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The map label for this gene is zwf [H]

Identifier: 148360967

GI number: 148360967

Start: 507048

End: 508538

Strand: Direct

Name: zwf [H]

Synonym: LPC_2927

Alternate gene names: 148360967

Gene position: 507048-508538 (Clockwise)

Preceding gene: 148360969

Following gene: 148360966

Centisome position: 14.18

GC content: 37.76

Gene sequence:

>1491_bases
ATGCTCTTAAAAGCAGAATCGAAGTATCCTTGTGATTTAATTTTGTTTGGTACGCTGGGTGACTTGTCTTGTCGAAAATT
GTTGCCCGCATTATATCAACTAGAACTGGCTAATTTACTTCACGAAAAAACAAGAATTATTGGGTGTGCCCGAGAAGAGC
TCGATTTTTCTGCTTATGCTGACTTGATTAAAAATAAAATTCAGCAATTTTTATTTGATGAAATTGATGAAGCAGTCTGG
TTACGTTTTATAAAGAAACTGGCTTATTGCAAGCTTGATCTGAATCAATCAGATGATTATCAAAAATTAACGGACTATGT
TAACCCTTCTGAGCGAGTGGTTATTTCTTACTTGGCAATTCCTCCAAGCCTTTATTCTCAAACTTGCCGCAGTCTTGCTC
GCCTTAATCTAACCCAGAAACCATCGCGAGTTGTTTTGGAAAAACCTATTGGTCATGATTTGCCTTCTTCTGTAGCAACC
AACGAACAAGTGGCTTGTTTTTTTTCTGAAGATCAGATTTATCGAATTGATCATTATCTGGGTAAAGAAACCGTCTTGAA
TTTATTAGTGCTTCGCTTTGCTAATTCCATATTTTCAACCAATTGGGATAATCGCGTTATTGATCGAGTTGAAATTTCTG
TTGCCGAAGAAATCGGTGTTGAAGGCCGTTGGGAATATTATGATAAGTCGGGCCAAGTCAGGGACATGCTGCAAAATCAT
TTGTTACAAATATTATCTTTAGTTGCGATGGAACCCCCCTTAAGCCTTTCAGCAGAAAGTATCAGAAGCGAAAAATTAAA
AGTACTGAAATCTTTGCGTTTTATTAACAAGTCCAATGCTCATGATCATACAGTACGAGCTCAATATGTGGCTAATAATT
TAGCAAATGGTAAAAAAATACCTGGTTATTTGGAAGAGGTGGGTGCTAATCAGGCATCTACAACAGAAACTTTTGTTGCT
ATCAAAGCCTATGTTGATAATTGGCGATGGTCTGGTGTTCCATTCTATATGCTTACTGGCAAAAGATTACCCAAAAAGCA
AAGCGAAGTGGTTATTTATTTTAAACCACAGCCTTATAATATCTTTCATCCCTTAAATGAAGAATTGTACCCTAATCAGT
TAATTATTCGCTTACAACCCGATGAAGGGGTGGAGGTGAGGATAATGAATAAAATTCCGGGTCTTGGTGAGCGTATGATG
TTGCATGATTCCAAGTTGGATTTAAATTTCCATCATAGTTTTAAAACGCAAAGGATTGCTGATGCCTATGAGAGATTATT
GCTAGAGGTCATGTTAGGTAATCAGTATCTTTTTGTAAGCCGAGAAGAAATTGAACAGGCTTGGCAATGGATTGACAGTA
TTGTATCGGCATGGGAAGAAGATAATATTCCGCTGTATACCTATCCAGCTTGTACCTGGGGGCCAAAGGAAGTCATACGC
TTATTTAACGGGCAAGCACATGTTTGGGGTGATCACAATGCAGTTTCATAG

Upstream 100 bases:

>100_bases
AGAATGAGCGAAAAAAATCAATTTTGATTGACGCTTGATTCCAGTGATGTAAAATCGATGCAATTTCAGGGACATAGTTA
TTGTAACTTTGGGATGATAT

Downstream 100 bases:

>100_bases
TTTTAGGGATGCCAAACAGTTGATTCATGACATGGTGGAAAAATTAAGAACTATTCTATCAGATGCAATCAAACGAAGAG
GGCAAGCTTTTTTGGTGGTT

Product: glucose-6-phosphate 1-dehydrogenase

Products: NA

Alternate protein names: G6PD [H]

Number of amino acids: Translated: 496; Mature: 496

Protein sequence:

>496_residues
MLLKAESKYPCDLILFGTLGDLSCRKLLPALYQLELANLLHEKTRIIGCAREELDFSAYADLIKNKIQQFLFDEIDEAVW
LRFIKKLAYCKLDLNQSDDYQKLTDYVNPSERVVISYLAIPPSLYSQTCRSLARLNLTQKPSRVVLEKPIGHDLPSSVAT
NEQVACFFSEDQIYRIDHYLGKETVLNLLVLRFANSIFSTNWDNRVIDRVEISVAEEIGVEGRWEYYDKSGQVRDMLQNH
LLQILSLVAMEPPLSLSAESIRSEKLKVLKSLRFINKSNAHDHTVRAQYVANNLANGKKIPGYLEEVGANQASTTETFVA
IKAYVDNWRWSGVPFYMLTGKRLPKKQSEVVIYFKPQPYNIFHPLNEELYPNQLIIRLQPDEGVEVRIMNKIPGLGERMM
LHDSKLDLNFHHSFKTQRIADAYERLLLEVMLGNQYLFVSREEIEQAWQWIDSIVSAWEEDNIPLYTYPACTWGPKEVIR
LFNGQAHVWGDHNAVS

Sequences:

>Translated_496_residues
MLLKAESKYPCDLILFGTLGDLSCRKLLPALYQLELANLLHEKTRIIGCAREELDFSAYADLIKNKIQQFLFDEIDEAVW
LRFIKKLAYCKLDLNQSDDYQKLTDYVNPSERVVISYLAIPPSLYSQTCRSLARLNLTQKPSRVVLEKPIGHDLPSSVAT
NEQVACFFSEDQIYRIDHYLGKETVLNLLVLRFANSIFSTNWDNRVIDRVEISVAEEIGVEGRWEYYDKSGQVRDMLQNH
LLQILSLVAMEPPLSLSAESIRSEKLKVLKSLRFINKSNAHDHTVRAQYVANNLANGKKIPGYLEEVGANQASTTETFVA
IKAYVDNWRWSGVPFYMLTGKRLPKKQSEVVIYFKPQPYNIFHPLNEELYPNQLIIRLQPDEGVEVRIMNKIPGLGERMM
LHDSKLDLNFHHSFKTQRIADAYERLLLEVMLGNQYLFVSREEIEQAWQWIDSIVSAWEEDNIPLYTYPACTWGPKEVIR
LFNGQAHVWGDHNAVS
>Mature_496_residues
MLLKAESKYPCDLILFGTLGDLSCRKLLPALYQLELANLLHEKTRIIGCAREELDFSAYADLIKNKIQQFLFDEIDEAVW
LRFIKKLAYCKLDLNQSDDYQKLTDYVNPSERVVISYLAIPPSLYSQTCRSLARLNLTQKPSRVVLEKPIGHDLPSSVAT
NEQVACFFSEDQIYRIDHYLGKETVLNLLVLRFANSIFSTNWDNRVIDRVEISVAEEIGVEGRWEYYDKSGQVRDMLQNH
LLQILSLVAMEPPLSLSAESIRSEKLKVLKSLRFINKSNAHDHTVRAQYVANNLANGKKIPGYLEEVGANQASTTETFVA
IKAYVDNWRWSGVPFYMLTGKRLPKKQSEVVIYFKPQPYNIFHPLNEELYPNQLIIRLQPDEGVEVRIMNKIPGLGERMM
LHDSKLDLNFHHSFKTQRIADAYERLLLEVMLGNQYLFVSREEIEQAWQWIDSIVSAWEEDNIPLYTYPACTWGPKEVIR
LFNGQAHVWGDHNAVS

Specific function: Pentose phosphate pathway; first step. [C]

COG id: COG0364

COG function: function code G; Glucose-6-phosphate 1-dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glucose-6-phosphate dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI109389365, Length=475, Percent_Identity=37.4736842105263, Blast_Score=303, Evalue=2e-82,
Organism=Homo sapiens, GI108773793, Length=475, Percent_Identity=37.4736842105263, Blast_Score=303, Evalue=3e-82,
Organism=Homo sapiens, GI52145310, Length=505, Percent_Identity=27.9207920792079, Blast_Score=165, Evalue=1e-40,
Organism=Escherichia coli, GI1788158, Length=487, Percent_Identity=53.1827515400411, Blast_Score=558, Evalue=1e-160,
Organism=Caenorhabditis elegans, GI17538218, Length=487, Percent_Identity=37.9876796714579, Blast_Score=308, Evalue=3e-84,
Organism=Saccharomyces cerevisiae, GI6324088, Length=474, Percent_Identity=34.1772151898734, Blast_Score=261, Evalue=1e-70,
Organism=Drosophila melanogaster, GI24643350, Length=485, Percent_Identity=36.4948453608247, Blast_Score=290, Evalue=1e-78,
Organism=Drosophila melanogaster, GI24643352, Length=485, Percent_Identity=36.4948453608247, Blast_Score=290, Evalue=1e-78,
Organism=Drosophila melanogaster, GI221513548, Length=480, Percent_Identity=28.9583333333333, Blast_Score=189, Evalue=4e-48,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001282
- InterPro:   IPR019796
- InterPro:   IPR022675
- InterPro:   IPR022674
- InterPro:   IPR016040 [H]

Pfam domain/function: PF02781 G6PD_C; PF00479 G6PD_N [H]

EC number: =1.1.1.49 [H]

Molecular weight: Translated: 57269; Mature: 57269

Theoretical pI: Translated: 6.25; Mature: 6.25

Prosite motif: PS00069 G6P_DEHYDROGENASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLLKAESKYPCDLILFGTLGDLSCRKLLPALYQLELANLLHEKTRIIGCAREELDFSAYA
CCCCCCCCCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHH
DLIKNKIQQFLFDEIDEAVWLRFIKKLAYCKLDLNQSDDYQKLTDYVNPSERVVISYLAI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEECCCCCCHHHHHHCCCCCCCEEEEEEEC
PPSLYSQTCRSLARLNLTQKPSRVVLEKPIGHDLPSSVATNEQVACFFSEDQIYRIDHYL
CHHHHHHHHHHHHHCCCCCCCCCEEEECCCCCCCCCCCCCCCCEEEEECCCCEEEHHHHC
GKETVLNLLVLRFANSIFSTNWDNRVIDRVEISVAEEIGVEGRWEYYDKSGQVRDMLQNH
CHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCCEEEECCCCHHHHHHHHH
LLQILSLVAMEPPLSLSAESIRSEKLKVLKSLRFINKSNAHDHTVRAQYVANNLANGKKI
HHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCCCC
PGYLEEVGANQASTTETFVAIKAYVDNWRWSGVPFYMLTGKRLPKKQSEVVIYFKPQPYN
CCHHHHHCCCCCCCHHHHHHHEEHHCCCCCCCCCEEEECCCCCCCCCCCEEEEECCCCCC
IFHPLNEELYPNQLIIRLQPDEGVEVRIMNKIPGLGERMMLHDSKLDLNFHHSFKTQRIA
CCCCCCCCCCCCEEEEEECCCCCCEEEEECCCCCCCCCCEEECCCCCEEECCCHHHHHHH
DAYERLLLEVMLGNQYLFVSREEIEQAWQWIDSIVSAWEEDNIPLYTYPACTWGPKEVIR
HHHHHHHHHHHHCCEEEEEEHHHHHHHHHHHHHHHHHHCCCCCCEEECCCCCCCHHHHHH
LFNGQAHVWGDHNAVS
HHCCCEEEECCCCCCC
>Mature Secondary Structure
MLLKAESKYPCDLILFGTLGDLSCRKLLPALYQLELANLLHEKTRIIGCAREELDFSAYA
CCCCCCCCCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHH
DLIKNKIQQFLFDEIDEAVWLRFIKKLAYCKLDLNQSDDYQKLTDYVNPSERVVISYLAI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEECCCCCCHHHHHHCCCCCCCEEEEEEEC
PPSLYSQTCRSLARLNLTQKPSRVVLEKPIGHDLPSSVATNEQVACFFSEDQIYRIDHYL
CHHHHHHHHHHHHHCCCCCCCCCEEEECCCCCCCCCCCCCCCCEEEEECCCCEEEHHHHC
GKETVLNLLVLRFANSIFSTNWDNRVIDRVEISVAEEIGVEGRWEYYDKSGQVRDMLQNH
CHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCCEEEECCCCHHHHHHHHH
LLQILSLVAMEPPLSLSAESIRSEKLKVLKSLRFINKSNAHDHTVRAQYVANNLANGKKI
HHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCCCC
PGYLEEVGANQASTTETFVAIKAYVDNWRWSGVPFYMLTGKRLPKKQSEVVIYFKPQPYN
CCHHHHHCCCCCCCHHHHHHHEEHHCCCCCCCCCEEEECCCCCCCCCCCEEEEECCCCCC
IFHPLNEELYPNQLIIRLQPDEGVEVRIMNKIPGLGERMMLHDSKLDLNFHHSFKTQRIA
CCCCCCCCCCCCEEEEEECCCCCCEEEEECCCCCCCCCCEEECCCCCEEECCCHHHHHHH
DAYERLLLEVMLGNQYLFVSREEIEQAWQWIDSIVSAWEEDNIPLYTYPACTWGPKEVIR
HHHHHHHHHHHHCCEEEEEEHHHHHHHHHHHHHHHHHHCCCCCCEEECCCCCCCHHHHHH
LFNGQAHVWGDHNAVS
HHCCCEEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8145647 [H]