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The map label for this gene is tdcB [H]

Identifier: 148381444

GI number: 148381444

Start: 3730040

End: 3731263

Strand: Reverse

Name: tdcB [H]

Synonym: CBO3502

Alternate gene names: 148381444

Gene position: 3731263-3730040 (Counterclockwise)

Preceding gene: 148381445

Following gene: 148381443

Centisome position: 96.0

GC content: 32.35

Gene sequence:

>1224_bases
ATGATTATGGAGTTAAACTTAGATACAATAAAAAAAGCTCAAAATAACATAAAAACAGTAGTTAGAAAAACACCTTTGTT
TTATTCAAGCACTTTTTCTAGAAAAACAGGATATGAAGTATATTTAAAATGTGAAAATAAACAAAAGACTGGAGCTTTTA
AATTAAGAGGCGCATATAACAAGATAGTTTCATTAACTGAGGAAGAAAGAAAAAAGGGGGTCATTGCATCTTCAGCAGGA
AACCATGCTCAAGGTGTTGCTTATGCAGCTACCGCCTTTGGAATAAAATCTACTATAGCTATGCCTAAAACTGCTCCTCA
AGCTAAGGTTATGGCAACAAAAGGATATGGAGCAGAAGTTGTTCAGCACGGGGAAGTTTATGATGAATGTTATGAAAAAG
CATTAGAAATACAAAAGGCTACAGGAGCTACTTTTGTACATCCTTTTAATGATATACACGTTATGGCGGGTCAAGGCACA
ATAGCATTAGAAATATTAGAAGAAATAGAAGATATAGATGCTATAATAGTTCCAATAGGAGGAGGAGGGCTAATATCAGG
AATAGCTGTAGCAGCTAAATCCATAAAGCGAGATATAAAAATTATAGGAGTTCAATCAGCTATTATAGCCTCTACAAAGG
CGTCATTAGAAAAAAATGAAATTGTAACTTTGCCAGGAGCTAAGTCTTTAGCAGATGGTATTTCAGTAAAGACTCCAGGG
GATATTGCTTTTAAATATATTAGAGAATATGTAGATGAAGTAGTTACAGTTACAGAAGATGAAATAGCTTATGGAATTTT
CGAACTTATTGAGAAGACGAAAGTTATTGCAGAAGGTGCGGGAGCATCAACTGTTGCAGCTTTATTAGCTAATAAGATTA
ATATTAAAGGTAAAAAGGTTGTAGCTCTAATAAGTGGCGGTAATATAGATATAGCTATGATATCTAAAATAATAGATAGA
CAGCTTATAATGCTTAAGAGAAGAATAAGATTTAAAGTAGAATTACAGGATAAAATAGGAGAATTCGAAGATGTTATTTC
GAATATTGTTTCTACAGGAGCTAATATAGTTAAGGCTAGACAGGACACTAATTGGAGTGAAAAAGGACTAGAATATGCAA
ATGTAATATTTGAAGTAGAAGTTCAAAGTAAAGAACAAGGAGATAAGTTATTGAAACAACTTAGCGAAAAAGGGTATAAT
ATACAAACAAATATATGTATGTAA

Upstream 100 bases:

>100_bases
AAGAAAGTATTAAAAGTTTATTGGGTATAGGTTAATAGATTGAATAAAAATATTATATGGTTTATTATAAAAATATAATT
TAGAATGGGATGGGAGATAG

Downstream 100 bases:

>100_bases
TAAATTTAGTAAAATAGGAGGTAAATAGATGAAGGTTTACAATACTTTAACTAATAAAAAAGAAGAGTTTCTTACGTTAG
TACCAGGAGAAGTTAAAATG

Product: threonine dehydratase

Products: NA

Alternate protein names: Threonine deaminase [H]

Number of amino acids: Translated: 407; Mature: 407

Protein sequence:

>407_residues
MIMELNLDTIKKAQNNIKTVVRKTPLFYSSTFSRKTGYEVYLKCENKQKTGAFKLRGAYNKIVSLTEEERKKGVIASSAG
NHAQGVAYAATAFGIKSTIAMPKTAPQAKVMATKGYGAEVVQHGEVYDECYEKALEIQKATGATFVHPFNDIHVMAGQGT
IALEILEEIEDIDAIIVPIGGGGLISGIAVAAKSIKRDIKIIGVQSAIIASTKASLEKNEIVTLPGAKSLADGISVKTPG
DIAFKYIREYVDEVVTVTEDEIAYGIFELIEKTKVIAEGAGASTVAALLANKINIKGKKVVALISGGNIDIAMISKIIDR
QLIMLKRRIRFKVELQDKIGEFEDVISNIVSTGANIVKARQDTNWSEKGLEYANVIFEVEVQSKEQGDKLLKQLSEKGYN
IQTNICM

Sequences:

>Translated_407_residues
MIMELNLDTIKKAQNNIKTVVRKTPLFYSSTFSRKTGYEVYLKCENKQKTGAFKLRGAYNKIVSLTEEERKKGVIASSAG
NHAQGVAYAATAFGIKSTIAMPKTAPQAKVMATKGYGAEVVQHGEVYDECYEKALEIQKATGATFVHPFNDIHVMAGQGT
IALEILEEIEDIDAIIVPIGGGGLISGIAVAAKSIKRDIKIIGVQSAIIASTKASLEKNEIVTLPGAKSLADGISVKTPG
DIAFKYIREYVDEVVTVTEDEIAYGIFELIEKTKVIAEGAGASTVAALLANKINIKGKKVVALISGGNIDIAMISKIIDR
QLIMLKRRIRFKVELQDKIGEFEDVISNIVSTGANIVKARQDTNWSEKGLEYANVIFEVEVQSKEQGDKLLKQLSEKGYN
IQTNICM
>Mature_407_residues
MIMELNLDTIKKAQNNIKTVVRKTPLFYSSTFSRKTGYEVYLKCENKQKTGAFKLRGAYNKIVSLTEEERKKGVIASSAG
NHAQGVAYAATAFGIKSTIAMPKTAPQAKVMATKGYGAEVVQHGEVYDECYEKALEIQKATGATFVHPFNDIHVMAGQGT
IALEILEEIEDIDAIIVPIGGGGLISGIAVAAKSIKRDIKIIGVQSAIIASTKASLEKNEIVTLPGAKSLADGISVKTPG
DIAFKYIREYVDEVVTVTEDEIAYGIFELIEKTKVIAEGAGASTVAALLANKINIKGKKVVALISGGNIDIAMISKIIDR
QLIMLKRRIRFKVELQDKIGEFEDVISNIVSTGANIVKARQDTNWSEKGLEYANVIFEVEVQSKEQGDKLLKQLSEKGYN
IQTNICM

Specific function: Acts on both serine and threonine, and properly considered as a hydroxy amino acid deaminase [H]

COG id: COG1171

COG function: function code E; Threonine dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the serine/threonine dehydratase family [H]

Homologues:

Organism=Homo sapiens, GI11345492, Length=310, Percent_Identity=36.7741935483871, Blast_Score=198, Evalue=9e-51,
Organism=Homo sapiens, GI33469958, Length=321, Percent_Identity=30.2180685358255, Blast_Score=91, Evalue=2e-18,
Organism=Homo sapiens, GI19923959, Length=327, Percent_Identity=27.5229357798165, Blast_Score=86, Evalue=5e-17,
Organism=Escherichia coli, GI1789505, Length=317, Percent_Identity=47.3186119873817, Blast_Score=254, Evalue=7e-69,
Organism=Escherichia coli, GI1790207, Length=383, Percent_Identity=33.9425587467363, Blast_Score=207, Evalue=1e-54,
Organism=Caenorhabditis elegans, GI71991565, Length=384, Percent_Identity=37.7604166666667, Blast_Score=226, Evalue=2e-59,
Organism=Caenorhabditis elegans, GI17537387, Length=393, Percent_Identity=34.8600508905852, Blast_Score=188, Evalue=5e-48,
Organism=Caenorhabditis elegans, GI17508781, Length=314, Percent_Identity=30.5732484076433, Blast_Score=144, Evalue=1e-34,
Organism=Saccharomyces cerevisiae, GI6322631, Length=306, Percent_Identity=39.2156862745098, Blast_Score=201, Evalue=2e-52,
Organism=Saccharomyces cerevisiae, GI6320930, Length=399, Percent_Identity=33.0827067669173, Blast_Score=188, Evalue=1e-48,
Organism=Saccharomyces cerevisiae, GI6319788, Length=305, Percent_Identity=24.2622950819672, Blast_Score=80, Evalue=8e-16,
Organism=Drosophila melanogaster, GI21355833, Length=350, Percent_Identity=39.7142857142857, Blast_Score=205, Evalue=6e-53,
Organism=Drosophila melanogaster, GI24645328, Length=266, Percent_Identity=38.3458646616541, Blast_Score=141, Evalue=7e-34,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001926
- InterPro:   IPR000634
- InterPro:   IPR005789 [H]

