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The map label for this gene is pgi [H]

Identifier: 148360587

GI number: 148360587

Start: 938566

End: 940050

Strand: Direct

Name: pgi [H]

Synonym: LPC_2533

Alternate gene names: 148360587

Gene position: 938566-940050 (Clockwise)

Preceding gene: 148360588

Following gene: 148360586

Centisome position: 26.24

GC content: 35.22

Gene sequence:

>1485_bases
ATGAAGTCTCACACAGAATTATTGTCATGGAATTTGCTTCAAAAAGAAGCGGATAGAGTGCGTCTAAATTCAGATTCTCT
AACATGCGTTGTTCCGGATTCCAACAATTATGAATCCAGTAAACAGATCAATTATATTGAGTACGACTATTCCAGGCAGA
GAGTAAACAGAACCATCATTGATTTGCTTATCGATTTGGCTAATGAAGTCAAATTACAAGAAAAAATTGATAACTTAATC
AATGGTAAAAAAATCAATATCAGCGAAAACAGGCCTGCACTACATACTGCACTTAGGGACTTAGGTAATAAATCGATAAT
GATTGATGGACTGGATATTATGTCCGCAGTTATAAATACTCGTGAAAAAATTAAAGTTATATCCAATCAGATCAGGGAAA
AGAGGTGGCTGGGCTATTCAGGTTTACCAATAACTGATATTGTAAACATAGGTATTGGTGGCTCGGATTTAGGTCCTCGT
GTATGCATCCATGCCTTATCTAATTATGTTTCCAAAGAATTTAATTATCATTTTATCTCAGATGTTGATCCGGCCAGTTT
TAGCGATGTTATTGCAAAAATTAATCCGCAAACCACCTTATTTATTGTTTCTTCCAAATCATTTACTACAAAAGAAACTC
TATTAAATGCCAGAAAAGCTTTTGCATTGTATGAGGATACGGCCTTTATCGATCAACATTTTATAGCTGTAACCGCACAT
CCGGAAAGAGCTTATCAAATGGGTATTAAAACTATTTTACCGATTTGGGATTGGGTTGGTGGTCGATTTTCTTTTTGTTC
CGCAGTTAATTTAATTACTGCGATTGCAATTGGTTATGAACAATTTGTTGAATTGCTGGCTGGTGCCCATGATGTCGATA
CTCATGTCCAATTTACTGATTTTAAAAATAATATTCCTGTGCTAATGGCTTTAATCGGTATATGGAATAACAATTTTTTG
AATATTCATAATTTACTTATTCTTACCTATTCAAAAAAACTGGAGTACTTTGTTCCTTATGTACAACAGCTGGATATGGA
GAGTAATGGGAAATCCATTGATGTGAATGGAAGAATGGTAGATTACGCCACTGGACCTATCGTTTGGGGTGGATTAGGAA
ATCAGGCACAGCATAGCTATTTTCAATTATTATGTCAGGGTACGCATCGATGTGTTGGCGATTTTATTACTTTGAAAACT
AATGATGAGCATGAGATTAATTCCATGTGTCATTATAAAATGAAAGTTTTAAGTGAGGGAATTCAAACAATTGAAAATCC
TTATGGGTATATTCCTGGCAATATGCCAATGAATCATCTCATTTTGTCAGATTGTTCTCCTTATACATTAGGGGCTCTGG
TGGCACTCTATGAACATAAGATTTTTGTACAAAGTGTGATATGGAATATTAACCCATTCGATCAGCCCGGTATTGAAAGC
GCCAAGAGTGCTCACAGAGAAATCACATTGTCAAGCGAATCATAA

Upstream 100 bases:

>100_bases
CAGTTCATCATTACTTAACACGGTATGAGCGCGAAATTAATATTTAATAAATTGAAAATAATCAGGTAACATAGACTTTA
TTTTGATGATTAGAAATAGC

Downstream 100 bases:

>100_bases
AGGGGCGCTCAATGCTATAAATTAGTTTAATTGTTAAACTAAACTTTATATTTTATTGACATTATCAACGTATTTTAATG
TATTACTTCAATAAACTTGA

Product: glucose-6-phosphate isomerase

Products: NA

Alternate protein names: GPI; Phosphoglucose isomerase; PGI; Phosphohexose isomerase; PHI [H]

Number of amino acids: Translated: 494; Mature: 494

Protein sequence:

>494_residues
MKSHTELLSWNLLQKEADRVRLNSDSLTCVVPDSNNYESSKQINYIEYDYSRQRVNRTIIDLLIDLANEVKLQEKIDNLI
NGKKINISENRPALHTALRDLGNKSIMIDGLDIMSAVINTREKIKVISNQIREKRWLGYSGLPITDIVNIGIGGSDLGPR
VCIHALSNYVSKEFNYHFISDVDPASFSDVIAKINPQTTLFIVSSKSFTTKETLLNARKAFALYEDTAFIDQHFIAVTAH
PERAYQMGIKTILPIWDWVGGRFSFCSAVNLITAIAIGYEQFVELLAGAHDVDTHVQFTDFKNNIPVLMALIGIWNNNFL
NIHNLLILTYSKKLEYFVPYVQQLDMESNGKSIDVNGRMVDYATGPIVWGGLGNQAQHSYFQLLCQGTHRCVGDFITLKT
NDEHEINSMCHYKMKVLSEGIQTIENPYGYIPGNMPMNHLILSDCSPYTLGALVALYEHKIFVQSVIWNINPFDQPGIES
AKSAHREITLSSES

Sequences:

>Translated_494_residues
MKSHTELLSWNLLQKEADRVRLNSDSLTCVVPDSNNYESSKQINYIEYDYSRQRVNRTIIDLLIDLANEVKLQEKIDNLI
NGKKINISENRPALHTALRDLGNKSIMIDGLDIMSAVINTREKIKVISNQIREKRWLGYSGLPITDIVNIGIGGSDLGPR
VCIHALSNYVSKEFNYHFISDVDPASFSDVIAKINPQTTLFIVSSKSFTTKETLLNARKAFALYEDTAFIDQHFIAVTAH
PERAYQMGIKTILPIWDWVGGRFSFCSAVNLITAIAIGYEQFVELLAGAHDVDTHVQFTDFKNNIPVLMALIGIWNNNFL
NIHNLLILTYSKKLEYFVPYVQQLDMESNGKSIDVNGRMVDYATGPIVWGGLGNQAQHSYFQLLCQGTHRCVGDFITLKT
NDEHEINSMCHYKMKVLSEGIQTIENPYGYIPGNMPMNHLILSDCSPYTLGALVALYEHKIFVQSVIWNINPFDQPGIES
AKSAHREITLSSES
>Mature_494_residues
MKSHTELLSWNLLQKEADRVRLNSDSLTCVVPDSNNYESSKQINYIEYDYSRQRVNRTIIDLLIDLANEVKLQEKIDNLI
NGKKINISENRPALHTALRDLGNKSIMIDGLDIMSAVINTREKIKVISNQIREKRWLGYSGLPITDIVNIGIGGSDLGPR
VCIHALSNYVSKEFNYHFISDVDPASFSDVIAKINPQTTLFIVSSKSFTTKETLLNARKAFALYEDTAFIDQHFIAVTAH
PERAYQMGIKTILPIWDWVGGRFSFCSAVNLITAIAIGYEQFVELLAGAHDVDTHVQFTDFKNNIPVLMALIGIWNNNFL
NIHNLLILTYSKKLEYFVPYVQQLDMESNGKSIDVNGRMVDYATGPIVWGGLGNQAQHSYFQLLCQGTHRCVGDFITLKT
NDEHEINSMCHYKMKVLSEGIQTIENPYGYIPGNMPMNHLILSDCSPYTLGALVALYEHKIFVQSVIWNINPFDQPGIES
AKSAHREITLSSES

Specific function: Involved in glycolysis and in gluconeogenesis. [C]

COG id: COG0166

COG function: function code G; Glucose-6-phosphate isomerase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GPI family [H]

Homologues:

Organism=Homo sapiens, GI18201905, Length=506, Percent_Identity=37.5494071146245, Blast_Score=358, Evalue=9e-99,
Organism=Homo sapiens, GI296080693, Length=506, Percent_Identity=34.1897233201581, Blast_Score=305, Evalue=8e-83,
Organism=Escherichia coli, GI1790457, Length=509, Percent_Identity=40.2750491159136, Blast_Score=375, Evalue=1e-105,
Organism=Caenorhabditis elegans, GI71996708, Length=505, Percent_Identity=37.2277227722772, Blast_Score=344, Evalue=7e-95,
Organism=Caenorhabditis elegans, GI71996703, Length=505, Percent_Identity=37.2277227722772, Blast_Score=344, Evalue=8e-95,
Organism=Saccharomyces cerevisiae, GI6319673, Length=496, Percent_Identity=37.7016129032258, Blast_Score=331, Evalue=2e-91,
Organism=Drosophila melanogaster, GI24651916, Length=473, Percent_Identity=39.7463002114165, Blast_Score=355, Evalue=4e-98,
Organism=Drosophila melanogaster, GI24651914, Length=473, Percent_Identity=39.7463002114165, Blast_Score=355, Evalue=4e-98,
Organism=Drosophila melanogaster, GI17737445, Length=473, Percent_Identity=39.7463002114165, Blast_Score=355, Evalue=4e-98,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001672
- InterPro:   IPR018189 [H]

Pfam domain/function: PF00342 PGI [H]

EC number: =5.3.1.9 [H]

Molecular weight: Translated: 55790; Mature: 55790

Theoretical pI: Translated: 6.30; Mature: 6.30

Prosite motif: PS00765 P_GLUCOSE_ISOMERASE_1 ; PS00174 P_GLUCOSE_ISOMERASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKSHTELLSWNLLQKEADRVRLNSDSLTCVVPDSNNYESSKQINYIEYDYSRQRVNRTII
CCCCHHHHHHHHHHHHHHHEEECCCCEEEEECCCCCCCCCCCCEEEEECHHHHHHHHHHH
DLLIDLANEVKLQEKIDNLINGKKINISENRPALHTALRDLGNKSIMIDGLDIMSAVINT
HHHHHHHHHHHHHHHHHHHHCCCEEEECCCCCHHHHHHHHCCCCEEEEECHHHHHHHHCC
REKIKVISNQIREKRWLGYSGLPITDIVNIGIGGSDLGPRVCIHALSNYVSKEFNYHFIS
HHHHHHHHHHHHHHHCCCCCCCCHHHHEECCCCCCCCCHHHHHHHHHHHHHHCCCEEEEC
DVDPASFSDVIAKINPQTTLFIVSSKSFTTKETLLNARKAFALYEDTAFIDQHFIAVTAH
CCCCCCHHHHHHHCCCCEEEEEEECCCCCHHHHHHHHHHHHHEECCHHHHCCEEEEEEEC
PERAYQMGIKTILPIWDWVGGRFSFCSAVNLITAIAIGYEQFVELLAGAHDVDTHVQFTD
CHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCHHHHHHHHCCCCCCCCCEEEEC
FKNNIPVLMALIGIWNNNFLNIHNLLILTYSKKLEYFVPYVQQLDMESNGKSIDVNGRMV
CCCCHHHHHHHHHHHCCCEEEEEEEEEEEECHHHHHHHHHHHHCCCCCCCCEEECCCEEE
DYATGPIVWGGLGNQAQHSYFQLLCQGTHRCVGDFITLKTNDEHEINSMCHYKMKVLSEG
EEECCCEEECCCCCHHHHHHHHHHHHHHHHHCCCEEEEECCCCHHHHHHHHHHHHHHHHH
IQTIENPYGYIPGNMPMNHLILSDCSPYTLGALVALYEHKIFVQSVIWNINPFDQPGIES
HHHHCCCCCCCCCCCCHHHEEECCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHH
AKSAHREITLSSES
HHHHCCEEEECCCC
>Mature Secondary Structure
MKSHTELLSWNLLQKEADRVRLNSDSLTCVVPDSNNYESSKQINYIEYDYSRQRVNRTII
CCCCHHHHHHHHHHHHHHHEEECCCCEEEEECCCCCCCCCCCCEEEEECHHHHHHHHHHH
DLLIDLANEVKLQEKIDNLINGKKINISENRPALHTALRDLGNKSIMIDGLDIMSAVINT
HHHHHHHHHHHHHHHHHHHHCCCEEEECCCCCHHHHHHHHCCCCEEEEECHHHHHHHHCC
REKIKVISNQIREKRWLGYSGLPITDIVNIGIGGSDLGPRVCIHALSNYVSKEFNYHFIS
HHHHHHHHHHHHHHHCCCCCCCCHHHHEECCCCCCCCCHHHHHHHHHHHHHHCCCEEEEC
DVDPASFSDVIAKINPQTTLFIVSSKSFTTKETLLNARKAFALYEDTAFIDQHFIAVTAH
CCCCCCHHHHHHHCCCCEEEEEEECCCCCHHHHHHHHHHHHHEECCHHHHCCEEEEEEEC
PERAYQMGIKTILPIWDWVGGRFSFCSAVNLITAIAIGYEQFVELLAGAHDVDTHVQFTD
CHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCHHHHHHHHCCCCCCCCCEEEEC
FKNNIPVLMALIGIWNNNFLNIHNLLILTYSKKLEYFVPYVQQLDMESNGKSIDVNGRMV
CCCCHHHHHHHHHHHCCCEEEEEEEEEEEECHHHHHHHHHHHHCCCCCCCCEEECCCEEE
DYATGPIVWGGLGNQAQHSYFQLLCQGTHRCVGDFITLKTNDEHEINSMCHYKMKVLSEG
EEECCCEEECCCCCHHHHHHHHHHHHHHHHHCCCEEEEECCCCHHHHHHHHHHHHHHHHH
IQTIENPYGYIPGNMPMNHLILSDCSPYTLGALVALYEHKIFVQSVIWNINPFDQPGIES
HHHHCCCCCCCCCCCCHHHEEECCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHH
AKSAHREITLSSES
HHHHCCEEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA