residues
MIQKSFVMMKPDAVQRRLMGKILSRFEEKGLQIVAVKLMQIDEDLAKTHYGEHADKPFFGSLIEYITSSPSLAMVIEGEE
AISTIRKLVGATNPLEADLGTIRGDFAMDTGRNIIHASDSPDSAEREINLFFNEDEICDYEIVDNKLIYE

Specific function: Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate

COG id: COG0105

COG function: function code F; Nucleoside diphosphate kinase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the NDK family

Homologues:

Organism=Homo sapiens, GI37693993, Length=148, Percent_Identity=48.6486486486487, Blast_Score=165, Evalue=2e-41,
Organism=Homo sapiens, GI38045913, Length=148, Percent_Identity=49.3243243243243, Blast_Score=162, Evalue=7e-41,
Organism=Homo sapiens, GI4557797, Length=148, Percent_Identity=49.3243243243243, Blast_Score=162, Evalue=8e-41,
Organism=Homo sapiens, GI66392227, Length=149, Percent_Identity=46.3087248322148, Blast_Score=156, Evalue=8e-39,
Organism=Homo sapiens, GI66392205, Length=149, Percent_Identity=46.3087248322148, Blast_Score=156, Evalue=8e-39,
Organism=Homo sapiens, GI4505409, Length=149, Percent_Identity=46.3087248322148, Blast_Score=156, Evalue=8e-39,
Organism=Homo sapiens, GI66392192, Length=149, Percent_Identity=46.3087248322148, Blast_Score=156, Evalue=8e-39,
Organism=Homo sapiens, GI66392203, Length=149, Percent_Identity=46.3087248322148, Blast_Score=155, Evalue=8e-39,
Organism=Homo sapiens, GI4826862, Length=138, Percent_Identity=43.4782608695652, Blast_Score=137, Evalue=3e-33,
Organism=Homo sapiens, GI7019465, Length=139, Percent_Identity=33.8129496402878, Blast_Score=80, Evalue=5e-16,
Organism=Homo sapiens, GI37574614, Length=139, Percent_Identity=33.8129496402878, Blast_Score=80, Evalue=5e-16,
Organism=Homo sapiens, GI5031951, Length=136, Percent_Identity=33.0882352941176, Blast_Score=67, Evalue=4e-12,
Organism=Homo sapiens, GI4505413, Length=136, Percent_Identity=30.1470588235294, Blast_Score=65, Evalue=3e-11,
Organism=Homo sapiens, GI148839372, Length=138, Percent_Identity=27.536231884058, Blast_Score=64, Evalue=3e-11,
Organism=Escherichia coli, GI1788866, Length=137, Percent_Identity=44.5255474452555, Blast_Score=133, Evalue=6e-33,
Organism=Caenorhabditis elegans, GI17506807, Length=149, Percent_Identity=48.993288590604, Blast_Score=154, Evalue=2e-38,
Organism=Caenorhabditis elegans, GI71995094, Length=132, Percent_Identity=35.6060606060606, Blast_Score=80, Evalue=3e-16,
Organism=Saccharomyces cerevisiae, GI6322783, Length=148, Percent_Identity=51.3513513513513, Blast_Score=171, Evalue=5e-44,
Organism=Drosophila melanogaster, GI45549037, Length=148, Percent_Identity=46.6216216216216, Blast_Score=157, Evalue=3e-39,
Organism=Drosophila melanogaster, GI18860097, Length=133, Percent_Identity=29.3233082706767, Blast_Score=70, Evalue=7e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NDK_METS3 (A5UJN0)

Other databases:

- EMBL:   CP000678
- RefSeq:   YP_001272776.1
- ProteinModelPortal:   A5UJN0
- SMR:   A5UJN0
- STRING:   A5UJN0
- GeneID:   5215791
- GenomeReviews:   CP000678_GR
- KEGG:   msi:Msm_0203
- eggNOG:   arNOG07660
- HOGENOM:   HBG445152
- OMA:   IRAEFAE
- ProtClustDB:   PRK00668
- GO:   GO:0005737
- HAMAP:   MF_00451
- InterPro:   IPR001564
- InterPro:   IPR023005
- Gene3D:   G3DSA:3.30.70.141
- PANTHER:   PTHR11349
- PRINTS:   PR01243
- SMART:   SM00562

Pfam domain/function: PF00334 NDK; SSF54919 NDK

EC number: =2.7.4.6

Molecular weight: Translated: 16903; Mature: 16903

Theoretical pI: Translated: 4.40; Mature: 4.40

Prosite motif: PS00469 NDP_KINASES

Important sites: ACT_SITE 116-116 BINDING 10-10 BINDING 58-58 BINDING 86-86 BINDING 92-92 BINDING 103-103 BINDING 113-113

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
4.7 %Met     (Translated Protein)
5.3 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
4.7 %Met     (Mature Protein)
5.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIQKSFVMMKPDAVQRRLMGKILSRFEEKGLQIVAVKLMQIDEDLAKTHYGEHADKPFFG
CCCCCEEEECCHHHHHHHHHHHHHHHHHCCCEEEHHHHHHHHHHHHHHCCCCCCCCCHHH
SLIEYITSSPSLAMVIEGEEAISTIRKLVGATNPLEADLGTIRGDFAMDTGRNIIHASDS
HHHHHHHCCCCEEEEEECHHHHHHHHHHHCCCCCCCCCHHHHCCCCEECCCCCEEECCCC
PDSAEREINLFFNEDEICDYEIVDNKLIYE
CCCCCEEEEEEECCCCCCCEEEECCEECCC
>Mature Secondary Structure
MIQKSFVMMKPDAVQRRLMGKILSRFEEKGLQIVAVKLMQIDEDLAKTHYGEHADKPFFG
CCCCCEEEECCHHHHHHHHHHHHHHHHHCCCEEEHHHHHHHHHHHHHHCCCCCCCCCHHH
SLIEYITSSPSLAMVIEGEEAISTIRKLVGATNPLEADLGTIRGDFAMDTGRNIIHASDS
HHHHHHHCCCCEEEEEECHHHHHHHHHHHCCCCCCCCCHHHHCCCCEECCCCCEEECCCC
PDSAEREINLFFNEDEICDYEIVDNKLIYE
CCCCCEEEEEEECCCCCCCEEEECCEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA