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The map label for this gene is mutL [H]

Identifier: 148358566

GI number: 148358566

Start: 3226036

End: 3227766

Strand: Reverse

Name: mutL [H]

Synonym: LPC_0438

Alternate gene names: 148358566

Gene position: 3227766-3226036 (Counterclockwise)

Preceding gene: 148358565

Following gene: 148358567

Centisome position: 90.25

GC content: 40.09

Gene sequence:

>1731_bases
ATGGTCTTAAGGATACATCAACTTTCGCCAGCAATAGCCAATCAGATTGCAGCAGGAGAAGTTATAGAAAGACCTGCTTC
GGTAGTCAAGGAGCTGCTGGAAAACTCTTTGGATGCTGGTGCCAGTGTGATTGGTGTCGATGTCAATTATGGGGGATTGC
TGCAGATTACAGTAAGTGATAATGGTTCAGGAATCGTTGGAGACGACTTGCCTTTAGCTGTTGCAGCTCATGCGACCAGT
AAAATCAGAACGCTTGATGATTTATATTCCATTGATAGTATGGGCTTTAGAGGGGAGGCATTGGCAAGTATTGCCTCTGT
TGCCAAAGTGACTATCATTTCAAAGCCTGAGGAGCAGGACAATGCGATGATGTTGCGAGTAGAGGGGGAGAACAGGACTC
TCTCTCCTTGTGCGCGCAATATTGGCACTACCATCGATGTTTCTGATTTATTCTATAATGCGCCAGTTCGTAAGCGGTTT
TTAAAAAATGAAAAACTGGAATTTCAAGCTATTGAAATGGTTGTGAAACGGTTTGCATTAAGTGCTCCCCGAATTGCATT
AACGCTTAAGCATAATAAGAAACTGATTTTTTCATTACCGCCAGCGTTAAGTGAGCAAGCCAAAGCCATTCGTATGGGTC
GAATTTTGGGCAATACTTTCATGAGAGAAGCTATTTTTCTTGATGTGGAGCACAGCGGTATGCGTCTTTATGGCTGGATA
AGTAACCAGAGTTTGCAACGCAGCCAGAATGATAGGCAGTGGATTTATGTGAATCAACGCATGGTAAAAGATAAATTACT
TCAACATGCAGTAAAACAAGCTTATGATGGCTTATTGCATGCAGGCAGGTTTCCAATTTGTTTGTTGTATTTTTCTCTAC
CTGCTTCTGAAGTGGATGTGAATGTCCATCCTACAAAGCATGAAGTGAGATTCCAACAGCCCCGCCTGGTGCATGATTTT
TTTACTTCCCAATTGACGAAAGCGTTGCAATCGACTCTTGACCATTCAGATATGAGGGAATACGCATATGCTGCTTCCTC
TTGTAATGAGCAGAAAAATACAGTTTCGGAACCTTCCCATATCTGCAATGACAGAGAGTCCCATGAAGGGGAAAAAGCTT
TATTCCCAAGCTGGAGTGGCAATTCATTATCATCATCTATAACCAGCAAAAGGTATAAAAAAAACAGCTCTGTATATCAT
CCAGAAACAGAGTCTCAGTGGGTTATCTTAAATGAGCGGTTTATTTTAGTTTTTATAAAGCAACAGCCTTACCTTGCAGA
CATTGTAGCACTGTTTCAAGAATGGATAGAAAAACAGCTAATGCAAAAGGCATTGCCTCTGGAGAGCAGGCCTTTATTGA
TTTCAATTCGTTACTCATTACCAAACCAATGGATACATAAGCCGGAGCAATTAAAGCATGAGTTGGCTCGTGTTGGGATA
CAAATTGAGTATTCTAATGCTGATGATTTGTTAATTCGCAGCATCCCTTTAAATGCGCCCTATTTAGATGTTCGTCGTTT
TTTTAATATTCTCTGCGAACTGGATTTTTTTGATACTGAGCAATTGATAGCGTTAATTAGCCGCTCTCAAATATTTGACC
CAAAACAATTAACAGTTGAAGAGCGTATTGAAATGAATCAATTGTTGCTGGAACTCTCTCTTAAAGAAGAGAAACATAAT
ATATGTAAAGCGTTAACTATAGATAATTGTCGGATGTTATTGCATGAATAA

Upstream 100 bases:

>100_bases
CTGCTCGATATAGGGTATCTGTGAGCGCATTACAATCAATTAACCGTCTTCAGGCAAGGGCAAGGCTAATGCCCGGGCAA
AAATTAGTGATACCTGGCAC

Downstream 100 bases:

>100_bases
GCTAGTGTTTTGTTTAATGGGACCAACTGCTTCAGGAAAGACAGGGTTAGCATGCGAGTTGCTAACTCATTTCCCTTTTG
AAATTATTAGTGTTGATTCC

Product: DNA mismatch repair protein MutL

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 576; Mature: 576

Protein sequence:

>576_residues
MVLRIHQLSPAIANQIAAGEVIERPASVVKELLENSLDAGASVIGVDVNYGGLLQITVSDNGSGIVGDDLPLAVAAHATS
KIRTLDDLYSIDSMGFRGEALASIASVAKVTIISKPEEQDNAMMLRVEGENRTLSPCARNIGTTIDVSDLFYNAPVRKRF
LKNEKLEFQAIEMVVKRFALSAPRIALTLKHNKKLIFSLPPALSEQAKAIRMGRILGNTFMREAIFLDVEHSGMRLYGWI
SNQSLQRSQNDRQWIYVNQRMVKDKLLQHAVKQAYDGLLHAGRFPICLLYFSLPASEVDVNVHPTKHEVRFQQPRLVHDF
FTSQLTKALQSTLDHSDMREYAYAASSCNEQKNTVSEPSHICNDRESHEGEKALFPSWSGNSLSSSITSKRYKKNSSVYH
PETESQWVILNERFILVFIKQQPYLADIVALFQEWIEKQLMQKALPLESRPLLISIRYSLPNQWIHKPEQLKHELARVGI
QIEYSNADDLLIRSIPLNAPYLDVRRFFNILCELDFFDTEQLIALISRSQIFDPKQLTVEERIEMNQLLLELSLKEEKHN
ICKALTIDNCRMLLHE

Sequences:

>Translated_576_residues
MVLRIHQLSPAIANQIAAGEVIERPASVVKELLENSLDAGASVIGVDVNYGGLLQITVSDNGSGIVGDDLPLAVAAHATS
KIRTLDDLYSIDSMGFRGEALASIASVAKVTIISKPEEQDNAMMLRVEGENRTLSPCARNIGTTIDVSDLFYNAPVRKRF
LKNEKLEFQAIEMVVKRFALSAPRIALTLKHNKKLIFSLPPALSEQAKAIRMGRILGNTFMREAIFLDVEHSGMRLYGWI
SNQSLQRSQNDRQWIYVNQRMVKDKLLQHAVKQAYDGLLHAGRFPICLLYFSLPASEVDVNVHPTKHEVRFQQPRLVHDF
FTSQLTKALQSTLDHSDMREYAYAASSCNEQKNTVSEPSHICNDRESHEGEKALFPSWSGNSLSSSITSKRYKKNSSVYH
PETESQWVILNERFILVFIKQQPYLADIVALFQEWIEKQLMQKALPLESRPLLISIRYSLPNQWIHKPEQLKHELARVGI
QIEYSNADDLLIRSIPLNAPYLDVRRFFNILCELDFFDTEQLIALISRSQIFDPKQLTVEERIEMNQLLLELSLKEEKHN
ICKALTIDNCRMLLHE
>Mature_576_residues
MVLRIHQLSPAIANQIAAGEVIERPASVVKELLENSLDAGASVIGVDVNYGGLLQITVSDNGSGIVGDDLPLAVAAHATS
KIRTLDDLYSIDSMGFRGEALASIASVAKVTIISKPEEQDNAMMLRVEGENRTLSPCARNIGTTIDVSDLFYNAPVRKRF
LKNEKLEFQAIEMVVKRFALSAPRIALTLKHNKKLIFSLPPALSEQAKAIRMGRILGNTFMREAIFLDVEHSGMRLYGWI
SNQSLQRSQNDRQWIYVNQRMVKDKLLQHAVKQAYDGLLHAGRFPICLLYFSLPASEVDVNVHPTKHEVRFQQPRLVHDF
FTSQLTKALQSTLDHSDMREYAYAASSCNEQKNTVSEPSHICNDRESHEGEKALFPSWSGNSLSSSITSKRYKKNSSVYH
PETESQWVILNERFILVFIKQQPYLADIVALFQEWIEKQLMQKALPLESRPLLISIRYSLPNQWIHKPEQLKHELARVGI
QIEYSNADDLLIRSIPLNAPYLDVRRFFNILCELDFFDTEQLIALISRSQIFDPKQLTVEERIEMNQLLLELSLKEEKHN
ICKALTIDNCRMLLHE

Specific function: This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a "molecular matchmaker", a protein that promotes the formation of a stable complex between two or more DNA-bindi

COG id: COG0323

COG function: function code L; DNA mismatch repair enzyme (predicted ATPase)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DNA mismatch repair mutL/hexB family [H]

Homologues:

Organism=Homo sapiens, GI4557757, Length=313, Percent_Identity=37.6996805111821, Blast_Score=194, Evalue=2e-49,
Organism=Homo sapiens, GI4505911, Length=328, Percent_Identity=32.0121951219512, Blast_Score=146, Evalue=6e-35,
Organism=Homo sapiens, GI189458898, Length=328, Percent_Identity=32.0121951219512, Blast_Score=145, Evalue=8e-35,
Organism=Homo sapiens, GI189458896, Length=321, Percent_Identity=30.5295950155763, Blast_Score=137, Evalue=4e-32,
Organism=Homo sapiens, GI4505913, Length=329, Percent_Identity=28.2674772036474, Blast_Score=127, Evalue=2e-29,
Organism=Homo sapiens, GI310128478, Length=329, Percent_Identity=28.2674772036474, Blast_Score=127, Evalue=2e-29,
Organism=Homo sapiens, GI91992162, Length=265, Percent_Identity=28.3018867924528, Blast_Score=107, Evalue=2e-23,
Organism=Homo sapiens, GI91992160, Length=265, Percent_Identity=28.3018867924528, Blast_Score=107, Evalue=3e-23,
Organism=Homo sapiens, GI263191589, Length=224, Percent_Identity=33.4821428571429, Blast_Score=105, Evalue=9e-23,
Organism=Homo sapiens, GI310128480, Length=291, Percent_Identity=26.1168384879725, Blast_Score=99, Evalue=1e-20,
Organism=Escherichia coli, GI1790612, Length=539, Percent_Identity=35.4359925788497, Blast_Score=306, Evalue=2e-84,
Organism=Caenorhabditis elegans, GI71991825, Length=323, Percent_Identity=33.4365325077399, Blast_Score=163, Evalue=2e-40,
Organism=Caenorhabditis elegans, GI17562796, Length=374, Percent_Identity=26.7379679144385, Blast_Score=140, Evalue=1e-33,
Organism=Saccharomyces cerevisiae, GI6323819, Length=374, Percent_Identity=33.9572192513369, Blast_Score=182, Evalue=1e-46,
Organism=Saccharomyces cerevisiae, GI6324247, Length=405, Percent_Identity=31.1111111111111, Blast_Score=156, Evalue=7e-39,
Organism=Saccharomyces cerevisiae, GI6325093, Length=314, Percent_Identity=28.0254777070064, Blast_Score=104, Evalue=5e-23,
Organism=Saccharomyces cerevisiae, GI6323063, Length=101, Percent_Identity=41.5841584158416, Blast_Score=80, Evalue=6e-16,
Organism=Drosophila melanogaster, GI17136968, Length=320, Percent_Identity=37.1875, Blast_Score=194, Evalue=1e-49,
Organism=Drosophila melanogaster, GI17136970, Length=358, Percent_Identity=27.9329608938547, Blast_Score=135, Evalue=1e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR002099
- InterPro:   IPR013507
- InterPro:   IPR014762
- InterPro:   IPR020667
- InterPro:   IPR014763
- InterPro:   IPR014790
- InterPro:   IPR020568
- InterPro:   IPR014721 [H]

Pfam domain/function: PF01119 DNA_mis_repair; PF02518 HATPase_c; PF08676 MutL_C [H]

