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The map label for this gene is hutU [H]

Identifier: 148358910

GI number: 148358910

Start: 1590974

End: 1592638

Strand: Direct

Name: hutU [H]

Synonym: LPC_0795

Alternate gene names: 148358910

Gene position: 1590974-1592638 (Clockwise)

Preceding gene: 148358904

Following gene: 148358911

Centisome position: 44.48

GC content: 43.66

Gene sequence:

>1665_bases
ATGAGCAAGGACAAGAATAAACGTGTTATTTCTGCCCCTAGAGGTACCGAAATTCAAGCTAAAAATTGGTTAACTGAGGC
GGCATTAAGGATGATTTGCAATAATTTGGATCCCAATGTTGCAGAGGATCCCGATTCTTTGATTGTTTATGGTGGATTGG
GCAAGGCAGCCAGAAACTGGGAATGTTTTGATGAAATTGTTCATGTATTGAAATTATTAAATAATGATCAGACTTTACTC
ATTCAGTCCGGAAAACCTGTCGGTGTATTTACTACCCATGAAGAGGCTCCCAGAATACTAATTGCCAATTCTAATTTGGT
ACCGCGCTGGGCTACTTGGGAGCATTTTAACGAACTGGATAAGAAAGGCCTGATGATGTATGGCCAGATGACCGCCGGCA
GCTGGATTTATATTGGTTCTCAAGGCATTGTGCAAGGAACTTATGAGACATTTGTTGCGGCAGCTAAAAAACATTATCAG
GGTGATTTGTCCGGGCGTTGGATTTTAACAGCGGGTTTAGGGGGAATGGGTGGAGCTCAACCTTTAGCTGGAACTATGGC
TGGTGCCAGCGTTCTGGCTGTAGAATGTGACAGGCAAAGGATTGAGAAACGTTTACAGACGAAATATCTGGATCGGTACA
CTGATAATTTAAGTGAAGCATTAGACTGGATTAATGAATCCTGTCGCTGTAAAAAGCCAGTTTCAGTAGCTGTTTTGGGA
AATGCTGCCGAAATATTTCCTCAGCTGGTTAAGTTGGGAGTTCACCCTTCCCTGGTTACCGATCAAACCAGTGCTCATGA
TCCGCTCAATGGCTATTTGCCATTAGGATGGACATTGGAACAAGCTGTTGAAATGAGAAAAAAATCACCAGAAGAGGTTG
TTGATGCAGCCAAGAAATCGATGGCTGTTCAAGTGCATGCAATGCTTGAGTTTCATAACAGAGGCATTCCTGTATTTGAT
TATGGCAATAACATTAGACAAATGGCATTTGAAGCGGGAGAAAAAAACGCTTTTTCCTTTGAGGGATTTGTACCGGCTTA
TATCAGGCCATTATTTTGCGAAGGAATCGGACCATTTCGATGGGTTGCATTGTCAGGTGATCCAGAAGATATTTATGCAA
CAGATGAGCGAGTAAAGCAGCTAATTCCTGATGATCCTCACTTACATCATTGGTTAGATATGGCCAGGGAAAAAATTTCA
TTTCAGGGATTACCAGCAAGGATATGTTGGGTAGGGTTAAAGGATAGAGCGCGCCTTGCCCTTGCTTTCAATGAAATGGT
TAAAAATAAACAAGTTAAAGCGCCTATTGTGATTGGCCGTGACCATTTAGATTCTGGTTCTGTGGCCAGCCCCAACCGCG
AAACAGAGGGTATGCTGGATGGCAGTGATGCTGTTTCTGATTGGCCTTTGCTTAATGCGCTGTTAAATTGTGCCAGTGGG
GCTACTTGGGTAAGCATTCATCATGGGGGAGGGGTTGGTATGGGCTTTTCTCAACATGCTGGCGTTGTGATCGTTGCTGA
TGGAACAGAAAAAGCGGCTAAACGATTGGCTCGCGTGCTACACAATGATCCTGCGACAGGGGTAATGAGGCATGCTGATG
CAGGTTATCAAATTGCCAAGCAATGTGCCAAAGAGAATTCGCTTTGGCTACCCATGGAATCTTAA

Upstream 100 bases:

>100_bases
CCGGAGGTAGTTGACTGGTGTATGATGCTAAAAAATTTTTTAATCGCTATTTGATAGGAAATAATAACTGAAGTTTTCAT
AGCAATAAGGAGTATTCTTG

Downstream 100 bases:

>100_bases
AAGGAGCAGGTTTATGTCAGAACATTTTATATTGCAGCCTGGCCAGTTATCGCTACTTTCTATTAAACAAATTTTAGATG
AGGAACTATCTTGCGTTCTT

Product: urocanate hydratase

Products: NA

Alternate protein names: Urocanase; Imidazolonepropionate hydrolase [H]

Number of amino acids: Translated: 554; Mature: 553

Protein sequence:

>554_residues
MSKDKNKRVISAPRGTEIQAKNWLTEAALRMICNNLDPNVAEDPDSLIVYGGLGKAARNWECFDEIVHVLKLLNNDQTLL
IQSGKPVGVFTTHEEAPRILIANSNLVPRWATWEHFNELDKKGLMMYGQMTAGSWIYIGSQGIVQGTYETFVAAAKKHYQ
GDLSGRWILTAGLGGMGGAQPLAGTMAGASVLAVECDRQRIEKRLQTKYLDRYTDNLSEALDWINESCRCKKPVSVAVLG
NAAEIFPQLVKLGVHPSLVTDQTSAHDPLNGYLPLGWTLEQAVEMRKKSPEEVVDAAKKSMAVQVHAMLEFHNRGIPVFD
YGNNIRQMAFEAGEKNAFSFEGFVPAYIRPLFCEGIGPFRWVALSGDPEDIYATDERVKQLIPDDPHLHHWLDMAREKIS
FQGLPARICWVGLKDRARLALAFNEMVKNKQVKAPIVIGRDHLDSGSVASPNRETEGMLDGSDAVSDWPLLNALLNCASG
ATWVSIHHGGGVGMGFSQHAGVVIVADGTEKAAKRLARVLHNDPATGVMRHADAGYQIAKQCAKENSLWLPMES

Sequences:

>Translated_554_residues
MSKDKNKRVISAPRGTEIQAKNWLTEAALRMICNNLDPNVAEDPDSLIVYGGLGKAARNWECFDEIVHVLKLLNNDQTLL
IQSGKPVGVFTTHEEAPRILIANSNLVPRWATWEHFNELDKKGLMMYGQMTAGSWIYIGSQGIVQGTYETFVAAAKKHYQ
GDLSGRWILTAGLGGMGGAQPLAGTMAGASVLAVECDRQRIEKRLQTKYLDRYTDNLSEALDWINESCRCKKPVSVAVLG
NAAEIFPQLVKLGVHPSLVTDQTSAHDPLNGYLPLGWTLEQAVEMRKKSPEEVVDAAKKSMAVQVHAMLEFHNRGIPVFD
YGNNIRQMAFEAGEKNAFSFEGFVPAYIRPLFCEGIGPFRWVALSGDPEDIYATDERVKQLIPDDPHLHHWLDMAREKIS
FQGLPARICWVGLKDRARLALAFNEMVKNKQVKAPIVIGRDHLDSGSVASPNRETEGMLDGSDAVSDWPLLNALLNCASG
ATWVSIHHGGGVGMGFSQHAGVVIVADGTEKAAKRLARVLHNDPATGVMRHADAGYQIAKQCAKENSLWLPMES
>Mature_553_residues
SKDKNKRVISAPRGTEIQAKNWLTEAALRMICNNLDPNVAEDPDSLIVYGGLGKAARNWECFDEIVHVLKLLNNDQTLLI
QSGKPVGVFTTHEEAPRILIANSNLVPRWATWEHFNELDKKGLMMYGQMTAGSWIYIGSQGIVQGTYETFVAAAKKHYQG
DLSGRWILTAGLGGMGGAQPLAGTMAGASVLAVECDRQRIEKRLQTKYLDRYTDNLSEALDWINESCRCKKPVSVAVLGN
AAEIFPQLVKLGVHPSLVTDQTSAHDPLNGYLPLGWTLEQAVEMRKKSPEEVVDAAKKSMAVQVHAMLEFHNRGIPVFDY
GNNIRQMAFEAGEKNAFSFEGFVPAYIRPLFCEGIGPFRWVALSGDPEDIYATDERVKQLIPDDPHLHHWLDMAREKISF
QGLPARICWVGLKDRARLALAFNEMVKNKQVKAPIVIGRDHLDSGSVASPNRETEGMLDGSDAVSDWPLLNALLNCASGA
TWVSIHHGGGVGMGFSQHAGVVIVADGTEKAAKRLARVLHNDPATGVMRHADAGYQIAKQCAKENSLWLPMES

Specific function: Unknown

COG id: COG2987

COG function: function code E; Urocanate hydratase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the urocanase family [H]

Homologues:

Organism=Homo sapiens, GI21389467, Length=554, Percent_Identity=35.1985559566787, Blast_Score=315, Evalue=1e-85,
Organism=Homo sapiens, GI260306182, Length=614, Percent_Identity=32.7361563517915, Blast_Score=293, Evalue=2e-79,
Organism=Caenorhabditis elegans, GI71997891, Length=563, Percent_Identity=35.5239786856128, Blast_Score=329, Evalue=3e-90,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000193 [H]

Pfam domain/function: PF01175 Urocanase [H]

EC number: =4.2.1.49 [H]

Molecular weight: Translated: 60973; Mature: 60842

Theoretical pI: Translated: 6.76; Mature: 6.76

Prosite motif: PS01233 UROCANASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKDKNKRVISAPRGTEIQAKNWLTEAALRMICNNLDPNVAEDPDSLIVYGGLGKAARNW
CCCCCCCEEEECCCCCEEHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEECCCCCCCCCH
ECFDEIVHVLKLLNNDQTLLIQSGKPVGVFTTHEEAPRILIANSNLVPRWATWEHFNELD
HHHHHHHHHHHHHCCCCEEEEECCCCEEEEECCCCCCEEEEECCCCCCCCCCHHHHHHHC
KKGLMMYGQMTAGSWIYIGSQGIVQGTYETFVAAAKKHYQGDLSGRWILTAGLGGMGGAQ
CCCEEEEEEECCCCEEEECCCCCCCHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCCCCC
PLAGTMAGASVLAVECDRQRIEKRLQTKYLDRYTDNLSEALDWINESCRCKKPVSVAVLG
CHHHHHCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEC
NAAEIFPQLVKLGVHPSLVTDQTSAHDPLNGYLPLGWTLEQAVEMRKKSPEEVVDAAKKS
CHHHHHHHHHHHCCCCCEECCCCCCCCCCCCCCCCCCCHHHHHHHHHCCHHHHHHHHHHH
MAVQVHAMLEFHNRGIPVFDYGNNIRQMAFEAGEKNAFSFEGFVPAYIRPLFCEGIGPFR
HHHHHHHHHHHHCCCCEEEECCCHHHHHHHHCCCCCCEEECCCCHHHHHHHHHCCCCCEE
WVALSGDPEDIYATDERVKQLIPDDPHLHHWLDMAREKISFQGLPARICWVGLKDRARLA
EEEECCCCCCCCCCHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCCEEEEEEECCCCHHHH
LAFNEMVKNKQVKAPIVIGRDHLDSGSVASPNRETEGMLDGSDAVSDWPLLNALLNCASG
HHHHHHHCCCCCCCCEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHCCC
ATWVSIHHGGGVGMGFSQHAGVVIVADGTEKAAKRLARVLHNDPATGVMRHADAGYQIAK
CEEEEEECCCCCCCCCCCCCCEEEEECCCHHHHHHHHHHHCCCCCHHHHHHCCCCHHHHH
QCAKENSLWLPMES
HHHCCCCEEECCCC
>Mature Secondary Structure 
SKDKNKRVISAPRGTEIQAKNWLTEAALRMICNNLDPNVAEDPDSLIVYGGLGKAARNW
CCCCCCEEEECCCCCEEHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEECCCCCCCCCH
ECFDEIVHVLKLLNNDQTLLIQSGKPVGVFTTHEEAPRILIANSNLVPRWATWEHFNELD
HHHHHHHHHHHHHCCCCEEEEECCCCEEEEECCCCCCEEEEECCCCCCCCCCHHHHHHHC
KKGLMMYGQMTAGSWIYIGSQGIVQGTYETFVAAAKKHYQGDLSGRWILTAGLGGMGGAQ
CCCEEEEEEECCCCEEEECCCCCCCHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCCCCC
PLAGTMAGASVLAVECDRQRIEKRLQTKYLDRYTDNLSEALDWINESCRCKKPVSVAVLG
CHHHHHCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEC
NAAEIFPQLVKLGVHPSLVTDQTSAHDPLNGYLPLGWTLEQAVEMRKKSPEEVVDAAKKS
CHHHHHHHHHHHCCCCCEECCCCCCCCCCCCCCCCCCCHHHHHHHHHCCHHHHHHHHHHH
MAVQVHAMLEFHNRGIPVFDYGNNIRQMAFEAGEKNAFSFEGFVPAYIRPLFCEGIGPFR
HHHHHHHHHHHHCCCCEEEECCCHHHHHHHHCCCCCCEEECCCCHHHHHHHHHCCCCCEE
WVALSGDPEDIYATDERVKQLIPDDPHLHHWLDMAREKISFQGLPARICWVGLKDRARLA
EEEECCCCCCCCCCHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCCEEEEEEECCCCHHHH
LAFNEMVKNKQVKAPIVIGRDHLDSGSVASPNRETEGMLDGSDAVSDWPLLNALLNCASG
HHHHHHHCCCCCCCCEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHCCC
ATWVSIHHGGGVGMGFSQHAGVVIVADGTEKAAKRLARVLHNDPATGVMRHADAGYQIAK
CEEEEEECCCCCCCCCCCCCCEEEEECCCHHHHHHHHHHHCCCCCHHHHHHCCCCHHHHH
QCAKENSLWLPMES
HHHCCCCEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA