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The map label for this gene is lysC [H]

Identifier: 148381279

GI number: 148381279

Start: 3562731

End: 3563933

Strand: Reverse

Name: lysC [H]

Synonym: CBO3337

Alternate gene names: 148381279

Gene position: 3563933-3562731 (Counterclockwise)

Preceding gene: 148381280

Following gene: 148381278

Centisome position: 91.69

GC content: 29.01

Gene sequence:

>1203_bases
ATGGCAACAATCGTTCAAAAATATGGAGGTACATCTGTAGCAACTGTAGAAAAGATAAAAAACGTAGCCAAATTCATCGT
AAAAAGAAAAAGGGAAGGAAATGATATAGTAATTGTTGTTTCTGCTATGGGACACACTACAGATAATCTTATAAATTTAG
CTAAAGATATAAGCAATGTACCAGATAAAAGAGAATTAGATGCATTAATTTCTACAGGGGAAATGGTATCATCTTCACTT
TTATCTATGGCAATTAAGGAACTAGGGGAAGATGCTATAAGTTATACTGCTTATCAAATCAATATAAGCACTAATGGACA
ACATGGAAAATCTTTAATAAATGATATAGATAAAAAAAAGATAGATAAAAGCTTAAAGGAAGGAAAGGTCGTTGTTGTCG
CAGGATTTCAAGGAATAAATTGTGATGGTAACATAACAACTTTAGGTAGAGGGGGGTCTGATACCTCAGCAGTAGCAATA
GCAGCAAAGCTAAATAATGCTATATGTGAAATATACACAGATGTAGATGGAATATATAGTGTAGATCCAAGAGTATATGA
TAGAGCTAAAAAATTAGATTATATAGATTATGAAGAAATGTTAGAATTATCTAGCTTAGGTGCACAGGTGATGCATTCAA
GATCTATAGAATTAGCTGAAAAATATAATATACCAATTTATGTAGGATTAAGTAATAGTAATATCAAGGGAACAGTTATT
AGGAGGATGAATAATATGAATATGGAAATGAAATCAGTAACAGGATTAGCAACTAGTGATGATGATGTTGCAATAACAAT
GGAAGATATAAATGAAAATATAAACATAGTAGCAGATATATTTAGTAAATTAGCAGAAAAGCAGATTAATGTAGATATGA
TAAGCCAAACAGCACCTATAAATAGTAGAATAAGTCTATCCTTTACTATACCAAAAGAAGATTTACAGGAAGGCATGAAG
ATAATAAGAAATTATGCCTCAAAGGATAAAATAAAAATTGATGAAAACTTAACTAAATTTTCTATAGTGGGAATAGGAAT
GAAAAATACATCCGGTGTAGCAGCTAAAATGTTAAAAATTTTTAGTGATAATAATATAAAGGTAAAAATGATAACAACCT
CAGAAATAAGAATCACTTGTGCAATAAATGTAAGGGATAAAATAAATGCTATAAATTTAGTAGTAAAAGAATTTAATTTA
TAA

Upstream 100 bases:

>100_bases
TGCATTATTTTTTATTTTTATAAAATACATAAGTTAGAGTATTTATTAAATTTTAGAGAAACATTTAAAATATTTTATTT
ATAAATAGGGGGGTATTTAT

Downstream 100 bases:

>100_bases
ATAGGATGTGGGAGTATGAAACTTTTTGGAAGTATGAATATAAAGAACAATAATTTATATATAGGTGAAATAAATACGTT
AGACTTGGCTAAGAAATTTA

Product: aspartokinase II

Products: NA

Alternate protein names: Aspartate kinase 2; Aspartokinase II [H]

Number of amino acids: Translated: 400; Mature: 399

Protein sequence:

>400_residues
MATIVQKYGGTSVATVEKIKNVAKFIVKRKREGNDIVIVVSAMGHTTDNLINLAKDISNVPDKRELDALISTGEMVSSSL
LSMAIKELGEDAISYTAYQINISTNGQHGKSLINDIDKKKIDKSLKEGKVVVVAGFQGINCDGNITTLGRGGSDTSAVAI
AAKLNNAICEIYTDVDGIYSVDPRVYDRAKKLDYIDYEEMLELSSLGAQVMHSRSIELAEKYNIPIYVGLSNSNIKGTVI
RRMNNMNMEMKSVTGLATSDDDVAITMEDINENINIVADIFSKLAEKQINVDMISQTAPINSRISLSFTIPKEDLQEGMK
IIRNYASKDKIKIDENLTKFSIVGIGMKNTSGVAAKMLKIFSDNNIKVKMITTSEIRITCAINVRDKINAINLVVKEFNL

Sequences:

>Translated_400_residues
MATIVQKYGGTSVATVEKIKNVAKFIVKRKREGNDIVIVVSAMGHTTDNLINLAKDISNVPDKRELDALISTGEMVSSSL
LSMAIKELGEDAISYTAYQINISTNGQHGKSLINDIDKKKIDKSLKEGKVVVVAGFQGINCDGNITTLGRGGSDTSAVAI
AAKLNNAICEIYTDVDGIYSVDPRVYDRAKKLDYIDYEEMLELSSLGAQVMHSRSIELAEKYNIPIYVGLSNSNIKGTVI
RRMNNMNMEMKSVTGLATSDDDVAITMEDINENINIVADIFSKLAEKQINVDMISQTAPINSRISLSFTIPKEDLQEGMK
IIRNYASKDKIKIDENLTKFSIVGIGMKNTSGVAAKMLKIFSDNNIKVKMITTSEIRITCAINVRDKINAINLVVKEFNL
>Mature_399_residues
ATIVQKYGGTSVATVEKIKNVAKFIVKRKREGNDIVIVVSAMGHTTDNLINLAKDISNVPDKRELDALISTGEMVSSSLL
SMAIKELGEDAISYTAYQINISTNGQHGKSLINDIDKKKIDKSLKEGKVVVVAGFQGINCDGNITTLGRGGSDTSAVAIA
AKLNNAICEIYTDVDGIYSVDPRVYDRAKKLDYIDYEEMLELSSLGAQVMHSRSIELAEKYNIPIYVGLSNSNIKGTVIR
RMNNMNMEMKSVTGLATSDDDVAITMEDINENINIVADIFSKLAEKQINVDMISQTAPINSRISLSFTIPKEDLQEGMKI
IRNYASKDKIKIDENLTKFSIVGIGMKNTSGVAAKMLKIFSDNNIKVKMITTSEIRITCAINVRDKINAINLVVKEFNL

Specific function: Catalyzes 2 nonconsecutive reactions in the common biosynthetic pathway leading from Asp to diaminopimelate and Lys, to Met, and to Thr and Ile. [C]

COG id: COG0527

COG function: function code E; Aspartokinases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 ACT domains [H]

Homologues:

Organism=Escherichia coli, GI1786183, Length=468, Percent_Identity=25.8547008547009, Blast_Score=140, Evalue=1e-34,
Organism=Escherichia coli, GI1790455, Length=372, Percent_Identity=25, Blast_Score=115, Evalue=4e-27,
Organism=Escherichia coli, GI1790376, Length=406, Percent_Identity=26.8472906403941, Blast_Score=91, Evalue=2e-19,
Organism=Saccharomyces cerevisiae, GI6320893, Length=299, Percent_Identity=28.7625418060201, Blast_Score=106, Evalue=8e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR001048
- InterPro:   IPR005260
- InterPro:   IPR001341
- InterPro:   IPR018042 [H]

Pfam domain/function: PF00696 AA_kinase; PF01842 ACT [H]

EC number: =2.7.2.4 [H]

Molecular weight: Translated: 43893; Mature: 43762

Theoretical pI: Translated: 7.43; Mature: 7.43

Prosite motif: PS00324 ASPARTOKINASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MATIVQKYGGTSVATVEKIKNVAKFIVKRKREGNDIVIVVSAMGHTTDNLINLAKDISNV
CCCEEHHCCCCCHHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCHHHHHHHHHHHHCC
PDKRELDALISTGEMVSSSLLSMAIKELGEDAISYTAYQINISTNGQHGKSLINDIDKKK
CCHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHEEEEEEEEEECCCCHHHHHHHHHHHHH
IDKSLKEGKVVVVAGFQGINCDGNITTLGRGGSDTSAVAIAAKLNNAICEIYTDVDGIYS
HHHHHHCCCEEEEECCCCCCCCCCEEEECCCCCCCCCEEEEEHHCCCEEEEEECCCCEEE
VDPRVYDRAKKLDYIDYEEMLELSSLGAQVMHSRSIELAEKYNIPIYVGLSNSNIKGTVI
CCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHCCCEEEEEECCCCCCCCEE
RRMNNMNMEMKSVTGLATSDDDVAITMEDINENINIVADIFSKLAEKQINVDMISQTAPI
EHHCCCCEEEHHHCCCCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHCCCCEEECCCCCC
NSRISLSFTIPKEDLQEGMKIIRNYASKDKIKIDENLTKFSIVGIGMKNTSGVAAKMLKI
CCEEEEEEECCHHHHHHHHHHHHHHCCCCCEEECCCCEEEEEEEECCCCCCHHHHHHHHH
FSDNNIKVKMITTSEIRITCAINVRDKINAINLVVKEFNL
HCCCCEEEEEEEECEEEEEEEEECCCCCCCEEEEEEECCC
>Mature Secondary Structure 
ATIVQKYGGTSVATVEKIKNVAKFIVKRKREGNDIVIVVSAMGHTTDNLINLAKDISNV
CCEEHHCCCCCHHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCHHHHHHHHHHHHCC
PDKRELDALISTGEMVSSSLLSMAIKELGEDAISYTAYQINISTNGQHGKSLINDIDKKK
CCHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHEEEEEEEEEECCCCHHHHHHHHHHHHH
IDKSLKEGKVVVVAGFQGINCDGNITTLGRGGSDTSAVAIAAKLNNAICEIYTDVDGIYS
HHHHHHCCCEEEEECCCCCCCCCCEEEECCCCCCCCCEEEEEHHCCCEEEEEECCCCEEE
VDPRVYDRAKKLDYIDYEEMLELSSLGAQVMHSRSIELAEKYNIPIYVGLSNSNIKGTVI
CCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHCCCEEEEEECCCCCCCCEE
RRMNNMNMEMKSVTGLATSDDDVAITMEDINENINIVADIFSKLAEKQINVDMISQTAPI
EHHCCCCEEEHHHCCCCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHCCCCEEECCCCCC
NSRISLSFTIPKEDLQEGMKIIRNYASKDKIKIDENLTKFSIVGIGMKNTSGVAAKMLKI
CCEEEEEEECCHHHHHHHHHHHHHHCCCCCEEECCCCEEEEEEEECCCCCCHHHHHHHHH
FSDNNIKVKMITTSEIRITCAINVRDKINAINLVVKEFNL
HCCCCEEEEEEEECEEEEEEEEECCCCCCCEEEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8635739 [H]