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The map label for this gene is yqjD [H]

Identifier: 148359769

GI number: 148359769

Start: 2633614

End: 2635035

Strand: Reverse

Name: yqjD [H]

Synonym: LPC_1694

Alternate gene names: 148359769

Gene position: 2635035-2633614 (Counterclockwise)

Preceding gene: 148359776

Following gene: 148359768

Centisome position: 73.68

GC content: 40.93

Gene sequence:

>1422_bases
ATGTCTTCCCAACATACAGATAAGACGTTAATTAAATGGATAGATAATTTTATTGATGAACAAAGCTTTTTACCAATTGG
TTCTGAATATATTCCGGATAATAAATTTCATTCCCTGCCTGGCTCTGAGGTGATTACCGGATTAGCCAAAGTGAATCAAA
GGCCAGTAGCGATTTATGCTCATGATTCTTCAGTCAACAGGGGATATGTTACCCGACAAGGCGCTCGAAAGATTATTCAT
TTAATGGATAAAGCGGAAAAATTACGCATTCCCATCGTTGCCTTTTTAGCATCTCCCGGGGTTTCTCTCGAAGAAAATTT
ATTAAGTGGTGACGAATACACTCAAATTATTGCTCGAAATATTAGACTGTCAGGAATTATCCCACAATTTGCAGTGATAC
TGGCACCCACTCTTGGAGCGCCGGCTTATTCCGCTGTGTTAATGGATTTATTATTTTTTAACAAGCACAGAAGCTATCTT
ATGGTGACTAGTCCTACAGTCGTACAACAAGCCATTGGTGAAAAAGTGACTATGGGCGAGCTGGGGAGCGCAACACTGCA
TGCTACGACAACGGGTATTGCTGATTTCGTGGATGATAGTGTTACGGCACAAATAAACCATGTGAAAGCGATGCTTGGTT
TTTTTCCTCTACATACCGATGAACGTCCCCCTGTACTTCCTATAATGGAACCTAATCATTCCATTCCTGATATTCCTGCA
AATCCCAGAATGCCATTTAATATGCTTAATTTAATTCAGGCTGTCGTGGATAATTCAAACGTTATCCAGTACAAAAGGAC
TTATGGACAGGCAATGATTTGTGCTTTTGTGCATATACACGGCTTTGCTGTTGGGGTTGTCGCTAATCAAAGTATTCGTT
ACAGCGGAGCCATTGATTCCGATGCGGCTCAAAAAGCAGCCAAATTTATAAGAATATGTGATGCTTATTCTATACCGATT
TTGACTTTTATCGATGTTCCCGGTTTTATGCCTGGTAAAAGAGAGGAGCAAAAGGGATTATTGCAGCATGGTGCAAGATT
TTGTGTGGCGATGCAAACCAGAGTGCCAAGGCTAAGTGTCATCGTGCGTAAATGTTATGGAGCGGCTGCTTTTCTAATGA
TGCAAACCAAATCACAGAATGGAGATTTGGTTTTGGCTCTGGAAACAGCAAATCTTGGTGTCATGGGGAAGGAAACGACC
AATAAGGTGCAAGCCATGGATGGTCAACCAGCACAGGAACCATCACAATCCCAATTGACAGAAAAATCTCAAATTGATGA
TTCCCTCATGGAAGCTTATTCTTTGGGCTTGATTGATGAAATTATTCACGCAGCACAAATTCGCAGTCGCCTTGCGTCTC
ATTTGGAATTTTTATATCGAAGAATGGAAATCATGCCTCCGGCAAAACACTCTATTGTATAA

Upstream 100 bases:

>100_bases
GTAGCCTATTTTGGGGATTAAGTTATTATGACTTTTCATCAAATTGCCAAATTAGAGAGTCTCGGGCTCCAGGGTTTGAA
TATTGCAAGAGGAAAGTGGC

Downstream 100 bases:

>100_bases
GGAAAATAATGACTTCTTATGAAAATTTGATACAACTGTCTGAATTTTTTGAGTCATGTCTGGGTAATCCTTTGGATGAC
AATTCTCCTGTTAATTTTCA

Product: acetyl CoA carboxylase subunit alpha

Products: NA

Alternate protein names: PCCase; Propanoyl-CoA:carbon dioxide ligase [H]

Number of amino acids: Translated: 473; Mature: 472

Protein sequence:

>473_residues
MSSQHTDKTLIKWIDNFIDEQSFLPIGSEYIPDNKFHSLPGSEVITGLAKVNQRPVAIYAHDSSVNRGYVTRQGARKIIH
LMDKAEKLRIPIVAFLASPGVSLEENLLSGDEYTQIIARNIRLSGIIPQFAVILAPTLGAPAYSAVLMDLLFFNKHRSYL
MVTSPTVVQQAIGEKVTMGELGSATLHATTTGIADFVDDSVTAQINHVKAMLGFFPLHTDERPPVLPIMEPNHSIPDIPA
NPRMPFNMLNLIQAVVDNSNVIQYKRTYGQAMICAFVHIHGFAVGVVANQSIRYSGAIDSDAAQKAAKFIRICDAYSIPI
LTFIDVPGFMPGKREEQKGLLQHGARFCVAMQTRVPRLSVIVRKCYGAAAFLMMQTKSQNGDLVLALETANLGVMGKETT
NKVQAMDGQPAQEPSQSQLTEKSQIDDSLMEAYSLGLIDEIIHAAQIRSRLASHLEFLYRRMEIMPPAKHSIV

Sequences:

>Translated_473_residues
MSSQHTDKTLIKWIDNFIDEQSFLPIGSEYIPDNKFHSLPGSEVITGLAKVNQRPVAIYAHDSSVNRGYVTRQGARKIIH
LMDKAEKLRIPIVAFLASPGVSLEENLLSGDEYTQIIARNIRLSGIIPQFAVILAPTLGAPAYSAVLMDLLFFNKHRSYL
MVTSPTVVQQAIGEKVTMGELGSATLHATTTGIADFVDDSVTAQINHVKAMLGFFPLHTDERPPVLPIMEPNHSIPDIPA
NPRMPFNMLNLIQAVVDNSNVIQYKRTYGQAMICAFVHIHGFAVGVVANQSIRYSGAIDSDAAQKAAKFIRICDAYSIPI
LTFIDVPGFMPGKREEQKGLLQHGARFCVAMQTRVPRLSVIVRKCYGAAAFLMMQTKSQNGDLVLALETANLGVMGKETT
NKVQAMDGQPAQEPSQSQLTEKSQIDDSLMEAYSLGLIDEIIHAAQIRSRLASHLEFLYRRMEIMPPAKHSIV
>Mature_472_residues
SSQHTDKTLIKWIDNFIDEQSFLPIGSEYIPDNKFHSLPGSEVITGLAKVNQRPVAIYAHDSSVNRGYVTRQGARKIIHL
MDKAEKLRIPIVAFLASPGVSLEENLLSGDEYTQIIARNIRLSGIIPQFAVILAPTLGAPAYSAVLMDLLFFNKHRSYLM
VTSPTVVQQAIGEKVTMGELGSATLHATTTGIADFVDDSVTAQINHVKAMLGFFPLHTDERPPVLPIMEPNHSIPDIPAN
PRMPFNMLNLIQAVVDNSNVIQYKRTYGQAMICAFVHIHGFAVGVVANQSIRYSGAIDSDAAQKAAKFIRICDAYSIPIL
TFIDVPGFMPGKREEQKGLLQHGARFCVAMQTRVPRLSVIVRKCYGAAAFLMMQTKSQNGDLVLALETANLGVMGKETTN
KVQAMDGQPAQEPSQSQLTEKSQIDDSLMEAYSLGLIDEIIHAAQIRSRLASHLEFLYRRMEIMPPAKHSIV

Specific function: This Protein Is A Component Of The Acetyl Coenzyme A Carboxylase Complex; First, Biotin Carboxylase Catalyzes The Carboxylation Of The Carrier Protein And Then The Transcarboxylase Transfers The Carboxyl Group To Form Malonyl-CoA. [C]

COG id: COG4799

COG function: function code I; Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 carboxyltransferase domain [H]

Homologues:

Organism=Homo sapiens, GI119943100, Length=444, Percent_Identity=32.8828828828829, Blast_Score=260, Evalue=2e-69,
Organism=Homo sapiens, GI295821216, Length=464, Percent_Identity=31.6810344827586, Blast_Score=249, Evalue=3e-66,
Organism=Homo sapiens, GI11545863, Length=446, Percent_Identity=25.5605381165919, Blast_Score=127, Evalue=2e-29,
Organism=Caenorhabditis elegans, GI25147362, Length=438, Percent_Identity=29.4520547945205, Blast_Score=240, Evalue=1e-63,
Organism=Caenorhabditis elegans, GI25147359, Length=438, Percent_Identity=29.4520547945205, Blast_Score=240, Evalue=1e-63,
Organism=Caenorhabditis elegans, GI17552936, Length=403, Percent_Identity=25.0620347394541, Blast_Score=136, Evalue=3e-32,
Organism=Drosophila melanogaster, GI24586065, Length=417, Percent_Identity=23.7410071942446, Blast_Score=133, Evalue=2e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000438
- InterPro:   IPR000022
- InterPro:   IPR011763
- InterPro:   IPR011762 [H]