Pfam domain/function: PF00291 PALP [H]

EC number: =4.3.1.19 [H]

Molecular weight: Translated: 44241; Mature: 44241

Theoretical pI: Translated: 8.88; Mature: 8.88

Prosite motif: PS00165 DEHYDRATASE_SER_THR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIMELNLDTIKKAQNNIKTVVRKTPLFYSSTFSRKTGYEVYLKCENKQKTGAFKLRGAYN
CEEECCHHHHHHHHHHHHHHHHHCCCEEECCCCCCCCCEEEEEECCCCCCCCEEECCHHH
KIVSLTEEERKKGVIASSAGNHAQGVAYAATAFGIKSTIAMPKTAPQAKVMATKGYGAEV
HHHHCCHHHHHCCEEEECCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCEEEEECCCCHHH
VQHGEVYDECYEKALEIQKATGATFVHPFNDIHVMAGQGTIALEILEEIEDIDAIIVPIG
HHCCHHHHHHHHHHHHHHHCCCCEEEECCCCEEEEECCCCCHHHHHHHHHCCCEEEEEEC
GGGLISGIAVAAKSIKRDIKIIGVQSAIIASTKASLEKNEIVTLPGAKSLADGISVKTPG
CCHHHHHHHHHHHHHHCCEEEEEEHHHHHHHHHHCCCCCCEEECCCCHHHHCCCCCCCCH
DIAFKYIREYVDEVVTVTEDEIAYGIFELIEKTKVIAEGAGASTVAALLANKINIKGKKV
HHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCEE
VALISGGNIDIAMISKIIDRQLIMLKRRIRFKVELQDKIGEFEDVISNIVSTGANIVKAR
EEEEECCCCHHHHHHHHHHHHHHHHHHHHHEEEEEHHHCCHHHHHHHHHHHCCCCEEEEC
QDTNWSEKGLEYANVIFEVEVQSKEQGDKLLKQLSEKGYNIQTNICM
CCCCHHHHCCEEEEEEEEEEECCCHHHHHHHHHHHHCCCEEEEECCC
>Mature Secondary Structure
MIMELNLDTIKKAQNNIKTVVRKTPLFYSSTFSRKTGYEVYLKCENKQKTGAFKLRGAYN
CEEECCHHHHHHHHHHHHHHHHHCCCEEECCCCCCCCCEEEEEECCCCCCCCEEECCHHH
KIVSLTEEERKKGVIASSAGNHAQGVAYAATAFGIKSTIAMPKTAPQAKVMATKGYGAEV
HHHHCCHHHHHCCEEEECCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCEEEEECCCCHHH
VQHGEVYDECYEKALEIQKATGATFVHPFNDIHVMAGQGTIALEILEEIEDIDAIIVPIG
HHCCHHHHHHHHHHHHHHHCCCCEEEECCCCEEEEECCCCCHHHHHHHHHCCCEEEEEEC
GGGLISGIAVAAKSIKRDIKIIGVQSAIIASTKASLEKNEIVTLPGAKSLADGISVKTPG
CCHHHHHHHHHHHHHHCCEEEEEEHHHHHHHHHHCCCCCCEEECCCCHHHHCCCCCCCCH
DIAFKYIREYVDEVVTVTEDEIAYGIFELIEKTKVIAEGAGASTVAALLANKINIKGKKV
HHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCEE
VALISGGNIDIAMISKIIDRQLIMLKRRIRFKVELQDKIGEFEDVISNIVSTGANIVKAR
EEEEECCCCHHHHHHHHHHHHHHHHHHHHHEEEEEHHHCCHHHHHHHHHHHCCCCEEEEC
QDTNWSEKGLEYANVIFEVEVQSKEQGDKLLKQLSEKGYNIQTNICM
CCCCHHHHCCEEEEEEEEEEECCCHHHHHHHHHHHHCCCEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA