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The map label for this gene is pepP [H]

Identifier: 148358237

GI number: 148358237

Start: 96661

End: 97971

Strand: Direct

Name: pepP [H]

Synonym: LPC_0099

Alternate gene names: 148358237

Gene position: 96661-97971 (Clockwise)

Preceding gene: 148358236

Following gene: 148358238

Centisome position: 2.7

GC content: 42.94

Gene sequence:

>1311_bases
ATGATAAGCCAACAAGAATATAAGGCGAGAAGAAAAAAATTAGCTGCGCAATTGCCTGATGACAGTGTTGCTGTAATACC
TGCAGCACATGAAGTGCTGCGCAGTGGAGATACTCATTATCGATTTCGACAGGACAGTGATTTTTATTATTTAACAGGAT
TTAATGAGCCTGATGCTTTGCTGGTCATTATTGCGGGAAAGGATAGCCAAAGTATTTTGTTTAATCGCCCAAGAAATCCT
GCAGAAGAACAATGGACAGGTAAACGATTAGGTCAGGATGGCGCTTTGCAAGAGCTTGGAGTGCAGGCGGCATACCCATT
AAGCAGTATTGCAGAAGAGCTTCCTAAACTATTCAGCGGGAAATCTGCCATATACTATGACCTCGGCCGTAATTTATCAT
TGGAAAAAAAAATCAGGCATGTTTTATCTTCACTAAAAGCTCAGGTGAGAAGAGGCATTAAGGCACCTGAGTCGTTATGC
GATCTCGAACCTATTCTAAGCGAAATGCGTTTGCTTAAAAGCGATGCGGAATTAGAGTTAATGAGACAGGCAGCCCGTAT
TTCAGTGGCTGCTCATAAACGAGCGATGCAAGTTTGTCAGAAAATGGAATATGAGTACCAACTGGAGGCAGAATTAATCT
ATGAGTTTAGCCGTCATGGCTGTCGTAGTGTAGCTTATGACCCTATCGTGGGTGGTGGCGCCAATGCCTGCATTCTTCAT
TATACAGAAAATAACAAACCTTTGCGCCGTGGCGATTTGGTGCTCATTGATGCAGGGGGCGAATATGGTAGTTATGCCGC
AGACATTACCAGAACTTTCCCGGTAAGCGGTACTTTTAGCCCTGAGCAGAAAATCATTTATGAATTGGTATTGAAAGCAC
AAAAAGCTGGCATAGCAGCGATTGAACCGGGCCTTCCCTGGAATCATATTCAGCAGACTATTATCAGAATTCTTACTGAG
GGTCTCTGTGATATAGGAATTTTAAAGGGCGATTTGGAGGAGCTCATTAAAAATGAAGCCTATAAACCATTTTATATGCA
TAATTCAGGACATTGGTTAGGATTGGATGTGCATGATGTCGGGCGATATAAAATCAATAATGAATGGCGTCCTTTAGAGG
CCGGAATGGTATTAACAGTAGAACCAGGGCTGTATATAAGCGCAGGGATGGAAGGCGTTGATAAACGATGGTGGGATATC
GGTGTGCGTATAGAAGATGATATTCTGGTAACCAGGGCGGGATATGAGGTATTGACCGGTGACTTGCCTGTTAATGTAGA
TGATATTGAGGCTTTGATGCGTGGCGAATAA

Upstream 100 bases:

>100_bases
AAGTTGAGAAGGTATCAAAGTTGTTTGTATTTATTGGTTTCTTTGATTTTTTAAGGATTGCTCATTTGTTCTATTTATTA
AAGTGAAAAGGGAAATTGAT

Downstream 100 bases:

>100_bases
AGAGACTGATATACTGATTATTGGCGGTGGTTTGACTGGCGCAAGCTTATCCCTGGCTCTGCAGGGATTAGGTTTCTCTG
TCACGTTAGTAGAATCCAGG

Product: hypothetical protein

Products: NA

Alternate protein names: Aminoacylproline aminopeptidase; Aminopeptidase P II; APP-II; X-Pro aminopeptidase [H]

Number of amino acids: Translated: 436; Mature: 436

Protein sequence:

>436_residues
MISQQEYKARRKKLAAQLPDDSVAVIPAAHEVLRSGDTHYRFRQDSDFYYLTGFNEPDALLVIIAGKDSQSILFNRPRNP
AEEQWTGKRLGQDGALQELGVQAAYPLSSIAEELPKLFSGKSAIYYDLGRNLSLEKKIRHVLSSLKAQVRRGIKAPESLC
DLEPILSEMRLLKSDAELELMRQAARISVAAHKRAMQVCQKMEYEYQLEAELIYEFSRHGCRSVAYDPIVGGGANACILH
YTENNKPLRRGDLVLIDAGGEYGSYAADITRTFPVSGTFSPEQKIIYELVLKAQKAGIAAIEPGLPWNHIQQTIIRILTE
GLCDIGILKGDLEELIKNEAYKPFYMHNSGHWLGLDVHDVGRYKINNEWRPLEAGMVLTVEPGLYISAGMEGVDKRWWDI
GVRIEDDILVTRAGYEVLTGDLPVNVDDIEALMRGE

Sequences:

>Translated_436_residues
MISQQEYKARRKKLAAQLPDDSVAVIPAAHEVLRSGDTHYRFRQDSDFYYLTGFNEPDALLVIIAGKDSQSILFNRPRNP
AEEQWTGKRLGQDGALQELGVQAAYPLSSIAEELPKLFSGKSAIYYDLGRNLSLEKKIRHVLSSLKAQVRRGIKAPESLC
DLEPILSEMRLLKSDAELELMRQAARISVAAHKRAMQVCQKMEYEYQLEAELIYEFSRHGCRSVAYDPIVGGGANACILH
YTENNKPLRRGDLVLIDAGGEYGSYAADITRTFPVSGTFSPEQKIIYELVLKAQKAGIAAIEPGLPWNHIQQTIIRILTE
GLCDIGILKGDLEELIKNEAYKPFYMHNSGHWLGLDVHDVGRYKINNEWRPLEAGMVLTVEPGLYISAGMEGVDKRWWDI
GVRIEDDILVTRAGYEVLTGDLPVNVDDIEALMRGE
>Mature_436_residues
MISQQEYKARRKKLAAQLPDDSVAVIPAAHEVLRSGDTHYRFRQDSDFYYLTGFNEPDALLVIIAGKDSQSILFNRPRNP
AEEQWTGKRLGQDGALQELGVQAAYPLSSIAEELPKLFSGKSAIYYDLGRNLSLEKKIRHVLSSLKAQVRRGIKAPESLC
DLEPILSEMRLLKSDAELELMRQAARISVAAHKRAMQVCQKMEYEYQLEAELIYEFSRHGCRSVAYDPIVGGGANACILH
YTENNKPLRRGDLVLIDAGGEYGSYAADITRTFPVSGTFSPEQKIIYELVLKAQKAGIAAIEPGLPWNHIQQTIIRILTE
GLCDIGILKGDLEELIKNEAYKPFYMHNSGHWLGLDVHDVGRYKINNEWRPLEAGMVLTVEPGLYISAGMEGVDKRWWDI
GVRIEDDILVTRAGYEVLTGDLPVNVDDIEALMRGE

Specific function: Unknown

COG id: COG0006

COG function: function code E; Xaa-Pro aminopeptidase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M24B family [H]

Homologues:

Organism=Homo sapiens, GI11559925, Length=446, Percent_Identity=34.304932735426, Blast_Score=252, Evalue=4e-67,
Organism=Homo sapiens, GI149589008, Length=461, Percent_Identity=34.2733188720174, Blast_Score=206, Evalue=3e-53,
Organism=Homo sapiens, GI260593665, Length=307, Percent_Identity=37.785016286645, Blast_Score=192, Evalue=7e-49,
Organism=Homo sapiens, GI260593663, Length=459, Percent_Identity=31.1546840958606, Blast_Score=169, Evalue=7e-42,
Organism=Homo sapiens, GI264681563, Length=343, Percent_Identity=27.9883381924198, Blast_Score=72, Evalue=7e-13,
Organism=Escherichia coli, GI1789275, Length=434, Percent_Identity=47.4654377880184, Blast_Score=404, Evalue=1e-114,
Organism=Escherichia coli, GI1788728, Length=254, Percent_Identity=31.496062992126, Blast_Score=116, Evalue=2e-27,
Organism=Escherichia coli, GI1790282, Length=292, Percent_Identity=30.1369863013699, Blast_Score=98, Evalue=1e-21,
Organism=Caenorhabditis elegans, GI17508215, Length=459, Percent_Identity=30.718954248366, Blast_Score=187, Evalue=1e-47,
Organism=Caenorhabditis elegans, GI71989583, Length=368, Percent_Identity=26.0869565217391, Blast_Score=126, Evalue=2e-29,
Organism=Saccharomyces cerevisiae, GI6320922, Length=445, Percent_Identity=31.9101123595506, Blast_Score=223, Evalue=6e-59,
Organism=Saccharomyces cerevisiae, GI6321118, Length=429, Percent_Identity=32.6340326340326, Blast_Score=198, Evalue=2e-51,
Organism=Drosophila melanogaster, GI19920384, Length=403, Percent_Identity=36.7245657568238, Blast_Score=224, Evalue=1e-58,
Organism=Drosophila melanogaster, GI21357079, Length=453, Percent_Identity=34.2163355408389, Blast_Score=211, Evalue=7e-55,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001714
- InterPro:   IPR000994
- InterPro:   IPR007865
- InterPro:   IPR001131 [H]

Pfam domain/function: PF05195 AMP_N; PF00557 Peptidase_M24 [H]

EC number: =3.4.11.9 [H]

Molecular weight: Translated: 48935; Mature: 48935

Theoretical pI: Translated: 5.52; Mature: 5.52

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MISQQEYKARRKKLAAQLPDDSVAVIPAAHEVLRSGDTHYRFRQDSDFYYLTGFNEPDAL
CCCHHHHHHHHHHHHHCCCCCCEEEEHHHHHHHHCCCCCEEEECCCCEEEEECCCCCCEE
LVIIAGKDSQSILFNRPRNPAEEQWTGKRLGQDGALQELGVQAAYPLSSIAEELPKLFSG
EEEEECCCCCCEEEECCCCCHHHHHHHHHCCCCCCHHHHCCCCCCCHHHHHHHHHHHHCC
KSAIYYDLGRNLSLEKKIRHVLSSLKAQVRRGIKAPESLCDLEPILSEMRLLKSDAELEL
CCEEEEECCCCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCHHHHH
MRQAARISVAAHKRAMQVCQKMEYEYQLEAELIYEFSRHGCRSVAYDPIVGGGANACILH
HHHHHHHHHHHHHHHHHHHHHCCCCEEHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEEE
YTENNKPLRRGDLVLIDAGGEYGSYAADITRTFPVSGTFSPEQKIIYELVLKAQKAGIAA
EECCCCCCCCCCEEEEECCCCCCCCHHHHEEECCCCCCCCHHHHHHHHHHHHHHHCCCEE
IEPGLPWNHIQQTIIRILTEGLCDIGILKGDLEELIKNEAYKPFYMHNSGHWLGLDVHDV
ECCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCCEEEECCCCEEEEEHHHC
GRYKINNEWRPLEAGMVLTVEPGLYISAGMEGVDKRWWDIGVRIEDDILVTRAGYEVLTG
CCEEECCCCCEECCCEEEEECCCEEEECCCCCCCCHHEEECCEEECCEEEEECCCEEEEC
DLPVNVDDIEALMRGE
CCCCCHHHHHHHHCCC
>Mature Secondary Structure
MISQQEYKARRKKLAAQLPDDSVAVIPAAHEVLRSGDTHYRFRQDSDFYYLTGFNEPDAL
CCCHHHHHHHHHHHHHCCCCCCEEEEHHHHHHHHCCCCCEEEECCCCEEEEECCCCCCEE
LVIIAGKDSQSILFNRPRNPAEEQWTGKRLGQDGALQELGVQAAYPLSSIAEELPKLFSG
EEEEECCCCCCEEEECCCCCHHHHHHHHHCCCCCCHHHHCCCCCCCHHHHHHHHHHHHCC
KSAIYYDLGRNLSLEKKIRHVLSSLKAQVRRGIKAPESLCDLEPILSEMRLLKSDAELEL
CCEEEEECCCCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCHHHHH
MRQAARISVAAHKRAMQVCQKMEYEYQLEAELIYEFSRHGCRSVAYDPIVGGGANACILH
HHHHHHHHHHHHHHHHHHHHHCCCCEEHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEEE
YTENNKPLRRGDLVLIDAGGEYGSYAADITRTFPVSGTFSPEQKIIYELVLKAQKAGIAA
EECCCCCCCCCCEEEEECCCCCCCCHHHHEEECCCCCCCCHHHHHHHHHHHHHHHCCCEE
IEPGLPWNHIQQTIIRILTEGLCDIGILKGDLEELIKNEAYKPFYMHNSGHWLGLDVHDV
ECCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCCEEEECCCCEEEEEHHHC
GRYKINNEWRPLEAGMVLTVEPGLYISAGMEGVDKRWWDIGVRIEDDILVTRAGYEVLTG
CCEEECCCCCEECCCEEEEECCCEEEECCCCCCCCHHEEECCEEECCEEEEECCCEEEEC
DLPVNVDDIEALMRGE
CCCCCHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2659585; 1339425; 9278503; 9520390 [H]