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The map label for this gene is pyrG

Identifier: 148358768

GI number: 148358768

Start: 1428629

End: 1430266

Strand: Direct

Name: pyrG

Synonym: LPC_0648

Alternate gene names: 148358768

Gene position: 1428629-1430266 (Clockwise)

Preceding gene: 148358767

Following gene: 148358769

Centisome position: 39.95

GC content: 39.87

Gene sequence:

>1638_bases
ATGACAAAATATATTTTTATTACTGGCGGGGTTGTGTCTTCTTTAGGAAAAGGCATAGCAGCCGCATCTCTTGCAGCTAT
TCTTGAAGCTCGTGGTCTTCGCGTTACGTTGATAAAGCTTGATCCCTACATTAACGTTGATCCTGGTACTATGAGTCCCT
TTCAGCATGGCGAGGTTTTCGTAACGAATGACGGGGCAGAGACCGATTTGGATTTGGGGCATTATGAGCGCTTTGTTAAA
ACAACAATGACCAAGCGTAATAATTTCACATCAGGAAAAATTTACGAAAATGTAATTAAGAAAGAAAGACGGGGTGATTA
TTTAGGAGGGACAGTTCAGGTTATTCCTCATATTACTAATGAAATCAAACGCTGTATCAAACTCGGTGCGGATGCATTCG
ATGTGGCTATGGTTGAAATAGGAGGAACTGTTGGTGATATTGAATCACTACCCTTTCTTGAAGCAATTAGGCAGATGCGT
ATTGAGTTAGGTTCACAACGAGCAATATTTATTCATCTTACTTTGGTTCCTTATATTGCTACTTCTGGGGAAACCAAAAC
CAAACCAACTCAACATTCGGTAAAGGAATTGCGTTCTATTGGTATCCAGCCAGATGTATTGATTTGCCGTTCAGAAAAAC
CATTATCCATGGCAGACAGGGCTAAAATCGCATTATTCACTAATGTTGAAAAAGAAGCTGTGATTTCTCTTGAGGATGCG
AATAGTATTTATCAAATACCTATGATTCTACATGCGCAGCATTTAGACGAAATTGTTGTTAAGAAACTAAGCCTGGAAGC
TAAGCAGGCTGATTTGAGCGAGTGGCAACGAGTAGTTGATATGCAAGCAGTTCAAACGATGACAGTGAAAATCGCTATGG
TAGGTAAATATACGGAGCTGAATGATGCCTACAAGTCGATTAATGAAGCTTTATTGCATGCTGGAATTCATACGGAAACA
AAAGTAGAAATTATCTATTTTGATGCTGAGATGATAGAAAAGCATGGCGCTTTATTGCTTGAATCCATTGATGCTATTTT
GGTACCTGGTGGTTTTGGTGAGAGAGGAGTCGAAGGCAAAATTAAGGCTATCCAATATGCTCGGGAGCATAAGGTTCCTT
TTTTAGGGATATGTTTGGGTATGCAAACAGCTGTTATTGAGTTTGCGAGAAATGTAGTTGGTTTAACAGGAGCCAATTCG
ACTGAGTTCAATAAAGAAACATTGTATCCAGTGCTTGGTTTAATTAGTGAATGGATGGATGCCGATGGTAGCAAGCAGAT
CAGGGACGAAAATACTGACTTGGGTGGAACCATGCGCTTGGGCGGACAATACTGTCATCTTGCTGAAGGCACTCTGGCAA
GAAAAGTTTATGGCAAACCACAAATTATAGAGCGTCATCGACATCGATATGAAGTCAATAACAAATATGTGGATAGTTTG
GTAAAACACGGCTTAATTATTTCAGGACGATCAGCAGATAATTCACTGGTTGAGATGATAGAATTAGCGGACCACCCCTG
GTTTTTAGCTTGTCAGTTTCATCCTGAATTCACATCGAATCCAAGAGATAGTCATCCTTTGTTTAAGGAATTTGTACTTG
CAGCTCGTATTCACCATCAAGAGAAGGACAAAAAATGA

Upstream 100 bases:

>100_bases
GTTATTTATATTTTCATTTTGATAGAATTGAATCCCGTTTACATGCAAATTAAATTGAACACCAAATTGGTGGATTCGGC
ATTTTGAGCGGGGTCAAAAA

Downstream 100 bases:

>100_bases
GATTATGTGGTTTTGAAGCAGGCTTGGATAAGCCATTGTTTTTGATTGCCGGCCCTTGTGTTATTGAAAGTGAAGAACTG
GCTTTAGAGACCGCAGGATA

Product: CTP synthetase

Products: NA

Alternate protein names: CTP synthetase; UTP--ammonia ligase

Number of amino acids: Translated: 545; Mature: 544

Protein sequence:

>545_residues
MTKYIFITGGVVSSLGKGIAAASLAAILEARGLRVTLIKLDPYINVDPGTMSPFQHGEVFVTNDGAETDLDLGHYERFVK
TTMTKRNNFTSGKIYENVIKKERRGDYLGGTVQVIPHITNEIKRCIKLGADAFDVAMVEIGGTVGDIESLPFLEAIRQMR
IELGSQRAIFIHLTLVPYIATSGETKTKPTQHSVKELRSIGIQPDVLICRSEKPLSMADRAKIALFTNVEKEAVISLEDA
NSIYQIPMILHAQHLDEIVVKKLSLEAKQADLSEWQRVVDMQAVQTMTVKIAMVGKYTELNDAYKSINEALLHAGIHTET
KVEIIYFDAEMIEKHGALLLESIDAILVPGGFGERGVEGKIKAIQYAREHKVPFLGICLGMQTAVIEFARNVVGLTGANS
TEFNKETLYPVLGLISEWMDADGSKQIRDENTDLGGTMRLGGQYCHLAEGTLARKVYGKPQIIERHRHRYEVNNKYVDSL
VKHGLIISGRSADNSLVEMIELADHPWFLACQFHPEFTSNPRDSHPLFKEFVLAARIHHQEKDKK

Sequences:

>Translated_545_residues
MTKYIFITGGVVSSLGKGIAAASLAAILEARGLRVTLIKLDPYINVDPGTMSPFQHGEVFVTNDGAETDLDLGHYERFVK
TTMTKRNNFTSGKIYENVIKKERRGDYLGGTVQVIPHITNEIKRCIKLGADAFDVAMVEIGGTVGDIESLPFLEAIRQMR
IELGSQRAIFIHLTLVPYIATSGETKTKPTQHSVKELRSIGIQPDVLICRSEKPLSMADRAKIALFTNVEKEAVISLEDA
NSIYQIPMILHAQHLDEIVVKKLSLEAKQADLSEWQRVVDMQAVQTMTVKIAMVGKYTELNDAYKSINEALLHAGIHTET
KVEIIYFDAEMIEKHGALLLESIDAILVPGGFGERGVEGKIKAIQYAREHKVPFLGICLGMQTAVIEFARNVVGLTGANS
TEFNKETLYPVLGLISEWMDADGSKQIRDENTDLGGTMRLGGQYCHLAEGTLARKVYGKPQIIERHRHRYEVNNKYVDSL
VKHGLIISGRSADNSLVEMIELADHPWFLACQFHPEFTSNPRDSHPLFKEFVLAARIHHQEKDKK
>Mature_544_residues
TKYIFITGGVVSSLGKGIAAASLAAILEARGLRVTLIKLDPYINVDPGTMSPFQHGEVFVTNDGAETDLDLGHYERFVKT
TMTKRNNFTSGKIYENVIKKERRGDYLGGTVQVIPHITNEIKRCIKLGADAFDVAMVEIGGTVGDIESLPFLEAIRQMRI
ELGSQRAIFIHLTLVPYIATSGETKTKPTQHSVKELRSIGIQPDVLICRSEKPLSMADRAKIALFTNVEKEAVISLEDAN
SIYQIPMILHAQHLDEIVVKKLSLEAKQADLSEWQRVVDMQAVQTMTVKIAMVGKYTELNDAYKSINEALLHAGIHTETK
VEIIYFDAEMIEKHGALLLESIDAILVPGGFGERGVEGKIKAIQYAREHKVPFLGICLGMQTAVIEFARNVVGLTGANST
EFNKETLYPVLGLISEWMDADGSKQIRDENTDLGGTMRLGGQYCHLAEGTLARKVYGKPQIIERHRHRYEVNNKYVDSLV
KHGLIISGRSADNSLVEMIELADHPWFLACQFHPEFTSNPRDSHPLFKEFVLAARIHHQEKDKK

Specific function: Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen

COG id: COG0504

COG function: function code F; CTP synthase (UTP-ammonia lyase)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 glutamine amidotransferase type-1 domain

Homologues:

Organism=Homo sapiens, GI148491070, Length=563, Percent_Identity=45.1154529307282, Blast_Score=488, Evalue=1e-138,
Organism=Homo sapiens, GI28559085, Length=557, Percent_Identity=45.0628366247756, Blast_Score=484, Evalue=1e-136,
Organism=Homo sapiens, GI28559083, Length=557, Percent_Identity=45.0628366247756, Blast_Score=484, Evalue=1e-136,
Organism=Homo sapiens, GI221316689, Length=557, Percent_Identity=45.0628366247756, Blast_Score=484, Evalue=1e-136,
Organism=Escherichia coli, GI1789142, Length=534, Percent_Identity=63.2958801498127, Blast_Score=701, Evalue=0.0,
Organism=Caenorhabditis elegans, GI25148299, Length=610, Percent_Identity=38.5245901639344, Blast_Score=433, Evalue=1e-121,
Organism=Saccharomyces cerevisiae, GI6322563, Length=569, Percent_Identity=43.585237258348, Blast_Score=462, Evalue=1e-131,
Organism=Saccharomyces cerevisiae, GI6319432, Length=572, Percent_Identity=42.8321678321678, Blast_Score=446, Evalue=1e-126,
Organism=Drosophila melanogaster, GI24664469, Length=558, Percent_Identity=43.9068100358423, Blast_Score=479, Evalue=1e-135,
Organism=Drosophila melanogaster, GI21357815, Length=503, Percent_Identity=42.3459244532803, Blast_Score=407, Evalue=1e-114,

Paralogues:

None

Copy number: 480 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): PYRG_LEGPA (Q5X5Y6)

Other databases:

- EMBL:   CR628336
- RefSeq:   YP_123508.1
- HSSP:   P0A7E5
- ProteinModelPortal:   Q5X5Y6
- SMR:   Q5X5Y6
- STRING:   Q5X5Y6
- GeneID:   3116679
- GenomeReviews:   CR628336_GR
- KEGG:   lpp:lpp1184
- LegioList:   lpp1184
- eggNOG:   COG0504
- HOGENOM:   HBG597806
- OMA:   RVTMQKL
- ProtClustDB:   PRK05380
- BioCyc:   LPNE297246:LPP1184-MONOMER
- HAMAP:   MF_01227
- InterPro:   IPR004468
- InterPro:   IPR017456
- InterPro:   IPR017926
- InterPro:   IPR000991
- TIGRFAMs:   TIGR00337

Pfam domain/function: PF06418 CTP_synth_N; PF00117 GATase

EC number: =6.3.4.2

Molecular weight: Translated: 60721; Mature: 60590

Theoretical pI: Translated: 6.77; Mature: 6.77

Prosite motif: PS51273 GATASE_TYPE_1; PS00442 GATASE_TYPE_I

Important sites: ACT_SITE 378-378 ACT_SITE 514-514 ACT_SITE 516-516

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTKYIFITGGVVSSLGKGIAAASLAAILEARGLRVTLIKLDPYINVDPGTMSPFQHGEVF
CCEEEEEECHHHHHHCCHHHHHHHHHHHHCCCCEEEEEEECCEEECCCCCCCCCCCCEEE
VTNDGAETDLDLGHYERFVKTTMTKRNNFTSGKIYENVIKKERRGDYLGGTVQVIPHITN
EECCCCCCCCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCCCCHHEEHHHHHH
EIKRCIKLGADAFDVAMVEIGGTVGDIESLPFLEAIRQMRIELGSQRAIFIHLTLVPYIA
HHHHHHHHCCCHHEEEEEEECCCCCCCCCCHHHHHHHHHHHHCCCCEEEEEEEEEEHHEE
TSGETKTKPTQHSVKELRSIGIQPDVLICRSEKPLSMADRAKIALFTNVEKEAVISLEDA
CCCCCCCCCHHHHHHHHHHCCCCCCEEEECCCCCCCCCCCCEEEEEECCCHHEEEEEECC
NSIYQIPMILHAQHLDEIVVKKLSLEAKQADLSEWQRVVDMQAVQTMTVKIAMVGKYTEL
CCEEEHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHEEEEEEEEEECCHHH
NDAYKSINEALLHAGIHTETKVEIIYFDAEMIEKHGALLLESIDAILVPGGFGERGVEGK
HHHHHHHHHHHHHCCCCCCCEEEEEEECHHHHHHCCHHHHHCCCEEEECCCCCCCCCCCH
IKAIQYAREHKVPFLGICLGMQTAVIEFARNVVGLTGANSTEFNKETLYPVLGLISEWMD
HHHHHHHHHCCCCEEEHHHHHHHHHHHHHHHHEECCCCCCCCCCHHHHHHHHHHHHHHHC
ADGSKQIRDENTDLGGTMRLGGQYCHLAEGTLARKVYGKPQIIERHRHRYEVNNKYVDSL
CCCCCCCCCCCCCCCCEEEECCCEEEECCCHHHHHHCCCCHHHHHHHHHHHCCHHHHHHH
VKHGLIISGRSADNSLVEMIELADHPWFLACQFHPEFTSNPRDSHPLFKEFVLAARIHHQ
HHCCEEEECCCCCHHHHHHHHHCCCCEEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHH
EKDKK
HCCCC
>Mature Secondary Structure 
TKYIFITGGVVSSLGKGIAAASLAAILEARGLRVTLIKLDPYINVDPGTMSPFQHGEVF
CEEEEEECHHHHHHCCHHHHHHHHHHHHCCCCEEEEEEECCEEECCCCCCCCCCCCEEE
VTNDGAETDLDLGHYERFVKTTMTKRNNFTSGKIYENVIKKERRGDYLGGTVQVIPHITN
EECCCCCCCCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCCCCHHEEHHHHHH
EIKRCIKLGADAFDVAMVEIGGTVGDIESLPFLEAIRQMRIELGSQRAIFIHLTLVPYIA
HHHHHHHHCCCHHEEEEEEECCCCCCCCCCHHHHHHHHHHHHCCCCEEEEEEEEEEHHEE
TSGETKTKPTQHSVKELRSIGIQPDVLICRSEKPLSMADRAKIALFTNVEKEAVISLEDA
CCCCCCCCCHHHHHHHHHHCCCCCCEEEECCCCCCCCCCCCEEEEEECCCHHEEEEEECC
NSIYQIPMILHAQHLDEIVVKKLSLEAKQADLSEWQRVVDMQAVQTMTVKIAMVGKYTEL
CCEEEHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHEEEEEEEEEECCHHH
NDAYKSINEALLHAGIHTETKVEIIYFDAEMIEKHGALLLESIDAILVPGGFGERGVEGK
HHHHHHHHHHHHHCCCCCCCEEEEEEECHHHHHHCCHHHHHCCCEEEECCCCCCCCCCCH
IKAIQYAREHKVPFLGICLGMQTAVIEFARNVVGLTGANSTEFNKETLYPVLGLISEWMD
HHHHHHHHHCCCCEEEHHHHHHHHHHHHHHHHEECCCCCCCCCCHHHHHHHHHHHHHHHC
ADGSKQIRDENTDLGGTMRLGGQYCHLAEGTLARKVYGKPQIIERHRHRYEVNNKYVDSL
CCCCCCCCCCCCCCCCEEEECCCEEEECCCHHHHHHCCCCHHHHHHHHHHHCCHHHHHHH
VKHGLIISGRSADNSLVEMIELADHPWFLACQFHPEFTSNPRDSHPLFKEFVLAARIHHQ
HHCCEEEECCCCCHHHHHHHHHCCCCEEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHH
EKDKK
HCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA