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The map label for this gene is oprM [H]

Identifier: 148360954

GI number: 148360954

Start: 519460

End: 520803

Strand: Direct

Name: oprM [H]

Synonym: LPC_2914

Alternate gene names: 148360954

Gene position: 519460-520803 (Clockwise)

Preceding gene: 148360956

Following gene: 148360953

Centisome position: 14.52

GC content: 38.24

Gene sequence:

>1344_bases
ATGCTTAAAAAATTAATGTTCTTATTATTGTTGGGAGCAGGTTTGTTAAGCTGTGGTCAAAGCACTGATCAGCAAATTTC
CAATATTATAACGCCGAAGCAATTCCCCTCCAGTCCCAGGGATTATCGACCAGTTCAGGAGTTGCCTTATTTGGCCTGGT
GGAAGCAATTTCAGGATCCAGAATTGGATCGTTTAATTGATACTGGATTGAAGACCAATATGGATATTCATATTGCAATG
GCTAATTTACAGCAAGCTCAAGGAGAGTTACAGCAAGTGAAGTTGAGTTGGATACCTAATGTTCAAATATTGGGAGGGTA
TTCAACTAATCCTGCTCTTGGTGTGCCAGGAGGGTTTTATGGAATATGGCCAAGTTATATTTTGAATATTATGCAACTTT
ATACTCAGCAAAAGCGTGCTCAATATCAGGTCCAATATCATCAGGCAGCAATCGATGGTTTGCGTTTGACCTTGATTGGT
CAGGTGGCAGCGGCTTATTTCACTTTGATTGCACAGTTGGAGCAACTTAAATTATTGTATAAACTGGATAGGGATTTAAA
GTCGTTAATTGCTTTGAGCAGGAAAGAAATCAACATAGGATTAAAAAATGATATTGATTTGGCTCAGTTGCAATCCAACG
AGCGCTTGATTGCAGCACAAATAAAACCCATTAAACACAACATTGTCGTTAGTCAGAATGCGTTGCGTTATTTAATAAAT
GAGAATCCTGGTTTAATCAAAAGCAAAAATAATTTTGCTCAATTGGATTTTACCCGCTTTAAACCAGGAAGTTTACCCGC
TAGCGTATTAAGTAATCGCCCTGATATGAAGATGGCGGAGTATTCCCTAAAAGCGGCTCGTGCAGGTATTTTTGTTGCTT
ATAGTGATTTTTTTCCTGTTATGCAGCTGGATGATTTTATTGGAGAGGCACATTTGCCTGATAGCACGTTTGAACAAGCG
ACCGATGCGTACGTAAACTGGACAATTAATCCCAATACTCTGGGTAAAATTTCAGTTAGCAAGGGAGTTTATAATGCAAA
ATTGGCCGAATACGTTAAGACAATCCGATTAATTTTAAAAGAAGTTGATAATGCTTTTTCAGCTAATAAGCGCATGAGAG
AGCAATTTTTATCTTATCGGCACGCACAAGAAGATTATCAGCATAAATACAAATTACAAAATGGTTTATTAAAATCAGGG
TTAATGTCCTATAAAGAGTTATTGGAGAGTAAGGTTTATCTGGATACCCTGGCGCTCTCAACAAATCAGGCTAAGCTGGA
ATTGGCCATGTCACTGGTTATGTTGTATCAAGATTTGGCTGGTGGGTATGCCTGTAGTGACTAA

Upstream 100 bases:

>100_bases
ATCATGAGAGCTCCTTGTTGAAATTTAAATATACTTTCACCATTAGATGAATTATAAATTACAATGATAAACATTCACTT
TGAAATAAACGATGATGTGC

Downstream 100 bases:

>100_bases
ATCGGTTTGGTTTGTAACGCACTGATTTTAAAAGTCGCCAGGCGGGCTAAAATTGCAGTTCTTGTCTCTTGAGCTGTTCG
ATGAGATAAGCTAATTTCGC

Product: outer membrane efflux protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 447; Mature: 447

