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The map label for this gene is hom [H]

Identifier: 148642214

GI number: 148642214

Start: 147589

End: 148608

Strand: Reverse

Name: hom [H]

Synonym: Msm_0154

Alternate gene names: 148642214

Gene position: 148608-147589 (Counterclockwise)

Preceding gene: 148642215

Following gene: 148642213

Centisome position: 8.02

GC content: 35.0

Gene sequence:

>1020_bases
ATGAAAGAATGTAAAGTCATAGTAATGGGATTTGGTGCAGTTGGTCAGGGTGTGGCTAGGGCAATCTCATTAAAAAAAGA
CATGATTAAAGAAAGATTTAATGTAGAATTAAAAATAGTAGCTGCTGCAGATTCTTCATCTTCTGCAATCTGTGCTGACG
GATTGGATGAAGAACTGCTTGTAAACACTAAAAATGAATTTGGAAAATTATCCAATTATCCTGAATACGGCAGTACCATT
TCAGGTTTGGATGTGTTGGATGCTGTGGAATATGACTGTTTGATGGAAGCAACTCCAACTAATATAACTGATGCAGAACC
TGCACTGTCTTTAACTTTAAAAGCATTTAAAGCTGGAAAAGATGTTGTAACATCAAATAAGGGACATTTAGCTTTAAAAT
TCAGAGAAGTTGTATCCGAAGCTGAGAAAAACAATGTTGAATTTAAATATGAAGCCAGTGTTGGTGGAGCAATGCCTATT
ATTAATTTCACAAAAGAAACACTTTCATCCTGTGGAATCAAATCAATTGTAGGAATATTGAACGGTACCACCAATTACAT
TTTATCAAGAATGGCATCCGAAGGTTCCTCCTATGATATAACCTTAAAAGAATCTCAAGAGTTGGGAATAGCTGAAACAG
ACCCAACTCAGGATGTTGAAGGTATTGATGCAGCTTGTAAAACTGTAATTTTAGCTAATTCACTTTTAGGAATTGATGCC
ACTTATAGTGATGTTGATGTTGAAGGTATTTCAAATATTACTTCACAGGCTATGGATTTAGCCAGAAAAGAAGGTTATTT
AATTAAATTAATAGCTGAAGTTTCTAAAGACAAACTGCAGGTATCACCACGTTTAGTTAAAAAAGGCAGTGCATATGATT
TAAGCGGAACTTTAAATATGGCTACTGTCCGCACTGACCTTGCAGGTGATGTTAGTGTTATTGGACTTGGAGCAGGATCT
CTTGAAACTGCTTCTGCGATGTTGACTGATTTGATTAGTATTTTAAAAGTTAAATACTAA

Upstream 100 bases:

>100_bases
ATTGAAACAGACTTTGGCATGAAAGAATTTATATTTGATAAGATTGGTAAAATAGCTGCAGAAAAAGATTTACTTATGAT
TAATGAAGTTTAGGGATAGT

Downstream 100 bases:

>100_bases
TTTACTTTTACTTTTTTTGATGATAGTATGAAATATGTAATTTTTATTCCTGACGGTTCAAGTGACTATCCAATCGACGA
ATTGGACGGCATGACTCCAC

Product: homoserine dehydrogenase

Products: NA

Alternate protein names: HDH [H]

Number of amino acids: Translated: 339; Mature: 339

Protein sequence:

>339_residues
MKECKVIVMGFGAVGQGVARAISLKKDMIKERFNVELKIVAAADSSSSAICADGLDEELLVNTKNEFGKLSNYPEYGSTI
SGLDVLDAVEYDCLMEATPTNITDAEPALSLTLKAFKAGKDVVTSNKGHLALKFREVVSEAEKNNVEFKYEASVGGAMPI
INFTKETLSSCGIKSIVGILNGTTNYILSRMASEGSSYDITLKESQELGIAETDPTQDVEGIDAACKTVILANSLLGIDA
TYSDVDVEGISNITSQAMDLARKEGYLIKLIAEVSKDKLQVSPRLVKKGSAYDLSGTLNMATVRTDLAGDVSVIGLGAGS
LETASAMLTDLISILKVKY

Sequences:

>Translated_339_residues
MKECKVIVMGFGAVGQGVARAISLKKDMIKERFNVELKIVAAADSSSSAICADGLDEELLVNTKNEFGKLSNYPEYGSTI
SGLDVLDAVEYDCLMEATPTNITDAEPALSLTLKAFKAGKDVVTSNKGHLALKFREVVSEAEKNNVEFKYEASVGGAMPI
INFTKETLSSCGIKSIVGILNGTTNYILSRMASEGSSYDITLKESQELGIAETDPTQDVEGIDAACKTVILANSLLGIDA
TYSDVDVEGISNITSQAMDLARKEGYLIKLIAEVSKDKLQVSPRLVKKGSAYDLSGTLNMATVRTDLAGDVSVIGLGAGS
LETASAMLTDLISILKVKY
>Mature_339_residues
MKECKVIVMGFGAVGQGVARAISLKKDMIKERFNVELKIVAAADSSSSAICADGLDEELLVNTKNEFGKLSNYPEYGSTI
SGLDVLDAVEYDCLMEATPTNITDAEPALSLTLKAFKAGKDVVTSNKGHLALKFREVVSEAEKNNVEFKYEASVGGAMPI
INFTKETLSSCGIKSIVGILNGTTNYILSRMASEGSSYDITLKESQELGIAETDPTQDVEGIDAACKTVILANSLLGIDA
TYSDVDVEGISNITSQAMDLARKEGYLIKLIAEVSKDKLQVSPRLVKKGSAYDLSGTLNMATVRTDLAGDVSVIGLGAGS
LETASAMLTDLISILKVKY

Specific function: Catalyzes 2 nonconsecutive reactions in the common biosynthetic pathway leading from Asp to diaminopimelate and Lys, to Met, and to Thr and Ile. [C]

COG id: COG0460

COG function: function code E; Homoserine dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the homoserine dehydrogenase family [H]

Homologues:

Organism=Escherichia coli, GI1786183, Length=340, Percent_Identity=22.6470588235294, Blast_Score=64, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005106
- InterPro:   IPR001342
- InterPro:   IPR019811
- InterPro:   IPR022697
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00742 Homoserine_dh; PF03447 NAD_binding_3 [H]

EC number: =1.1.1.3 [H]

Molecular weight: Translated: 36012; Mature: 36012

Theoretical pI: Translated: 4.48; Mature: 4.48

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKECKVIVMGFGAVGQGVARAISLKKDMIKERFNVELKIVAAADSSSSAICADGLDEELL
CCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHHCEEEEEEEECCCCCCEEECCCCCCHHE
VNTKNEFGKLSNYPEYGSTISGLDVLDAVEYDCLMEATPTNITDAEPALSLTLKAFKAGK
EECCHHHCCCCCCCCCCCCCCCCHHHHHHHHHHEEECCCCCCCCCCHHHHHHHHHHHCCC
DVVTSNKGHLALKFREVVSEAEKNNVEFKYEASVGGAMPIINFTKETLSSCGIKSIVGIL
CCEECCCCEEEEHHHHHHHHHHHCCCEEEEECCCCCCCCHHHHHHHHHHHCCHHHHHHHH
NGTTNYILSRMASEGSSYDITLKESQELGIAETDPTQDVEGIDAACKTVILANSLLGIDA
CCHHHHHHHHHHCCCCCEEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCC
TYSDVDVEGISNITSQAMDLARKEGYLIKLIAEVSKDKLQVSPRLVKKGSAYDLSGTLNM
CCCCCCHHHHHHHHHHHHHHHHHCCCEEEHHHHHHHHHEECCHHHHCCCCCEECCCCEEE
ATVRTDLAGDVSVIGLGAGSLETASAMLTDLISILKVKY
EEEEECCCCCEEEEEECCCCHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MKECKVIVMGFGAVGQGVARAISLKKDMIKERFNVELKIVAAADSSSSAICADGLDEELL
CCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHHCEEEEEEEECCCCCCEEECCCCCCHHE
VNTKNEFGKLSNYPEYGSTISGLDVLDAVEYDCLMEATPTNITDAEPALSLTLKAFKAGK
EECCHHHCCCCCCCCCCCCCCCCHHHHHHHHHHEEECCCCCCCCCCHHHHHHHHHHHCCC
DVVTSNKGHLALKFREVVSEAEKNNVEFKYEASVGGAMPIINFTKETLSSCGIKSIVGIL
CCEECCCCEEEEHHHHHHHHHHHCCCEEEEECCCCCCCCHHHHHHHHHHHCCHHHHHHHH
NGTTNYILSRMASEGSSYDITLKESQELGIAETDPTQDVEGIDAACKTVILANSLLGIDA
CCHHHHHHHHHHCCCCCEEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCC
TYSDVDVEGISNITSQAMDLARKEGYLIKLIAEVSKDKLQVSPRLVKKGSAYDLSGTLNM
CCCCCCHHHHHHHHHHHHHHHHHCCCEEEHHHHHHHHHEECCHHHHCCCCCEECCCCEEE
ATVRTDLAGDVSVIGLGAGSLETASAMLTDLISILKVKY
EEEEECCCCCEEEEEECCCCHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]