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The map label for this gene is edd [H]

Identifier: 148360965

GI number: 148360965

Start: 509226

End: 511064

Strand: Direct

Name: edd [H]

Synonym: LPC_2925

Alternate gene names: 148360965

Gene position: 509226-511064 (Clockwise)

Preceding gene: 148360966

Following gene: 148360964

Centisome position: 14.24

GC content: 43.18

Gene sequence:

>1839_bases
ATGCATCCTGTAATAAATCAAGTGACAGAAAATATCCAAAATCGTAGCGCTTCTAGAAGAGCAGCTTATCTGAATCAAAT
CGATAAGGCTCGTACTAAAGGCCCACAACGAAGTATTCTGCATTGTGGGAATTTGGCACATGGCTTCGCTGCTTGTGCTA
AACAGGACAAGGCTATTTTGAGAGGTAATGCAAAAGCCAATATTGCCATTATTTCGGCATATAACGATATGTTATCGGCG
CATCAACCGTATGCTGTTTTTCCTGATTTGATTAAGGAAGCGATCTCTGCTGCAGGAGGAGTTGCGCAATTTGCCGGGGG
CGTCCCAGCCATGTGCGATGGGATTACTCAGGGACAACCAGGGATGGAATTAAGTTTACTCAGCCGGGATGTGATCGCTT
TATCGACTGCTGTTGCTTTGTCACATAACATGTTTGATGGAGGGCTCCTCTTAGGTATTTGCGATAAAATAGTCCCTGGA
TTATTAATGGCTGCGCTGGCATTTGGCCATCTGCCTTTTATTTTTGTACCCGCGGGCCCAATGCCCTCTGGTATCTCCAA
TCAGGAAAAAGCAAGAATTCGTCAATTGTACGCAGCAGGCCAAGTCGACAAAAATGCCTTATTGGATGTGGAAGCAGCCT
CCTATCATACGGCTGGAACATGCACATTTTATGGTACGGCCAATTCAAATCAATTAGTTATTGAACTGATGGGGCTGCAG
CTCCCAGGCTCTTCCTTCGTGAATCCTAATACCCCGTTGCGCAATGAATTAACCAAAGCAGCAGCATGTCAGATTTTGTC
ATTAACAGATTTAAATTCTGATTATATGCCAATAGGGCAGATGCTTGATGTGAAAAATATTGTAAACGGTATTATCGGAT
TATTGGCTTCAGGGGGATCGACCAATCATACCATGCACCTCGTTGCGATAGCGGCTATGGCAGGGTATTGGGTAAATTGG
GATGATTTTGCGCAATTGTCGGCAATTATTCCATTAATCGCTCGAATTTATCCTAATGGTCAAGCAGACATCAATCATTT
TCAAAGAGCTGGAGGCATGGCTTATTTTGTTAAAACCTTGCTAGAGGCCGATTTACTTCATCCTGATGTCAACACAGTCG
TGGGTTTTGGACTGGATAAATATACGCAGCAGCCGCAATTGATTGACAATCGAGTGGTTTGGGTTAATGGTCCTGACAGC
TCAAGCAATAATGACGTATTAACCTCTGCTGCCGATCCATTTAAACCTCAGGGTGGTTTGCAGGTTTTAAGTGGCAATCT
TGGTAGAGCAATTATTAAGACGTCCAGTCTTTATGATGAGCATTATGTGATAGAAGCTCCCGCAGTCGTTTGCTCAAGCC
AAGAGGAATTTGAATATCTATTCAATCAAGGTTTGCTTAATAAAAATTGTGTGGTGGTAGTTCGTTTTCAAGGCCCAAAA
GCATGTGGAATGCCAGAATTACATCAATTAACGCCAAAACTTGGTGTGTTGATGGATAAAGGGTTTCATGTGGCATTGGT
TACTGATGGTCGAATGTCTGGCGCATCGGGCAAGGTTCCCGCTGCAATTCACGTTACTCCGGAAGCGGTTGATGGGGGCG
GGATTGCTAAAATTGAAACGGGCGATATGATTTTGATCGATTGTGAAAGAGGAATACTTCAATTATTAGTTTCTGATGAA
GAGTTAGCAGGCCGCTCTCCAGTTGCTATCGAAGGGTATTCCTCTGTTCTAGGCATGGGACGAGAATTGTTTGGTAATTT
AAGATTACATTTTACTGGTGCAGAACAGGGGGCATGTAGTCTATTTAAAGGAAATGAATTTTTTTATGATGCCTCATGA

Upstream 100 bases:

>100_bases
TGGCAACTAACAACCCGGAGATCCTGCCAATCTGCGCTATTTTAAATGCCCCGGATGCCAATGTTCAGGTGATGTATGCT
CCAAGCGATGAGGAAAAAGA

Downstream 100 bases:

>100_bases
TTTAGCGCAGTATGCGATTGTTGCGGACATAGGCGGTACTTTTGCTCGTTTCAGTAGAGTTAATCTTGTCAATTTGCAGA
TGGATAAAATTGAAATTTCT

Product: phosphogluconate dehydratase

Products: NA

Alternate protein names: 6-phosphogluconate dehydratase [H]

Number of amino acids: Translated: 612; Mature: 612

Protein sequence:

>612_residues
MHPVINQVTENIQNRSASRRAAYLNQIDKARTKGPQRSILHCGNLAHGFAACAKQDKAILRGNAKANIAIISAYNDMLSA
HQPYAVFPDLIKEAISAAGGVAQFAGGVPAMCDGITQGQPGMELSLLSRDVIALSTAVALSHNMFDGGLLLGICDKIVPG
LLMAALAFGHLPFIFVPAGPMPSGISNQEKARIRQLYAAGQVDKNALLDVEAASYHTAGTCTFYGTANSNQLVIELMGLQ
LPGSSFVNPNTPLRNELTKAAACQILSLTDLNSDYMPIGQMLDVKNIVNGIIGLLASGGSTNHTMHLVAIAAMAGYWVNW
DDFAQLSAIIPLIARIYPNGQADINHFQRAGGMAYFVKTLLEADLLHPDVNTVVGFGLDKYTQQPQLIDNRVVWVNGPDS
SSNNDVLTSAADPFKPQGGLQVLSGNLGRAIIKTSSLYDEHYVIEAPAVVCSSQEEFEYLFNQGLLNKNCVVVVRFQGPK
ACGMPELHQLTPKLGVLMDKGFHVALVTDGRMSGASGKVPAAIHVTPEAVDGGGIAKIETGDMILIDCERGILQLLVSDE
ELAGRSPVAIEGYSSVLGMGRELFGNLRLHFTGAEQGACSLFKGNEFFYDAS

Sequences:

>Translated_612_residues
MHPVINQVTENIQNRSASRRAAYLNQIDKARTKGPQRSILHCGNLAHGFAACAKQDKAILRGNAKANIAIISAYNDMLSA
HQPYAVFPDLIKEAISAAGGVAQFAGGVPAMCDGITQGQPGMELSLLSRDVIALSTAVALSHNMFDGGLLLGICDKIVPG
LLMAALAFGHLPFIFVPAGPMPSGISNQEKARIRQLYAAGQVDKNALLDVEAASYHTAGTCTFYGTANSNQLVIELMGLQ
LPGSSFVNPNTPLRNELTKAAACQILSLTDLNSDYMPIGQMLDVKNIVNGIIGLLASGGSTNHTMHLVAIAAMAGYWVNW
DDFAQLSAIIPLIARIYPNGQADINHFQRAGGMAYFVKTLLEADLLHPDVNTVVGFGLDKYTQQPQLIDNRVVWVNGPDS
SSNNDVLTSAADPFKPQGGLQVLSGNLGRAIIKTSSLYDEHYVIEAPAVVCSSQEEFEYLFNQGLLNKNCVVVVRFQGPK
ACGMPELHQLTPKLGVLMDKGFHVALVTDGRMSGASGKVPAAIHVTPEAVDGGGIAKIETGDMILIDCERGILQLLVSDE
ELAGRSPVAIEGYSSVLGMGRELFGNLRLHFTGAEQGACSLFKGNEFFYDAS
>Mature_612_residues
MHPVINQVTENIQNRSASRRAAYLNQIDKARTKGPQRSILHCGNLAHGFAACAKQDKAILRGNAKANIAIISAYNDMLSA
HQPYAVFPDLIKEAISAAGGVAQFAGGVPAMCDGITQGQPGMELSLLSRDVIALSTAVALSHNMFDGGLLLGICDKIVPG
LLMAALAFGHLPFIFVPAGPMPSGISNQEKARIRQLYAAGQVDKNALLDVEAASYHTAGTCTFYGTANSNQLVIELMGLQ
LPGSSFVNPNTPLRNELTKAAACQILSLTDLNSDYMPIGQMLDVKNIVNGIIGLLASGGSTNHTMHLVAIAAMAGYWVNW
DDFAQLSAIIPLIARIYPNGQADINHFQRAGGMAYFVKTLLEADLLHPDVNTVVGFGLDKYTQQPQLIDNRVVWVNGPDS
SSNNDVLTSAADPFKPQGGLQVLSGNLGRAIIKTSSLYDEHYVIEAPAVVCSSQEEFEYLFNQGLLNKNCVVVVRFQGPK
ACGMPELHQLTPKLGVLMDKGFHVALVTDGRMSGASGKVPAAIHVTPEAVDGGGIAKIETGDMILIDCERGILQLLVSDE
ELAGRSPVAIEGYSSVLGMGRELFGNLRLHFTGAEQGACSLFKGNEFFYDAS

Specific function: KEY ENZYME IN THE ENTNER-DOUDOROFF PATHWAY. [C]

COG id: COG0129

COG function: function code EG; Dihydroxyacid dehydratase/phosphogluconate dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ilvD/edd family [H]

Homologues:

Organism=Escherichia coli, GI1788157, Length=603, Percent_Identity=61.1940298507463, Blast_Score=758, Evalue=0.0,
Organism=Escherichia coli, GI48994964, Length=537, Percent_Identity=31.6573556797021, Blast_Score=195, Evalue=7e-51,
Organism=Escherichia coli, GI2367371, Length=490, Percent_Identity=30.6122448979592, Blast_Score=146, Evalue=4e-36,
Organism=Escherichia coli, GI1786464, Length=493, Percent_Identity=26.9776876267748, Blast_Score=119, Evalue=7e-28,
Organism=Saccharomyces cerevisiae, GI6322476, Length=478, Percent_Identity=30.9623430962343, Blast_Score=172, Evalue=2e-43,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004786
- InterPro:   IPR015928
- InterPro:   IPR000581
- InterPro:   IPR020558 [H]

Pfam domain/function: PF00920 ILVD_EDD [H]

EC number: =4.2.1.12 [H]

Molecular weight: Translated: 65221; Mature: 65221

Theoretical pI: Translated: 6.08; Mature: 6.08

Prosite motif: PS00886 ILVD_EDD_1 ; PS00887 ILVD_EDD_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHPVINQVTENIQNRSASRRAAYLNQIDKARTKGPQRSILHCGNLAHGFAACAKQDKAIL
CCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCHHHHHHCCHHHHHHHHHHCCCHHH
RGNAKANIAIISAYNDMLSAHQPYAVFPDLIKEAISAAGGVAQFAGGVPAMCDGITQGQP
CCCCCCCEEEEEECHHHHHCCCCCHHHHHHHHHHHHHCCCHHHHHCCCCHHHCCCCCCCC
GMELSLLSRDVIALSTAVALSHNMFDGGLLLGICDKIVPGLLMAALAFGHLPFIFVPAGP
CCCHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCC
MPSGISNQEKARIRQLYAAGQVDKNALLDVEAASYHTAGTCTFYGTANSNQLVIELMGLQ
CCCCCCCHHHHHHHHHHHCCCCCCCCEEEEECCCCCCCCEEEEEECCCCCEEEEEEEEEC
LPGSSFVNPNTPLRNELTKAAACQILSLTDLNSDYMPIGQMLDVKNIVNGIIGLLASGGS
CCCCCCCCCCCCHHHHHHHHHHHEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHCCCC
TNHTMHLVAIAAMAGYWVNWDDFAQLSAIIPLIARIYPNGQADINHFQRAGGMAYFVKTL
CCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCHHHHHHHH
LEADLLHPDVNTVVGFGLDKYTQQPQLIDNRVVWVNGPDSSSNNDVLTSAADPFKPQGGL
HHHHHCCCCHHHHHCCCHHHHCCCCHHHCCEEEEEECCCCCCCCCEEECCCCCCCCCCCC
QVLSGNLGRAIIKTSSLYDEHYVIEAPAVVCSSQEEFEYLFNQGLLNKNCVVVVRFQGPK
EEECCCCCCEEEECCCCCCCCEEEECCHHEECCHHHHHHHHHCCCCCCCCEEEEEECCCC
ACGMPELHQLTPKLGVLMDKGFHVALVTDGRMSGASGKVPAAIHVTPEAVDGGGIAKIET
CCCCCHHHHHCCHHHHEECCCEEEEEEECCCCCCCCCCCCEEEEECCCCCCCCCEEEEEC
GDMILIDCERGILQLLVSDEELAGRSPVAIEGYSSVLGMGRELFGNLRLHFTGAEQGACS
CCEEEEECCCCHHHHHCCCHHHCCCCCEEECCHHHHHHCCHHHHCCEEEEEECCCCCCEE
LFKGNEFFYDAS
EEECCEEEEECC
>Mature Secondary Structure
MHPVINQVTENIQNRSASRRAAYLNQIDKARTKGPQRSILHCGNLAHGFAACAKQDKAIL
CCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCHHHHHHCCHHHHHHHHHHCCCHHH
RGNAKANIAIISAYNDMLSAHQPYAVFPDLIKEAISAAGGVAQFAGGVPAMCDGITQGQP
CCCCCCCEEEEEECHHHHHCCCCCHHHHHHHHHHHHHCCCHHHHHCCCCHHHCCCCCCCC
GMELSLLSRDVIALSTAVALSHNMFDGGLLLGICDKIVPGLLMAALAFGHLPFIFVPAGP
CCCHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCC
MPSGISNQEKARIRQLYAAGQVDKNALLDVEAASYHTAGTCTFYGTANSNQLVIELMGLQ
CCCCCCCHHHHHHHHHHHCCCCCCCCEEEEECCCCCCCCEEEEEECCCCCEEEEEEEEEC
LPGSSFVNPNTPLRNELTKAAACQILSLTDLNSDYMPIGQMLDVKNIVNGIIGLLASGGS
CCCCCCCCCCCCHHHHHHHHHHHEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHCCCC
TNHTMHLVAIAAMAGYWVNWDDFAQLSAIIPLIARIYPNGQADINHFQRAGGMAYFVKTL
CCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCHHHHHHHH
LEADLLHPDVNTVVGFGLDKYTQQPQLIDNRVVWVNGPDSSSNNDVLTSAADPFKPQGGL
HHHHHCCCCHHHHHCCCHHHHCCCCHHHCCEEEEEECCCCCCCCCEEECCCCCCCCCCCC
QVLSGNLGRAIIKTSSLYDEHYVIEAPAVVCSSQEEFEYLFNQGLLNKNCVVVVRFQGPK
EEECCCCCCEEEECCCCCCCCEEEECCHHEECCHHHHHHHHHCCCCCCCCEEEEEECCCC
ACGMPELHQLTPKLGVLMDKGFHVALVTDGRMSGASGKVPAAIHVTPEAVDGGGIAKIET
CCCCCHHHHHCCHHHHEECCCEEEEEEECCCCCCCCCCCCEEEEECCCCCCCCCEEEEEC
GDMILIDCERGILQLLVSDEELAGRSPVAIEGYSSVLGMGRELFGNLRLHFTGAEQGACS
CCEEEEECCCCHHHHHCCCHHHCCCCCEEECCHHHHHHCCHHHHCCEEEEEECCCCCCEE
LFKGNEFFYDAS
EEECCEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]