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The map label for this gene is lysA [H]

Identifier: 148381278

GI number: 148381278

Start: 3561429

End: 3562715

Strand: Reverse

Name: lysA [H]

Synonym: CBO3336

Alternate gene names: 148381278

Gene position: 3562715-3561429 (Counterclockwise)

Preceding gene: 148381279

Following gene: 148381277

Centisome position: 91.66

GC content: 28.52

Gene sequence:

>1287_bases
ATGAAACTTTTTGGAAGTATGAATATAAAGAACAATAATTTATATATAGGTGAAATAAATACGTTAGACTTGGCTAAGAA
ATTTAAAACACCTTTATATGTAATGGATGAAACTCTTATAAGAGATAATTGTAGAAGATATGTAACTTCATTTGATAAAG
AAAAAAACAAAGTAGCTTATGCAGGAAAAGCTTTTCTTACTAAGGCTATGTGCAATTTAATAAAAGAAGAAGGGCTTTCT
TTAGATGTAGTATCAGGAGGAGAGATATTTACTGCTTATAGAAGTGGATTTCCTATGGACAAAGTGTATTTTCATGGTAA
TAATAAAACTATAGAAGAAATAGAAATGGCTATAAATTTAGGGGTCGGAACCTTTGTAGCAGATAATTTTCAGGAATTAG
ATAAGATAAACAATATCTGTAAAAATAAAAATATAAAGCAAAGAGTAATTTTAAGAATAATTCCAGGTATTGAGGCGCAT
ACCCATGAATATATTAGAACTGGCCAAATAGATTCCAAATTTGGATTTACATTAATAGATGATGGTGCTATCAAAGCAGT
AAAAAAAGCCTCTGAATTAGAAAACATACAATTTGTTGGGTTCCATTGTCATATAGGTTCTCAGATATTTGAAACAAAAC
CTTATGAAGAAGAAATAGAAATAATGCTTAGGTTAATAAAAAGAACTAATGAAGAACTAAATATAGATATAGAGGAACTA
GATTTAGGTGGGGGTTTTGGAATATATTATAAAGAGGGGGATGAACCTAAAAAAATAGAAGAGTTTTGCAAAATTATATT
AGATAAAACGAAAAGTTATTCAAAAGAGATAGGAGTTAAAGAACCTATTCTAGTAATAGAGCCAGGTAGATCTATAGTCG
GTAATTCAGGAGTTACATTGTATTCTGTAGGTTCTATTAAAGAAATCCCTAATATAGCTAAATATATAGCTGTAAATGGA
GGGATGACTGATAATATAAGACCTGCATTATATAAATCAGAATATGAATGTGTAGTATGTAACAAGGCTTTAGATAATCT
ATTAGAAGAAGTAAAAGTAGTGGGAAAATGTTGTGAATCAGGGGACATACTTATAGATAATGTAAAATTACCAATAGTAG
AAACGGATGATTTGCTCGCAATATTAAATACAGGAGCTTATGGATATTCTATGGCAAGTAATTATAATAAAGCATTATTA
CCATCTGTAGTCTTTGTTAATAATGATAAAACAAAATTAGTATGTAGAAGACAAAGCTATGAAAATTTAATACAAAATGA
AGTGTAA

Upstream 100 bases:

>100_bases
CTCAGAAATAAGAATCACTTGTGCAATAAATGTAAGGGATAAAATAAATGCTATAAATTTAGTAGTAAAAGAATTTAATT
TATAAATAGGATGTGGGAGT

Downstream 100 bases:

>100_bases
AATATTTATCAAAAACAATATAGTTACTGAAATAAATGTTTTTTAGTAATGATAAATAAAAAATCTTATTGAGTTGAATT
TGAACCAACTCAATAAGATT

Product: diaminopimelate decarboxilase

Products: NA

Alternate protein names: DAP decarboxylase [H]

Number of amino acids: Translated: 428; Mature: 428

Protein sequence:

>428_residues
MKLFGSMNIKNNNLYIGEINTLDLAKKFKTPLYVMDETLIRDNCRRYVTSFDKEKNKVAYAGKAFLTKAMCNLIKEEGLS
LDVVSGGEIFTAYRSGFPMDKVYFHGNNKTIEEIEMAINLGVGTFVADNFQELDKINNICKNKNIKQRVILRIIPGIEAH
THEYIRTGQIDSKFGFTLIDDGAIKAVKKASELENIQFVGFHCHIGSQIFETKPYEEEIEIMLRLIKRTNEELNIDIEEL
DLGGGFGIYYKEGDEPKKIEEFCKIILDKTKSYSKEIGVKEPILVIEPGRSIVGNSGVTLYSVGSIKEIPNIAKYIAVNG
GMTDNIRPALYKSEYECVVCNKALDNLLEEVKVVGKCCESGDILIDNVKLPIVETDDLLAILNTGAYGYSMASNYNKALL
PSVVFVNNDKTKLVCRRQSYENLIQNEV

Sequences:

>Translated_428_residues
MKLFGSMNIKNNNLYIGEINTLDLAKKFKTPLYVMDETLIRDNCRRYVTSFDKEKNKVAYAGKAFLTKAMCNLIKEEGLS
LDVVSGGEIFTAYRSGFPMDKVYFHGNNKTIEEIEMAINLGVGTFVADNFQELDKINNICKNKNIKQRVILRIIPGIEAH
THEYIRTGQIDSKFGFTLIDDGAIKAVKKASELENIQFVGFHCHIGSQIFETKPYEEEIEIMLRLIKRTNEELNIDIEEL
DLGGGFGIYYKEGDEPKKIEEFCKIILDKTKSYSKEIGVKEPILVIEPGRSIVGNSGVTLYSVGSIKEIPNIAKYIAVNG
GMTDNIRPALYKSEYECVVCNKALDNLLEEVKVVGKCCESGDILIDNVKLPIVETDDLLAILNTGAYGYSMASNYNKALL
PSVVFVNNDKTKLVCRRQSYENLIQNEV
>Mature_428_residues
MKLFGSMNIKNNNLYIGEINTLDLAKKFKTPLYVMDETLIRDNCRRYVTSFDKEKNKVAYAGKAFLTKAMCNLIKEEGLS
LDVVSGGEIFTAYRSGFPMDKVYFHGNNKTIEEIEMAINLGVGTFVADNFQELDKINNICKNKNIKQRVILRIIPGIEAH
THEYIRTGQIDSKFGFTLIDDGAIKAVKKASELENIQFVGFHCHIGSQIFETKPYEEEIEIMLRLIKRTNEELNIDIEEL
DLGGGFGIYYKEGDEPKKIEEFCKIILDKTKSYSKEIGVKEPILVIEPGRSIVGNSGVTLYSVGSIKEIPNIAKYIAVNG
GMTDNIRPALYKSEYECVVCNKALDNLLEEVKVVGKCCESGDILIDNVKLPIVETDDLLAILNTGAYGYSMASNYNKALL
PSVVFVNNDKTKLVCRRQSYENLIQNEV

Specific function: Lysine biosynthesis; last step. [C]

COG id: COG0019

COG function: function code E; Diaminopimelate decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the Orn/Lys/Arg decarboxylase class-II family [H]

Homologues:

Organism=Escherichia coli, GI1789203, Length=425, Percent_Identity=30.5882352941176, Blast_Score=165, Evalue=6e-42,
Organism=Drosophila melanogaster, GI24586472, Length=359, Percent_Identity=24.2339832869081, Blast_Score=70, Evalue=4e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009006
- InterPro:   IPR002986
- InterPro:   IPR022643
- InterPro:   IPR022657
- InterPro:   IPR022644
- InterPro:   IPR022653
- InterPro:   IPR000183 [H]

Pfam domain/function: PF02784 Orn_Arg_deC_N; PF00278 Orn_DAP_Arg_deC [H]

EC number: =4.1.1.20 [H]

Molecular weight: Translated: 48166; Mature: 48166

Theoretical pI: Translated: 5.43; Mature: 5.43

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.3 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
2.3 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKLFGSMNIKNNNLYIGEINTLDLAKKFKTPLYVMDETLIRDNCRRYVTSFDKEKNKVAY
CCCEECCEECCCCEEEEECCHHHHHHHHCCCEEEHHHHHHHHHHHHHHHHHCCCCCCEEE
AGKAFLTKAMCNLIKEEGLSLDVVSGGEIFTAYRSGFPMDKVYFHGNNKTIEEIEMAINL
HHHHHHHHHHHHHHHHCCCEEEEECCCCEEEHHHCCCCCCEEEEECCCCCHHHHHHHHHC
GVGTFVADNFQELDKINNICKNKNIKQRVILRIIPGIEAHTHEYIRTGQIDSKFGFTLID
CCHHHHHCCHHHHHHHHHHHHCCCHHHHHHHHHCCCCCHHHHHHHHCCCCCCCCCCEEEC
DGAIKAVKKASELENIQFVGFHCHIGSQIFETKPYEEEIEIMLRLIKRTNEELNIDIEEL
CHHHHHHHHHHHHCCEEEEEEEEECCCHHHCCCCCHHHHHHHHHHHHHCCCCCEEEHEEE
DLGGGFGIYYKEGDEPKKIEEFCKIILDKTKSYSKEIGVKEPILVIEPGRSIVGNSGVTL
ECCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCCCEECCCCEEE
YSVGSIKEIPNIAKYIAVNGGMTDNIRPALYKSEYECVVCNKALDNLLEEVKVVGKCCES
EECCCHHHCCHHHHHEEECCCCCCCCCCHHCCCCCCEEEEHHHHHHHHHHHHHHHHHCCC
GDILIDNVKLPIVETDDLLAILNTGAYGYSMASNYNKALLPSVVFVNNDKTKLVCRRQSY
CCEEEECEEEEEEECCCEEEEEECCCCCCHHHCCCCCCCCCEEEEEECCCEEEEEEHHHH
ENLIQNEV
HHHHHCCC
>Mature Secondary Structure
MKLFGSMNIKNNNLYIGEINTLDLAKKFKTPLYVMDETLIRDNCRRYVTSFDKEKNKVAY
CCCEECCEECCCCEEEEECCHHHHHHHHCCCEEEHHHHHHHHHHHHHHHHHCCCCCCEEE
AGKAFLTKAMCNLIKEEGLSLDVVSGGEIFTAYRSGFPMDKVYFHGNNKTIEEIEMAINL
HHHHHHHHHHHHHHHHCCCEEEEECCCCEEEHHHCCCCCCEEEEECCCCCHHHHHHHHHC
GVGTFVADNFQELDKINNICKNKNIKQRVILRIIPGIEAHTHEYIRTGQIDSKFGFTLID
CCHHHHHCCHHHHHHHHHHHHCCCHHHHHHHHHCCCCCHHHHHHHHCCCCCCCCCCEEEC
DGAIKAVKKASELENIQFVGFHCHIGSQIFETKPYEEEIEIMLRLIKRTNEELNIDIEEL
CHHHHHHHHHHHHCCEEEEEEEEECCCHHHCCCCCHHHHHHHHHHHHHCCCCCEEEHEEE
DLGGGFGIYYKEGDEPKKIEEFCKIILDKTKSYSKEIGVKEPILVIEPGRSIVGNSGVTL
ECCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCCCEECCCCEEE
YSVGSIKEIPNIAKYIAVNGGMTDNIRPALYKSEYECVVCNKALDNLLEEVKVVGKCCES
EECCCHHHCCHHHHHEEECCCCCCCCCCHHCCCCCCEEEEHHHHHHHHHHHHHHHHHCCC
GDILIDNVKLPIVETDDLLAILNTGAYGYSMASNYNKALLPSVVFVNNDKTKLVCRRQSY
CCEEEECEEEEEEECCCEEEEEECCCCCCHHHCCCCCCCCCEEEEEECCCEEEEEEHHHH
ENLIQNEV
HHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8215365 [H]