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The map label for this gene is tkt' [C]

Identifier: 148381334

GI number: 148381334

Start: 3634973

End: 3635914

Strand: Reverse

Name: tkt' [C]

Synonym: CBO3394

Alternate gene names: 148381334

Gene position: 3635914-3634973 (Counterclockwise)

Preceding gene: 148381335

Following gene: 148381333

Centisome position: 93.54

GC content: 33.33

Gene sequence:

>942_bases
ATGGGAGTTAAAATAGCTACAAGAGAAGCATACGGAAAAACATTAGCTAAATTAGCAGAAGAAAATTCAAAGATAGTGGT
TTTAGATGCAGACCTTTCAAAATCTACTAAAACTGCCGACTTTAAAAAAGTTTGTCCAGAAAGATTTATAAATGTAGGAA
TAGCGGAAGGTAATATGATGGGAATAGCTGCAGGACTATCAACTTGTGGTAAGATTCCTTTTGCTAGTACTTTTGCAATG
TTTGCTACAGGAAGAGCTTTTGAACAAATAAGAAATTCAATATGTTATCCAAACTTAAATGTTAAAGTATGTGCAACACA
TGCAGGAGTTACAGTAGGAGAAGATGGAGCTTCTCACCAATCTGTTGAAGATATATCACTAATGAGAAGTATACCAAATA
TGACCGTTATTTGTCCCAGTGATGCAGTAGAAACAGAAGCAGCTATAAGAGCTGTAGCAGAATATAATGGACCATGTTAT
GTAAGATTAGGAAGATCAGGAGTTCCAGTTATAAATGATAACAAAGAGTATAAATTTGAGATAGGAAAAGGAATAAAGTT
AAGAGAAGGAAAGGAAGCTACTATAATAGCTACAGGAATAATGATAGATGCAGCATTAGAAGCTTATAATATGTTGGCTG
TAGAGGGGATAAAGGTAAATGTTATAAACATACATACCATAAAACCTATAGATAAAGATATTATTATAGACGCTGCAAGA
AAAACTGGAGTAGTAATTACAGCAGAAGAACATAGCATAATAGGCGGGTTAGGATCAGCTGTATGTGAAGTTTTAAGTGA
AAACCATCCAGTACCAGTTCTAAGAGTAGGAATAAAGGATACCTTTGGTGAAAGTGGTAAACCTGCAGAGTTATTAAAAA
AATATGAATTAACATCAGAAGATATAGTAAAGGCTGTAAAAAAGGGATTAAAATTAAAATAG

Upstream 100 bases:

>100_bases
AGGGTGTTTCTTTTATGGAAAATGAAGCTGGATGGCATGGTAAAGCACCAAGTGCAGAAGAATGTGAAAAAGCTATATGT
GAAATCGGAGGTGACAAATA

Downstream 100 bases:

>100_bases
TGATTTTTTATTAAAAAGGGTTGGTACTTTACCTTCCCTTTTGTATTCTTAAAATTAAAGGAAGGATATTATATGAGATA
TTATTTAGAGGATATATTAT

Product: putative transketolase, C-terminal subunit

Products: NA

Alternate protein names: TK [H]

Number of amino acids: Translated: 313; Mature: 312

Protein sequence:

>313_residues
MGVKIATREAYGKTLAKLAEENSKIVVLDADLSKSTKTADFKKVCPERFINVGIAEGNMMGIAAGLSTCGKIPFASTFAM
FATGRAFEQIRNSICYPNLNVKVCATHAGVTVGEDGASHQSVEDISLMRSIPNMTVICPSDAVETEAAIRAVAEYNGPCY
VRLGRSGVPVINDNKEYKFEIGKGIKLREGKEATIIATGIMIDAALEAYNMLAVEGIKVNVINIHTIKPIDKDIIIDAAR
KTGVVITAEEHSIIGGLGSAVCEVLSENHPVPVLRVGIKDTFGESGKPAELLKKYELTSEDIVKAVKKGLKLK

Sequences:

>Translated_313_residues
MGVKIATREAYGKTLAKLAEENSKIVVLDADLSKSTKTADFKKVCPERFINVGIAEGNMMGIAAGLSTCGKIPFASTFAM
FATGRAFEQIRNSICYPNLNVKVCATHAGVTVGEDGASHQSVEDISLMRSIPNMTVICPSDAVETEAAIRAVAEYNGPCY
VRLGRSGVPVINDNKEYKFEIGKGIKLREGKEATIIATGIMIDAALEAYNMLAVEGIKVNVINIHTIKPIDKDIIIDAAR
KTGVVITAEEHSIIGGLGSAVCEVLSENHPVPVLRVGIKDTFGESGKPAELLKKYELTSEDIVKAVKKGLKLK
>Mature_312_residues
GVKIATREAYGKTLAKLAEENSKIVVLDADLSKSTKTADFKKVCPERFINVGIAEGNMMGIAAGLSTCGKIPFASTFAMF
ATGRAFEQIRNSICYPNLNVKVCATHAGVTVGEDGASHQSVEDISLMRSIPNMTVICPSDAVETEAAIRAVAEYNGPCYV
RLGRSGVPVINDNKEYKFEIGKGIKLREGKEATIIATGIMIDAALEAYNMLAVEGIKVNVINIHTIKPIDKDIIIDAARK
TGVVITAEEHSIIGGLGSAVCEVLSENHPVPVLRVGIKDTFGESGKPAELLKKYELTSEDIVKAVKKGLKLK

Specific function: Catalyzes The Acyloin Condensation Reaction Between C Atoms 2 And 3 Of Pyruvate And Glyceraldehyde 3-Phosphate To Yield 1-Deoxy-D-Xylulose-5-Phosphate (Dxp). [C]

COG id: COG3958

COG function: function code G; Transketolase, C-terminal subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transketolase family [H]

Homologues:

Organism=Homo sapiens, GI205277463, Length=311, Percent_Identity=40.5144694533762, Blast_Score=221, Evalue=5e-58,
Organism=Homo sapiens, GI4507521, Length=311, Percent_Identity=40.5144694533762, Blast_Score=221, Evalue=5e-58,
Organism=Homo sapiens, GI225637463, Length=312, Percent_Identity=41.6666666666667, Blast_Score=209, Evalue=4e-54,
Organism=Homo sapiens, GI225637459, Length=312, Percent_Identity=41.6666666666667, Blast_Score=208, Evalue=4e-54,
Organism=Homo sapiens, GI225637461, Length=312, Percent_Identity=41.6666666666667, Blast_Score=208, Evalue=5e-54,
Organism=Homo sapiens, GI133778974, Length=310, Percent_Identity=39.6774193548387, Blast_Score=194, Evalue=7e-50,
Organism=Homo sapiens, GI291084858, Length=330, Percent_Identity=23.6363636363636, Blast_Score=75, Evalue=1e-13,
Organism=Homo sapiens, GI156564403, Length=335, Percent_Identity=23.8805970149254, Blast_Score=72, Evalue=8e-13,
Organism=Escherichia coli, GI1786622, Length=302, Percent_Identity=29.8013245033113, Blast_Score=147, Evalue=1e-36,
Organism=Escherichia coli, GI48994911, Length=327, Percent_Identity=29.6636085626911, Blast_Score=99, Evalue=3e-22,
Organism=Escherichia coli, GI1788808, Length=332, Percent_Identity=27.710843373494, Blast_Score=89, Evalue=4e-19,
Organism=Caenorhabditis elegans, GI17539652, Length=311, Percent_Identity=38.5852090032154, Blast_Score=194, Evalue=5e-50,
Organism=Caenorhabditis elegans, GI17538422, Length=294, Percent_Identity=25.8503401360544, Blast_Score=74, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI17506935, Length=209, Percent_Identity=26.7942583732057, Blast_Score=68, Evalue=6e-12,
Organism=Saccharomyces cerevisiae, GI6319593, Length=323, Percent_Identity=26.625386996904, Blast_Score=86, Evalue=9e-18,
Organism=Saccharomyces cerevisiae, GI6325331, Length=336, Percent_Identity=25.8928571428571, Blast_Score=81, Evalue=2e-16,
Organism=Drosophila melanogaster, GI24645119, Length=316, Percent_Identity=37.9746835443038, Blast_Score=195, Evalue=3e-50,
Organism=Drosophila melanogaster, GI45551847, Length=316, Percent_Identity=37.9746835443038, Blast_Score=195, Evalue=3e-50,
Organism=Drosophila melanogaster, GI45550715, Length=316, Percent_Identity=37.9746835443038, Blast_Score=195, Evalue=3e-50,
Organism=Drosophila melanogaster, GI24666278, Length=310, Percent_Identity=36.4516129032258, Blast_Score=183, Evalue=1e-46,
Organism=Drosophila melanogaster, GI21358145, Length=251, Percent_Identity=25.4980079681275, Blast_Score=70, Evalue=1e-12,
Organism=Drosophila melanogaster, GI24650940, Length=251, Percent_Identity=25.4980079681275, Blast_Score=70, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009014
- InterPro:   IPR015941
- InterPro:   IPR005475
- InterPro:   IPR020826
- InterPro:   IPR005476 [H]

Pfam domain/function: PF02779 Transket_pyr; PF02780 Transketolase_C [H]

EC number: =2.2.1.1 [H]

Molecular weight: Translated: 33481; Mature: 33350

Theoretical pI: Translated: 7.76; Mature: 7.76

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.2 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
2.2 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGVKIATREAYGKTLAKLAEENSKIVVLDADLSKSTKTADFKKVCPERFINVGIAEGNMM
CCCEEECHHHHHHHHHHHHHCCCEEEEEECCCCCCCCCCHHHHHCHHHHHEEEEECCCEE
GIAAGLSTCGKIPFASTFAMFATGRAFEQIRNSICYPNLNVKVCATHAGVTVGEDGASHQ
EEHHHHHHHCCCCCHHHHHHHHCCHHHHHHHHCCCCCCCCEEEEEEECCEEECCCCCCCC
SVEDISLMRSIPNMTVICPSDAVETEAAIRAVAEYNGPCYVRLGRSGVPVINDNKEYKFE
HHHHHHHHHHCCCCEEECCCCCHHHHHHHHHHHHCCCCEEEEECCCCCCEEECCCEEEEE
IGKGIKLREGKEATIIATGIMIDAALEAYNMLAVEGIKVNVINIHTIKPIDKDIIIDAAR
ECCCEEEECCCCEEEEEEHHHHHHHHHHHHEEEECCEEEEEEEEEEECCCCCHHEEEECC
KTGVVITAEEHSIIGGLGSAVCEVLSENHPVPVLRVGIKDTFGESGKPAELLKKYELTSE
CCCEEEEECCCCHHHHHHHHHHHHHHCCCCCCEEEECCHHHCCCCCCCHHHHHHHCCCHH
DIVKAVKKGLKLK
HHHHHHHHCCCCC
>Mature Secondary Structure 
GVKIATREAYGKTLAKLAEENSKIVVLDADLSKSTKTADFKKVCPERFINVGIAEGNMM
CCEEECHHHHHHHHHHHHHCCCEEEEEECCCCCCCCCCHHHHHCHHHHHEEEEECCCEE
GIAAGLSTCGKIPFASTFAMFATGRAFEQIRNSICYPNLNVKVCATHAGVTVGEDGASHQ
EEHHHHHHHCCCCCHHHHHHHHCCHHHHHHHHCCCCCCCCEEEEEEECCEEECCCCCCCC
SVEDISLMRSIPNMTVICPSDAVETEAAIRAVAEYNGPCYVRLGRSGVPVINDNKEYKFE
HHHHHHHHHHCCCCEEECCCCCHHHHHHHHHHHHCCCCEEEEECCCCCCEEECCCEEEEE
IGKGIKLREGKEATIIATGIMIDAALEAYNMLAVEGIKVNVINIHTIKPIDKDIIIDAAR
ECCCEEEECCCCEEEEEEHHHHHHHHHHHHEEEECCEEEEEEEEEEECCCCCHHEEEECC
KTGVVITAEEHSIIGGLGSAVCEVLSENHPVPVLRVGIKDTFGESGKPAELLKKYELTSE
CCCEEEEECCCCHHHHHHHHHHHHHHCCCCCCEEEECCHHHCCCCCCCHHHHHHHCCCHH
DIVKAVKKGLKLK
HHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]