EC number: NA

Molecular weight: Translated: 65478; Mature: 65478

Theoretical pI: Translated: 6.99; Mature: 6.99

Prosite motif: PS00058 DNA_MISMATCH_REPAIR_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVLRIHQLSPAIANQIAAGEVIERPASVVKELLENSLDAGASVIGVDVNYGGLLQITVSD
CEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCEEEEEECC
NGSGIVGDDLPLAVAAHATSKIRTLDDLYSIDSMGFRGEALASIASVAKVTIISKPEEQD
CCCEECCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHEEEEECCCCCC
NAMMLRVEGENRTLSPCARNIGTTIDVSDLFYNAPVRKRFLKNEKLEFQAIEMVVKRFAL
CEEEEEECCCCCCCCHHHHHCCCEEEHHHHHHCCHHHHHHHHCCCCHHHHHHHHHHHHHC
SAPRIALTLKHNKKLIFSLPPALSEQAKAIRMGRILGNTFMREAIFLDVEHSGMRLYGWI
CCCCEEEEEECCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHEEEEEECCCEEEEEEE
SNQSLQRSQNDRQWIYVNQRMVKDKLLQHAVKQAYDGLLHAGRFPICLLYFSLPASEVDV
CCCHHHHCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCCEEE
NVHPTKHEVRFQQPRLVHDFFTSQLTKALQSTLDHSDMREYAYAASSCNEQKNTVSEPSH
EECCCHHHCCCCCCHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHCCCCHHHCCCCCHH
ICNDRESHEGEKALFPSWSGNSLSSSITSKRYKKNSSVYHPETESQWVILNERFILVFIK
HHCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCEEEEECCEEEEEEE
QQPYLADIVALFQEWIEKQLMQKALPLESRPLLISIRYSLPNQWIHKPEQLKHELARVGI
CCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEECCCHHHCCCHHHHHHHHHHCCE
QIEYSNADDLLIRSIPLNAPYLDVRRFFNILCELDFFDTEQLIALISRSQIFDPKQLTVE
EEEECCCCCEEEEECCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCHHCCHH
ERIEMNQLLLELSLKEEKHNICKALTIDNCRMLLHE
HHHHHHHHHHHHHHHHHHHHHHHHEEHHHHHHHHCC
>Mature Secondary Structure
MVLRIHQLSPAIANQIAAGEVIERPASVVKELLENSLDAGASVIGVDVNYGGLLQITVSD
CEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCEEEEEECC
NGSGIVGDDLPLAVAAHATSKIRTLDDLYSIDSMGFRGEALASIASVAKVTIISKPEEQD
CCCEECCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHEEEEECCCCCC
NAMMLRVEGENRTLSPCARNIGTTIDVSDLFYNAPVRKRFLKNEKLEFQAIEMVVKRFAL
CEEEEEECCCCCCCCHHHHHCCCEEEHHHHHHCCHHHHHHHHCCCCHHHHHHHHHHHHHC
SAPRIALTLKHNKKLIFSLPPALSEQAKAIRMGRILGNTFMREAIFLDVEHSGMRLYGWI
CCCCEEEEEECCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHEEEEEECCCEEEEEEE
SNQSLQRSQNDRQWIYVNQRMVKDKLLQHAVKQAYDGLLHAGRFPICLLYFSLPASEVDV
CCCHHHHCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCCEEE
NVHPTKHEVRFQQPRLVHDFFTSQLTKALQSTLDHSDMREYAYAASSCNEQKNTVSEPSH
EECCCHHHCCCCCCHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHCCCCHHHCCCCCHH
ICNDRESHEGEKALFPSWSGNSLSSSITSKRYKKNSSVYHPETESQWVILNERFILVFIK
HHCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCEEEEECCEEEEEEE
QQPYLADIVALFQEWIEKQLMQKALPLESRPLLISIRYSLPNQWIHKPEQLKHELARVGI
CCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEECCCHHHCCCHHHHHHHHHHCCE
QIEYSNADDLLIRSIPLNAPYLDVRRFFNILCELDFFDTEQLIALISRSQIFDPKQLTVE
EEEECCCCCEEEEECCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCHHCCHH
ERIEMNQLLLELSLKEEKHNICKALTIDNCRMLLHE
HHHHHHHHHHHHHHHHHHHHHHHHEEHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA