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The map label for this gene is ubiH [H]

Identifier: 148358238

GI number: 148358238

Start: 97961

End: 99163

Strand: Direct

Name: ubiH [H]

Synonym: LPC_0100

Alternate gene names: 148358238

Gene position: 97961-99163 (Clockwise)

Preceding gene: 148358237

Following gene: 148358239

Centisome position: 2.74

GC content: 42.56

Gene sequence:

>1203_bases
GTGGCGAATAAAGAGACTGATATACTGATTATTGGCGGTGGTTTGACTGGCGCAAGCTTATCCCTGGCTCTGCAGGGATT
AGGTTTCTCTGTCACGTTAGTAGAATCCAGGCCATACAGTGATAAGGTAAATCCTGACTTTGATGCTCGCTCATTGGCAT
TGTCGCCTGCAAGTCAACGTATATTGGCGATGCTGGGGGTTTGGGAGATTCTCAAAGAATATACAACACCAATTCATATG
ATTCATGTTTCTGATCAGCATCGCTTTGGGGTTTCTCGTTTGCATGGCGAAAAAAATAGTCCTTTGGGCTATGTGGTAGA
AATGCAATACATCAACAGGGCTTTGAGTATTCTACTCAATAAAGAACACTTGTTAGCTCCAGCGGCTTTAAAATCCATCG
ATTTTAACAATTCTACTGCCACTGTTGCTCATGGCGACGATATGATTTCTATCCAGGCTCAATTAATTGTCGCGGCCGAT
GGGACGGAATCGATGACTCGCCACCTCTGTAATCTGCCAGTCAAAATCAAAGATTATGCTCAAGACGCTATTGTCGCCAA
TGTGGGCCTGATAAAACCTCATGGTAATCGTGCTTTTGAGAGATTTACTCCTAATGGTCCTCTTGCATTATTGCCTATGA
TGAATGACAAAATGTCATTGGTATGGGCATCAAAGCCTGAAGAAGCAAAACGGTTAGTGATGTTGAATGATGGTGATTTT
TTGCGGGAACTGCAAACTGCTTTTGGGTATAGGTTAGGACGATTTGGTAAAGTAGGAAAGCGATACTCTTATCCTCTGAA
ACAAGTTTTAATGCCCCAGCAAACCAAATGGCCTGTTGTTTTTGTTGGTAATGCCGCTCACACTTTGCATCCAGTTGCGG
GTCAGGGGTTTAACTTGGGTTTAAGAGATATTGCGGCTTTGGCACAATGCGTCAGCCAAAAGGGATTAAATCCACAGATG
TTGGAGCATTATTTGAAATTACGAGCACATGATCAGCAAATGATTACCTGGCTAACAGACGGTTTAATACATCTATTTAC
GAGTCGTTTACCCGGTATGGGAGTAGCGCGTAACCTTGGATTGCTGGCACTTGATAATATACCGGCATTAAAAAATTTAT
TAGCACGATATGCGCGTGGTTTTGGCGGAATTACTCCTGATTTGGTTTGTGAAATTGCATTAAGCACTGGAGAATTTCAA
TGA

Upstream 100 bases:

>100_bases
GGTGTGCGTATAGAAGATGATATTCTGGTAACCAGGGCGGGATATGAGGTATTGACCGGTGACTTGCCTGTTAATGTAGA
TGATATTGAGGCTTTGATGC

Downstream 100 bases:

>100_bases
GCCAACATTTTGATGTACTTGTCATTGGAGGCGGGATTGTTGGCTTGACAGCAGCTTTAGCCATGGCCCAACGCCATTAT
ACTGTTGCTGTTATCGATGC

Product: 2-octaprenyl-6-methoxyphenol hydroxylase

Products: H2O; 2-octaprenyl-6-methoxy-1,4-benzoquinone [C]

Alternate protein names: NA

Number of amino acids: Translated: 400; Mature: 399

Protein sequence:

>400_residues
MANKETDILIIGGGLTGASLSLALQGLGFSVTLVESRPYSDKVNPDFDARSLALSPASQRILAMLGVWEILKEYTTPIHM
IHVSDQHRFGVSRLHGEKNSPLGYVVEMQYINRALSILLNKEHLLAPAALKSIDFNNSTATVAHGDDMISIQAQLIVAAD
GTESMTRHLCNLPVKIKDYAQDAIVANVGLIKPHGNRAFERFTPNGPLALLPMMNDKMSLVWASKPEEAKRLVMLNDGDF
LRELQTAFGYRLGRFGKVGKRYSYPLKQVLMPQQTKWPVVFVGNAAHTLHPVAGQGFNLGLRDIAALAQCVSQKGLNPQM
LEHYLKLRAHDQQMITWLTDGLIHLFTSRLPGMGVARNLGLLALDNIPALKNLLARYARGFGGITPDLVCEIALSTGEFQ

Sequences:

>Translated_400_residues
MANKETDILIIGGGLTGASLSLALQGLGFSVTLVESRPYSDKVNPDFDARSLALSPASQRILAMLGVWEILKEYTTPIHM
IHVSDQHRFGVSRLHGEKNSPLGYVVEMQYINRALSILLNKEHLLAPAALKSIDFNNSTATVAHGDDMISIQAQLIVAAD
GTESMTRHLCNLPVKIKDYAQDAIVANVGLIKPHGNRAFERFTPNGPLALLPMMNDKMSLVWASKPEEAKRLVMLNDGDF
LRELQTAFGYRLGRFGKVGKRYSYPLKQVLMPQQTKWPVVFVGNAAHTLHPVAGQGFNLGLRDIAALAQCVSQKGLNPQM
LEHYLKLRAHDQQMITWLTDGLIHLFTSRLPGMGVARNLGLLALDNIPALKNLLARYARGFGGITPDLVCEIALSTGEFQ
>Mature_399_residues
ANKETDILIIGGGLTGASLSLALQGLGFSVTLVESRPYSDKVNPDFDARSLALSPASQRILAMLGVWEILKEYTTPIHMI
HVSDQHRFGVSRLHGEKNSPLGYVVEMQYINRALSILLNKEHLLAPAALKSIDFNNSTATVAHGDDMISIQAQLIVAADG
TESMTRHLCNLPVKIKDYAQDAIVANVGLIKPHGNRAFERFTPNGPLALLPMMNDKMSLVWASKPEEAKRLVMLNDGDFL
RELQTAFGYRLGRFGKVGKRYSYPLKQVLMPQQTKWPVVFVGNAAHTLHPVAGQGFNLGLRDIAALAQCVSQKGLNPQML
EHYLKLRAHDQQMITWLTDGLIHLFTSRLPGMGVARNLGLLALDNIPALKNLLARYARGFGGITPDLVCEIALSTGEFQ

Specific function: Oxygenase that introduces the hydroxyl group at carbon four of 2-octaprenyl-6-methoxyphenol resulting in the formation of 2-octaprenyl-6-methoxy-1,4-benzoquinone [H]

COG id: COG0654

COG function: function code HC; 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ubiH/COQ6 family [H]

Homologues:

Organism=Homo sapiens, GI32967305, Length=402, Percent_Identity=25.8706467661692, Blast_Score=105, Evalue=7e-23,
Organism=Escherichia coli, GI1789274, Length=391, Percent_Identity=36.3171355498721, Blast_Score=243, Evalue=1e-65,
Organism=Escherichia coli, GI1789273, Length=399, Percent_Identity=32.5814536340852, Blast_Score=179, Evalue=3e-46,
Organism=Escherichia coli, GI1786883, Length=393, Percent_Identity=30.7888040712468, Blast_Score=163, Evalue=2e-41,
Organism=Caenorhabditis elegans, GI25146631, Length=440, Percent_Identity=26.3636363636364, Blast_Score=125, Evalue=4e-29,
Organism=Drosophila melanogaster, GI19920760, Length=400, Percent_Identity=26, Blast_Score=103, Evalue=2e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002938
- InterPro:   IPR003042
- InterPro:   IPR018168
- InterPro:   IPR010971
- InterPro:   IPR011295 [H]

Pfam domain/function: PF01494 FAD_binding_3 [H]

EC number: 1.14.13.- [C]

Molecular weight: Translated: 43938; Mature: 43807

Theoretical pI: Translated: 9.23; Mature: 9.23

Prosite motif: PS01304 UBIH

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MANKETDILIIGGGLTGASLSLALQGLGFSVTLVESRPYSDKVNPDFDARSLALSPASQR
CCCCCCCEEEEECCCCCCCHHHEEECCCEEEEEEECCCCCCCCCCCCCCHHEEECCHHHH
ILAMLGVWEILKEYTTPIHMIHVSDQHRFGVSRLHGEKNSPLGYVVEMQYINRALSILLN
HHHHHHHHHHHHHHCCCEEEEEECCCCCCCHHHHCCCCCCCCEEEEEHHHHHHHHHHHHC
KEHLLAPAALKSIDFNNSTATVAHGDDMISIQAQLIVAADGTESMTRHLCNLPVKIKDYA
CCHHHCHHHHHHCCCCCCEEEEECCCCEEEEEEEEEEEECCHHHHHHHHHCCCEEEHHHH
QDAIVANVGLIKPHGNRAFERFTPNGPLALLPMMNDKMSLVWASKPEEAKRLVMLNDGDF
HHHHEEECEEECCCCCCHHHHCCCCCCEEEEEECCCCEEEEECCCCCCCCEEEEECCCHH
LRELQTAFGYRLGRFGKVGKRYSYPLKQVLMPQQTKWPVVFVGNAAHTLHPVAGQGFNLG
HHHHHHHHHHHHHHHHCCCCCCCCCHHHHHCCCCCCCCEEEECCCCCEECCCCCCCCCCC
LRDIAALAQCVSQKGLNPQMLEHYLKLRAHDQQMITWLTDGLIHLFTSRLPGMGVARNLG
HHHHHHHHHHHHHCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCCCHHHCCC
LLALDNIPALKNLLARYARGFGGITPDLVCEIALSTGEFQ
EEEECCCHHHHHHHHHHHHHCCCCCHHHHEEEEECCCCCC
>Mature Secondary Structure 
ANKETDILIIGGGLTGASLSLALQGLGFSVTLVESRPYSDKVNPDFDARSLALSPASQR
CCCCCCEEEEECCCCCCCHHHEEECCCEEEEEEECCCCCCCCCCCCCCHHEEECCHHHH
ILAMLGVWEILKEYTTPIHMIHVSDQHRFGVSRLHGEKNSPLGYVVEMQYINRALSILLN
HHHHHHHHHHHHHHCCCEEEEEECCCCCCCHHHHCCCCCCCCEEEEEHHHHHHHHHHHHC
KEHLLAPAALKSIDFNNSTATVAHGDDMISIQAQLIVAADGTESMTRHLCNLPVKIKDYA
CCHHHCHHHHHHCCCCCCEEEEECCCCEEEEEEEEEEEECCHHHHHHHHHCCCEEEHHHH
QDAIVANVGLIKPHGNRAFERFTPNGPLALLPMMNDKMSLVWASKPEEAKRLVMLNDGDF
HHHHEEECEEECCCCCCHHHHCCCCCCEEEEEECCCCEEEEECCCCCCCCEEEEECCCHH
LRELQTAFGYRLGRFGKVGKRYSYPLKQVLMPQQTKWPVVFVGNAAHTLHPVAGQGFNLG
HHHHHHHHHHHHHHHHCCCCCCCCCHHHHHCCCCCCCCEEEECCCCCEECCCCCCCCCCC
LRDIAALAQCVSQKGLNPQMLEHYLKLRAHDQQMITWLTDGLIHLFTSRLPGMGVARNLG
HHHHHHHHHHHHHCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCCCHHHCCC
LLALDNIPALKNLLARYARGFGGITPDLVCEIALSTGEFQ
EEEECCCHHHHHHHHHHHHHCCCCCHHHHEEEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: 2-octaprenyl-6-methoxyphenol; O2 [C]

Specific reaction: 2-octaprenyl-6-methoxyphenol + O2 = H2O + 2-octaprenyl-6-methoxy-1,4-benzoquinone [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1339425; 9278503 [H]