Protein sequence:

>447_residues
MLKKLMFLLLLGAGLLSCGQSTDQQISNIITPKQFPSSPRDYRPVQELPYLAWWKQFQDPELDRLIDTGLKTNMDIHIAM
ANLQQAQGELQQVKLSWIPNVQILGGYSTNPALGVPGGFYGIWPSYILNIMQLYTQQKRAQYQVQYHQAAIDGLRLTLIG
QVAAAYFTLIAQLEQLKLLYKLDRDLKSLIALSRKEINIGLKNDIDLAQLQSNERLIAAQIKPIKHNIVVSQNALRYLIN
ENPGLIKSKNNFAQLDFTRFKPGSLPASVLSNRPDMKMAEYSLKAARAGIFVAYSDFFPVMQLDDFIGEAHLPDSTFEQA
TDAYVNWTINPNTLGKISVSKGVYNAKLAEYVKTIRLILKEVDNAFSANKRMREQFLSYRHAQEDYQHKYKLQNGLLKSG
LMSYKELLESKVYLDTLALSTNQAKLELAMSLVMLYQDLAGGYACSD

Sequences:

>Translated_447_residues
MLKKLMFLLLLGAGLLSCGQSTDQQISNIITPKQFPSSPRDYRPVQELPYLAWWKQFQDPELDRLIDTGLKTNMDIHIAM
ANLQQAQGELQQVKLSWIPNVQILGGYSTNPALGVPGGFYGIWPSYILNIMQLYTQQKRAQYQVQYHQAAIDGLRLTLIG
QVAAAYFTLIAQLEQLKLLYKLDRDLKSLIALSRKEINIGLKNDIDLAQLQSNERLIAAQIKPIKHNIVVSQNALRYLIN
ENPGLIKSKNNFAQLDFTRFKPGSLPASVLSNRPDMKMAEYSLKAARAGIFVAYSDFFPVMQLDDFIGEAHLPDSTFEQA
TDAYVNWTINPNTLGKISVSKGVYNAKLAEYVKTIRLILKEVDNAFSANKRMREQFLSYRHAQEDYQHKYKLQNGLLKSG
LMSYKELLESKVYLDTLALSTNQAKLELAMSLVMLYQDLAGGYACSD
>Mature_447_residues
MLKKLMFLLLLGAGLLSCGQSTDQQISNIITPKQFPSSPRDYRPVQELPYLAWWKQFQDPELDRLIDTGLKTNMDIHIAM
ANLQQAQGELQQVKLSWIPNVQILGGYSTNPALGVPGGFYGIWPSYILNIMQLYTQQKRAQYQVQYHQAAIDGLRLTLIG
QVAAAYFTLIAQLEQLKLLYKLDRDLKSLIALSRKEINIGLKNDIDLAQLQSNERLIAAQIKPIKHNIVVSQNALRYLIN
ENPGLIKSKNNFAQLDFTRFKPGSLPASVLSNRPDMKMAEYSLKAARAGIFVAYSDFFPVMQLDDFIGEAHLPDSTFEQA
TDAYVNWTINPNTLGKISVSKGVYNAKLAEYVKTIRLILKEVDNAFSANKRMREQFLSYRHAQEDYQHKYKLQNGLLKSG
LMSYKELLESKVYLDTLALSTNQAKLELAMSLVMLYQDLAGGYACSD

Specific function: The outer membrane component of an antibiotic efflux pump. Confers resistance to numerous structurally unrelated antibiotics such as carbenicillin, chloramphenicol, erythromycin, novobiocin, streptomycin and tetracycline. Is not involved in organic solven

COG id: COG1538

COG function: function code MU; Outer membrane protein

Gene ontology:

Cell location: Cell outer membrane; Lipid-anchor (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the outer membrane factor (OMF) (TC 1.B.17) family [H]

Homologues:

Organism=Escherichia coli, GI1786785, Length=463, Percent_Identity=23.7580993520518, Blast_Score=71, Evalue=2e-13,
Organism=Escherichia coli, GI2367348, Length=331, Percent_Identity=22.0543806646526, Blast_Score=62, Evalue=9e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003423
- InterPro:   IPR010131 [H]

Pfam domain/function: PF02321 OEP [H]

EC number: NA

Molecular weight: Translated: 50562; Mature: 50562

Theoretical pI: Translated: 9.34; Mature: 9.34

Prosite motif: PS00013 PROKAR_LIPOPROTEIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLKKLMFLLLLGAGLLSCGQSTDQQISNIITPKQFPSSPRDYRPVQELPYLAWWKQFQDP
CHHHHHHHHHHHHHHHHCCCCHHHHHHHCCCCCCCCCCCCCCCCHHHCCHHHHHHHCCCC
ELDRLIDTGLKTNMDIHIAMANLQQAQGELQQVKLSWIPNVQILGGYSTNPALGVPGGFY
CHHHHHHCCCCCCCEEEEEHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCCCCHH
GIWPSYILNIMQLYTQQKRAQYQVQYHQAAIDGLRLTLIGQVAAAYFTLIAQLEQLKLLY
HHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
KLDRDLKSLIALSRKEINIGLKNDIDLAQLQSNERLIAAQIKPIKHNIVVSQNALRYLIN
HHHHHHHHHHHHHHHHEECCCCCCCCHHHHCCCCCEEEEECCCCHHEEEECHHHHHHHHC
ENPGLIKSKNNFAQLDFTRFKPGSLPASVLSNRPDMKMAEYSLKAARAGIFVAYSDFFPV
CCCCCEECCCCCEEEEEEECCCCCCCHHHHCCCCCCHHHHHHHHHHHCCEEEEECCCCCH
MQLDDFIGEAHLPDSTFEQATDAYVNWTINPNTLGKISVSKGVYNAKLAEYVKTIRLILK
HHHHHHHCCCCCCCHHHHHCCCCEEEEEECCCCCCEEEECCCCHHHHHHHHHHHHHHHHH
EVDNAFSANKRMREQFLSYRHAQEDYQHKYKLQNGLLKSGLMSYKELLESKVYLDTLALS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
TNQAKLELAMSLVMLYQDLAGGYACSD
CCHHHHHHHHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure
MLKKLMFLLLLGAGLLSCGQSTDQQISNIITPKQFPSSPRDYRPVQELPYLAWWKQFQDP
CHHHHHHHHHHHHHHHHCCCCHHHHHHHCCCCCCCCCCCCCCCCHHHCCHHHHHHHCCCC
ELDRLIDTGLKTNMDIHIAMANLQQAQGELQQVKLSWIPNVQILGGYSTNPALGVPGGFY
CHHHHHHCCCCCCCEEEEEHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCCCCHH
GIWPSYILNIMQLYTQQKRAQYQVQYHQAAIDGLRLTLIGQVAAAYFTLIAQLEQLKLLY
HHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
KLDRDLKSLIALSRKEINIGLKNDIDLAQLQSNERLIAAQIKPIKHNIVVSQNALRYLIN
HHHHHHHHHHHHHHHHEECCCCCCCCHHHHCCCCCEEEEECCCCHHEEEECHHHHHHHHC
ENPGLIKSKNNFAQLDFTRFKPGSLPASVLSNRPDMKMAEYSLKAARAGIFVAYSDFFPV
CCCCCEECCCCCEEEEEEECCCCCCCHHHHCCCCCCHHHHHHHHHHHCCEEEEECCCCCH
MQLDDFIGEAHLPDSTFEQATDAYVNWTINPNTLGKISVSKGVYNAKLAEYVKTIRLILK
HHHHHHHCCCCCCCHHHHHCCCCEEEEEECCCCCCEEEECCCCHHHHHHHHHHHHHHHHH
EVDNAFSANKRMREQFLSYRHAQEDYQHKYKLQNGLLKSGLMSYKELLESKVYLDTLALS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
TNQAKLELAMSLVMLYQDLAGGYACSD
CCHHHHHHHHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11160799 [H]