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The map label for this gene is kmo

Identifier: 148360462

GI number: 148360462

Start: 1073459

End: 1074808

Strand: Direct

Name: kmo

Synonym: LPC_2401

Alternate gene names: 148360462

Gene position: 1073459-1074808 (Clockwise)

Preceding gene: 148360463

Following gene: 148360461

Centisome position: 30.01

GC content: 36.59

Gene sequence:

>1350_bases
ATGAAGCACATTACCATAATTGGAGCCGGGTTAGCGGGAACTTTGTGTGGTTTATATCTTGCTAGAAGAGGCTATGAAGT
AGAGTTGTTTGAATCAAGACCAGACATTCGTAATAGTCCGACTGATTATGGACGCTCCATTAATCTTGCTTTGTCATGCA
GAGGAATTACCGCTTTAAAAGCAATGAACCTGTTAAGTGAAGTAAATAAAATTATGGTTCCAATGCGGGCAAGAGCTATT
CACGAAGCCAATGGCGAGGTTCACTATCAACCATTTGGACGTCACATTGATGAATATATCAATGCTATTTCTCGTTCTGA
TCTCAATGCCTTGCTTTTAAATAAAGCGGAATTATGCCCTAACATTAAATTACACTTTAATATGAAATTGCACTCTCTTG
ATATTCATAATAAAAAAATTAAATTTGAAAATAAAAATGGTGATTTTGTTGAGGCCTCATATCATAGACTAATTGGAGCA
GATGGTGCGCCGTCTCATGTAAGGGATATGCTGAAAAATGAAGGGATAGTTAGTGCAAGCAGAGATTTTTTATCTCATGG
ATACAAGGAGCTTTCAATTAGCAAAAAACATACAAAAGGGATGGCTAGAGAGCATTTGCATTTATGGCCACGTGATTCGT
TTATGCTATTAGGTAACCCTAATCCTGACGATTCAATTACAGGTTCTTTGTTTTTAGCTAATGAAGGGAAAGACAGTTTT
GCTGAACTAAATAACGAAGAAAAATTACATTTATTTTTTAAAACACAGTTCCCGGATGCCTATGCAGCTATGCCAAATTT
GGTTCAAGAATTTTTTGGTAATCCTACTGGACATTTGAGTACTATCCAATGCTCACCCTGGTACTATAAAGACGAATGCT
TATTAATAGGTGATGCGGCACATGGGATAATTCCATTCTTTGGGCAAGGAATGAATAGCGCATTTGAAGATTGCCGTATT
CTTGATGAATTACTGGATGAATACCAAGACGATTGGTCGCGGGTGACCCCTGTTTTTTATGAACAAAGAAAAGTGAATAC
CGATGCGATAGCGAAAATGTCCATGGATAATTATCATGAGATTCATTCGGACATAAGAAATCCAAAATTTATTTTACAAA
AGCAGATTGAACGGGAACTCATGTTGCGATACCCGGAACATTATGTTTCCATGCATGTTTTGGTTATGTTTACCAATACC
CCGTATGCTAAAGCGATGGCAATAGGAGAGTTACAATCTGGCCTTTTAGAGCAAATTTGTTTCCCAATAACTGATATTAA
GGAGTTAAATTGGCAGGAAGTAGAGAAATTACTTAGCATATATGACAAAAAATTGGCGAAAATTATTTGA

Upstream 100 bases:

>100_bases
GTTTTACTTTTATTCAAGCAATATATTGATTGAATTTGTGTATTTTTTAAGGAGATTCGGAATAGATGTCGTGTTGATAT
AGAATGGGTTGGGAGGATAA

Downstream 100 bases:

>100_bases
TTTAATTTATGTCATTCATTTTAAATGAAATTTATAGTCAAAGTTTTGTCAGAAAAGATGGATTCAGGGACATTTTTTTG
TCGCTACCTGAGGGTTATTA

Product: kynurenine 3-monooxygenase

Products: NA

Alternate protein names: Kynurenine 3-hydroxylase

Number of amino acids: Translated: 449; Mature: 449

Protein sequence:

>449_residues
MKHITIIGAGLAGTLCGLYLARRGYEVELFESRPDIRNSPTDYGRSINLALSCRGITALKAMNLLSEVNKIMVPMRARAI
HEANGEVHYQPFGRHIDEYINAISRSDLNALLLNKAELCPNIKLHFNMKLHSLDIHNKKIKFENKNGDFVEASYHRLIGA
DGAPSHVRDMLKNEGIVSASRDFLSHGYKELSISKKHTKGMAREHLHLWPRDSFMLLGNPNPDDSITGSLFLANEGKDSF
AELNNEEKLHLFFKTQFPDAYAAMPNLVQEFFGNPTGHLSTIQCSPWYYKDECLLIGDAAHGIIPFFGQGMNSAFEDCRI
LDELLDEYQDDWSRVTPVFYEQRKVNTDAIAKMSMDNYHEIHSDIRNPKFILQKQIERELMLRYPEHYVSMHVLVMFTNT
PYAKAMAIGELQSGLLEQICFPITDIKELNWQEVEKLLSIYDKKLAKII

Sequences:

>Translated_449_residues
MKHITIIGAGLAGTLCGLYLARRGYEVELFESRPDIRNSPTDYGRSINLALSCRGITALKAMNLLSEVNKIMVPMRARAI
HEANGEVHYQPFGRHIDEYINAISRSDLNALLLNKAELCPNIKLHFNMKLHSLDIHNKKIKFENKNGDFVEASYHRLIGA
DGAPSHVRDMLKNEGIVSASRDFLSHGYKELSISKKHTKGMAREHLHLWPRDSFMLLGNPNPDDSITGSLFLANEGKDSF
AELNNEEKLHLFFKTQFPDAYAAMPNLVQEFFGNPTGHLSTIQCSPWYYKDECLLIGDAAHGIIPFFGQGMNSAFEDCRI
LDELLDEYQDDWSRVTPVFYEQRKVNTDAIAKMSMDNYHEIHSDIRNPKFILQKQIERELMLRYPEHYVSMHVLVMFTNT
PYAKAMAIGELQSGLLEQICFPITDIKELNWQEVEKLLSIYDKKLAKII
>Mature_449_residues
MKHITIIGAGLAGTLCGLYLARRGYEVELFESRPDIRNSPTDYGRSINLALSCRGITALKAMNLLSEVNKIMVPMRARAI
HEANGEVHYQPFGRHIDEYINAISRSDLNALLLNKAELCPNIKLHFNMKLHSLDIHNKKIKFENKNGDFVEASYHRLIGA
DGAPSHVRDMLKNEGIVSASRDFLSHGYKELSISKKHTKGMAREHLHLWPRDSFMLLGNPNPDDSITGSLFLANEGKDSF
AELNNEEKLHLFFKTQFPDAYAAMPNLVQEFFGNPTGHLSTIQCSPWYYKDECLLIGDAAHGIIPFFGQGMNSAFEDCRI
LDELLDEYQDDWSRVTPVFYEQRKVNTDAIAKMSMDNYHEIHSDIRNPKFILQKQIERELMLRYPEHYVSMHVLVMFTNT
PYAKAMAIGELQSGLLEQICFPITDIKELNWQEVEKLLSIYDKKLAKII

Specific function: Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid

COG id: COG0654

COG function: function code HC; 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the aromatic-ring hydroxylase family. KMO subfamily

Homologues:

Organism=Homo sapiens, GI187960045, Length=423, Percent_Identity=37.1158392434988, Blast_Score=290, Evalue=3e-78,
Organism=Caenorhabditis elegans, GI17562934, Length=443, Percent_Identity=32.0541760722348, Blast_Score=235, Evalue=4e-62,
Organism=Caenorhabditis elegans, GI212646493, Length=353, Percent_Identity=30.5949008498584, Blast_Score=168, Evalue=5e-42,
Organism=Caenorhabditis elegans, GI193208447, Length=310, Percent_Identity=30.6451612903226, Blast_Score=142, Evalue=4e-34,
Organism=Saccharomyces cerevisiae, GI6319372, Length=435, Percent_Identity=31.7241379310345, Blast_Score=204, Evalue=2e-53,
Organism=Drosophila melanogaster, GI28573964, Length=422, Percent_Identity=35.781990521327, Blast_Score=248, Evalue=8e-66,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): KMO_LEGPC (A5IG23)

Other databases:

- EMBL:   CP000675
- RefSeq:   YP_001251669.1
- STRING:   A5IG23
- GeneID:   5180232
- GenomeReviews:   CP000675_GR
- KEGG:   lpc:LPC_2401
- eggNOG:   COG0654
- HOGENOM:   HBG430104
- OMA:   HWQKKVI
- ProtClustDB:   CLSK903475
- BioCyc:   LPNE400673:LPC_2401-MONOMER
- InterPro:   IPR002938
- InterPro:   IPR003042
- PRINTS:   PR00420

Pfam domain/function: PF01494 FAD_binding_3

EC number: =1.14.13.9

Molecular weight: Translated: 51310; Mature: 51310

Theoretical pI: Translated: 6.68; Mature: 6.68

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKHITIIGAGLAGTLCGLYLARRGYEVELFESRPDIRNSPTDYGRSINLALSCRGITALK
CCEEEEEECCHHHHHHHHHHHHCCCEEEEECCCCCCCCCCCCCCCEEEEEEEECCHHHHH
AMNLLSEVNKIMVPMRARAIHEANGEVHYQPFGRHIDEYINAISRSDLNALLLNKAELCP
HHHHHHHHHHHHHHHHHHHHHHCCCEEEECHHHHHHHHHHHHHHHCCCHHHHHCHHHHCC
NIKLHFNMKLHSLDIHNKKIKFENKNGDFVEASYHRLIGADGAPSHVRDMLKNEGIVSAS
CCEEEEEEEEEEEECCCCEEEEECCCCCEEEHHHHHHHCCCCCHHHHHHHHHCCCCCHHH
RDFLSHGYKELSISKKHTKGMAREHLHLWPRDSFMLLGNPNPDDSITGSLFLANEGKDSF
HHHHHCCCHHHCCCHHHHHHHHHHHCEECCCCCEEEECCCCCCCCCCEEEEEECCCCHHH
AELNNEEKLHLFFKTQFPDAYAAMPNLVQEFFGNPTGHLSTIQCSPWYYKDECLLIGDAA
HHCCCCCEEEEEEEECCCCHHHHHHHHHHHHCCCCCCCEEEEEECCCEECCCEEEEECCC
HGIIPFFGQGMNSAFEDCRILDELLDEYQDDWSRVTPVFYEQRKVNTDAIAKMSMDNYHE
CCCHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHCCCHHHHHHHCCHHHHH
IHSDIRNPKFILQKQIERELMLRYPEHYVSMHVLVMFTNTPYAKAMAIGELQSGLLEQIC
HHHHHCCCHHHHHHHHHHHHHHHCCHHHHEEEEEEEEECCCHHHHHHHHHHHHHHHHHHH
FPITDIKELNWQEVEKLLSIYDKKLAKII
CCCCCHHCCCHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MKHITIIGAGLAGTLCGLYLARRGYEVELFESRPDIRNSPTDYGRSINLALSCRGITALK
CCEEEEEECCHHHHHHHHHHHHCCCEEEEECCCCCCCCCCCCCCCEEEEEEEECCHHHHH
AMNLLSEVNKIMVPMRARAIHEANGEVHYQPFGRHIDEYINAISRSDLNALLLNKAELCP
HHHHHHHHHHHHHHHHHHHHHHCCCEEEECHHHHHHHHHHHHHHHCCCHHHHHCHHHHCC
NIKLHFNMKLHSLDIHNKKIKFENKNGDFVEASYHRLIGADGAPSHVRDMLKNEGIVSAS
CCEEEEEEEEEEEECCCCEEEEECCCCCEEEHHHHHHHCCCCCHHHHHHHHHCCCCCHHH
RDFLSHGYKELSISKKHTKGMAREHLHLWPRDSFMLLGNPNPDDSITGSLFLANEGKDSF
HHHHHCCCHHHCCCHHHHHHHHHHHCEECCCCCEEEECCCCCCCCCCEEEEEECCCCHHH
AELNNEEKLHLFFKTQFPDAYAAMPNLVQEFFGNPTGHLSTIQCSPWYYKDECLLIGDAA
HHCCCCCEEEEEEEECCCCHHHHHHHHHHHHCCCCCCCEEEEEECCCEECCCEEEEECCC
HGIIPFFGQGMNSAFEDCRILDELLDEYQDDWSRVTPVFYEQRKVNTDAIAKMSMDNYHE
CCCHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHCCCHHHHHHHCCHHHHH
IHSDIRNPKFILQKQIERELMLRYPEHYVSMHVLVMFTNTPYAKAMAIGELQSGLLEQIC
HHHHHCCCHHHHHHHHHHHHHHHCCHHHHEEEEEEEEECCCHHHHHHHHHHHHHHHHHHH
FPITDIKELNWQEVEKLLSIYDKKLAKII
CCCCCHHCCCHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA