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The map label for this gene is mdtN [H]

Identifier: 148360953

GI number: 148360953

Start: 520943

End: 521980

Strand: Direct

Name: mdtN [H]

Synonym: LPC_2913

Alternate gene names: 148360953

Gene position: 520943-521980 (Clockwise)

Preceding gene: 148360954

Following gene: 148360952

Centisome position: 14.57

GC content: 36.9

Gene sequence:

>1038_bases
ATGAAAAAATTGATGGAATATGGTGGAAAAATAAAAGAGTACTTGCTTCGTTTAAAACCAAAACGCTGGCTTACTCTTAC
TAACGTCATTATTTTTATCGGTTTTCTTACTGCAATTATCTATGTTTTTTCCTATTTGATCCCTTTTACTGATAACGCGT
TTGTAGTAAACAATGTACGTCCGGTTGCGGCATTAACAAGCGGATATATAACCGAGCTTTATGTAAAAAATGGTGATGCG
GTGCGGAAGGGACAAAAACTATTTACCGTATTCAAAAAGCCCTATGAATACACAGTTGAACAGCTCAGTGCTGATTTAGC
TGGAGCACAGGCAAAGTTGGCAGTATTAAAAGCTACGTACGAACGGGATTTGAAGCTTAGCGAAAATGAGCAAAAAATAT
ATAAAAAGCTGGCGCAAGATGATCAAAAGTACCTTAAAGGGTATGCTATAAAATCTGTTTCTCTGATTACCCTGCAAAAC
TCCCAGCAAGAAACAAAAGCAGCTAAAGATAAATGGCAGGCTTCATTAAAACAACTTGAAATAGATCAGCATCAAATAAC
AGTTCAGGAAAATGAAATAAAATCCATTCAGGCCCGGTTAAAAAATGCCAAAGTCAATTTGGATTTAACGGATGTTTATG
CTCAGGGTAATGGAGTTATTCAAAATTTGTTTTTTACCATAGGAACTCCAGTCAATATCAATCAGCCATTATTCTCATTG
GTTGATCAGGATAATATTTATATTCAGGCCAATTTTAACGAGACGGATTTGCGTGATGTGCGCAAGGGCTCAAAGGTATT
GATATTTCCAAGAATGTATTTAGGAAGAAAAATATTTCATGGTGTTATTGATTCGGATTATTGGTCCGCGAATAGGCAAT
TGGTGGATGATCGTACTCAGCTGCAAAATGTTATCAATGAAAATCAATGGATTTTATTGCCCCAGCGCCTTCCTGTGATT
ATAAAGGTTACTGACCCTGACCCTAAATACCCGCTTCGTGTTGGAGCTAGCGCTTATGTCTATGTCGAAGTTTATTGA

Upstream 100 bases:

>100_bases
AGGCGGGCTAAAATTGCAGTTCTTGTCTCTTGAGCTGTTCGATGAGATAAGCTAATTTCGCATTATTGTTATATACCAAG
GGAAACTGGTTGGCTATTTT

Downstream 100 bases:

>100_bases
ATGGATTGATAAGGTTGATCCTTATGCTGTTCAACGAATAGCGCTCTATAAATCACTTTTTATTGCCACCGTAATGGCCT
ATGTTTATTGGGTATTTCGT

Product: multidrug resistance efflux pump PmrA

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 345; Mature: 345

Protein sequence:

>345_residues
MKKLMEYGGKIKEYLLRLKPKRWLTLTNVIIFIGFLTAIIYVFSYLIPFTDNAFVVNNVRPVAALTSGYITELYVKNGDA
VRKGQKLFTVFKKPYEYTVEQLSADLAGAQAKLAVLKATYERDLKLSENEQKIYKKLAQDDQKYLKGYAIKSVSLITLQN
SQQETKAAKDKWQASLKQLEIDQHQITVQENEIKSIQARLKNAKVNLDLTDVYAQGNGVIQNLFFTIGTPVNINQPLFSL
VDQDNIYIQANFNETDLRDVRKGSKVLIFPRMYLGRKIFHGVIDSDYWSANRQLVDDRTQLQNVINENQWILLPQRLPVI
IKVTDPDPKYPLRVGASAYVYVEVY

Sequences:

>Translated_345_residues
MKKLMEYGGKIKEYLLRLKPKRWLTLTNVIIFIGFLTAIIYVFSYLIPFTDNAFVVNNVRPVAALTSGYITELYVKNGDA
VRKGQKLFTVFKKPYEYTVEQLSADLAGAQAKLAVLKATYERDLKLSENEQKIYKKLAQDDQKYLKGYAIKSVSLITLQN
SQQETKAAKDKWQASLKQLEIDQHQITVQENEIKSIQARLKNAKVNLDLTDVYAQGNGVIQNLFFTIGTPVNINQPLFSL
VDQDNIYIQANFNETDLRDVRKGSKVLIFPRMYLGRKIFHGVIDSDYWSANRQLVDDRTQLQNVINENQWILLPQRLPVI
IKVTDPDPKYPLRVGASAYVYVEVY
>Mature_345_residues
MKKLMEYGGKIKEYLLRLKPKRWLTLTNVIIFIGFLTAIIYVFSYLIPFTDNAFVVNNVRPVAALTSGYITELYVKNGDA
VRKGQKLFTVFKKPYEYTVEQLSADLAGAQAKLAVLKATYERDLKLSENEQKIYKKLAQDDQKYLKGYAIKSVSLITLQN
SQQETKAAKDKWQASLKQLEIDQHQITVQENEIKSIQARLKNAKVNLDLTDVYAQGNGVIQNLFFTIGTPVNINQPLFSL
VDQDNIYIQANFNETDLRDVRKGSKVLIFPRMYLGRKIFHGVIDSDYWSANRQLVDDRTQLQNVINENQWILLPQRLPVI
IKVTDPDPKYPLRVGASAYVYVEVY

Specific function: Could be involved in resistance to puromycin, acriflavine and tetraphenylarsonium chloride [H]

COG id: COG1566

COG function: function code V; Multidrug resistance efflux pump

Gene ontology:

Cell location: Cell inner membrane; Single-pass type II membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family [H]

Homologues:

Organism=Escherichia coli, GI1790519, Length=329, Percent_Identity=27.0516717325228, Blast_Score=94, Evalue=1e-20,
Organism=Escherichia coli, GI1788711, Length=338, Percent_Identity=25.1479289940828, Blast_Score=77, Evalue=2e-15,
Organism=Escherichia coli, GI87081951, Length=297, Percent_Identity=24.2424242424242, Blast_Score=76, Evalue=3e-15,
Organism=Escherichia coli, GI1789041, Length=329, Percent_Identity=26.1398176291793, Blast_Score=74, Evalue=1e-14,
Organism=Escherichia coli, GI1790024, Length=288, Percent_Identity=23.9583333333333, Blast_Score=70, Evalue=3e-13,
Organism=Escherichia coli, GI1790012, Length=283, Percent_Identity=23.321554770318, Blast_Score=63, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005694
- InterPro:   IPR006143 [H]

Pfam domain/function: PF00529 HlyD [H]

EC number: NA

Molecular weight: Translated: 39659; Mature: 39659

Theoretical pI: Translated: 9.83; Mature: 9.83

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
0.9 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
0.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKLMEYGGKIKEYLLRLKPKRWLTLTNVIIFIGFLTAIIYVFSYLIPFTDNAFVVNNVR
CCCHHHHCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCC
PVAALTSGYITELYVKNGDAVRKGQKLFTVFKKPYEYTVEQLSADLAGAQAKLAVLKATY
HHHHHHCCCEEEEEEECCCHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCHHHHHHHHHHH
ERDLKLSENEQKIYKKLAQDDQKYLKGYAIKSVSLITLQNSQQETKAAKDKWQASLKQLE
HCCCCCCCCHHHHHHHHHHHHHHHHHHHEECEEEEEEECCCCHHHHHHHHHHHHHHHHHC
IDQHQITVQENEIKSIQARLKNAKVNLDLTDVYAQGNGVIQNLFFTIGTPVNINQPLFSL
CCCCEEEEEHHHHHHHHHHHHCCEEEEEEEEEEECCCCHHHHHHHHCCCCCCCCCHHHHH
VDQDNIYIQANFNETDLRDVRKGSKVLIFPRMYLGRKIFHGVIDSDYWSANRQLVDDRTQ
HCCCCEEEEECCCCHHHHHHHCCCEEEEECHHHHHHHHHHHHCCCCHHCCCCHHHHHHHH
LQNVINENQWILLPQRLPVIIKVTDPDPKYPLRVGASAYVYVEVY
HHHHHCCCCEEEEECCCCEEEEECCCCCCCCEEECCEEEEEEEEC
>Mature Secondary Structure
MKKLMEYGGKIKEYLLRLKPKRWLTLTNVIIFIGFLTAIIYVFSYLIPFTDNAFVVNNVR
CCCHHHHCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCC
PVAALTSGYITELYVKNGDAVRKGQKLFTVFKKPYEYTVEQLSADLAGAQAKLAVLKATY
HHHHHHCCCEEEEEEECCCHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCHHHHHHHHHHH
ERDLKLSENEQKIYKKLAQDDQKYLKGYAIKSVSLITLQNSQQETKAAKDKWQASLKQLE
HCCCCCCCCHHHHHHHHHHHHHHHHHHHEECEEEEEEECCCCHHHHHHHHHHHHHHHHHC
IDQHQITVQENEIKSIQARLKNAKVNLDLTDVYAQGNGVIQNLFFTIGTPVNINQPLFSL
CCCCEEEEEHHHHHHHHHHHHCCEEEEEEEEEEECCCCHHHHHHHHCCCCCCCCCHHHHH
VDQDNIYIQANFNETDLRDVRKGSKVLIFPRMYLGRKIFHGVIDSDYWSANRQLVDDRTQ
HCCCCEEEEECCCCHHHHHHHCCCEEEEECHHHHHHHHHHHHCCCCHHCCCCHHHHHHHH
LQNVINENQWILLPQRLPVIIKVTDPDPKYPLRVGASAYVYVEVY
HHHHHCCCCEEEEECCCCEEEEECCCCCCCCEEECCEEEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]