Pfam domain/function: PF01039 Carboxyl_trans [H]

EC number: =6.4.1.3 [H]

Molecular weight: Translated: 52124; Mature: 51993

Theoretical pI: Translated: 7.47; Mature: 7.47

Prosite motif: PS50980 COA_CT_NTER ; PS50989 COA_CT_CTER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSSQHTDKTLIKWIDNFIDEQSFLPIGSEYIPDNKFHSLPGSEVITGLAKVNQRPVAIYA
CCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCEEEEE
HDSSVNRGYVTRQGARKIIHLMDKAEKLRIPIVAFLASPGVSLEENLLSGDEYTQIIARN
ECCCCCCCCEEHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCHHHHHCCCHHHHHHHHHH
IRLSGIIPQFAVILAPTLGAPAYSAVLMDLLFFNKHRSYLMVTSPTVVQQAIGEKVTMGE
CHHCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCEEEEECHHHHHHHHCCCEECCC
LGSATLHATTTGIADFVDDSVTAQINHVKAMLGFFPLHTDERPPVLPIMEPNHSIPDIPA
CCCCEEEEHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCCCCEEEEECCCCCCCCCCC
NPRMPFNMLNLIQAVVDNSNVIQYKRTYGQAMICAFVHIHGFAVGVVANQSIRYSGAIDS
CCCCCHHHHHHHHHHHCCCCEEEEHHHHHHHHHHHHHHHHHEEEEEEECCCEEECCCCCH
DAAQKAAKFIRICDAYSIPILTFIDVPGFMPGKREEQKGLLQHGARFCVAMQTRVPRLSV
HHHHHHHHHHHHHCCCCCCEEEEECCCCCCCCCCHHHHHHHHHCHHEEEHHHHCCCHHHH
IVRKCYGAAAFLMMQTKSQNGDLVLALETANLGVMGKETTNKVQAMDGQPAQEPSQSQLT
HHHHHHHHHEEEEEEECCCCCCEEEEEEECCCCEECCCCCCHHEECCCCCCCCCCHHHHH
EKSQIDDSLMEAYSLGLIDEIIHAAQIRSRLASHLEFLYRRMEIMPPAKHSIV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHCCC
>Mature Secondary Structure 
SSQHTDKTLIKWIDNFIDEQSFLPIGSEYIPDNKFHSLPGSEVITGLAKVNQRPVAIYA
CCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCEEEEE
HDSSVNRGYVTRQGARKIIHLMDKAEKLRIPIVAFLASPGVSLEENLLSGDEYTQIIARN
ECCCCCCCCEEHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCHHHHHCCCHHHHHHHHHH
IRLSGIIPQFAVILAPTLGAPAYSAVLMDLLFFNKHRSYLMVTSPTVVQQAIGEKVTMGE
CHHCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCEEEEECHHHHHHHHCCCEECCC
LGSATLHATTTGIADFVDDSVTAQINHVKAMLGFFPLHTDERPPVLPIMEPNHSIPDIPA
CCCCEEEEHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCCCCEEEEECCCCCCCCCCC
NPRMPFNMLNLIQAVVDNSNVIQYKRTYGQAMICAFVHIHGFAVGVVANQSIRYSGAIDS
CCCCCHHHHHHHHHHHCCCCEEEEHHHHHHHHHHHHHHHHHEEEEEEECCCEEECCCCCH
DAAQKAAKFIRICDAYSIPILTFIDVPGFMPGKREEQKGLLQHGARFCVAMQTRVPRLSV
HHHHHHHHHHHHHCCCCCCEEEEECCCCCCCCCCHHHHHHHHHCHHEEEHHHHCCCHHHH
IVRKCYGAAAFLMMQTKSQNGDLVLALETANLGVMGKETTNKVQAMDGQPAQEPSQSQLT
HHHHHHHHHEEEEEEECCCCCCEEEEEEECCCCEECCCCCCHHEECCCCCCCCCCHHHHH
EKSQIDDSLMEAYSLGLIDEIIHAAQIRSRLASHLEFLYRRMEIMPPAKHSIV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8969508; 9384377 [H]