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The map label for this gene is hemL

Identifier: 148359068

GI number: 148359068

Start: 1766315

End: 1767604

Strand: Reverse

Name: hemL

Synonym: LPC_0955

Alternate gene names: 148359068

Gene position: 1767604-1766315 (Counterclockwise)

Preceding gene: 148359070

Following gene: 148359067

Centisome position: 49.42

GC content: 38.76

Gene sequence:

>1290_bases
ATGAGCCGTTCTTCAGATTTATTTCATAAAGCACAAACAATCATTCCCGGAGGTGTTAACTCACCGGTTCGAGCCTTCAA
AGGTGTTGGAGGTGAACCTGTTTTTTTCAAATCTGGCAAAGGTGCCTACCTGACGGATGTAGATGATAAACAATATATTG
ATTATGTTGGATCATGGGGACCACTTATCCTCGGACACTGCCATCCCAAGGTGATAGAAGCTGTGGATAATGTATTACAT
AGTGGTATGAGTTTTGGTGCTCCAACAGAACTGGAAATACAATTAGCTGAAAAAATTGCTTCCCTAATGCCATCAATAGA
AAAAATTCGCATGGTGAACTCAGGGACTGAAGCAACTATGACTGCAATTCGGCTGGCGCGCGGATTCACTAATAAAAATA
AATTTATTAAATTTAATGGCTGTTATCATGGGCATAGCGATAGCCTATTAGTTAAAGCGGGATCTGGTTTGCTTACTCTC
GGAATTCCTTCAACTCCAGGCATTCCACAAAGCATTACCGAACATACTTTAACGGCTGATTTTAATAACCTGGAACAAGT
TGCTCAACTCTTTGAAAAATATCCAAACGATATCGCTACTGTAATTTTGGAACCTGTTCCTGGCAATATGGGATTTATCC
TACCTAAGATAGAGTTTTTAAAAGGATTACGTGAGCTTTGCGATCAATATAATGCTTTGTTAATTTTTGATGAAGTAATG
ACTGGATTTAGAGTTGGTTTACATGGTGCACAGGGCTTGTTTGGGATTAAACCTGATATCACAACACTTGGAAAAATCAT
AGGTGGTGGTATGCCTGTAGGTGCTTTAGGCGGTAAACGTGAAATTATGTCCTTTCTGGCGCCTGAAGGCCCTGTATATC
AGGCTGGTACTCTTTCAGGAAATCCATTGGCTATGGCCGCAGGTTTGGCTACTTTAAAAGAGATTGAAAAAATTAATTTT
TTTGAAGATTTAAGCAATGCGACTAATAAATTAACCGAGGCATTAGCTGATGCGGCAGAAAACGCAAACATTCCATTTTT
TGCTGCATCATTGGGCGGAATGTTCGGGTTTTGTTTTACAGATAAGAATAGTGTTGAAAATTATTTGGATGTTGCTTCCT
CGGATGAAGTTTTATTTAAGAAATTTTTTCATGCTATGCTTGCTCAAGGAGTATATTTTGCGCCATCCATGTATGAAGCT
GGATTTGTCTCCAGTATGCATGGTGATTTGGAAATACAAAAAACATATGATGCTGCTGAATTGGTACTGAATCAATTAAA
ATCTGCCTGA

Upstream 100 bases:

>100_bases
AATATTTTAACATTTTTTGTATAATAAATTTCTGAAACATCTTGAATATTAAAAATAATAACTGATATTTGTCTAAAGTT
TATCATTTTTGGGATTTTCT

Downstream 100 bases:

>100_bases
TAGCAGAATTGTACCTTATTACCCTAAGTTACTTAAATACAATCTTTAAAATCAGTATTTGGGTAATTAAGTTCAGTAAA
GCGTCTAAATGTGATTGCAG

Product: glutamate-1-semialdehyde aminotransferase

Products: NA

Alternate protein names: GSA; Glutamate-1-semialdehyde aminotransferase; GSA-AT

Number of amino acids: Translated: 429; Mature: 428

Protein sequence:

>429_residues
MSRSSDLFHKAQTIIPGGVNSPVRAFKGVGGEPVFFKSGKGAYLTDVDDKQYIDYVGSWGPLILGHCHPKVIEAVDNVLH
SGMSFGAPTELEIQLAEKIASLMPSIEKIRMVNSGTEATMTAIRLARGFTNKNKFIKFNGCYHGHSDSLLVKAGSGLLTL
GIPSTPGIPQSITEHTLTADFNNLEQVAQLFEKYPNDIATVILEPVPGNMGFILPKIEFLKGLRELCDQYNALLIFDEVM
TGFRVGLHGAQGLFGIKPDITTLGKIIGGGMPVGALGGKREIMSFLAPEGPVYQAGTLSGNPLAMAAGLATLKEIEKINF
FEDLSNATNKLTEALADAAENANIPFFAASLGGMFGFCFTDKNSVENYLDVASSDEVLFKKFFHAMLAQGVYFAPSMYEA
GFVSSMHGDLEIQKTYDAAELVLNQLKSA

Sequences:

>Translated_429_residues
MSRSSDLFHKAQTIIPGGVNSPVRAFKGVGGEPVFFKSGKGAYLTDVDDKQYIDYVGSWGPLILGHCHPKVIEAVDNVLH
SGMSFGAPTELEIQLAEKIASLMPSIEKIRMVNSGTEATMTAIRLARGFTNKNKFIKFNGCYHGHSDSLLVKAGSGLLTL
GIPSTPGIPQSITEHTLTADFNNLEQVAQLFEKYPNDIATVILEPVPGNMGFILPKIEFLKGLRELCDQYNALLIFDEVM
TGFRVGLHGAQGLFGIKPDITTLGKIIGGGMPVGALGGKREIMSFLAPEGPVYQAGTLSGNPLAMAAGLATLKEIEKINF
FEDLSNATNKLTEALADAAENANIPFFAASLGGMFGFCFTDKNSVENYLDVASSDEVLFKKFFHAMLAQGVYFAPSMYEA
GFVSSMHGDLEIQKTYDAAELVLNQLKSA
>Mature_428_residues
SRSSDLFHKAQTIIPGGVNSPVRAFKGVGGEPVFFKSGKGAYLTDVDDKQYIDYVGSWGPLILGHCHPKVIEAVDNVLHS
GMSFGAPTELEIQLAEKIASLMPSIEKIRMVNSGTEATMTAIRLARGFTNKNKFIKFNGCYHGHSDSLLVKAGSGLLTLG
IPSTPGIPQSITEHTLTADFNNLEQVAQLFEKYPNDIATVILEPVPGNMGFILPKIEFLKGLRELCDQYNALLIFDEVMT
GFRVGLHGAQGLFGIKPDITTLGKIIGGGMPVGALGGKREIMSFLAPEGPVYQAGTLSGNPLAMAAGLATLKEIEKINFF
EDLSNATNKLTEALADAAENANIPFFAASLGGMFGFCFTDKNSVENYLDVASSDEVLFKKFFHAMLAQGVYFAPSMYEAG
FVSSMHGDLEIQKTYDAAELVLNQLKSA

Specific function: Porphyrin biosynthesis by the C5 pathway; second step. [C]

COG id: COG0001

COG function: function code H; Glutamate-1-semialdehyde aminotransferase

Gene ontology:

Cell location: Cytoplasm (Potential)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily

Homologues:

Organism=Homo sapiens, GI4557809, Length=309, Percent_Identity=31.7152103559871, Blast_Score=122, Evalue=9e-28,
Organism=Homo sapiens, GI13994255, Length=328, Percent_Identity=29.2682926829268, Blast_Score=112, Evalue=1e-24,
Organism=Homo sapiens, GI24119277, Length=305, Percent_Identity=27.8688524590164, Blast_Score=100, Evalue=4e-21,
Organism=Homo sapiens, GI284507298, Length=226, Percent_Identity=31.4159292035398, Blast_Score=83, Evalue=6e-16,
Organism=Escherichia coli, GI1786349, Length=426, Percent_Identity=58.6854460093897, Blast_Score=525, Evalue=1e-150,
Organism=Escherichia coli, GI1789016, Length=355, Percent_Identity=30.9859154929577, Blast_Score=158, Evalue=8e-40,
Organism=Escherichia coli, GI1787560, Length=382, Percent_Identity=32.4607329842932, Blast_Score=146, Evalue=3e-36,
Organism=Escherichia coli, GI1789759, Length=308, Percent_Identity=31.8181818181818, Blast_Score=139, Evalue=4e-34,
Organism=Escherichia coli, GI145693181, Length=299, Percent_Identity=34.7826086956522, Blast_Score=138, Evalue=6e-34,
Organism=Escherichia coli, GI1788044, Length=313, Percent_Identity=31.629392971246, Blast_Score=130, Evalue=2e-31,
Organism=Escherichia coli, GI1786991, Length=336, Percent_Identity=29.1666666666667, Blast_Score=100, Evalue=1e-22,
Organism=Caenorhabditis elegans, GI71992977, Length=334, Percent_Identity=28.1437125748503, Blast_Score=119, Evalue=4e-27,
Organism=Caenorhabditis elegans, GI25144271, Length=302, Percent_Identity=28.476821192053, Blast_Score=116, Evalue=2e-26,
Organism=Caenorhabditis elegans, GI25144274, Length=293, Percent_Identity=26.962457337884, Blast_Score=95, Evalue=6e-20,
Organism=Caenorhabditis elegans, GI32564660, Length=355, Percent_Identity=27.6056338028169, Blast_Score=92, Evalue=4e-19,
Organism=Saccharomyces cerevisiae, GI6323470, Length=306, Percent_Identity=29.4117647058824, Blast_Score=115, Evalue=1e-26,
Organism=Saccharomyces cerevisiae, GI6324432, Length=327, Percent_Identity=25.9938837920489, Blast_Score=89, Evalue=9e-19,
Organism=Saccharomyces cerevisiae, GI6324386, Length=362, Percent_Identity=26.2430939226519, Blast_Score=78, Evalue=3e-15,
Organism=Drosophila melanogaster, GI21357415, Length=304, Percent_Identity=28.6184210526316, Blast_Score=113, Evalue=2e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): GSA_LEGPC (A5IC29)

Other databases:

- EMBL:   CP000675
- RefSeq:   YP_001250275.1
- ProteinModelPortal:   A5IC29
- SMR:   A5IC29
- STRING:   A5IC29
- GeneID:   5180784
- GenomeReviews:   CP000675_GR
- KEGG:   lpc:LPC_0955
- eggNOG:   COG0001
- HOGENOM:   HBG725944
- OMA:   NANIPFF
- ProtClustDB:   PRK00062
- BioCyc:   LPNE400673:LPC_0955-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00375
- InterPro:   IPR004639
- InterPro:   IPR005814
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422
- Gene3D:   G3DSA:3.40.640.10
- Gene3D:   G3DSA:3.90.1150.10
- PANTHER:   PTHR11986
- TIGRFAMs:   TIGR00713

Pfam domain/function: PF00202 Aminotran_3; SSF53383 PyrdxlP-dep_Trfase_major

EC number: =5.4.3.8

Molecular weight: Translated: 46168; Mature: 46036

Theoretical pI: Translated: 5.42; Mature: 5.42

Prosite motif: PS00600 AA_TRANSFER_CLASS_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSRSSDLFHKAQTIIPGGVNSPVRAFKGVGGEPVFFKSGKGAYLTDVDDKQYIDYVGSWG
CCCCHHHHHHHHHHCCCCCCCHHHHHHCCCCCEEEEECCCCCEEECCCCHHHHHHHCCCC
PLILGHCHPKVIEAVDNVLHSGMSFGAPTELEIQLAEKIASLMPSIEKIRMVNSGTEATM
CEEEECCCHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHCCCHHHHHHHCCCCHHHH
TAIRLARGFTNKNKFIKFNGCYHGHSDSLLVKAGSGLLTLGIPSTPGIPQSITEHTLTAD
HHHHHHHCCCCCCCEEEEECEECCCCCCEEEEECCCEEEECCCCCCCCCHHHHHHHHHCC
FNNLEQVAQLFEKYPNDIATVILEPVPGNMGFILPKIEFLKGLRELCDQYNALLIFDEVM
HHHHHHHHHHHHHCCCCEEEEEEECCCCCCCEEHHHHHHHHHHHHHHHHCCEEEEEHHHH
TGFRVGLHGAQGLFGIKPDITTLGKIIGGGMPVGALGGKREIMSFLAPEGPVYQAGTLSG
HHHHHHCCCCCCCCCCCCCHHHHHHHHCCCCCCCCCCCHHHHHHHHCCCCCCEECCCCCC
NPLAMAAGLATLKEIEKINFFEDLSNATNKLTEALADAAENANIPFFAASLGGMFGFCFT
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEHHHHCCCEEEEEC
DKNSVENYLDVASSDEVLFKKFFHAMLAQGVYFAPSMYEAGFVSSMHGDLEIQKTYDAAE
CCHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHCCCCEEEEEHHHHHH
LVLNQLKSA
HHHHHHHCC
>Mature Secondary Structure 
SRSSDLFHKAQTIIPGGVNSPVRAFKGVGGEPVFFKSGKGAYLTDVDDKQYIDYVGSWG
CCCHHHHHHHHHHCCCCCCCHHHHHHCCCCCEEEEECCCCCEEECCCCHHHHHHHCCCC
PLILGHCHPKVIEAVDNVLHSGMSFGAPTELEIQLAEKIASLMPSIEKIRMVNSGTEATM
CEEEECCCHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHCCCHHHHHHHCCCCHHHH
TAIRLARGFTNKNKFIKFNGCYHGHSDSLLVKAGSGLLTLGIPSTPGIPQSITEHTLTAD
HHHHHHHCCCCCCCEEEEECEECCCCCCEEEEECCCEEEECCCCCCCCCHHHHHHHHHCC
FNNLEQVAQLFEKYPNDIATVILEPVPGNMGFILPKIEFLKGLRELCDQYNALLIFDEVM
HHHHHHHHHHHHHCCCCEEEEEEECCCCCCCEEHHHHHHHHHHHHHHHHCCEEEEEHHHH
TGFRVGLHGAQGLFGIKPDITTLGKIIGGGMPVGALGGKREIMSFLAPEGPVYQAGTLSG
HHHHHHCCCCCCCCCCCCCHHHHHHHHCCCCCCCCCCCHHHHHHHHCCCCCCEECCCCCC
NPLAMAAGLATLKEIEKINFFEDLSNATNKLTEALADAAENANIPFFAASLGGMFGFCFT
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEHHHHCCCEEEEEC
DKNSVENYLDVASSDEVLFKKFFHAMLAQGVYFAPSMYEAGFVSSMHGDLEIQKTYDAAE
CCHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHCCCCEEEEEHHHHHH
LVLNQLKSA
HHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA