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The map label for this gene is mutH [H]

Identifier: 148359009

GI number: 148359009

Start: 1697514

End: 1698188

Strand: Direct

Name: mutH [H]

Synonym: LPC_0894

Alternate gene names: 148359009

Gene position: 1697514-1698188 (Clockwise)

Preceding gene: 148359008

Following gene: 148359011

Centisome position: 47.46

GC content: 38.07

Gene sequence:

>675_bases
GTGATTTTAGCCTTAAAAAGCAAACCACCGAAGAATGAAAAAGAACTTTTGGAGCAATGCCAGCGAATTGAAGGGTTGAG
TTTCGCTCAGTTAGCTCTTGAATTGGGTCTATTTACCCCTTTAAACCCTGTTCATCGAAAAGGATGGGTCGGACAAGCTC
TCGAGATAGCTTTAGGTACTGATGCAAAAAATGAGTCGCTACCTGATTTTAAGCAGTTGGGCATTGAATTAAAAACGATA
CCTATTAATAAATCAGGGAAACCGGCCGAATCCACATTTATTGTTTCTATTCCACTACTGACCATCCATCAACAAAGTTG
GGAGTCTTCTCAATGTTACGCTAAATTAAAAAGGGTATTATGGATTCCTATAGAGGGAGATACAGATATTCCTTTTCCTC
ATAGGAGAATTGGACGTGGATTTTTATGGTCTCCGAATAAAGATCAGAAATCTGTTCTTGCAGAAGATTGGAATTATTTA
ACAAACCAAATTGTTCTGGGACAATTAGAAACATTAAACTCCTCTTCGGGAGAGTATCTTCAAGTGAGGCCTAAGGCTGC
CAATGGAAAATCTTTATGTTATGGTTATGACCCAGAAGGTAATCGTATAAGAACGTTACCACGAGGATTTTATTTACGCT
CCTGTTTTACATCCGTAATTTTAAGTCAATCCTAA

Upstream 100 bases:

>100_bases
GTAAGGTCAAAAGTCTTGTTTGCCATAACTGCACAGTTTAAAGCGGCAGGAATACAGCCGCCAATTGAGCCTATTACTGT
TGAACTAAAAGAGAGCTCCA

Downstream 100 bases:

>100_bases
TTTTAAGGATAAAGTAAGCACCATCTGTTTACCGATATTATGATAAATTTTACAGATATTAGGGAAAGCTCATTATAGCT
TTTGTCGATTAGTATGCATG

Product: DNA mismatch repair protein

Products: NA

Alternate protein names: Methyl-directed mismatch repair protein [H]

Number of amino acids: Translated: 224; Mature: 224

Protein sequence:

>224_residues
MILALKSKPPKNEKELLEQCQRIEGLSFAQLALELGLFTPLNPVHRKGWVGQALEIALGTDAKNESLPDFKQLGIELKTI
PINKSGKPAESTFIVSIPLLTIHQQSWESSQCYAKLKRVLWIPIEGDTDIPFPHRRIGRGFLWSPNKDQKSVLAEDWNYL
TNQIVLGQLETLNSSSGEYLQVRPKAANGKSLCYGYDPEGNRIRTLPRGFYLRSCFTSVILSQS

Sequences:

>Translated_224_residues
MILALKSKPPKNEKELLEQCQRIEGLSFAQLALELGLFTPLNPVHRKGWVGQALEIALGTDAKNESLPDFKQLGIELKTI
PINKSGKPAESTFIVSIPLLTIHQQSWESSQCYAKLKRVLWIPIEGDTDIPFPHRRIGRGFLWSPNKDQKSVLAEDWNYL
TNQIVLGQLETLNSSSGEYLQVRPKAANGKSLCYGYDPEGNRIRTLPRGFYLRSCFTSVILSQS
>Mature_224_residues
MILALKSKPPKNEKELLEQCQRIEGLSFAQLALELGLFTPLNPVHRKGWVGQALEIALGTDAKNESLPDFKQLGIELKTI
PINKSGKPAESTFIVSIPLLTIHQQSWESSQCYAKLKRVLWIPIEGDTDIPFPHRRIGRGFLWSPNKDQKSVLAEDWNYL
TNQIVLGQLETLNSSSGEYLQVRPKAANGKSLCYGYDPEGNRIRTLPRGFYLRSCFTSVILSQS

Specific function: Sequence-specific endonuclease that cleaves unmethylated GATC sequences. It is involved in DNA mismatch repair [H]

COG id: COG3066

COG function: function code L; DNA mismatch repair protein

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the mutH family [H]

Homologues:

Organism=Escherichia coli, GI1789196, Length=215, Percent_Identity=48.8372093023256, Blast_Score=218, Evalue=2e-58,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004230
- InterPro:   IPR011337
- InterPro:   IPR011335 [H]

Pfam domain/function: PF02976 MutH [H]

EC number: NA

Molecular weight: Translated: 25194; Mature: 25194

Theoretical pI: Translated: 9.15; Mature: 9.15

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
0.4 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
0.4 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MILALKSKPPKNEKELLEQCQRIEGLSFAQLALELGLFTPLNPVHRKGWVGQALEIALGT
CEEEECCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCHHHHCCCCCCEEEEEECC
DAKNESLPDFKQLGIELKTIPINKSGKPAESTFIVSIPLLTIHQQSWESSQCYAKLKRVL
CCCCCCCCCHHHCCEEEEEEECCCCCCCCCCEEEEEEEEEEEECCCCCCHHHHHHHHHEE
WIPIEGDTDIPFPHRRIGRGFLWSPNKDQKSVLAEDWNYLTNQIVLGQLETLNSSSGEYL
EEECCCCCCCCCCHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHEEEHHHHCCCCCCCEE
QVRPKAANGKSLCYGYDPEGNRIRTLPRGFYLRSCFTSVILSQS
EEECCCCCCCEEEEEECCCCCEEEECCCHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MILALKSKPPKNEKELLEQCQRIEGLSFAQLALELGLFTPLNPVHRKGWVGQALEIALGT
CEEEECCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCHHHHCCCCCCEEEEEECC
DAKNESLPDFKQLGIELKTIPINKSGKPAESTFIVSIPLLTIHQQSWESSQCYAKLKRVL
CCCCCCCCCHHHCCEEEEEEECCCCCCCCCCEEEEEEEEEEEECCCCCCHHHHHHHHHEE
WIPIEGDTDIPFPHRRIGRGFLWSPNKDQKSVLAEDWNYLTNQIVLGQLETLNSSSGEYL
EEECCCCCCCCCCHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHEEEHHHHCCCCCCCEE
QVRPKAANGKSLCYGYDPEGNRIRTLPRGFYLRSCFTSVILSQS
EEECCCCCCCEEEEEECCCCCEEEECCCHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA