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The map label for this gene is hutH [H]

Identifier: 148358911

GI number: 148358911

Start: 1592652

End: 1594169

Strand: Direct

Name: hutH [H]

Synonym: LPC_0796

Alternate gene names: 148358911

Gene position: 1592652-1594169 (Clockwise)

Preceding gene: 148358910

Following gene: 148358912

Centisome position: 44.53

GC content: 40.32

Gene sequence:

>1518_bases
ATGTCAGAACATTTTATATTGCAGCCTGGCCAGTTATCGCTACTTTCTATTAAACAAATTTTAGATGAGGAACTATCTTG
CGTTCTTGCTGAGAACGCCTTTGAATTAATTAGAGCATCTCACCAAACGGTAAAAAAAGTAATCGATGAAAAGAAAACAG
TATATGGAATCAATACAGGTTTTGGTTCTCTGGCAAACCAGACCATTTCTTCAGATTGTTTGAAAGAGTTGCAGCGTAAT
ATTGTACTTTCTCATGCTTGTGGAACAGGTAAATTATTGCCGGATGACGTGGTTGCCTTGATTTTGCTTTTGAAAATTAA
TAATTTGTCTCAAGGGTATTCCGGAGTTAGGCTGGAATTAATCAATGCATTGATTGCTTTGTTTAATCATAAAGTATATC
CATGCATTCCTTCTAAGGGTTCGGTAGGTGCGTCCGGAGATTTAGTCCCGCTTGCGCATTTGTCTTTACCTTTGTTAGGA
GAAGGCGAAGTAAGGCATCAAGGTCAGGTGATCAGTGCTGAGGAAGGGCTAAAACTGGCTGGATTGAAACCGCTTGAATT
GGAAGCTAAAGAAGGATTAGCACTGCTTAATGGCTTACAGGTATCTACCGCTTTAGCTTTGTCAGCTCTGTTTATTAGTG
AGACATTGTTTGAAACAGCGATTATTTCTGGCAGTTTGTCAGTAGATGCTGCCAGTGGGAGTGATGTGCCCTTTGATGAC
AGAATACATCAAATTCGAGGACATCAAGCTCAAATTTCTGCTGCCAGGATGTACAGAAATTTATTGGCAGGCAGTCAAAT
TCGAGAGTCACACAGGTATTGTAATCGTGTTCAGGATCCTTATTCTTTAAGATGTCAGCCACAAATCATGGGGGCAGTTC
TTCATCAGATGGAGTTTGTTGGACAAACTCTTCAAGTAGAGGCCAATGCAATTTCCGATAATCCTCTCGTTTTTGCAGAG
CAGGGGGATATTTTGTCTGGGGGGAATTTTCATGGTGAAATCATCGCAATGGCTGCTGACAATTTAGCATTGGCATTATC
CGAGATAGGAGGTAGTGCAGAACGGCGAATCGCTTTATTAATTGATAAAAATTTTAGTGGATTGCCTGCTTTCCTGGTTA
GAGAAAGCGGCTTAAATTCAGGTTTTATGATTGCCCATGTTACTGCTGCCTCCTGTGCCAGTGATAACAAAGCGCTTGCT
CATCCGCACTCCGTCGATAGTTTGCCTACCTCGGCAAATCAGGAAGATCATGTTTCTATGGCAACTAGCGCAGCACGTCG
ACTGCATGAAATGATCGATAATACTTCAACAATTCTTGCTATTGAGTTATTGGCAGCTTGTCAAGGACTGGAATTTCACA
AACCTCTAAAGACATCACCGCAATTGGATAAAATTTATCAAAGCGTAAGAAGCGTGGTTAAAGAGTATGATAAAGATCGC
TATTTTGCGCCTGATATAGAAAAAATTAAAAAGAAGATTTTAGATAAGGAATTCTCATTACTCACACTCACGAATTAA

Upstream 100 bases:

>100_bases
GGGGTAATGAGGCATGCTGATGCAGGTTATCAAATTGCCAAGCAATGTGCCAAAGAGAATTCGCTTTGGCTACCCATGGA
ATCTTAAAAGGAGCAGGTTT

Downstream 100 bases:

>100_bases
TAGCAGGAAAAATACAATGGAATTGATGGCAGAATTTCTAGCTTTGCATCAACAACACAAAAACAATCCTTATCCTTCTT
TGTCTGAAAGAAAAAAATTG

Product: histidine ammonia-lyase

Products: NA

Alternate protein names: Histidase [H]

Number of amino acids: Translated: 505; Mature: 504

Protein sequence:

>505_residues
MSEHFILQPGQLSLLSIKQILDEELSCVLAENAFELIRASHQTVKKVIDEKKTVYGINTGFGSLANQTISSDCLKELQRN
IVLSHACGTGKLLPDDVVALILLLKINNLSQGYSGVRLELINALIALFNHKVYPCIPSKGSVGASGDLVPLAHLSLPLLG
EGEVRHQGQVISAEEGLKLAGLKPLELEAKEGLALLNGLQVSTALALSALFISETLFETAIISGSLSVDAASGSDVPFDD
RIHQIRGHQAQISAARMYRNLLAGSQIRESHRYCNRVQDPYSLRCQPQIMGAVLHQMEFVGQTLQVEANAISDNPLVFAE
QGDILSGGNFHGEIIAMAADNLALALSEIGGSAERRIALLIDKNFSGLPAFLVRESGLNSGFMIAHVTAASCASDNKALA
HPHSVDSLPTSANQEDHVSMATSAARRLHEMIDNTSTILAIELLAACQGLEFHKPLKTSPQLDKIYQSVRSVVKEYDKDR
YFAPDIEKIKKKILDKEFSLLTLTN

Sequences:

>Translated_505_residues
MSEHFILQPGQLSLLSIKQILDEELSCVLAENAFELIRASHQTVKKVIDEKKTVYGINTGFGSLANQTISSDCLKELQRN
IVLSHACGTGKLLPDDVVALILLLKINNLSQGYSGVRLELINALIALFNHKVYPCIPSKGSVGASGDLVPLAHLSLPLLG
EGEVRHQGQVISAEEGLKLAGLKPLELEAKEGLALLNGLQVSTALALSALFISETLFETAIISGSLSVDAASGSDVPFDD
RIHQIRGHQAQISAARMYRNLLAGSQIRESHRYCNRVQDPYSLRCQPQIMGAVLHQMEFVGQTLQVEANAISDNPLVFAE
QGDILSGGNFHGEIIAMAADNLALALSEIGGSAERRIALLIDKNFSGLPAFLVRESGLNSGFMIAHVTAASCASDNKALA
HPHSVDSLPTSANQEDHVSMATSAARRLHEMIDNTSTILAIELLAACQGLEFHKPLKTSPQLDKIYQSVRSVVKEYDKDR
YFAPDIEKIKKKILDKEFSLLTLTN
>Mature_504_residues
SEHFILQPGQLSLLSIKQILDEELSCVLAENAFELIRASHQTVKKVIDEKKTVYGINTGFGSLANQTISSDCLKELQRNI
VLSHACGTGKLLPDDVVALILLLKINNLSQGYSGVRLELINALIALFNHKVYPCIPSKGSVGASGDLVPLAHLSLPLLGE
GEVRHQGQVISAEEGLKLAGLKPLELEAKEGLALLNGLQVSTALALSALFISETLFETAIISGSLSVDAASGSDVPFDDR
IHQIRGHQAQISAARMYRNLLAGSQIRESHRYCNRVQDPYSLRCQPQIMGAVLHQMEFVGQTLQVEANAISDNPLVFAEQ
GDILSGGNFHGEIIAMAADNLALALSEIGGSAERRIALLIDKNFSGLPAFLVRESGLNSGFMIAHVTAASCASDNKALAH
PHSVDSLPTSANQEDHVSMATSAARRLHEMIDNTSTILAIELLAACQGLEFHKPLKTSPQLDKIYQSVRSVVKEYDKDRY
FAPDIEKIKKKILDKEFSLLTLTN

Specific function: Unknown

COG id: COG2986

COG function: function code E; Histidine ammonia-lyase

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PAL/histidase family [H]

Homologues:

Organism=Homo sapiens, GI4504333, Length=474, Percent_Identity=47.6793248945148, Blast_Score=434, Evalue=1e-122,
Organism=Caenorhabditis elegans, GI17567831, Length=498, Percent_Identity=44.7791164658635, Blast_Score=388, Evalue=1e-108,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005921
- InterPro:   IPR008948
- InterPro:   IPR001106
- InterPro:   IPR022313 [H]

Pfam domain/function: PF00221 PAL [H]

EC number: =4.3.1.3 [H]

Molecular weight: Translated: 54666; Mature: 54535

Theoretical pI: Translated: 6.16; Mature: 6.16

Prosite motif: PS00488 PAL_HISTIDASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSEHFILQPGQLSLLSIKQILDEELSCVLAENAFELIRASHQTVKKVIDEKKTVYGINTG
CCCCEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCC
FGSLANQTISSDCLKELQRNIVLSHACGTGKLLPDDVVALILLLKINNLSQGYSGVRLEL
CHHHHHHHHHHHHHHHHHHHEEEEECCCCCCCCHHHHHHHHHHHHHCCCCCCCCCHHHHH
INALIALFNHKVYPCIPSKGSVGASGDLVPLAHLSLPLLGEGEVRHQGQVISAEEGLKLA
HHHHHHHHCCCCEECCCCCCCCCCCCCEEEHHHCCCCCCCCCCCCCCCEEEECCCCCEEC
GLKPLELEAKEGLALLNGLQVSTALALSALFISETLFETAIISGSLSVDAASGSDVPFDD
CCCCCCCCHHCCHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEECCCCCCCCHHH
RIHQIRGHQAQISAARMYRNLLAGSQIRESHRYCNRVQDPYSLRCQPQIMGAVLHQMEFV
HHHHHCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHH
GQTLQVEANAISDNPLVFAEQGDILSGGNFHGEIIAMAADNLALALSEIGGSAERRIALL
CCEEEEEEEECCCCCEEEEECCCEECCCCCCCEEEEEECCCHHHHHHHHCCCCCCEEEEE
IDKNFSGLPAFLVRESGLNSGFMIAHVTAASCASDNKALAHPHSVDSLPTSANQEDHVSM
EECCCCCCCHHHEECCCCCCCEEEEEEEHHHHCCCCCCCCCCCCCCCCCCCCCCHHHHHH
ATSAARRLHEMIDNTSTILAIELLAACQGLEFHKPLKTSPQLDKIYQSVRSVVKEYDKDR
HHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCC
YFAPDIEKIKKKILDKEFSLLTLTN
CCCCCHHHHHHHHHCCCCCEEEECC
>Mature Secondary Structure 
SEHFILQPGQLSLLSIKQILDEELSCVLAENAFELIRASHQTVKKVIDEKKTVYGINTG
CCCEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCC
FGSLANQTISSDCLKELQRNIVLSHACGTGKLLPDDVVALILLLKINNLSQGYSGVRLEL
CHHHHHHHHHHHHHHHHHHHEEEEECCCCCCCCHHHHHHHHHHHHHCCCCCCCCCHHHHH
INALIALFNHKVYPCIPSKGSVGASGDLVPLAHLSLPLLGEGEVRHQGQVISAEEGLKLA
HHHHHHHHCCCCEECCCCCCCCCCCCCEEEHHHCCCCCCCCCCCCCCCEEEECCCCCEEC
GLKPLELEAKEGLALLNGLQVSTALALSALFISETLFETAIISGSLSVDAASGSDVPFDD
CCCCCCCCHHCCHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEECCCCCCCCHHH
RIHQIRGHQAQISAARMYRNLLAGSQIRESHRYCNRVQDPYSLRCQPQIMGAVLHQMEFV
HHHHHCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHH
GQTLQVEANAISDNPLVFAEQGDILSGGNFHGEIIAMAADNLALALSEIGGSAERRIALL
CCEEEEEEEECCCCCEEEEECCCEECCCCCCCEEEEEECCCHHHHHHHHCCCCCCEEEEE
IDKNFSGLPAFLVRESGLNSGFMIAHVTAASCASDNKALAHPHSVDSLPTSANQEDHVSM
EECCCCCCCHHHEECCCCCCCEEEEEEEHHHHCCCCCCCCCCCCCCCCCCCCCCHHHHHH
ATSAARRLHEMIDNTSTILAIELLAACQGLEFHKPLKTSPQLDKIYQSVRSVVKEYDKDR
HHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCC
YFAPDIEKIKKKILDKEFSLLTLTN
CCCCCHHHHHHHHHCCCCCEEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA