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The map label for this gene is tmk [H]

Identifier: 148358930

GI number: 148358930

Start: 1609347

End: 1609985

Strand: Direct

Name: tmk [H]

Synonym: LPC_0815

Alternate gene names: 148358930

Gene position: 1609347-1609985 (Clockwise)

Preceding gene: 148358929

Following gene: 148358931

Centisome position: 45.0

GC content: 37.25

Gene sequence:

>639_bases
ATGTCATCGTTAACCGGGAAATTGATAGTTATTGAAGGTTTGGAGGGGGCAGGAAAATCTACAGCTGTCAATTTAGTTGT
TGAACTGTTATCCCAAAAAAAAATCAGTACTATAACCACGAGAGAACCCGGAGGAACAAGAATAGGTGAAATTTTAAGAA
GTATTATTAAAAATCCAGAGTACAATAATGTTCTGGATGACAGAAGCGAATTACTTCTCCTGTATGCCGCAAGAATACAA
CTGATTGAGCAAGTGATCAAACCCGCTTTAAATGAGGGGCAGTGGGTCATAGCTGATCGATTTGAGCTTTCCACTTTAGC
TTATCAGGGAGGGGGCCGCAAAATGGATATGCGGGTTATTAATGAGCTATCGAATTTCTGTTTAAAAGGATTCAAACCTG
ATCTTACTTTATATTTAGACATTAATCCCGAGCTTGGCATGATAAGAGCTAAATCAAGGGGAAAATTTGACAGGATTGAG
CAGGAATCAATTGAGTTTTTTCATAGAATACATGATACATATCATATTCTTGTTAAACAAAACCCGGAAATTATGATGAT
TGATGCTAACAGGCCTTTGGAAGATGTTCAATCTTCCATTCAATCAGTAATCGAGGAGTTTATAGAGCATAACCTATGA

Upstream 100 bases:

>100_bases
ATTTATACTTTGTTGCCAAAGGAGATGGCACTCATCAATTCTCCGAAACTTATGAGCAACAAAGACAAGCAATTAACCAA
TACAGACGCAAGGATTATTA

Downstream 100 bases:

>100_bases
TTACTTATCAAGAACAATGGCAGAAAATGCAAATGGCCTTGGCGATAAGACGAATTCCTCAAGCCATGCTATTTTTGGGT
TCTTTGCATTGTGGTCTTAT

Product: thymidylate kinase

Products: NA

Alternate protein names: dTMP kinase [H]

Number of amino acids: Translated: 212; Mature: 211

Protein sequence:

>212_residues
MSSLTGKLIVIEGLEGAGKSTAVNLVVELLSQKKISTITTREPGGTRIGEILRSIIKNPEYNNVLDDRSELLLLYAARIQ
LIEQVIKPALNEGQWVIADRFELSTLAYQGGGRKMDMRVINELSNFCLKGFKPDLTLYLDINPELGMIRAKSRGKFDRIE
QESIEFFHRIHDTYHILVKQNPEIMMIDANRPLEDVQSSIQSVIEEFIEHNL

Sequences:

>Translated_212_residues
MSSLTGKLIVIEGLEGAGKSTAVNLVVELLSQKKISTITTREPGGTRIGEILRSIIKNPEYNNVLDDRSELLLLYAARIQ
LIEQVIKPALNEGQWVIADRFELSTLAYQGGGRKMDMRVINELSNFCLKGFKPDLTLYLDINPELGMIRAKSRGKFDRIE
QESIEFFHRIHDTYHILVKQNPEIMMIDANRPLEDVQSSIQSVIEEFIEHNL
>Mature_211_residues
SSLTGKLIVIEGLEGAGKSTAVNLVVELLSQKKISTITTREPGGTRIGEILRSIIKNPEYNNVLDDRSELLLLYAARIQL
IEQVIKPALNEGQWVIADRFELSTLAYQGGGRKMDMRVINELSNFCLKGFKPDLTLYLDINPELGMIRAKSRGKFDRIEQ
ESIEFFHRIHDTYHILVKQNPEIMMIDANRPLEDVQSSIQSVIEEFIEHNL

Specific function: Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis [H]

COG id: COG0125

COG function: function code F; Thymidylate kinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thymidylate kinase family [H]

Homologues:

Organism=Homo sapiens, GI42544174, Length=214, Percent_Identity=29.9065420560748, Blast_Score=72, Evalue=4e-13,
Organism=Escherichia coli, GI1787340, Length=206, Percent_Identity=51.4563106796116, Blast_Score=214, Evalue=4e-57,
Organism=Saccharomyces cerevisiae, GI6322517, Length=218, Percent_Identity=28.4403669724771, Blast_Score=65, Evalue=7e-12,
Organism=Drosophila melanogaster, GI28573735, Length=207, Percent_Identity=30.9178743961353, Blast_Score=79, Evalue=2e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR018094 [H]

Pfam domain/function: PF02223 Thymidylate_kin [H]

EC number: =2.7.4.9 [H]

Molecular weight: Translated: 24082; Mature: 23951

Theoretical pI: Translated: 5.39; Mature: 5.39

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSSLTGKLIVIEGLEGAGKSTAVNLVVELLSQKKISTITTREPGGTRIGEILRSIIKNPE
CCCCCCCEEEEECCCCCCCHHHHHHHHHHHHCCHHHEEECCCCCCCHHHHHHHHHHCCCC
YNNVLDDRSELLLLYAARIQLIEQVIKPALNEGQWVIADRFELSTLAYQGGGRKMDMRVI
CCCHHCCHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECEEHHHEEECCCCCCHHHHHH
NELSNFCLKGFKPDLTLYLDINPELGMIRAKSRGKFDRIEQESIEFFHRIHDTYHILVKQ
HHHHHHHHCCCCCCEEEEEEECCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHEEEEEEC
NPEIMMIDANRPLEDVQSSIQSVIEEFIEHNL
CCCEEEEECCCCHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
SSLTGKLIVIEGLEGAGKSTAVNLVVELLSQKKISTITTREPGGTRIGEILRSIIKNPE
CCCCCCEEEEECCCCCCCHHHHHHHHHHHHCCHHHEEECCCCCCCHHHHHHHHHHCCCC
YNNVLDDRSELLLLYAARIQLIEQVIKPALNEGQWVIADRFELSTLAYQGGGRKMDMRVI
CCCHHCCHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECEEHHHEEECCCCCCHHHHHH
NELSNFCLKGFKPDLTLYLDINPELGMIRAKSRGKFDRIEQESIEFFHRIHDTYHILVKQ
HHHHHHHHCCCCCCEEEEEEECCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHEEEEEEC
NPEIMMIDANRPLEDVQSSIQSVIEEFIEHNL
CCCEEEEECCCCHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA