| Definition | Orientia tsutsugamushi Boryong, complete genome. |
|---|---|
| Accession | NC_009488 |
| Length | 2,127,051 |
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The map label for this gene is virB4 [H]
Identifier: 148285050
GI number: 148285050
Start: 1877046
End: 1879463
Strand: Direct
Name: virB4 [H]
Synonym: OTBS_1950
Alternate gene names: 148285050
Gene position: 1877046-1879463 (Clockwise)
Preceding gene: 148285049
Following gene: 148285051
Centisome position: 88.25
GC content: 33.62
Gene sequence:
>2418_bases ATGAAATTTTTTAAGACTAAAGTAGCAAGGGAGTACTACTCTAAGAGAGAGGTTCATGTTGCTAAATTTATTCCATATGC TTATCATTGGAATAAATCTACTATTATTACAAAAAAGAATGAGCTAATTAAGGTTATTAAAATTAGCGGGTTTGCTTTTG AAACAGCTGATGATCAAGATCTAGATATTAGAAAAAGGCTTCGAAATCTTTTATTTAAAGGTATGGCTTCAGGTAGCCTA AATTTATATTTTCACATAATTAGACGTCGAAAGCAGCTAGCTTCAGCTATGGATGAAGGTGACATTGATCCTACTGCAGG TAGGGCAAAAGATTTTGTTACTTATGTTGATAATGAGTGGAAAAAGAAATATTCTGATTTTCAGTCTTTTGTAAATGATA TTTATATCACTATTTTATATAAACCTGATGTTGAAGGTGGAGAAATTTTAAAGTATTTTTACAATAAATTATTGCAAAAG TCTGATAAAAATGCATGGATGCAAAGTATGAATGAAATGTATGCTAACCTTGATGAGATGGTATCAAGAGTAGTGACTAC ATTTAGCGATTATGATGCACAAATATTAAAGGTTAAAAATGAACCTAATGGAGTTTTTTGTGAGATATTGGAATTTTTAG CTACTATAGTTAATTGCGGCAGTTCTATGCCTGTACTTTTACCTAGAGGGTCAATAGATAGTTATATACCTACACATAGG TTATTTTTTGGAGATCGTTCAATTGAAGCTAGAGGAGCAGGGCAGCGTAGATATGCTGGCATAGTTAGCATTCAAGAGTA TGGACCAAAAACTTCAGCTGGAGTATTAGATTCATTTTTGCAACTTCCTTTTGAGCTTATTATTAGCCAAAGTTTTCAGT TTTCTAGTCGTACAGCTGCAATTAATAAAATGCAATTGCAACAAAATAGAATGATTCAAACTGAAGATAAAGCAGTATCC CAGATTGCTGAGATTTCTCAGGCATTAGATATGGCGACCAGTGGTGAAATTGGTTTTGGCGAACATCATTTAACAGTATT ATGTATAGCTGATAGTTTGAAAGCCTTGGAAAACGCACTTTCTATTGCTTCAGTTGAAATTGCAAACACTGGTATGCAGC CAGTACGTGAGAAAGTGAATTTAGAAGCTGCTTATTGGGCACAACTGCCAGGGAATATAGAATATGCTGTAAGAAAATCA GTAATTAATACTTTAAATCTTGCAGGGTTTGCATCTATGCATAATTACCTGCCTGGAAAAGCTAAGGGAAATCACTGGGG AGATAGCGTTACAGTATTGGATACAAGCTCTGGTACTCCGTTTTACTTTAACTTTCACGTACGTGATGTTGGACATACTT TATTAATTGGGCCTACTGGAGCTGGGAAAACAGTGTTAATGAATTTTTTATGCGCTCAAGCTCAAAAATTTTATCCTAGA ACTTTCTTTTTTGATAAAGATAGAGGTGCAGAGATTTTTATCAGAGCTCTAGATGGAAAGTATACTGTAATTAATCCGTT TCAACAATGTAATTTTAATCCTTTACAATTGCCTGATACTAATGAAAATCGTAATTTTTTAGTAGAATGGATAAAAACGT TAGTTACTTCAAATGGTGAATCTATTAGCGCAGACGATATGCATTATATTACGTTAGCTGTGGAAGGGAATTATAAGCTT AATCCATCTGATCGTTACTTAAGTAATATAGTAGCATTTTTAGGAATTGGGGGTCCTGATACTCTAGCTGGAAGGATTGC AATATGGCATGGCACAGGTGCTAAAGCTGGAATATTTGATAATATTCATGATAATATGGATTTGCAAAGTGGTAGAGTTT TTGGTTTTGAGATGGGTGAGTTATTAAAAGATCCTGTTAGCTTAGCTCCAGTATTATTATATTTGTTTCACCGTATCAAT TTATCGTTGGATGGTTCACCAACTATGATAGTATTAGATGAGGCATGGGCTTTGATTGATAATCCTGTTTTTGCTCCTAA GATTAAAGATTGGTTGAAGGTATTGCGTAAGTTAAATACTTTTGTTATATTTGCTACTCAGAGTGTGGAAGATGCTTCAA AGAGCTCAATTAGTGATACTCTGATTCAGCAAACTGCTACTCAGATTTTTTTACCAAATTTAAAAGCAACCGATATCTAT AGAACTGCTTTTATGTTGAGTGAAAGGGAATTTTCTATTATTAAATCCACAGATCCTGGTTCACGGTATTTTCTAATAAA ACAAGGAATTGGTTCTGTAGTAGCTAAATTAAATTTAGCTGGCATGAATAATATCATAGGAGTGCTCTCAGGCCGAGTTG AAACTGTAATATTATTAGATCAGTTAAGAAGCGAATATGGAGATGATTCTAGAAAATGGTTGCCTAAATTTTATAAGCAC TTAGAAACAGCGAAATAA
Upstream 100 bases:
>100_bases CGTTTTATGGAAATTTACTTAATGAGAGCTCAAAAGTTTAATAAATGTCCTAATAGACTTTATTATGGCGCTAATTCATA TGGTATATAGTATTTAAATA
Downstream 100 bases:
>100_bases TGCAGTGGTTGTATCAATTAGCTAAAATAGTTATATTAATATCAGTATTTGCACTACAAATTGAAGCTATTAAGGCTATT CCCGCAATTGATATGATTAA
Product: type IV secretion system ATPase VirB4
Products: NA
Alternate protein names: NA
Number of amino acids: Translated: 805; Mature: 805
Protein sequence:
>805_residues MKFFKTKVAREYYSKREVHVAKFIPYAYHWNKSTIITKKNELIKVIKISGFAFETADDQDLDIRKRLRNLLFKGMASGSL NLYFHIIRRRKQLASAMDEGDIDPTAGRAKDFVTYVDNEWKKKYSDFQSFVNDIYITILYKPDVEGGEILKYFYNKLLQK SDKNAWMQSMNEMYANLDEMVSRVVTTFSDYDAQILKVKNEPNGVFCEILEFLATIVNCGSSMPVLLPRGSIDSYIPTHR LFFGDRSIEARGAGQRRYAGIVSIQEYGPKTSAGVLDSFLQLPFELIISQSFQFSSRTAAINKMQLQQNRMIQTEDKAVS QIAEISQALDMATSGEIGFGEHHLTVLCIADSLKALENALSIASVEIANTGMQPVREKVNLEAAYWAQLPGNIEYAVRKS VINTLNLAGFASMHNYLPGKAKGNHWGDSVTVLDTSSGTPFYFNFHVRDVGHTLLIGPTGAGKTVLMNFLCAQAQKFYPR TFFFDKDRGAEIFIRALDGKYTVINPFQQCNFNPLQLPDTNENRNFLVEWIKTLVTSNGESISADDMHYITLAVEGNYKL NPSDRYLSNIVAFLGIGGPDTLAGRIAIWHGTGAKAGIFDNIHDNMDLQSGRVFGFEMGELLKDPVSLAPVLLYLFHRIN LSLDGSPTMIVLDEAWALIDNPVFAPKIKDWLKVLRKLNTFVIFATQSVEDASKSSISDTLIQQTATQIFLPNLKATDIY RTAFMLSEREFSIIKSTDPGSRYFLIKQGIGSVVAKLNLAGMNNIIGVLSGRVETVILLDQLRSEYGDDSRKWLPKFYKH LETAK
Sequences:
>Translated_805_residues MKFFKTKVAREYYSKREVHVAKFIPYAYHWNKSTIITKKNELIKVIKISGFAFETADDQDLDIRKRLRNLLFKGMASGSL NLYFHIIRRRKQLASAMDEGDIDPTAGRAKDFVTYVDNEWKKKYSDFQSFVNDIYITILYKPDVEGGEILKYFYNKLLQK SDKNAWMQSMNEMYANLDEMVSRVVTTFSDYDAQILKVKNEPNGVFCEILEFLATIVNCGSSMPVLLPRGSIDSYIPTHR LFFGDRSIEARGAGQRRYAGIVSIQEYGPKTSAGVLDSFLQLPFELIISQSFQFSSRTAAINKMQLQQNRMIQTEDKAVS QIAEISQALDMATSGEIGFGEHHLTVLCIADSLKALENALSIASVEIANTGMQPVREKVNLEAAYWAQLPGNIEYAVRKS VINTLNLAGFASMHNYLPGKAKGNHWGDSVTVLDTSSGTPFYFNFHVRDVGHTLLIGPTGAGKTVLMNFLCAQAQKFYPR TFFFDKDRGAEIFIRALDGKYTVINPFQQCNFNPLQLPDTNENRNFLVEWIKTLVTSNGESISADDMHYITLAVEGNYKL NPSDRYLSNIVAFLGIGGPDTLAGRIAIWHGTGAKAGIFDNIHDNMDLQSGRVFGFEMGELLKDPVSLAPVLLYLFHRIN LSLDGSPTMIVLDEAWALIDNPVFAPKIKDWLKVLRKLNTFVIFATQSVEDASKSSISDTLIQQTATQIFLPNLKATDIY RTAFMLSEREFSIIKSTDPGSRYFLIKQGIGSVVAKLNLAGMNNIIGVLSGRVETVILLDQLRSEYGDDSRKWLPKFYKH LETAK >Mature_805_residues MKFFKTKVAREYYSKREVHVAKFIPYAYHWNKSTIITKKNELIKVIKISGFAFETADDQDLDIRKRLRNLLFKGMASGSL NLYFHIIRRRKQLASAMDEGDIDPTAGRAKDFVTYVDNEWKKKYSDFQSFVNDIYITILYKPDVEGGEILKYFYNKLLQK SDKNAWMQSMNEMYANLDEMVSRVVTTFSDYDAQILKVKNEPNGVFCEILEFLATIVNCGSSMPVLLPRGSIDSYIPTHR LFFGDRSIEARGAGQRRYAGIVSIQEYGPKTSAGVLDSFLQLPFELIISQSFQFSSRTAAINKMQLQQNRMIQTEDKAVS QIAEISQALDMATSGEIGFGEHHLTVLCIADSLKALENALSIASVEIANTGMQPVREKVNLEAAYWAQLPGNIEYAVRKS VINTLNLAGFASMHNYLPGKAKGNHWGDSVTVLDTSSGTPFYFNFHVRDVGHTLLIGPTGAGKTVLMNFLCAQAQKFYPR TFFFDKDRGAEIFIRALDGKYTVINPFQQCNFNPLQLPDTNENRNFLVEWIKTLVTSNGESISADDMHYITLAVEGNYKL NPSDRYLSNIVAFLGIGGPDTLAGRIAIWHGTGAKAGIFDNIHDNMDLQSGRVFGFEMGELLKDPVSLAPVLLYLFHRIN LSLDGSPTMIVLDEAWALIDNPVFAPKIKDWLKVLRKLNTFVIFATQSVEDASKSSISDTLIQQTATQIFLPNLKATDIY RTAFMLSEREFSIIKSTDPGSRYFLIKQGIGSVVAKLNLAGMNNIIGVLSGRVETVILLDQLRSEYGDDSRKWLPKFYKH LETAK
Specific function: The type IV secretion system VirB/VirD4 is a major virulence determinant for subversion of human endothelial cell (HEC) function. VirB-dependent changes of HEC include massive cytoskeletal rearrangements, a proinflammatory activation by nuclear factor NF-
COG id: COG3451
COG function: function code U; Type IV secretory pathway, VirB4 components
Gene ontology:
Cell location: Cell inner membrane (Potential) [H]
Metaboloic importance: NA
Operon status: Not Known
Operon components: None
Similarity: Belongs to the trbE/virB4 family [H]
Homologues:
None
Paralogues:
None
Copy number: NA
Swissprot (AC and ID): NA
Other databases:
- InterPro: IPR003593 - InterPro: IPR004346 - InterPro: IPR018145 [H]
Pfam domain/function: PF03135 CagE_TrbE_VirB [H]
EC number: NA
Molecular weight: Translated: 90622; Mature: 90622
Theoretical pI: Translated: 8.17; Mature: 8.17
Prosite motif: NA
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
0.6 %Cys (Translated Protein) 2.5 %Met (Translated Protein) 3.1 %Cys+Met (Translated Protein) 0.6 %Cys (Mature Protein) 2.5 %Met (Mature Protein) 3.1 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MKFFKTKVAREYYSKREVHVAKFIPYAYHWNKSTIITKKNELIKVIKISGFAFETADDQD CCHHHHHHHHHHHHHCCEEHHHHCCEEEEECCEEEEEECCCEEEEEEEECEEEECCCCCC LDIRKRLRNLLFKGMASGSLNLYFHIIRRRKQLASAMDEGDIDPTAGRAKDFVTYVDNEW CHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHCHHH KKKYSDFQSFVNDIYITILYKPDVEGGEILKYFYNKLLQKSDKNAWMQSMNEMYANLDEM HHHHHHHHHHHCCEEEEEEECCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCHHHH VSRVVTTFSDYDAQILKVKNEPNGVFCEILEFLATIVNCGSSMPVLLPRGSIDSYIPTHR HHHHHHHHCCCCEEEEEEECCCCCHHHHHHHHHHHHHHCCCCCCEEEECCCCCCCCCCCE LFFGDRSIEARGAGQRRYAGIVSIQEYGPKTSAGVLDSFLQLPFELIISQSFQFSSRTAA EEECCCCCCCCCCCCCHHEEEEEHHHCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCHHHH INKMQLQQNRMIQTEDKAVSQIAEISQALDMATSGEIGFGEHHLTVLCIADSLKALENAL HHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEEEEHHHHHHHHHHH SIASVEIANTGMQPVREKVNLEAAYWAQLPGNIEYAVRKSVINTLNLAGFASMHNYLPGK HHHEEEHHCCCCHHHHHHHCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCC AKGNHWGDSVTVLDTSSGTPFYFNFHVRDVGHTLLIGPTGAGKTVLMNFLCAQAQKFYPR CCCCCCCCEEEEEECCCCCCEEEEEEEEECCCEEEEECCCCCHHHHHHHHHHHHHHCCCC TFFFDKDRGAEIFIRALDGKYTVINPFQQCNFNPLQLPDTNENRNFLVEWIKTLVTSNGE EEEEECCCCCEEEEEEECCCEEEECCHHHCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCC SISADDMHYITLAVEGNYKLNPSDRYLSNIVAFLGIGGPDTLAGRIAIWHGTGAKAGIFD CCCCCCEEEEEEEEECCEEECCHHHHHHHHHHHHCCCCCCCCCCEEEEEECCCCCCCCCC NIHDNMDLQSGRVFGFEMGELLKDPVSLAPVLLYLFHRINLSLDGSPTMIVLDEAWALID CCCCCCCCCCCCEEEEEHHHHHHCHHHHHHHHHHHHHHHCEEECCCCCEEEEECCHHHHC NPVFAPKIKDWLKVLRKLNTFVIFATQSVEDASKSSISDTLIQQTATQIFLPNLKATDIY CCCCCHHHHHHHHHHHHCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHH RTAFMLSEREFSIIKSTDPGSRYFLIKQGIGSVVAKLNLAGMNNIIGVLSGRVETVILLD HHHHHHCCCCEEEEECCCCCCEEEEEECCHHHHHHHHHHCCHHHHHHHHCCCHHHHHHHH QLRSEYGDDSRKWLPKFYKHLETAK HHHHHHCCCHHHHHHHHHHHHHCCC >Mature Secondary Structure MKFFKTKVAREYYSKREVHVAKFIPYAYHWNKSTIITKKNELIKVIKISGFAFETADDQD CCHHHHHHHHHHHHHCCEEHHHHCCEEEEECCEEEEEECCCEEEEEEEECEEEECCCCCC LDIRKRLRNLLFKGMASGSLNLYFHIIRRRKQLASAMDEGDIDPTAGRAKDFVTYVDNEW CHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHCHHH KKKYSDFQSFVNDIYITILYKPDVEGGEILKYFYNKLLQKSDKNAWMQSMNEMYANLDEM HHHHHHHHHHHCCEEEEEEECCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCHHHH VSRVVTTFSDYDAQILKVKNEPNGVFCEILEFLATIVNCGSSMPVLLPRGSIDSYIPTHR HHHHHHHHCCCCEEEEEEECCCCCHHHHHHHHHHHHHHCCCCCCEEEECCCCCCCCCCCE LFFGDRSIEARGAGQRRYAGIVSIQEYGPKTSAGVLDSFLQLPFELIISQSFQFSSRTAA EEECCCCCCCCCCCCCHHEEEEEHHHCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCHHHH INKMQLQQNRMIQTEDKAVSQIAEISQALDMATSGEIGFGEHHLTVLCIADSLKALENAL HHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEEEEHHHHHHHHHHH SIASVEIANTGMQPVREKVNLEAAYWAQLPGNIEYAVRKSVINTLNLAGFASMHNYLPGK HHHEEEHHCCCCHHHHHHHCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCC AKGNHWGDSVTVLDTSSGTPFYFNFHVRDVGHTLLIGPTGAGKTVLMNFLCAQAQKFYPR CCCCCCCCEEEEEECCCCCCEEEEEEEEECCCEEEEECCCCCHHHHHHHHHHHHHHCCCC TFFFDKDRGAEIFIRALDGKYTVINPFQQCNFNPLQLPDTNENRNFLVEWIKTLVTSNGE EEEEECCCCCEEEEEEECCCEEEECCHHHCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCC SISADDMHYITLAVEGNYKLNPSDRYLSNIVAFLGIGGPDTLAGRIAIWHGTGAKAGIFD CCCCCCEEEEEEEEECCEEECCHHHHHHHHHHHHCCCCCCCCCCEEEEEECCCCCCCCCC NIHDNMDLQSGRVFGFEMGELLKDPVSLAPVLLYLFHRINLSLDGSPTMIVLDEAWALID CCCCCCCCCCCCEEEEEHHHHHHCHHHHHHHHHHHHHHHCEEECCCCCEEEEECCHHHHC NPVFAPKIKDWLKVLRKLNTFVIFATQSVEDASKSSISDTLIQQTATQIFLPNLKATDIY CCCCCHHHHHHHHHHHHCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHH RTAFMLSEREFSIIKSTDPGSRYFLIKQGIGSVVAKLNLAGMNNIIGVLSGRVETVILLD HHHHHHCCCCEEEEECCCCCCEEEEEECCHHHHHHHHHHCCHHHHHHHHCCCHHHHHHHH QLRSEYGDDSRKWLPKFYKHLETAK HHHHHHCCCHHHHHHHHHHHHHCCC
PDB accession: NA
Resolution: NA
Structure class: Alpha Beta
Cofactors: NA
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): NA
Substrates: NA
Specific reaction: NA
General reaction: NA
Inhibitor: NA
Structure determination priority: 6.0
TargetDB status: NA
Availability: NA
References: 10749166; 10882236; 7494028 [H]