Click here to switch to the map view.

The map label for this gene is rnc [H]

Identifier: 148642236

GI number: 148642236

Start: 178707

End: 179378

Strand: Reverse

Name: rnc [H]

Synonym: Msm_0176

Alternate gene names: 148642236

Gene position: 179378-178707 (Counterclockwise)

Preceding gene: 148642238

Following gene: 148642235

Centisome position: 9.68

GC content: 30.65

Gene sequence:

>672_bases
ATGAATTTATTAGAAAAATTTAACATACTCCCAAAGGACAGGCATCTATATGATGTTGCATTTACTCACGGGTCTTATGG
AACAAAACATGGTTTAGATTATACATATGAAAGATTGGAGTTTTTAGGTGACTCTGTTTTGAACATGATTGTTTCAGAAT
ATTTATATAAACAGTATCCGGATTATGAAGAAGGTAAATTAACTAAACTGCGAGCAAATTATGTTTGTCAAACAGCATTA
ATTTATTATTCACATGAACTGGGTTTGGATAAGCATATCAAAATATATGGTGATGACAGCAAAATAACTGAAAATGAGGT
TTTGTCAATTACCGCAGATGTTTTTGAATCATTTTTAGGAGCAATATTCTTGGATCAGGGTATAGAATTTGCAAAGGATT
ACATTTCAAAAATAATATTCCCATACATCGATGCAAAAAAAGTGTTTTTCTTTGATTATAAATCAGTAATAAAAGAATAC
GGGGATGCCCAGGAAGTGGATATTGAATATAAAATAATTGATGAATGCGGTGTGCCTCATAATAAAACATTTATAATCTC
TATATTGATTGACGGAAAGGAAATGGGTGTTGGTAAAGGTAAAAACAAAAAAGAAGCTGAACAGGCTGCTTCAAAACAGG
CTATGAAAAAACTGAAAATACAGAAATATTAG

Upstream 100 bases:

>100_bases
TTTATAACGATAGTTATATATACTTCTTTTTACAACTATAAATTTATATAAGCCTAAAAACAAAGTGTATTAACATATTT
AAAGAAATTTGGTCTTTATT

Downstream 100 bases:

>100_bases
GTGTTTTAAATGAAAAAAGAATCAGTTGGAGTTGTTCAAACAAAGTATTATAATATTGAAGAGCCAATTGAACTAGAAAG
TGGAAAGACTCTTGATAACA

Product: ribonuclease III (dsRNA-specific), Rnc

Products: NA

Alternate protein names: Ribonuclease III; RNase III [H]

Number of amino acids: Translated: 223; Mature: 223

Protein sequence:

>223_residues
MNLLEKFNILPKDRHLYDVAFTHGSYGTKHGLDYTYERLEFLGDSVLNMIVSEYLYKQYPDYEEGKLTKLRANYVCQTAL
IYYSHELGLDKHIKIYGDDSKITENEVLSITADVFESFLGAIFLDQGIEFAKDYISKIIFPYIDAKKVFFFDYKSVIKEY
GDAQEVDIEYKIIDECGVPHNKTFIISILIDGKEMGVGKGKNKKEAEQAASKQAMKKLKIQKY

Sequences:

>Translated_223_residues
MNLLEKFNILPKDRHLYDVAFTHGSYGTKHGLDYTYERLEFLGDSVLNMIVSEYLYKQYPDYEEGKLTKLRANYVCQTAL
IYYSHELGLDKHIKIYGDDSKITENEVLSITADVFESFLGAIFLDQGIEFAKDYISKIIFPYIDAKKVFFFDYKSVIKEY
GDAQEVDIEYKIIDECGVPHNKTFIISILIDGKEMGVGKGKNKKEAEQAASKQAMKKLKIQKY
>Mature_223_residues
MNLLEKFNILPKDRHLYDVAFTHGSYGTKHGLDYTYERLEFLGDSVLNMIVSEYLYKQYPDYEEGKLTKLRANYVCQTAL
IYYSHELGLDKHIKIYGDDSKITENEVLSITADVFESFLGAIFLDQGIEFAKDYISKIIFPYIDAKKVFFFDYKSVIKEY
GDAQEVDIEYKIIDECGVPHNKTFIISILIDGKEMGVGKGKNKKEAEQAASKQAMKKLKIQKY

Specific function: Digests double-stranded RNA. Involved in the processing of ribosomal RNA precursors and of some mRNAs [H]

COG id: COG0571

COG function: function code K; dsRNA-specific ribonuclease

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 RNase III domain [H]

Homologues:

Organism=Homo sapiens, GI155030234, Length=209, Percent_Identity=30.1435406698565, Blast_Score=104, Evalue=6e-23,
Organism=Homo sapiens, GI155030236, Length=209, Percent_Identity=30.1435406698565, Blast_Score=104, Evalue=8e-23,
Organism=Escherichia coli, GI1788920, Length=214, Percent_Identity=30.3738317757009, Blast_Score=84, Evalue=6e-18,
Organism=Caenorhabditis elegans, GI17506883, Length=194, Percent_Identity=28.8659793814433, Blast_Score=81, Evalue=4e-16,
Organism=Caenorhabditis elegans, GI193202651, Length=194, Percent_Identity=28.8659793814433, Blast_Score=81, Evalue=4e-16,
Organism=Saccharomyces cerevisiae, GI6323895, Length=116, Percent_Identity=34.4827586206897, Blast_Score=70, Evalue=4e-13,
Organism=Drosophila melanogaster, GI17137682, Length=209, Percent_Identity=29.1866028708134, Blast_Score=96, Evalue=2e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001159
- InterPro:   IPR014720
- InterPro:   IPR000999
- InterPro:   IPR011907 [H]

Pfam domain/function: PF00035 dsrm; PF00636 Ribonuclease_3 [H]

EC number: =3.1.26.3 [H]

Molecular weight: Translated: 25775; Mature: 25775

Theoretical pI: Translated: 5.97; Mature: 5.97

Prosite motif: PS50137 DS_RBD ; PS00517 RNASE_3_1 ; PS50142 RNASE_3_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNLLEKFNILPKDRHLYDVAFTHGSYGTKHGLDYTYERLEFLGDSVLNMIVSEYLYKQYP
CCHHHHCCCCCCCCEEEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCC
DYEEGKLTKLRANYVCQTALIYYSHELGLDKHIKIYGDDSKITENEVLSITADVFESFLG
CCCCCCEEEHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHH
AIFLDQGIEFAKDYISKIIFPYIDAKKVFFFDYKSVIKEYGDAQEVDIEYKIIDECGVPH
HHHHHCCHHHHHHHHHHHHHHCCCCCEEEEHHHHHHHHHCCCCCCEEEEEEEEECCCCCC
NKTFIISILIDGKEMGVGKGKNKKEAEQAASKQAMKKLKIQKY
CCEEEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MNLLEKFNILPKDRHLYDVAFTHGSYGTKHGLDYTYERLEFLGDSVLNMIVSEYLYKQYP
CCHHHHCCCCCCCCEEEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCC
DYEEGKLTKLRANYVCQTALIYYSHELGLDKHIKIYGDDSKITENEVLSITADVFESFLG
CCCCCCEEEHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHH
AIFLDQGIEFAKDYISKIIFPYIDAKKVFFFDYKSVIKEYGDAQEVDIEYKIIDECGVPH
HHHHHCCHHHHHHHHHHHHHHCCCCCEEEEHHHHHHHHHCCCCCCEEEEEEEEECCCCCC
NKTFIISILIDGKEMGVGKGKNKKEAEQAASKQAMKKLKIQKY
CCEEEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA