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The map label for this gene is czcD [H]

Identifier: 148358521

GI number: 148358521

Start: 3267794

End: 3268717

Strand: Reverse

Name: czcD [H]

Synonym: LPC_0391

Alternate gene names: 148358521

Gene position: 3268717-3267794 (Counterclockwise)

Preceding gene: 148358520

Following gene: 148358526

Centisome position: 91.4

GC content: 38.85

Gene sequence:

>924_bases
ATGAGTAAGCATTCGCATGATGGAGCACACCATCATGAGCATGGGGAAGTGACTTATGACAGGGCTTTTATAATTGCAAT
TACTGCGAATGGCCTTTTTGTTGTGATGCAAATTATTTTTGCCTATTTAGCGAATTCTACCAGCTTGCTAGCAGATGCTT
TTCATAATTTAGGTGATGTATTAGGGCTGATTTTAGCATGGGTAGCAACCGGATTAATGAAGAGAAAACCTACCCATAAA
GCAACGTATGGATTTAAAAAAACCTCTATTTTAGCGGCATTGGCCAATGGAGCGTTACTGGTATTTACTTGCGGGATCAT
AGCGACAGATGCTATGTATAAGTTATTTTCACCGACTGAAATTCAAGCTGTCTCTGTGATGATAGTAGCCGCGATTGGTA
TAGTCGTGAACTTCTCTACAGCGCTCTTGTTTTTACGGGGTTCCGATGATCTCAATATTCGAGGAGCTTACTTACATTTA
TTTTATGATGCCTTGATCTCGGTAGGTGTTGTTTTATCAGCGGGTGTATTATACCTGACGGGTTGGTTATGGATAGATCC
GGTTGTCGGACTATTAATTGCATTAGTGATTTTGAAGGGCACTTGGTCACTATTTGCTGATAGTTTCAGATTAATTATTG
ATGGTGTTCCCCGTGATATATCCTGGATTAAAGTCAGTGATTTTCTCTTGGCTATACCTGGCGTTAAATCTATTCATGAT
TTACATATTTGGGCAATCAGTACGAAAGAGAATGCACTTTCTGTTCATTTATTTATGCCAGAGGAGCCATTATCTGATGA
TTTGCGTAGAGAGCTGGTTGAAAAATTAAAGCATGATTTCAGCATTCAGCATGTCACTATTCAAGTTGAAAAAACAGAAG
CAGAATGCAATGACGCTTGTCATAATCCCAGGATAATCATTTAA

Upstream 100 bases:

>100_bases
ATTCTTTACGAGATACGAATGCCTGGCGCAAGCAAAATACAAGAGATCGCATTAAAATTGGACTTAATTATTACTCTGAA
AGCAAGAACGAAGGAGAATT

Downstream 100 bases:

>100_bases
TTAGGGCAGGATTTACGACTTCTAATCTCTTGGTTAAAAAATGGGTTTAGTTTATTCATTAATTGTATCTACACGCCCTC
ATTAAAAACATTTTTGTCTT

Product: cation efflux system protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 307; Mature: 306

Protein sequence:

>307_residues
MSKHSHDGAHHHEHGEVTYDRAFIIAITANGLFVVMQIIFAYLANSTSLLADAFHNLGDVLGLILAWVATGLMKRKPTHK
ATYGFKKTSILAALANGALLVFTCGIIATDAMYKLFSPTEIQAVSVMIVAAIGIVVNFSTALLFLRGSDDLNIRGAYLHL
FYDALISVGVVLSAGVLYLTGWLWIDPVVGLLIALVILKGTWSLFADSFRLIIDGVPRDISWIKVSDFLLAIPGVKSIHD
LHIWAISTKENALSVHLFMPEEPLSDDLRRELVEKLKHDFSIQHVTIQVEKTEAECNDACHNPRIII

Sequences:

>Translated_307_residues
MSKHSHDGAHHHEHGEVTYDRAFIIAITANGLFVVMQIIFAYLANSTSLLADAFHNLGDVLGLILAWVATGLMKRKPTHK
ATYGFKKTSILAALANGALLVFTCGIIATDAMYKLFSPTEIQAVSVMIVAAIGIVVNFSTALLFLRGSDDLNIRGAYLHL
FYDALISVGVVLSAGVLYLTGWLWIDPVVGLLIALVILKGTWSLFADSFRLIIDGVPRDISWIKVSDFLLAIPGVKSIHD
LHIWAISTKENALSVHLFMPEEPLSDDLRRELVEKLKHDFSIQHVTIQVEKTEAECNDACHNPRIII
>Mature_306_residues
SKHSHDGAHHHEHGEVTYDRAFIIAITANGLFVVMQIIFAYLANSTSLLADAFHNLGDVLGLILAWVATGLMKRKPTHKA
TYGFKKTSILAALANGALLVFTCGIIATDAMYKLFSPTEIQAVSVMIVAAIGIVVNFSTALLFLRGSDDLNIRGAYLHLF
YDALISVGVVLSAGVLYLTGWLWIDPVVGLLIALVILKGTWSLFADSFRLIIDGVPRDISWIKVSDFLLAIPGVKSIHDL
HIWAISTKENALSVHLFMPEEPLSDDLRRELVEKLKHDFSIQHVTIQVEKTEAECNDACHNPRIII

Specific function: Involved in divalent cation and potassium homeostasis in the cell. Catalyzes the active efflux of zinc, cadmium and cobalt, in exchange for potassium and H(+) ions [H]

COG id: COG1230

COG function: function code P; Co/Zn/Cd efflux system component

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily [H]

Homologues:

Organism=Homo sapiens, GI52352805, Length=322, Percent_Identity=24.223602484472, Blast_Score=125, Evalue=6e-29,
Organism=Homo sapiens, GI289803013, Length=317, Percent_Identity=26.4984227129338, Blast_Score=122, Evalue=5e-28,
Organism=Homo sapiens, GI289803009, Length=317, Percent_Identity=26.4984227129338, Blast_Score=122, Evalue=5e-28,
Organism=Homo sapiens, GI289803007, Length=317, Percent_Identity=26.4984227129338, Blast_Score=122, Evalue=5e-28,
Organism=Homo sapiens, GI289803003, Length=317, Percent_Identity=26.4984227129338, Blast_Score=122, Evalue=5e-28,
Organism=Homo sapiens, GI64762489, Length=317, Percent_Identity=26.4984227129338, Blast_Score=121, Evalue=7e-28,
Organism=Homo sapiens, GI21361112, Length=312, Percent_Identity=25.3205128205128, Blast_Score=112, Evalue=4e-25,
Organism=Homo sapiens, GI21359890, Length=303, Percent_Identity=25.7425742574257, Blast_Score=108, Evalue=4e-24,
Organism=Homo sapiens, GI14210520, Length=231, Percent_Identity=25.1082251082251, Blast_Score=96, Evalue=4e-20,
Organism=Homo sapiens, GI20070323, Length=322, Percent_Identity=24.5341614906832, Blast_Score=95, Evalue=7e-20,
Organism=Homo sapiens, GI52351208, Length=175, Percent_Identity=28.5714285714286, Blast_Score=80, Evalue=3e-15,
Organism=Escherichia coli, GI1786966, Length=288, Percent_Identity=30.5555555555556, Blast_Score=120, Evalue=1e-28,
Organism=Caenorhabditis elegans, GI193210990, Length=328, Percent_Identity=28.3536585365854, Blast_Score=139, Evalue=2e-33,
Organism=Caenorhabditis elegans, GI17555794, Length=325, Percent_Identity=24, Blast_Score=116, Evalue=1e-26,
Organism=Caenorhabditis elegans, GI17555796, Length=322, Percent_Identity=22.6708074534161, Blast_Score=112, Evalue=3e-25,
Organism=Caenorhabditis elegans, GI32564488, Length=285, Percent_Identity=26.6666666666667, Blast_Score=105, Evalue=3e-23,
Organism=Saccharomyces cerevisiae, GI6320411, Length=167, Percent_Identity=30.5389221556886, Blast_Score=81, Evalue=2e-16,
Organism=Saccharomyces cerevisiae, GI6323899, Length=128, Percent_Identity=35.9375, Blast_Score=79, Evalue=1e-15,
Organism=Saccharomyces cerevisiae, GI6324892, Length=144, Percent_Identity=33.3333333333333, Blast_Score=77, Evalue=4e-15,
Organism=Drosophila melanogaster, GI24656728, Length=329, Percent_Identity=27.0516717325228, Blast_Score=94, Evalue=8e-20,
Organism=Drosophila melanogaster, GI24656724, Length=329, Percent_Identity=27.0516717325228, Blast_Score=94, Evalue=8e-20,
Organism=Drosophila melanogaster, GI24656720, Length=329, Percent_Identity=27.0516717325228, Blast_Score=94, Evalue=8e-20,
Organism=Drosophila melanogaster, GI24656715, Length=329, Percent_Identity=27.0516717325228, Blast_Score=94, Evalue=8e-20,
Organism=Drosophila melanogaster, GI21357035, Length=329, Percent_Identity=27.0516717325228, Blast_Score=94, Evalue=8e-20,
Organism=Drosophila melanogaster, GI24583858, Length=338, Percent_Identity=23.3727810650888, Blast_Score=87, Evalue=1e-17,
Organism=Drosophila melanogaster, GI24584409, Length=162, Percent_Identity=27.1604938271605, Blast_Score=82, Evalue=5e-16,
Organism=Drosophila melanogaster, GI28574430, Length=162, Percent_Identity=27.1604938271605, Blast_Score=82, Evalue=6e-16,
Organism=Drosophila melanogaster, GI24585900, Length=147, Percent_Identity=29.2517006802721, Blast_Score=74, Evalue=1e-13,
Organism=Drosophila melanogaster, GI24585898, Length=147, Percent_Identity=29.2517006802721, Blast_Score=74, Evalue=1e-13,
Organism=Drosophila melanogaster, GI24585896, Length=147, Percent_Identity=29.2517006802721, Blast_Score=74, Evalue=1e-13,
Organism=Drosophila melanogaster, GI19921672, Length=147, Percent_Identity=29.2517006802721, Blast_Score=74, Evalue=1e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002524 [H]

Pfam domain/function: PF01545 Cation_efflux [H]

EC number: NA

Molecular weight: Translated: 33807; Mature: 33676

Theoretical pI: Translated: 6.68; Mature: 6.68

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKHSHDGAHHHEHGEVTYDRAFIIAITANGLFVVMQIIFAYLANSTSLLADAFHNLGDV
CCCCCCCCCCCCCCCCEEECCEEEEEEECCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHH
LGLILAWVATGLMKRKPTHKATYGFKKTSILAALANGALLVFTCGIIATDAMYKLFSPTE
HHHHHHHHHHHHHHCCCCCHHHCCCHHHHHHHHHHCCEEEEEEHHHHHHHHHHHHCCCCH
IQAVSVMIVAAIGIVVNFSTALLFLRGSDDLNIRGAYLHLFYDALISVGVVLSAGVLYLT
HHHHHHHHHHHHHHHHHHHEEEEEEECCCCCCEEHHHHHHHHHHHHHHHHHHHCCHHHHH
GWLWIDPVVGLLIALVILKGTWSLFADSFRLIIDGVPRDISWIKVSDFLLAIPGVKSIHD
HHHHHHHHHHHHHHHHHHHCCHHHHHHHHHEEEECCCCCCEEEEECHHEEECCCCCCEEE
LHIWAISTKENALSVHLFMPEEPLSDDLRRELVEKLKHDFSIQHVTIQVEKTEAECNDAC
EEEEEEECCCCEEEEEEECCCCCCCHHHHHHHHHHHHHCCCEEEEEEEEECCCHHHHHCC
HNPRIII
CCCEEEC
>Mature Secondary Structure 
SKHSHDGAHHHEHGEVTYDRAFIIAITANGLFVVMQIIFAYLANSTSLLADAFHNLGDV
CCCCCCCCCCCCCCCEEECCEEEEEEECCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHH
LGLILAWVATGLMKRKPTHKATYGFKKTSILAALANGALLVFTCGIIATDAMYKLFSPTE
HHHHHHHHHHHHHHCCCCCHHHCCCHHHHHHHHHHCCEEEEEEHHHHHHHHHHHHCCCCH
IQAVSVMIVAAIGIVVNFSTALLFLRGSDDLNIRGAYLHLFYDALISVGVVLSAGVLYLT
HHHHHHHHHHHHHHHHHHHEEEEEEECCCCCCEEHHHHHHHHHHHHHHHHHHHCCHHHHH
GWLWIDPVVGLLIALVILKGTWSLFADSFRLIIDGVPRDISWIKVSDFLLAIPGVKSIHD
HHHHHHHHHHHHHHHHHHHCCHHHHHHHHHEEEECCCCCCEEEEECHHEEECCCCCCEEE
LHIWAISTKENALSVHLFMPEEPLSDDLRRELVEKLKHDFSIQHVTIQVEKTEAECNDAC
EEEEEEECCCCEEEEEEECCCCCCCHHHHHHHHHHHHHCCCEEEEEEEEECCCHHHHHCC
HNPRIII
CCCEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 9308178; 9384377; 9099864 [H]